EP2734301B1 - Partie adaptation de liaison de pointes de pipette - Google Patents

Partie adaptation de liaison de pointes de pipette Download PDF

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Publication number
EP2734301B1
EP2734301B1 EP12740432.5A EP12740432A EP2734301B1 EP 2734301 B1 EP2734301 B1 EP 2734301B1 EP 12740432 A EP12740432 A EP 12740432A EP 2734301 B1 EP2734301 B1 EP 2734301B1
Authority
EP
European Patent Office
Prior art keywords
adapter
pipettor
tubes
sealing
array
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
EP12740432.5A
Other languages
German (de)
English (en)
Other versions
EP2734301A1 (fr
Inventor
Richard Cote
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Avidien Technologies
Original Assignee
Avidien Technologies
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Avidien Technologies filed Critical Avidien Technologies
Priority to EP20159231.8A priority Critical patent/EP3682969B1/fr
Priority to EP18184263.4A priority patent/EP3412362B1/fr
Publication of EP2734301A1 publication Critical patent/EP2734301A1/fr
Application granted granted Critical
Publication of EP2734301B1 publication Critical patent/EP2734301B1/fr
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5025—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures for parallel transport of multiple samples
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/021—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids
    • B01L3/0217—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids of the plunger pump type
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/021—Adjust spacings in an array of wells, pipettes or holders, format transfer between arrays of different size or geometry
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/023—Adapting objects or devices to another adapted for different sizes of tubes, tips or container
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/025—Align devices or objects to ensure defined positions relative to each other
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0829—Multi-well plates; Microtitration plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/0275—Interchangeable or disposable dispensing tips
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/56—Labware specially adapted for transferring fluids
    • B01L3/563—Joints or fittings ; Separable fluid transfer means to transfer fluids between at least two containers, e.g. connectors
    • B01L3/5635—Joints or fittings ; Separable fluid transfer means to transfer fluids between at least two containers, e.g. connectors connecting two containers face to face, e.g. comprising a filter

