EP2685891A2 - Méthode diagnostique et dispositif d'analyse de gaz respiratoire - Google Patents
Méthode diagnostique et dispositif d'analyse de gaz respiratoireInfo
- Publication number
- EP2685891A2 EP2685891A2 EP12757976.1A EP12757976A EP2685891A2 EP 2685891 A2 EP2685891 A2 EP 2685891A2 EP 12757976 A EP12757976 A EP 12757976A EP 2685891 A2 EP2685891 A2 EP 2685891A2
- Authority
- EP
- European Patent Office
- Prior art keywords
- sensor
- hydrogen
- detector
- detector according
- concentration
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 238000012360 testing method Methods 0.000 title abstract description 22
- 238000002405 diagnostic procedure Methods 0.000 title abstract description 7
- 239000001257 hydrogen Substances 0.000 claims abstract description 39
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract description 39
- 208000015943 Coeliac disease Diseases 0.000 claims abstract description 25
- 206010025476 Malabsorption Diseases 0.000 claims abstract description 11
- 208000004155 Malabsorption Syndromes Diseases 0.000 claims abstract description 11
- 239000002070 nanowire Substances 0.000 claims abstract description 11
- 230000002496 gastric effect Effects 0.000 claims abstract description 10
- 238000010884 ion-beam technique Methods 0.000 claims abstract description 5
- 239000010409 thin film Substances 0.000 claims abstract 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 25
- 150000002431 hydrogen Chemical class 0.000 claims description 15
- 238000000034 method Methods 0.000 claims description 13
- 238000001514 detection method Methods 0.000 claims description 5
- 230000004044 response Effects 0.000 claims description 3
- 239000010408 film Substances 0.000 claims 3
- 230000000007 visual effect Effects 0.000 claims 3
- 239000002131 composite material Substances 0.000 claims 2
- 238000003745 diagnosis Methods 0.000 abstract description 11
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
- 201000010099 disease Diseases 0.000 description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 5
- 230000035945 sensitivity Effects 0.000 description 5
- 239000000600 sorbitol Substances 0.000 description 5
- SRBFZHDQGSBBOR-IOVATXLUSA-N D-xylopyranose Chemical compound O[C@@H]1COC(O)[C@H](O)[C@H]1O SRBFZHDQGSBBOR-IOVATXLUSA-N 0.000 description 4
- 150000001720 carbohydrates Chemical class 0.000 description 4
- 235000014633 carbohydrates Nutrition 0.000 description 4
- 230000037406 food intake Effects 0.000 description 4
- 239000007789 gas Substances 0.000 description 4
- 210000002966 serum Anatomy 0.000 description 4
- 108010068370 Glutens Proteins 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- SRBFZHDQGSBBOR-UHFFFAOYSA-N beta-D-Pyranose-Lyxose Natural products OC1COC(O)C(O)C1O SRBFZHDQGSBBOR-UHFFFAOYSA-N 0.000 description 3
- 235000021312 gluten Nutrition 0.000 description 3
- 239000000758 substrate Substances 0.000 description 3
- BBMCTIGTTCKYKF-UHFFFAOYSA-N 1-heptanol Chemical compound CCCCCCCO BBMCTIGTTCKYKF-UHFFFAOYSA-N 0.000 description 2
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 2
- 201000010538 Lactose Intolerance Diseases 0.000 description 2
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 2
- 230000008021 deposition Effects 0.000 description 2
- ZSIAUFGUXNUGDI-UHFFFAOYSA-N hexan-1-ol Chemical compound CCCCCCO ZSIAUFGUXNUGDI-UHFFFAOYSA-N 0.000 description 2
- 238000001878 scanning electron micrograph Methods 0.000 description 2
- 238000012819 small-bowel biopsy Methods 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- 206010012735 Diarrhoea Diseases 0.000 description 1
- 208000012868 Overgrowth Diseases 0.000 description 1
- 241000209140 Triticum Species 0.000 description 1
- 235000021307 Triticum Nutrition 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 208000007502 anemia Diseases 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- PYMYPHUHKUWMLA-UHFFFAOYSA-N arabinose Natural products OCC(O)C(O)C(O)C=O PYMYPHUHKUWMLA-UHFFFAOYSA-N 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 238000009534 blood test Methods 0.000 description 1
- 238000000451 chemical ionisation Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 206010016165 failure to thrive Diseases 0.000 description 1
- 238000004817 gas chromatography Methods 0.000 description 1
- 230000002068 genetic effect Effects 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 238000001000 micrograph Methods 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 1
- 238000000824 selected ion flow tube mass spectrometry Methods 0.000 description 1
