EP2680905B1 - Injection devices - Google Patents
Injection devices Download PDFInfo
- Publication number
- EP2680905B1 EP2680905B1 EP12709359.9A EP12709359A EP2680905B1 EP 2680905 B1 EP2680905 B1 EP 2680905B1 EP 12709359 A EP12709359 A EP 12709359A EP 2680905 B1 EP2680905 B1 EP 2680905B1
- Authority
- EP
- European Patent Office
- Prior art keywords
- indicator
- plunger
- indicator element
- finger
- injection device
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Links
- 238000002347 injection Methods 0.000 title claims description 26
- 239000007924 injection Substances 0.000 title claims description 26
- 238000010304 firing Methods 0.000 claims description 7
- 230000000007 visual effect Effects 0.000 claims description 6
- 230000000712 assembly Effects 0.000 description 2
- 238000000429 assembly Methods 0.000 description 2
- 229940090047 auto-injector Drugs 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 210000001217 buttock Anatomy 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 238000012790 confirmation Methods 0.000 description 1
- 230000000994 depressogenic effect Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000037452 priming Effects 0.000 description 1
- 230000000452 restraining effect Effects 0.000 description 1
- 238000012163 sequencing technique Methods 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31533—Dosing mechanisms, i.e. setting a dose
- A61M5/31535—Means improving security or handling thereof, e.g. blocking means, means preventing insufficient dosing, means allowing correction of overset dose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
- A61M5/2033—Spring-loaded one-shot injectors with or without automatic needle insertion
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
- A61M2005/2006—Having specific accessories
- A61M2005/202—Having specific accessories cocking means, e.g. to bias the main drive spring of an injector
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
- A61M2005/206—With automatic needle insertion
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
- A61M2005/2073—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically preventing premature release, e.g. by making use of a safety lock
- A61M2005/208—Release is possible only when device is pushed against the skin, e.g. using a trigger which is blocked or inactive when the device is not pushed against the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/58—Means for facilitating use, e.g. by people with impaired vision
- A61M2205/581—Means for facilitating use, e.g. by people with impaired vision by audible feedback
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/58—Means for facilitating use, e.g. by people with impaired vision
- A61M2205/582—Means for facilitating use, e.g. by people with impaired vision by tactile feedback
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/58—Means for facilitating use, e.g. by people with impaired vision
- A61M2205/583—Means for facilitating use, e.g. by people with impaired vision by visual feedback
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
- A61M5/31566—Means improving security or handling thereof
- A61M5/3157—Means providing feedback signals when administration is completed
Definitions
- This invention relates to injection devices and in particular, but not exclusively, to reusable autoinjector devices comprising a housing into which a disposable syringe may be inserted to effect the injection and then removed and replaced as required for the next injection.
- autoinjectors signal to the user when the injection is complete by means of an 'injection complete' signal.
- 'injection complete' is used to refer to a condition in which a satisfactory delivery of the drug has been achieved. It is also desirable that this indication is not only visual but also audible and/or tactile, to provide confirmation to the user when injection site is out of sight, or would require some straining to see, for example in the buttocks or upper arm.
- EP 0937472 A2 discloses a medication delivery pen which provides an audible and/or tactile indication that provides feedback to a user that the full intended dose has been delivered.
- the energy required to generate the audible or tactile signal does not subtract significant energy from the main drive source of the device as this might impair efficient sequencing and delivery.
- this invention provides an injection device including an injection complete indicator for providing a kinetic impact indication, the device including:
- said indicator element also provides a visual indication upon approaching or reaching its extended position.
- the indicator element is provided with its own bias and that the motive force for moving the indicator forward after the indicator latch arrangement has been released may be provided by the indicator bias.
- said motion transfer arrangement comprises an abutment surface associated with one of said plunger and said indicator element and a cooperating projection associated with the other thereof.
- said indicator latch arrangement includes a flexible latch finger associated with said housing and having a latching tooth past which a flexible finger on the indicator element may snap as the indicator element is moved to its retracted position.
- the latch finger associated with the housing is advantageously resiliently deflectable to allow said indicator finger to move forwardly, with the deflection being prevented except when the plunger is at or near the end of its stroke. Once deflection is possible the indicator may be released for forward movement.
- the plunger is movable longitudinally between its cocked and fired positions, and the body finger preferably extends generally longitudinally, with the plunger having a support surface which underlies the body finger, until the plunger nears or reaches the end of its stroke.
