EP2741771A4 - Methods and compositions for the treatment of autoimmune and inflammatory diseases - Google Patents

Methods and compositions for the treatment of autoimmune and inflammatory diseases

Info

Publication number
EP2741771A4
EP2741771A4 EP20120821568 EP12821568A EP2741771A4 EP 2741771 A4 EP2741771 A4 EP 2741771A4 EP 20120821568 EP20120821568 EP 20120821568 EP 12821568 A EP12821568 A EP 12821568A EP 2741771 A4 EP2741771 A4 EP 2741771A4
Authority
EP
European Patent Office
Prior art keywords
autoimmune
compositions
treatment
methods
inflammatory diseases
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP20120821568
Other languages
German (de)
French (fr)
Other versions
EP2741771B1 (en
EP2741771A2 (en
Inventor
Lisa Laury-Kleintop
Laura Mandik-Nayak
George C Prendergast
James Duhadaway
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lankenau Institute for Medical Research
Original Assignee
Lankenau Institute for Medical Research
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lankenau Institute for Medical Research filed Critical Lankenau Institute for Medical Research
Publication of EP2741771A2 publication Critical patent/EP2741771A2/en
Publication of EP2741771A4 publication Critical patent/EP2741771A4/en
Application granted granted Critical
Publication of EP2741771B1 publication Critical patent/EP2741771B1/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
    • C07K14/39—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts
    • C07K14/40—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts from Candida
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0008—Antigens related to auto-immune diseases; Preparations to induce self-tolerance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A61K2039/575—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 humoral response
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A61K2039/577—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 tolerising response

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pain & Pain Management (AREA)
  • Emergency Medicine (AREA)
  • Neurology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Transplantation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
EP12821568.8A 2011-08-10 2012-08-09 Methods and compositions for the treatment of autoimmune and inflammatory diseases Active EP2741771B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161522009P 2011-08-10 2011-08-10
PCT/US2012/050146 WO2013023059A2 (en) 2011-08-10 2012-08-09 Methods and compositions for the treatment of autoimmune and inflammatory diseases

Publications (3)

Publication Number Publication Date
EP2741771A2 EP2741771A2 (en) 2014-06-18
EP2741771A4 true EP2741771A4 (en) 2015-04-15
EP2741771B1 EP2741771B1 (en) 2020-04-29

Family

ID=47669232

Family Applications (1)

Application Number Title Priority Date Filing Date
EP12821568.8A Active EP2741771B1 (en) 2011-08-10 2012-08-09 Methods and compositions for the treatment of autoimmune and inflammatory diseases

Country Status (10)

Country Link
US (3) US9879092B2 (en)
EP (1) EP2741771B1 (en)
JP (1) JP6253580B2 (en)
KR (2) KR102101478B1 (en)
CN (1) CN104114184B (en)
AU (1) AU2012294342B2 (en)
CA (1) CA2844668C (en)
ES (1) ES2813415T3 (en)
RU (1) RU2639540C2 (en)
WO (1) WO2013023059A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20150231215A1 (en) 2012-06-22 2015-08-20 Randolph J. Noelle VISTA Antagonist and Methods of Use
CN109793893B (en) 2012-09-07 2023-05-26 达特茅斯大学理事会 VISTA modulators for diagnosis and treatment of cancer
US11447568B2 (en) * 2014-04-10 2022-09-20 Lankenau Institute For Medical Research Methods and compositions for the treatment of ocular diseases and disorders
MX2018009800A (en) 2016-02-12 2018-11-09 Janssen Pharmaceutica Nv Anti-vista (b7h5) antibodies.
CA3020848A1 (en) 2016-04-15 2017-10-19 Janssen Pharmaceuticals, Inc. Anti-human vista antibodies and use thereof
US20200200760A1 (en) * 2017-05-16 2020-06-25 Lankenau Institute Of Medical Research Compositions comprising ligands to rhob protein and the uses thereof
KR102276941B1 (en) * 2018-07-03 2021-07-14 서울대학교산학협력단 Peptides for treating rheumatoid arthritis and uses thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5962672A (en) * 1998-09-18 1999-10-05 Isis Pharmaceuticals Inc. Antisense modulation of RhoB expression

