EP2728287A3 - Method for freeze drying a moist product which is provided with a solvent - Google Patents

Method for freeze drying a moist product which is provided with a solvent Download PDF

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Publication number
EP2728287A3
EP2728287A3 EP13004181.7A EP13004181A EP2728287A3 EP 2728287 A3 EP2728287 A3 EP 2728287A3 EP 13004181 A EP13004181 A EP 13004181A EP 2728287 A3 EP2728287 A3 EP 2728287A3
Authority
EP
European Patent Office
Prior art keywords
product
freezing
phase
drying
freeze
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP13004181.7A
Other languages
German (de)
French (fr)
Other versions
EP2728287B1 (en
EP2728287A2 (en
Inventor
Hans-Georg Hof
Gerhard Schilder
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
HOF Sonderanlagenbau GmbH
Original Assignee
HOF Sonderanlagenbau GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by HOF Sonderanlagenbau GmbH filed Critical HOF Sonderanlagenbau GmbH
Publication of EP2728287A2 publication Critical patent/EP2728287A2/en
Publication of EP2728287A3 publication Critical patent/EP2728287A3/en
Application granted granted Critical
Publication of EP2728287B1 publication Critical patent/EP2728287B1/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F26—DRYING
    • F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
    • F26B5/00—Drying solid materials or objects by processes not involving the application of heat
    • F26B5/04—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum
    • F26B5/06—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum the process involving freezing
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F26—DRYING
    • F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
    • F26B21/00—Arrangements or duct systems, e.g. in combination with pallet boxes, for supplying and controlling air or gases for drying solid materials or objects
    • F26B21/06—Controlling, e.g. regulating, parameters of gas supply
    • F26B21/10—Temperature; Pressure

Abstract

Gegenstand der Erfindung ist ein Verfahren zur Gefriertrocknung eines mit einem Lösungsmittel versehenen, feuchten Produktes, insbesondere wenn das Produkt in einer Anzahl von Vials, Injektionsflachen oder Produktschalen gehalten ist, wobei das feuchte Produkt in einer Beladungsphase (A) im flüssigen Zustand, vorteilhafterweise bei Umgebungstemperatur (1) und/oder bei Umgebungsdruck (2), in eine Trocknungskammer einer Gefriertrocknungsanlage eingebracht wird, wobei das Produkt in einer Ausfrierphase (D) bei Ausfriertemperatur (6) und bei Ausfrierdruck (7) ausgefroren wird, und wobei das Produkt anschließend in einer Trocknungsphase (E) auf das gewünschte Maß getrocknet wird. Ein Verfahren zur Gefriertrocknung zu schaffen, bei dem das Austreten von Gasen während der Ausfrierphase verhindert, zumindest jedoch auf ein Minimum reduziert wird, wird dadurch erreicht, dass der Ausfrierphase (D) eine Ausgasungsphase (B) vorgeschaltet ist, in der dem feuchten Produkt Gase entzogen werden.

Figure imgaf001
The invention relates to a process for the freeze-drying of a wet product provided with a solvent, in particular when the product is held in a number of vials, injection surfaces or product trays, wherein the moist product in a loading phase (A) in the liquid state, advantageously at ambient temperature (1) and / or at ambient pressure (2), is introduced into a drying chamber of a freeze-drying plant, wherein the product in a freezing (D) at freezing temperature (6) and freezing pressure (7) is frozen, and wherein the product is then in a Drying phase (E) is dried to the desired level. To provide a process for freeze-drying in which the escape of gases during the freezing phase is prevented, or at least reduced to a minimum, is achieved by preceding the freezing phase (D) with an outgassing phase (B) in which the moist product releases gases be withdrawn.
Figure imgaf001
EP13004181.7A 2012-11-03 2013-08-24 Method for freeze drying a moist product which is provided with a solvent Active EP2728287B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102012021655.6A DE102012021655B4 (en) 2012-11-03 2012-11-03 Process for freeze-drying a moist product provided with a solvent

Publications (3)

Publication Number Publication Date
EP2728287A2 EP2728287A2 (en) 2014-05-07
EP2728287A3 true EP2728287A3 (en) 2016-10-19
EP2728287B1 EP2728287B1 (en) 2021-03-10

Family

ID=49123617

Family Applications (1)

Application Number Title Priority Date Filing Date
EP13004181.7A Active EP2728287B1 (en) 2012-11-03 2013-08-24 Method for freeze drying a moist product which is provided with a solvent

Country Status (3)

Country Link
EP (1) EP2728287B1 (en)
DE (1) DE102012021655B4 (en)
DK (1) DK2728287T3 (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB997246A (en) * 1963-01-31 1965-07-07 Vickers Armstrongs Ltd Improvements in or relating to methods of freeze-drying foodstuffs
US20090018479A1 (en) * 2002-06-14 2009-01-15 Hemcon Medical Technologies, Inc. Absorbable tissue dressing assemblies, systems, and methods formed from hydrophilic polymer sponge structures such as chistosan
US20120116054A1 (en) * 2005-07-22 2012-05-10 Sampathkumar Krishnan Concentrated protein lyophilates, methods, and uses

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5275016A (en) 1992-04-24 1994-01-04 Abaxis, Inc. Cryogenic apparatus
DK1401352T3 (en) 2001-06-14 2012-06-25 Kenton W Gregory PROCEDURE FOR PREPARING A CHITOSANOUS COMPOUND
WO2007065862A1 (en) 2005-12-05 2007-06-14 Sandoz Ag Process for the perparation of lyophilized piperacilline sodium with improved stability after reconstitution
US8793895B2 (en) 2006-02-10 2014-08-05 Praxair Technology, Inc. Lyophilization system and method

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB997246A (en) * 1963-01-31 1965-07-07 Vickers Armstrongs Ltd Improvements in or relating to methods of freeze-drying foodstuffs
US20090018479A1 (en) * 2002-06-14 2009-01-15 Hemcon Medical Technologies, Inc. Absorbable tissue dressing assemblies, systems, and methods formed from hydrophilic polymer sponge structures such as chistosan
US20120116054A1 (en) * 2005-07-22 2012-05-10 Sampathkumar Krishnan Concentrated protein lyophilates, methods, and uses

Also Published As

Publication number Publication date
DK2728287T3 (en) 2021-05-03
DE102012021655A1 (en) 2014-05-08
DE102012021655B4 (en) 2023-03-30
EP2728287B1 (en) 2021-03-10
EP2728287A2 (en) 2014-05-07

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