- the latch tooth comprises respective ramp surfaces facing in the cocking and firing directions respectively, with the ramp surfaces providing a profile in which the inclination of the ramp face first contacted by the indicator finger when moving to its retracted position is shallower than the other face, whereby the indicator finger can snap past the latch tooth when moving in the direction of retraction, but not in the opposite direction.
- a preferred embodiment of autoinjector comprises a separable body comprising a front body assembly 10 screwed or otherwise releasably coupled to a rear body 12 having an outer slideable cover 14.
- the device is designed to be reusable with the user separating the front and rear body assemblies, inserting or replacing a syringe 22 housed in the front body assembly, priming or cocking a drive mechanism contained in the rear body assembly, and connecting the front and rear body assemblies together.
- This is similar to our well known Autoject® II device and as described in WO2004/108194 .
- the cover 14 is biased rearwardly to a position where it interlocks with a trigger 16 to prevent actuation thereof.
- the cover 14 also has a window 18 through which an indicator sleeve 20 becomes visible upon satisfactory completion of an injection (see Figure 1(d) ).
- the operator grasps the cover 14 and presses the front end of the front body assembly 10 against the injection site, thus shifting the cover 14 forwardly to release the mechanical interlock.
- the drive mechanism inside the rear body housing moves a plunger forwardly which initially advances the syringe 22 so that its needle 24 penetrates the injection site and thereafter the plunger moves the syringe piston to expel a dose.
- the plunger Upon nearing or reaching the forward end of its stroke, the plunger releases the indicator sleeve 20 which shoots forward to become visible to give a visual indication in window 18 and also to impact an internal surface to create an audible and tactile signal ( Figure 1(d) ).
- the reaction force On removing the device from the injection site the reaction force is removed and so the cover 14 again shifts rearwardly on the rear body to interlock with the trigger 16.
- the rear body assembly 12 comprises a rear body housing 26 of generally cylindrical form cut away on its upper surface to provide an open wide slot 28 bridged at its forward end by a bridge 30 and supporting the trigger 16 at its rear end by means of live hinges 32.
- a parallel axial finger 34 hinged at its rear end by a live hinge 36 so that it can deflect resiliently into the bore of the rear body housing 26.
- the axial finger 34 has an asymmetric latch tooth 38 having a shallowly inclined forward ramp face 40 and a steeper rear ramp face 42.
- a narrow slot 44 which allows a lost motion connection between the indicator sleeve 20 and the plunger 45 as to be described below.
- the bridge 30 includes an anchorage 48 for one end of an indicator spring 50.
- the plunger is generally of stepped cylindrical form having a flat front end face 52 for engaging the syringe plunger (not shown) and open at its rear end to receive the front end of a drive spring 54.
- Side ribs 53 run in the guide grooves 46 of the rear body housing.
- Extending rearwardly from the upper side of the plunger as viewed is a tab 56 having a latch rib 58 which cooperates with a complementary latch rib 60 on the trigger 16 when the plunger is in its cocked position.
- a stop 62 upstands from a forward region of the tab 56 and cooperates with the bridge 30 on the rear body housing 26 to limit forward movement of the plunger.
- Extending along the entire length of the main plunger body 45 is a part cylindrical support surface 65 which cooperates with the latch finger 34 to prevent inward resilient deflection of the axial finger 34 until the plunger is at or near its forwardmost position.
- the indicator sleeve 20 is slideably mounted around the outside of the rear body housing 26 for movement between the forwardmost, indicating, position shown in Figures 7(a) and 8(a) to the retracted position shown in Figures 7(d) and 8(d) .
- the indicator 20 is biased forwardly by means of the indicator spring 50 which is a tension spring.
- the indicator spring 50 is connected to the indicator 20 at a spring anchorage 64.
- a collar fitting 66 clips to the front end of the rear body housing 26 by means of sprung arms 68 which clip around the bridge 30.
- the collar fitting provides an annular stop surface 69 (see Figure 3 ) which limits forward movement of the indicator sleeve 20 and also acts as an impact surface to generate an audible/tactile signal.
- the collar fitting 66 also includes a thread 67 to allow the rear body assembly to be screwed to the front body assembly 10.
- the indicator sleeve 20 is cut away on its upper surface to leave a cutaway region at the forward end of which is a circumferential finger 70 resiliently attached by a live hinge 72 to the indicator sleeve 20.
- the circumferential finger 70 cooperates with the latch tooth 38 on the axial finger 34 of the rear body assembly in a manner to be described below.