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993022332A2 (en) * 1992-04-24 1993-11-11 Board Of Regents, The University Of Texas System Recombinant production of immunoglobulin-like domains in prokaryotic cells
US6458783B1 (en) * 1997-09-29 2002-10-01 Bristol-Myers Squibb Company Non-imidazole benzodiazepine inhibitors of farnesyl protein transferase
CA2304473A1 (en) * 1997-09-29 1999-04-22 Rajeev S. Bhide Inhibitors of farnesyl protein transferase
US20050032733A1 (en) 2001-05-18 2005-02-10 Sirna Therapeutics, Inc. RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (SiNA)
EP1656156A2 (en) * 2003-08-13 2006-05-17 Children's Hospital Medical Center Mobilization of hematopoietic cells
JP4967137B2 (en) * 2005-04-18 2012-07-04 国立大学法人浜松医科大学 Cancer treatment composition
US20070213354A1 (en) 2006-03-08 2007-09-13 Amplimed Corporation Compositions and Methods for the Treatment of Multiple Sclerosis
RU2489166C2 (en) * 2006-04-09 2013-08-10 Джинентех, Инк. Using antibodies for treating autoimmune diseases in patient with inadequate response to tnf-alpha inhibitor
JP5354634B2 (en) * 2007-01-25 2013-11-27 国立大学法人大阪大学 Human ABH8 protein, gene encoding it, and therapeutic or diagnostic uses thereof
EP2221063A1 (en) 2009-02-20 2010-08-25 Ganymed Pharmaceuticals AG Methods and compositions for diagnosis and treatment of cancer

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5962672A (en) * 1998-09-18 1999-10-05 Isis Pharmaceuticals Inc. Antisense modulation of RhoB expression

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
ANDRÉA SILVEIRA SANTOS-BREDARIOL ET AL: "Small GTP-binding protein RhoB is expressed in glial müller cells in the vertebrate retina", THE JOURNAL OF COMPARATIVE NEUROLOGY, vol. 494, no. 6, 20 February 2006 (2006-02-20), pages 976 - 985, XP055172812, ISSN: 0021-9967, DOI: 10.1002/cne.20861 *
ANONYMOUS: "Rho B Antibody (C-5) | Santa Cruz Biotech", 1 January 2015 (2015-01-01), XP055172701, Retrieved from the Internet <URL:http://www.scbt.com/datasheet-8048-rho-b-c-5-antibody.html> [retrieved on 20150227] *
JEAN-PIERRE SEGAIN ET AL: "Rho kinase blockade prevents inflammation via nuclear factor kappaB inhibition: Evidence in Crohn's disease and experimental colitis", vol. 124, no. 5, 1 May 2003 (2003-05-01), pages 1180 - 1187, XP002699002, ISSN: 0016-5085, Retrieved from the Internet <URL:http://www.sciencedirect.com/science/article/pii/S001650850300283X> [retrieved on 20150303], DOI: 10.1016/S0016-5085(03)00283-X *
See also references of WO2013023059A2 *
SUN X ET AL: "The selective Rho-kinase inhibitor Fasudil is protective and therapeutic in experimental autoimmune encephalomyelitis", JOURNAL OF NEUROIMMUNOLOGY, ELSEVIER SCIENCE PUBLISHERS BV, NL, vol. 180, no. 1-2, 1 November 2006 (2006-11-01), pages 126 - 134, XP027901570, ISSN: 0165-5728, [retrieved on 20061101] *
WANG L ET AL: "A novel strategy for specifically down-regulating individual Rho GTPase activity in tumor cells", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, US, vol. 278, no. 45, 7 November 2003 (2003-11-07), pages 44617 - 44625, XP002312008, ISSN: 0021-9258, DOI: 10.1074/JBC.M308929200 *
ZHAO DEZHENG ET AL: "Rho GTPases as therapeutic targets for the treatment of inflammatory diseases", EXPERT OPINION ON THERAPEUTIC TARGETS, INFORMA HEALTHCARE, GB, vol. 7, no. 5, 1 October 2003 (2003-10-01), pages 583 - 592, XP009182895, ISSN: 1744-7631 *

Also Published As

Publication number Publication date
KR102221068B1 (en) 2021-02-25
US20210040230A1 (en) 2021-02-11
ES2813415T3 (en) 2021-03-23
RU2639540C2 (en) 2017-12-21
US20140227279A1 (en) 2014-08-14
KR20140067027A (en) 2014-06-03
KR102101478B1 (en) 2020-04-16
RU2014106933A (en) 2015-09-20
US20180094076A1 (en) 2018-04-05
EP2741771B1 (en) 2020-04-29
JP6253580B2 (en) 2017-12-27
JP2014529590A (en) 2014-11-13
CN104114184B (en) 2017-04-19
WO2013023059A2 (en) 2013-02-14
KR20200042013A (en) 2020-04-22
AU2012294342A1 (en) 2014-03-06
EP2741771A2 (en) 2014-06-18
AU2012294342B2 (en) 2017-07-27
CA2844668C (en) 2021-03-09
CN104114184A (en) 2014-10-22
WO2013023059A3 (en) 2013-04-04
CA2844668A1 (en) 2013-02-14
US9879092B2 (en) 2018-01-30

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