Definitions

  • This invention relates generally to multichannel air displacement pipettors employing disposable pipette tips, and is concerned in the particular with the provision of an adapter for providing an interface between the pipette tips and the pipettor.
  • Air displacement pipettors are typically used to transfer liquids between vessels as part of an assay.
  • Common vessels are microtiter plates, test tubes and reservoirs.
  • Air displacement pipettors frequently make use of a piston and cylinder arrangement, which is used to create positive and negative pressure in an attached pipette tip. When the open end of the tip is placed into a liquid, the change in pressure causes the liquid to be aspirated into, or dispensed from, the interior of the pipette tip.
  • Cross contamination can occur when a first liquid sample aspirated into and then dispensed from a pipette tip leaves a residual amount of sample in the tip. A subsequently aspirated sample mixes with the residual first sample and is thus contaminated. This type of cross contamination can also occur through residual sample on the exterior of the pipette tip.
  • pipette tips are commonly injection molded in a chemically resistant material such as polypropylene. They are conical in shape.
  • the pipettor's mounting shaft is typically cylindrical with a slight taper that closely matches the conical angle and diameter of the tip.
  • the tip is installed by applying an axial force to the mounting shaft that forces the tapered portion of the shaft into the tip. Flexibility of the tip material allows it to stretch radially and provide both an air-tight seal and mechanical stability of the tip to the pipetting device.
  • the typical axial force required to securely mount a single tip onto a tip mounting shaft is between 1.5 and 4 lbs (6.7 and 1.8 N).
  • a stripper mechanism is typically used to push the tip from the mounting shaft. Tip ejection forces are in the same range as the mounting forces.
  • Pipette tips are frequently packaged in a rack that positions them with their top surfaces in a common plane with centerline spacing that matches that of the instrument. For example, a 96 channel pipette tip rack holds an 8 x 12 array of tips with 9mm between centers. The high forces required to attach all of the tips in the rack often causes the tip rack to bow in the center of the array, resulting in poor sealing and attachment of centrally located tips. To counter this, tip manufacturers reinforce the tip racks intended for use with multichannel pipettors. This, in turn, increases the cost of the racks and therefore the cost to operate the instrument.
  • US 2002/086440 A1 dislcoses a known multichannel pipetting apparatus for simultaneous pipetting of a plurality of sample wells or containers.
  • the pipetting channels of the apparatus have been divided into groups, which are connected via an adapter containing a plurality of channels to pipetting tips of a known type.
  • an adapter containing a plurality of channels to pipetting tips of a known type.
  • embodiments of the present invention address the drawbacks of the prior art by providing a pipette tip adapter whose purpose is to adapt commonly available low cost pipette tips to a multichannel air displacement pipettor in a way that reduces the mounting and ejection forces described above.
  • Any universal pipette tip available in the marketplace can be assembled to the pipette tip adapter.
  • End users of the related multichannel air displacement pipettor designed to accept the pipette tip adapter would install the assembly onto the pipettor.
  • the pipette tip adapter reduces the forces required to mount and seal the tips to less than 10 lbs (44 N). Ejection forces are equally reduced.
  • the pipette tip adapter of the present invention comprises a planar base with an array of openings extending between its top and bottom surfaces. Sealing tubes project upwardly from top surface of the base, and tip mounting tubes project downwardly from the bottom surface of the base. Pairs of sealing tubes and tip mounting tubes re arranged coaxially and in communication with respective ones of the openings in the base.
  • the tip mounting tubes are externally dimensioned and configured for insertion into the conical upper ends of pipette tips, and the sealing tubes are externally configured and dimensioned for insertion into ports of a multichannel air displacement pipettor.
  • the base may preferably be strengthened by networks of reinforcing ribs on its top and/or bottom surfaces.
  • a pipettor tip adapter in accordance with an exemplary embodiment of the present invention is generally indicated at 10.
  • the pipette tip adapter comprises a planar base 12 with an array of openings 14 extending between bottom and top surface 16, 18 of the base.
  • Sealing tubes indicated typically at 20 project upwardly from the top surface 16, and tip mounting tubes indicated typically at 22 project downwardly from the bottom surface 18. Pairs of sealing tubes 20 and mounting tubes 22 are arranges coaxially and in communication with respective ones of the openings 14 in the base 12.
  • the sealing tubes 20 and tip mounting tubes 22 may be arranged in an array of rows and columns.