- a projection 74 Opposite the cutaway region and projecting inwardly from the inner wall of the indicator is a projection 74 which extends through the narrow slot 44 in the base of the rear body assembly 26 to project into the path of the rear of the plunger as it is moved rearwardly to cock the device.
- Figure 7(a) shows the various components of the rear body assembly in the configuration prior to cocking.
- the indicator sleeve 20 and the plunger 45 are at their forwardmost positions with the indicator spring 50 and main drive springs 54 in relatively relaxed conditions.
- the front end of the front body assembly 10 (or any other suitable tool) is placed against the front end face 52 of the plunger to urge the plunger rearwardly.
- the main drive spring 54 is compressed ( Figures 7(b) and 8(b) ).
- the force of the extended indicator spring 50, the ramp angle of the steep rearward ramp face 42 and the flexibility of the live hinge 72 are selected such that the tension spring is not strong enough to pull the circumferential finger 70 back past the latch tooth 38 when the axial finger 34 is held against inward deflection.
- the rear assembly is now in a cocked position ready for firing and the device can be assembled by loading a syringe into the front body portion and screwing it onto the rear body portion.
- the trigger 16 is depressed, releasing the plunger 45 for forward movement ( Figures 7(e) and 8(e) ).
- the plunger 45 then moves forwardly to extend the syringe and, during all but the last part of the stroke of movement of the piston, the support surface 65 thereon underlies the axial finger 34 and prevents it from displacing inwardly and so the indicator sleeve 20 is held in its rearmost position (see Figures 7(f) and (g) ).
- the plunger 45 is in a position where the support surface 62 is forwardly of the axial finger, no longer supporting it, so that the circumferential finger 70 on the indicator sleeve may cam the axial finger 34 downwardly, releasing the indicator sleeve to shoot forwards to impact the collar fitting 66, emitting an audible and tactile signal as the forward facing circumferential edge on the indicator element strikes a corresponding rearward surface on the collar fitting 66, and also making the indicator visible behind window 18 of the cover 14.
- audible, visual and tactile indications of end of dose are provided for the user without significantly diverting the energy of the main drive spring 54. Also the indicator is reset automatically each time the device is locked.
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- Health & Medical Sciences (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Injection Moulding Of Plastics Or The Like (AREA)
Description
- This invention relates to injection devices and in particular, but not exclusively, to reusable autoinjector devices comprising a housing into which a disposable syringe may be inserted to effect the injection and then removed and replaced as required for the next injection.
- It is a common requirement that autoinjectors signal to the user when the injection is complete by means of an 'injection complete' signal. The term 'injection complete' is used to refer to a condition in which a satisfactory delivery of the drug has been achieved. It is also desirable that this indication is not only visual but also audible and/or tactile, to provide confirmation to the user when injection site is out of sight, or would require some straining to see, for example in the buttocks or upper arm.
-
EP 0937472 A2 discloses a medication delivery pen which provides an audible and/or tactile indication that provides feedback to a user that the full intended dose has been delivered. - It is also desirable that the energy required to generate the audible or tactile signal does not subtract significant energy from the main drive source of the device as this might impair efficient sequencing and delivery. We have designed an injection device which provides an audible and/or tactile indication to the user as well as a visual indication, without taking significant energy from the main drive source. It is additionally desirable to provide an arrangement in which the indicator is reset automatically for each injection cycle.
- Accordingly, in one aspect, this invention provides an injection device including an injection complete indicator for providing a kinetic impact indication, the device including:
- a housing;
- a plunger movable in said housing between cocked and fired positions under the influence of a plunger drive source; and
- an indicator element,
- the device being characterised in that the indicator element (20) is movable between an extended position and a retracted position and being biased towards said extended position by an indicator bias; and in that the device further includes
- an indicator latch arrangement for latching said indicator element in a retracted position;
- a motion transfer arrangement between the plunger and the indicator element for retracting said indicator element to said retracted position as said plunger is moved to its cocked position but allowing forward movement of said plunger relative to the indicator element;
- the device being arranged such that, after firing, as the plunger nears or reaches the end of its operating stroke, it enables release of the indicator latch arrangement to cause the indicator element to move to its extended position under the influence of said bias to impact a stop surface to create said kinetic impact.
- Preferably, said indicator element also provides a visual indication upon approaching or reaching its extended position.
- It will be noted that the indicator element is provided with its own bias and that the motive force for moving the indicator forward after the indicator latch arrangement has been released may be provided by the indicator bias. Conveniently said motion transfer arrangement comprises an abutment surface associated with one of said plunger and said indicator element and a cooperating projection associated with the other thereof.