- 238000004611 spectroscopical analysis Methods 0.000 description 1
- 230000004580 weight loss Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/08—Detecting, measuring or recording devices for evaluating the respiratory organs
- A61B5/082—Evaluation by breath analysis, e.g. determination of the chemical composition of exhaled breath
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/42—Detecting, measuring or recording for evaluating the gastrointestinal, the endocrine or the exocrine systems
- A61B5/4216—Diagnosing or evaluating gastrointestinal ulcers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/497—Physical analysis of biological material of gaseous biological material, e.g. breath
- G01N33/4975—Physical analysis of biological material of gaseous biological material, e.g. breath other than oxygen, carbon dioxide or alcohol, e.g. organic vapours
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/84—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving inorganic compounds or pH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
- A61B2562/02—Details of sensors specially adapted for in-vivo measurements
- A61B2562/0285—Nanoscale sensors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/08—Detecting, measuring or recording devices for evaluating the respiratory organs
- A61B5/097—Devices for facilitating collection of breath or for directing breath into or through measuring devices
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/02—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance
- G01N27/04—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating resistance
- G01N27/12—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating resistance of a solid body in dependence upon absorption of a fluid; of a solid body in dependence upon reaction with a fluid, for detecting components in the fluid
- G01N27/125—Composition of the body, e.g. the composition of its sensitive layer
- G01N27/127—Composition of the body, e.g. the composition of its sensitive layer comprising nanoparticles
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/0004—Gaseous mixtures, e.g. polluted air
- G01N33/0009—General constructional details of gas analysers, e.g. portable test equipment
- G01N33/0027—General constructional details of gas analysers, e.g. portable test equipment concerning the detector
- G01N33/0036—General constructional details of gas analysers, e.g. portable test equipment concerning the detector specially adapted to detect a particular component
- G01N33/005—H2
Definitions
- the present invention relates to a diagnostic method and breath-testing device for the diagnosis of celiac disease or other gastrointestinal malabsorption in adults and children.
- Celiac disease is defined as a disease of the small bowel caused by a permanent intolerance to gluten. Most common symptoms of the disease are weight loss due to malabsorption, diarrhea, anemia, and growth failure. Celiac disease affects people of all ages and gender. Its incidence is on the rise worldwide due to environmental and genetic factors, currently affecting, on average, 1/300 people (children and adults) in the United States and in other developed countries. Up until recently celiac disease was considered a disease affecting predominantly people of Northern European origin this, however, is changing as cases are now reported in Asia and the Middle East, albeit at a much lower rate.
- Definitive diagnosis of the disease is made on the basis of small bowel biopsies obtained while the patient is on gluten containing diet and after the patient is taken off gluten and free of symptoms. While small bowel biopsy is an invasive diagnostic modality there are other diagnostic methods currently available.
- blood serum can be tested for the presence of D-xylose, a sugar detected in serum one hour after the ingestion of carbohydrates.
- D-xylose test is performed less frequently due to low sensitivity and specificity for the diagnosis of celiac disease and due to the broad use of the more specific antibody diagnostic tests.
- the present invention consists of a novel, inexpensive, non-invasive, point-of-care, handheld, device for the diagnosis of celiac disease using a selective hydrogen gas nanosensor.
- a person, adult or child, suspected of having celiac disease or other type of gastrointestinal malabsorption will provide one fasting breath sample through the mouth piece of the device. No ingestion of carbohydrate substrate is required.