  • the spacing of the rows and columns matches the commonly available tip spacing of both multichannel pipettors and associated racks found in the marketplace. These in turn match the well positions of commonly available microtiter plates.
  • Nine and four and a half millimeters are two common spacing distances.
  • a 96 channel pipettor has twelve rows and eight columns of tips on nine millimeter spacing
  • a 384 channel pipettor has a twenty four by sixteen matrix on a four and a half millimeter spacing.
  • This invention can also be used in a one-dimensional array format. For example, a single row of twelve on a nine mm spacing.
  • the tip mounting tubes 22 comprise truncated conical cones configured and dimensioned for insertion and sealing interengagement with the conical upper ends 24 of pipette tips 26.
  • Fig. 5 shows an array of pipette tips 26 secured to the tip mounting tubes of the adapter.
  • Base 12 may be advantageously strengthened by a network of upper reinforcing ribs 28 on its top surface 16, and/or a similar network of lower reinforcing ribs 30 on its bottom surface 18.
  • the sealing tubes 20 may be located where the upper reinforcing ribs 28 converge, whereas the tip mounting tubes 22 may be located in areas of the bottom surface bracketed by the lower reinforcing ribs 30.
  • the sealing tubes 20 have cylindrical walls with chamfered upper ends 20a.
  • the tip mounting tubes 22 project downwardly below the lower reinforcing ribs 30, and the sealing tubes 20 project upwardly above the upper reinforcing ribs 28.
  • a multichannel air displacement pipettor is generally indicated at 32.
  • the head 34 of the pipettor is designed to accept the pipette adapter 10 of the present invention.
  • the pipette adapter may be provided with laterally extending rails 36 which are designed to slide into receiving slots in the pipettor head.
  • Tabs 35 also may be provided to facilitate handling the adapter.
  • the pipettor head has an array of cylinders indicated typically at 38 matching the array of sealing tubes 20 of the tip adapter 10.
  • the cylinders 38 lead to ports lined with O-rings providing compliant internal sealing surfaces.
  • O-rings 40 are shown, any equivalent compliant seal material and appropriate geometry could be employed.
  • a sheet of elastomeric material with a matrix of aligned bore holes could be employed.
  • the chamfered upper ends 20a of the sealing tubes serve to lower the insertion forces of the sealing tubes into the ports of the pipettor cylinders 38 while also reducing wear and tear of the O-rings 40 or other like compliant sealing surfaces.
  • Pistons indicated typically at 42 are arranged for reciprocal movement in the cylinders 38.
  • the pistons 42 are withdrawn in the cylinders 38 away from the adapter 10, and in Fig. 10 , the pistons are shown advanced in the cylinders.
  • the tip adapter 10 is preferably injection molded using standard tooling methods and common processing techniques.
  • Materials can include any rigid injection moldable polymer, with polypropylene being preferred.
  • a polymer with an internal lubricant that blooms to the surface of the part is preferable because the presence of the lubricant on the surface will reduce insertion forces and wear and tear on the seals.
  • the exemplary embodiment herein described is preferably disposable.
  • a non-disposable version is also possible, its design being essentially identical but produced from a material that is more robust and autoclavable. In such a design, the tips are installed to the adapter by the user with a dedicated fixture.
  • tip size geometries can be accommodated in a single adapter by arranging the tip mounting tubes in a tiered geometry, where the larger tips fit on one tier and the smaller tips on a second tier.
  • disposable pipette tips incorporate filters.
  • the purpose of the filter is to avoid aerosol contamination of the pipette mechanism by the liquid being pipetted.
  • the pipette tip adapter of the present invention may be configured to accept such filters, thereby eliminating the need to use expensive tips with filters pre-installed in them.
  • the adapter of the present invention offers significant and heretofore unavailable advantages.
  • the chamfered upper ends 20a of the sealing tubes 20 interact with the O-rings or equivalent compliant sealing materials to beneficially reduce the forces required to connect the pipette tips to the pipettor.
  • the adapter's sealing tubes 20 can be successfully inserted into the cylinder ports of the pipettor with a minimal coupling force on the order of 10lbs (44 N). This can be accomplished safely without exposing an operator to potential injury.
  • the adapter base 12 preferably when strengthened by the upper and/or lower reinforcing ribs 28, 30, provides a rigid platform supporting the tip mounting tubes 22 and sealing tubes 20.
  • the adapter can be pressed onto an array of pipette tubes without undergoing deflection that might otherwise compromise uniform and reliable sealed insertion of the tip mounting tubes 22.
  • This same rigidity when coupled with the minimal coupling forces referenced above, results in a more uniform and reliable insertion of the sealing tubes into the pipettor cylinder ports.