- Preferably said indicator latch arrangement includes a flexible latch finger associated with said housing and having a latching tooth past which a flexible finger on the indicator element may snap as the indicator element is moved to its retracted position. The latch finger associated with the housing is advantageously resiliently deflectable to allow said indicator finger to move forwardly, with the deflection being prevented except when the plunger is at or near the end of its stroke. Once deflection is possible the indicator may be released for forward movement.
- In many configurations the plunger is movable longitudinally between its cocked and fired positions, and the body finger preferably extends generally longitudinally, with the plunger having a support surface which underlies the body finger, until the plunger nears or reaches the end of its stroke.
- Concurrently the latch tooth comprises respective ramp surfaces facing in the cocking and firing directions respectively, with the ramp surfaces providing a profile in which the inclination of the ramp face first contacted by the indicator finger when moving to its retracted position is shallower than the other face, whereby the indicator finger can snap past the latch tooth when moving in the direction of retraction, but not in the opposite direction.
- Whilst the invention has been described above, it extends to any novel combination of the features set out above, or in the following description or drawings. Whilst the invention may be performed in various ways, an embodiment thereof will now be described by way of example only, reference being made to the accompanying drawings in which:
-
Figures 1(a) to (e) are perspective views of an autoinjection device in accordance with this invention showing various stages in operation prior to, during and after firing; -
Figure 2 is an exploded view of the rear body assembly excluding the cover; -
Figure 3 is a view of the rear body assembly of the embodiment ofFigure 1 , with the cover removed; -
Figure 4 is a perspective view of the rear body housing of the rear body assembly; -
Figure 5 is a perspective view of the indicator and forward end of the rear body housing; -
Figure 6 is a perspective view of the plunger and part of the drive spring of the rear body assembly; -
Figures 7(a) to (h) are perspective views of the rear body assembly showing the configuration of the various components in sequence through a cocking and firing operation, and -
Figures 8(a) to (h) are corresponding side views of the rear assembly during these operations. - Referring initially to
Figures 1(a) to (e) , a preferred embodiment of autoinjector comprises a separable body comprising afront body assembly 10 screwed or otherwise releasably coupled to arear body 12 having an outerslideable cover 14. The device is designed to be reusable with the user separating the front and rear body assemblies, inserting or replacing asyringe 22 housed in the front body assembly, priming or cocking a drive mechanism contained in the rear body assembly, and connecting the front and rear body assemblies together. This is similar to our well known Autoject® II device and as described inWO2004/108194 . As in the arrangement ofWO2004/108194 , thecover 14 is biased rearwardly to a position where it interlocks with atrigger 16 to prevent actuation thereof. Thecover 14 also has awindow 18 through which anindicator sleeve 20 becomes visible upon satisfactory completion of an injection (seeFigure 1(d) ). In order to operate the device, the operator grasps thecover 14 and presses the front end of thefront body assembly 10 against the injection site, thus shifting thecover 14 forwardly to release the mechanical interlock. On pressing thetrigger 16, the drive mechanism inside the rear body housing moves a plunger forwardly which initially advances thesyringe 22 so that itsneedle 24 penetrates the injection site and thereafter the plunger moves the syringe piston to expel a dose. Upon nearing or reaching the forward end of its stroke, the plunger releases theindicator sleeve 20 which shoots forward to become visible to give a visual indication inwindow 18 and also to impact an internal surface to create an audible and tactile signal (Figure 1(d) ). On removing the device from the injection site the reaction force is removed and so thecover 14 again shifts rearwardly on the rear body to interlock with thetrigger 16. - Referring initially to
Figures 2 to 6 , therear body assembly 12 comprises arear body housing 26 of generally cylindrical form cut away on its upper surface to provide an openwide slot 28 bridged at its forward end by abridge 30 and supporting thetrigger 16 at its rear end by means oflive hinges 32. About half way down theslot 28 extends a parallelaxial finger 34 hinged at its rear end by alive hinge 36 so that it can deflect resiliently into the bore of therear body housing 26. Theaxial finger 34 has anasymmetric latch tooth 38 having a shallowly inclinedforward ramp face 40 and a steeperrear ramp face 42. In the base of therear body housing 26, opposite thewide slot 28 is anarrow slot 44 which allows a lost motion connection between theindicator sleeve 20 and theplunger 45 as to be described below. At 90° to theslots internal guide grooves 46 that constrain the plunger so that it moves longitudinally without rotational movement. Thebridge 30 includes ananchorage 48 for one end of anindicator spring 50. - The plunger is generally of stepped cylindrical form having a flat