- Figure 1 is a schematic block diagram of a breath analyzer device for the detection of hydrogen in breath according to the invention
- Figure 2a is a scanning electron micrograph in cross-section of ZnO nanowires grown in deposition region at the entrance zone (ratio 0/Zn>l);
- Figure 2b is a top view scanning micrograph of ZnO nanowires grown at the exit zone (ratio 0/Zn ⁇ 1);
- Figure 3 is a graph showing the 3 ⁇ 4 gas response for a lOOnm diameter ⁇ ,, ⁇ NW-based sensor.
- Figure 4 shows electronic circuitry of a device according to the invention.
- the breath analyzer detects the presence of hydrogen in a human breath sample.
- Figure 1 shows a sensor device which consists of a mouth piece, a trap for CO 2 , NH 3 and H 2 0, a hydrogen nanosensor, constant dry air flow and electronics.
- the electronics include an acquisition module, a memory/computation module, and two displays.
- the numerical display provides the concentration.
- the YES/NO display will provide the person with an answer indicating high (above the established for this device threshold) or low (below the established for this device threshold) level of hydrogen in breath.
- a high level will indicate celiac disease or another type of gastrointestinal malabsorption, and a low level will indicate normal gastrointestinal absorption i.e. less likely celiac disease.
- the sensor may be a nanosensor, or may be a hydrogen-selective film available from Giner, Inc., Newton, MA, which it calls a trace gas sensor. (See, www. ginerinc.com.)
- the characteristics of the sensor according to the invention are that 1) it is hydrogen selective; 2) can be ZnO nanowire-based (100 ⁇ in diameter) or other type of hydrogen- selective film or nanosensor; 3) can be a single ZnO nanowire sensor fabricated using focused ion beam (FIB/SEM) instrument (5); and 4) can be capable of operating at room temperature requiring a small pulse UV light to recover.
- FIB/SEM focused ion beam
- Figure 2a is a scanning electron micrograph in cross-section of ZnO nanowires grown in deposition region at the entrance zone (ratio 0/Zn>l).
- Figure 2b is a top view scanning micrograph of ZnO nanowires grown at the exit zone (ratio 0/Zn ⁇ 1 ).
- Figure 3 is a graph showing the IF gas response for a lOOnm diameter ⁇ ,, ⁇ NW-based sensor. The response curves of the individual nanowire-based sensor toward lOppm IF pulses. Before the test the nanowire was preconditioned in a constant dry air flow. An UV pulse is applied after 3 ⁇ 4 is turned off. Lupan O. el al. (5).
- Figure 4 shows the electronic circuitry of the device. Figure 4 shows a sensor, interface circuitry and display.
- a micro-controller ( ⁇ €) contains the Analog-to-Digital Converter memory (SRAM), and an Arithmetic Logic Unit (ALU).
- the V test is a voltage proportional to the resistance of the sensor.
- the sensor will detect hydrogen gas. If one wishes to detect gases other than hydrogen, other sensors could be used. More than one sensor could be incorporated, with a switch to select connection of the sensor to the circuit for the specific gas to be detected.
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Pathology (AREA)
- Urology & Nephrology (AREA)
- Analytical Chemistry (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Heart & Thoracic Surgery (AREA)
- Physiology (AREA)
- Medical Informatics (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Surgery (AREA)
- Veterinary Medicine (AREA)
- Microbiology (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Endocrinology (AREA)
- Inorganic Chemistry (AREA)
- Pulmonology (AREA)
- Gastroenterology & Hepatology (AREA)
- Rehabilitation Therapy (AREA)
- Rheumatology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analyzing Materials By The Use Of Fluid Adsorption Or Reactions (AREA)
Abstract
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161452507P | 2011-03-14 | 2011-03-14 | |