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Devices For Use In Laboratory Experiments (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)

Claims (15)

  1. Adaptateur (10) pour raccorder un dispositif de pipetage à déplacement d'air multicanal à un ensemble d'embouts de pipette (26), lesdits embouts de pipette (26) ayant des trous traversants avec des extrémités supérieures coniques (24), ledit dispositif de pipetage ayant une pluralité d'orifices avec des surfaces d'étanchéité internes compatibles (40), et ledit adaptateur (10) comprenant :
    une base plane (12) avec un ensemble d'ouvertures (14) s'étendant entre les surfaces supérieure et inférieure (16, 18) de ladite base (12) ; des tubes d'étanchéité (20) faisant saillie vers le haut à partir de ladite surface supérieure (16), et des tubes de montage d'embout (22) faisant saillie vers le bas à partir de ladite surface inférieure (18), les paires de tubes d'étanchéité (20) et de tubes de montage d'embout (22) étant disposées de manière coaxiale et en communication avec des ouvertures respectives des ouvertures (14) dans ladite base (12), lesdits tubes de montage d'embout (22) étant dimensionnés extérieurement et configurés pour une insertion dans les extrémités supérieures coniques (24) desdits embouts de pipette (26), et lesdits tubes d'étanchéité (20) étant configurés extérieurement et dimensionnés pour une insertion dans les orifices dudit dispositif de pipetage et une mise en prise réciproque d'étanchéité avec lesdites surfaces d'étanchéité internes compatibles (40) au sein de la pluralité d'orifices du dispositif de pipetage.
  2. Adaptateur (10) selon la revendication 1, dans lequel ladite base (12) est renforcée par un réseau de nervures de renfort supérieures (28) sur ladite surface supérieure (16).
  3. Adaptateur (10) selon la revendication 2, dans lequel lesdits tubes d'étanchéité (20) font saillie vers le haut au-dessus desdites nervures de renfort supérieures (28).
  4. Adaptateur (10) selon les revendications 1 ou 2, dans lequel ladite base (12) est renforcée par un réseau de nervures de renfort inférieures (30) sur ladite surface inférieure (18).
  5. Adaptateur (10) selon la revendication 4, dans lequel lesdits tubes de montage d'embout (22) font saillie vers le bas en dessous desdites nervures de renfort inférieures (30).
  6. Adaptateur (10) selon la revendication 1, dans lequel lesdits tubes de montage d'embout (22) comprennent des cônes tronconiques creux.
  7. Adaptateur (10) selon la revendication 1, dans lequel lesdits tubes d'étanchéité (20) comprennent des parois cylindriques avec des extrémités supérieures effilées (20a).
  8. Adaptateur (10) selon la revendication 1, l'adaptateur étant formé par un polymère moulable par injection.
  9. Adaptateur (10) selon la revendication 1, l'adaptateur incluant des rails d'extension latérale (36) qui sont adaptés pour coulisser dans des fentes de réception dans une tête de dispositif de pipetage.
  10. Adaptateur (10) selon la revendication 1, l'adaptateur incluant des pattes (35) pour faciliter la manipulation de l'adaptateur.
  11. Système de pipetage incluant l'adaptateur (10) selon l'une quelconque des revendications 1 à 10, et un dispositif de pipetage à déplacement d'air multicanal (32).
  12. Système de pipetage tel que revendiqué dans la revendication 11 dans lequel le dispositif de pipetage à déplacement d'air multicanal (32) inclut un ensemble de cylindres de dispositif de pipetage (38).
  13. Système de pipetage tel que revendiqué dans la revendication 12 dans lequel le pipetage à déplacement d'air multicanal (32) inclut en outre un ensemble de pistons (42) conçus pour un mouvement réciproque dans l'ensemble de cylindres de dispositif de pipetage (38).
  14. Système de pipetage tel que revendiqué dans la revendication 13 dans lequel chaque cylindre de dispositif de pipetage (38) du dispositif de pipetage à déplacement d'air multicanal (32) inclut en outre un matériau d'étanchéité compatible (40).
  15. Système de pipetage tel que revendiqué dans la revendication 14 dans lequel le matériau d'étanchéité compatible est fourni en tant qu'ensemble de joints toriques (40) qui interagissent avec une surface externe de chaque tube d'étanchéité (20).
EP12740432.5A 2011-07-20 2012-07-09 Partie adaptation de liaison de pointes de pipette Active EP2734301B1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP20159231.8A EP3682969B1 (fr) 2011-07-20 2012-07-09 Ensemble adaptateur pour embout de pipette
EP18184263.4A EP3412362B1 (fr) 2011-07-20 2012-07-09 Utilisation d'un adaptateur d'embout de pipette

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161509577P 2011-07-20 2011-07-20
PCT/US2012/045925 WO2013012588A1 (fr) 2011-07-20 2012-07-09 Adaptateur pour embout de pipette

Related Child Applications (3)