front end face 52 for engaging the syringe plunger (not shown) and open at its rear end to receive the front end of adrive spring 54.Side ribs 53 run in theguide grooves 46 of the rear body housing. Extending rearwardly from the upper side of the plunger as viewed is atab 56 having alatch rib 58 which cooperates with acomplementary latch rib 60 on thetrigger 16 when the plunger is in its cocked position. Astop 62 upstands from a forward region of thetab 56 and cooperates with thebridge 30 on the rear body housing 26 to limit forward movement of the plunger. Extending along the entire length of themain plunger body 45 is a partcylindrical support surface 65 which cooperates with thelatch finger 34 to prevent inward resilient deflection of theaxial finger 34 until the plunger is at or near its forwardmost position. - The
indicator sleeve 20 is slideably mounted around the outside of therear body housing 26 for movement between the forwardmost, indicating, position shown inFigures 7(a) and 8(a) to the retracted position shown inFigures 7(d) and 8(d) . Theindicator 20 is biased forwardly by means of theindicator spring 50 which is a tension spring. Theindicator spring 50 is connected to theindicator 20 at aspring anchorage 64. - A collar fitting 66 clips to the front end of the rear body housing 26 by means of sprung
arms 68 which clip around thebridge 30. The collar fitting provides an annular stop surface 69 (seeFigure 3 ) which limits forward movement of theindicator sleeve 20 and also acts as an impact surface to generate an audible/tactile signal. Thecollar fitting 66 also includes athread 67 to allow the rear body assembly to be screwed to thefront body assembly 10. - The
indicator sleeve 20 is cut away on its upper surface to leave a cutaway region at the forward end of which is acircumferential finger 70 resiliently attached by alive hinge 72 to theindicator sleeve 20. Thecircumferential finger 70 cooperates with thelatch tooth 38 on theaxial finger 34 of the rear body assembly in a manner to be described below. Opposite the cutaway region and projecting inwardly from the inner wall of the indicator is aprojection 74 which extends through thenarrow slot 44 in the base of therear body assembly 26 to project into the path of the rear of the plunger as it is moved rearwardly to cock the device. - Referring now more particularly to the sequence shown in
Figures 7(a) to (h) and 8(a) to (h) ,Figure 7(a) shows the various components of the rear body assembly in the configuration prior to cocking. Theindicator sleeve 20 and theplunger 45 are at their forwardmost positions with theindicator spring 50 and main drive springs 54 in relatively relaxed conditions. In order to cock the device, the front end of the front body assembly 10 (or any other suitable tool) is placed against the front end face 52 of the plunger to urge the plunger rearwardly. As the plunger moves rearwardly, themain drive spring 54 is compressed (Figures 7(b) and 8(b) ). After a small amount of rearward movement, the rearward surface of the plunger contacts theprojection 74 on theindicator sleeve 20 so that the two move rearwardly together (Figures 7(c) and 8(c) ). At this point, thesupport surface 65 on theplunger 45 is underlying theaxial finger 34 thereby preventing it from resilient inward movement. Further rearward movement of theplunger 45 carries theindicator sleeve 20 with it so that thecircumferential finger 70 engages the shallow inclined forward facingramp surface 40 on thelatch tooth 38 so as to snap past it (Figures 7(d) and 8(d) ). The force of theextended indicator spring 50, the ramp angle of the steeprearward ramp face 42 and the flexibility of thelive hinge 72 are selected such that the tension spring is not strong enough to pull thecircumferential finger 70 back past thelatch tooth 38 when theaxial finger 34 is held against inward deflection. - In this position, the
latch rib 58 on the plunger has snapped past thelatch rib 60 on thetrigger 16 thereby cocking the plunger and restraining it against movement, with thedrive spring 54 compressed. - The rear assembly is now in a cocked position ready for firing and the device can be assembled by loading a syringe into the front body portion and screwing it onto the rear body portion. To fire the device, the
trigger 16 is depressed, releasing theplunger 45 for forward movement (Figures 7(e) and 8(e) ). Theplunger 45 then moves forwardly to extend the syringe and, during all but the last part of the stroke of movement of the piston, thesupport surface 65 thereon underlies theaxial finger 34 and prevents it from displacing inwardly and so theindicator sleeve 20 is held in its rearmost position (seeFigures 7(f) and(g) ). But in the final part of the stroke theplunger 45 is in a position where thesupport surface 62 is forwardly of the axial finger, no longer supporting it, so that thecircumferential finger 70 on the indicator sleeve may cam theaxial finger 34 downwardly, releasing the indicator sleeve to shoot forwards to impact the collar fitting 66, emitting an audible and tactile signal as the forward facing circumferential edge on the indicator element strikes a corresponding rearward surface on the collar fitting 66, and also making the indicator visible behindwindow 18 of thecover 14. - In this manner, audible, visual and tactile indications of end of dose are provided for the user without significantly diverting the energy of the
main drive spring 54. Also the indicator is reset automatically each time the device is locked.