PCT/US2012/029087 WO2012125734A2 (fr) | 2011-03-14 | 2012-03-14 | Méthode diagnostique et dispositif d'analyse de gaz respiratoire |
Publications (2)
Publication Number | Publication Date |
---|---|
EP2685891A2 true EP2685891A2 (fr) | 2014-01-22 |
EP2685891A4 EP2685891A4 (fr) | 2015-03-18 |
Family
ID=46831323
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP12757976.1A Withdrawn EP2685891A4 (fr) | 2011-03-14 | 2012-03-14 | Méthode diagnostique et dispositif d'analyse de gaz respiratoire |
Country Status (2)
Country | Link |
---|---|
EP (1) | EP2685891A4 (fr) |
WO (1) | WO2012125734A2 (fr) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9678058B2 (en) | 2010-09-03 | 2017-06-13 | Anastasia Rigas | Diagnostic method and breath testing device |
US10401318B2 (en) | 2011-03-14 | 2019-09-03 | Anastasia Rigas | Breath analyzer and breath test methods |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104458886B (zh) * | 2014-12-09 | 2018-01-16 | 江苏师范大学 | 一种纳米呼吸传感器及其制备方法 |
EP3893736B1 (fr) * | 2018-12-10 | 2023-08-02 | Anastasia Rigas | Dispositifs analyseurs de gaz respiratoires et procédés de test de gaz respiratoires |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7104963B2 (en) * | 2002-01-22 | 2006-09-12 | University Of Florida Research Foundation, Inc. | Method and apparatus for monitoring intravenous (IV) drug concentration using exhaled breath |
US7522040B2 (en) * | 2004-04-20 | 2009-04-21 | Nanomix, Inc. | Remotely communicating, battery-powered nanostructure sensor devices |
US20100089772A1 (en) * | 2006-11-10 | 2010-04-15 | Deshusses Marc A | Nanomaterial-based gas sensors |
US20100212403A1 (en) * | 2004-09-25 | 2010-08-26 | University Of Central Florida Research Foundation Inc. | Room Temperature Hydrogen Sensor |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7048906B2 (en) * | 1995-05-17 | 2006-05-23 | Cedars-Sinai Medical Center | Methods of diagnosing and treating small intestinal bacterial overgrowth (SIBO) and SIBO-related conditions |
-
2012
- 2012-03-14 WO PCT/US2012/029087 patent/WO2012125734A2/fr active Application Filing
- 2012-03-14 EP EP12757976.1A patent/EP2685891A4/fr not_active Withdrawn
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7104963B2 (en) * | 2002-01-22 | 2006-09-12 | University Of Florida Research Foundation, Inc. | Method and apparatus for monitoring intravenous (IV) drug concentration using exhaled breath |
US7522040B2 (en) * | 2004-04-20 | 2009-04-21 | Nanomix, Inc. | Remotely communicating, battery-powered nanostructure sensor devices |
US20100212403A1 (en) * | 2004-09-25 | 2010-08-26 | University Of Central Florida Research Foundation Inc. | Room Temperature Hydrogen Sensor |
US20100089772A1 (en) * | 2006-11-10 | 2010-04-15 | Deshusses Marc A | Nanomaterial-based gas sensors |
Non-Patent Citations (2)
Title |
---|
LUPAN O ET AL: "Selective hydrogen gas nanosensor using individual ZnO nanowire with fast response at room temperature", SENSORS AND ACTUATORS B: CHEMICAL: INTERNATIONAL JOURNAL DEVOTED TO RESEARCH AND DEVELOPMENT OF PHYSICAL AND CHEMICAL TRANSDUCERS, ELSEVIER S.A, CH, vol. 144, no. 1, 29 January 2010 (2010-01-29), pages 56-66, XP026861996, ISSN: 0925-4005 [retrieved on 2009-10-20] * |
RANA S V ET AL: "Influence of Previously Ingested Wheat on Fasting Breath Hydrogen in Celiac Patients", DIGESTIVE DISEASES AND SCIENCES, KLUWER ACADEMIC PUBLISHERS-PLENUM PUBLISHERS, NE, vol. 54, no. 6, 29 October 2008 (2008-10-29), pages 1276-1279, XP019673533, ISSN: 1573-2568 * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9678058B2 (en) | 2010-09-03 | 2017-06-13 | Anastasia Rigas | Diagnostic method and breath testing device |
US10401318B2 (en) | 2011-03-14 | 2019-09-03 | Anastasia Rigas | Breath analyzer and breath test methods |
Also Published As
Publication number | Publication date |
---|---|
EP2685891A4 (fr) | 2015-03-18 |
WO2012125734A2 (fr) | 2012-09-20 |
WO2012125734A3 (fr) | 2014-03-13 |
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