Application Number Title Priority Date Filing Date
EP18184263.4A Division EP3412362B1 (fr) 2011-07-20 2012-07-09 Utilisation d'un adaptateur d'embout de pipette
EP18184263.4A Division-Into EP3412362B1 (fr) 2011-07-20 2012-07-09 Utilisation d'un adaptateur d'embout de pipette
EP20159231.8A Division EP3682969B1 (fr) 2011-07-20 2012-07-09 Ensemble adaptateur pour embout de pipette

Publications (2)

Publication Number Publication Date
EP2734301A1 EP2734301A1 (fr) 2014-05-28
EP2734301B1 true EP2734301B1 (fr) 2019-02-20

Family

ID=46583015

Family Applications (3)

Application Number Title Priority Date Filing Date
EP12740432.5A Active EP2734301B1 (fr) 2011-07-20 2012-07-09 Partie adaptation de liaison de pointes de pipette
EP20159231.8A Active EP3682969B1 (fr) 2011-07-20 2012-07-09 Ensemble adaptateur pour embout de pipette
EP18184263.4A Active EP3412362B1 (fr) 2011-07-20 2012-07-09 Utilisation d'un adaptateur d'embout de pipette

Family Applications After (2)

Application Number Title Priority Date Filing Date
EP20159231.8A Active EP3682969B1 (fr) 2011-07-20 2012-07-09 Ensemble adaptateur pour embout de pipette
EP18184263.4A Active EP3412362B1 (fr) 2011-07-20 2012-07-09 Utilisation d'un adaptateur d'embout de pipette

Country Status (3)

Country Link
US (1) US20180117584A1 (fr)
EP (3) EP2734301B1 (fr)
WO (1) WO2013012588A1 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11559802B2 (en) 2011-07-20 2023-01-24 Avidien Technologies, Inc. Pipette tip adapter
EP3221050B1 (fr) * 2014-11-18 2021-05-19 Avidien Technologies, Inc. Pipette à déplacement d'air à canaux multiples
DE102017117789A1 (de) * 2017-08-04 2019-02-07 Als Automated Lab Solutions Gmbh Adapter zur Aufnahme einer Kapillare und dessen Verwendung
US20220152616A1 (en) * 2019-03-27 2022-05-19 Avidien Technologies, Inc. Segmented pipette tip adapter
USD905267S1 (en) 2019-03-27 2020-12-15 Avidien Technologies, Inc. Pipette tip adapter
CN110813398A (zh) * 2019-11-18 2020-02-21 威尚生物技术（合肥）有限公司 一种移液器的枪头填装装置
DE102021107590A1 (de) 2021-03-25 2022-09-29 Heinrich-Heine-Universität Düsseldorf Vorrichtung zum effizienten Mediumwechsel in Mikrotiterplatten
USD1021135S1 (en) * 2022-05-31 2024-04-02 Tecan Trading Ag Tray for pipetting tips

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US4237095A (en) * 1978-04-25 1980-12-02 Kommandiittiyhtio Finnpipette Osmo A. Suovaniemi Tip vessel for use in connection with a dosage pipette
US6159368A (en) * 1998-10-29 2000-12-12 The Perkin-Elmer Corporation Multi-well microfiltration apparatus
FI20002761A0 (fi) * 2000-12-15 2000-12-15 Wallac Oy Monikanavainen pipetointilaitteisto
EP1372852A4 (fr) * 2001-03-08 2006-04-12 Exelixis Inc Appareil a puits multiples
US7335337B1 (en) * 2001-09-11 2008-02-26 Smith James C Ergonomic pipette tip and adapters
US20040071602A1 (en) * 2002-10-15 2004-04-15 Yiu Felix H. Pipettor head adapter
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WO2011007194A1 (fr) * 2009-07-15 2011-01-20 Becton Dickinson France Plateau pour le positionnement d'objets allongés, en particulier des corps de seringue ou des seringues

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Also Published As

Publication number Publication date
EP3682969A1 (fr) 2020-07-22
US20180117584A1 (en) 2018-05-03
EP3412362B1 (fr) 2020-04-01
EP3682969B1 (fr) 2022-03-23
EP3412362A1 (fr) 2018-12-12
EP2734301A1 (fr) 2014-05-28
WO2013012588A1 (fr) 2013-01-24

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