Claims (9)
- An injection device including an injection complete indicator for providing a kinetic impact indication, the device including:a housing (26);a plunger (45) movable in said housing between cocked and fired positions under the influence of a plunger drive source (54); andan indicator element (20),the device being characterised in that the indicator element (20) is movable between an extended position and a retracted position and being biased towards said extended position by an indicator bias (50); and in that the device includesan indicator latch arrangement (70,34) for latching said indicator element (20) in a retracted position;a motion transfer arrangement (74) between the plunger and the indicator element for retracting said indicator element (20) to said retracted position as said plunger (45) is moved to its cocked position but allowing forward movement of said plunger relative to the indicator element;the device being arranged such that, after firing, as the plunger (45) nears or reaches the end of its operating stroke, it enables release of the indicator latch arrangement (70,34) to cause the indicator element (20) to move to its extended position under the influence of said bias to impact a stop surface to create said kinetic impact.
- An injection device according to Claim 1, wherein said motion transfer arrangement comprises an abutment surface associated with one of said plunger (45) and said indicator element (20) and a cooperating projection (74) associated with the other thereof.
- An injection device according to Claim 1 or Claim 2, wherein said indicator latch arrangement includes a flexible latch finger (34) associated with said housing and having a latching tooth (38) past which a flexible finger (70) on the indicator element (20) may snap past as the indicator element is moved to its retracted position.
- An injection device according to Claim 3, wherein the latch finger (34) associated with the housing is resiliently deflectable to allow said indicator finger (70) to move forwardly, with the deflection being prevented except when the plunger is at or near the end of its stroke.
- An injection device according to Claim 4, wherein the plunger (45) is movable longitudinally between its cocked and fired positions, and the body finger (34) extends generally longitudinally, with the plunger (45) having a support surface (62) which underlies the body finger (34), until the plunger nears or reaches the end of its stroke.
- An injection device according to any of Claims 3 to 5, wherein the latch tooth (38) comprises respective ramp surfaces (40,42) facing in the cocking and firing directions respectively, with the ramp surfaces providing a profile in which the inclination of the ramp face first contacted by the indicator finger when moving to its retracted position is shallower than the other face, whereby the indicator finger (70) can snap past the latch tooth (38) when moving in the direction of retraction, but not in the opposite direction.
- An injection device according to any preceding Claim, wherein said indicator element (20) also provides a visual indication on approaching or arriving at said extended position.
- An injection device according to any of Claims, wherein the indicator element (20) comprises an element of sleeve or part sleeve mounted for sliding movement with respect to said housing (26).
- An injection device according to Claim 8, wherein said indicator element (20) is provided with a forward facing edge adapted to impact a rearward facing surface associated with said housing (26).
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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US201161448410P | 2011-03-02 | 2011-03-02 | |
GB1103558.1A GB2488579A (en) | 2011-03-02 | 2011-03-02 | Autoinjector with "injection complete" indicator |
PCT/GB2012/050467 WO2012117252A1 (en) | 2011-03-02 | 2012-03-02 | Injection devices |
Publications (2)
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EP2680905A1 EP2680905A1 (en) | 2014-01-08 |
EP2680905B1 true EP2680905B1 (en) | 2019-05-08 |
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EP12709359.9A Active EP2680905B1 (en) | 2011-03-02 | 2012-03-02 | Injection devices |
Country Status (4)
Country | Link |
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US (1) | US9744306B2 (en) |
EP (1) | EP2680905B1 (en) |
GB (1) | GB2488579A (en) |
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US20130338601A1 (en) | 2013-12-19 |
EP2680905A1 (en) | 2014-01-08 |
US9744306B2 (en) | 2017-08-29 |
WO2012117252A1 (en) | 2012-09-07 |
GB2488579A (en) | 2012-09-05 |
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