EP2678031A4 - Combined cell based gp96-ig-siv/hiv, recombinant gp120 protein vaccination for protection from siv/hiv - Google Patents
Combined cell based gp96-ig-siv/hiv, recombinant gp120 protein vaccination for protection from siv/hivInfo
- Publication number
- EP2678031A4 EP2678031A4 EP12750264.9A EP12750264A EP2678031A4 EP 2678031 A4 EP2678031 A4 EP 2678031A4 EP 12750264 A EP12750264 A EP 12750264A EP 2678031 A4 EP2678031 A4 EP 2678031A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- siv
- hiv
- recombinant
- protection
- cell based
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 238000002255 vaccination Methods 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
- A61K2239/31—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterized by the route of administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
- A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the dose, timing or administration schedule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/21—Retroviridae, e.g. equine infectious anemia virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/4644—Cancer antigens
- A61K39/464476—Heat shock proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/464838—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55516—Proteins; Peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6043—Heat shock proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6056—Antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/15011—Lentivirus, not HIV, e.g. FIV, SIV
- C12N2740/15034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Virology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Cell Biology (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Developmental Biology & Embryology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161445884P | 2011-02-23 | 2011-02-23 | |
PCT/US2012/026256 WO2012116142A2 (en) | 2011-02-23 | 2012-02-23 | Combined cell based gp96-ig-siv/hiv, recombinant gp120 protein vaccination for protection from siv/hiv |
Publications (2)
Publication Number | Publication Date |
---|---|
EP2678031A2 EP2678031A2 (en) | 2014-01-01 |
EP2678031A4 true EP2678031A4 (en) | 2015-09-02 |
Family
ID=46721440
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP12750264.9A Withdrawn EP2678031A4 (en) | 2011-02-23 | 2012-02-23 | Combined cell based gp96-ig-siv/hiv, recombinant gp120 protein vaccination for protection from siv/hiv |
Country Status (9)
Country | Link |
---|---|
US (1) | US20140286991A1 (en) |
EP (1) | EP2678031A4 (en) |
JP (1) | JP2014508762A (en) |
KR (1) | KR20140045341A (en) |
CN (1) | CN103501807A (en) |
AU (1) | AU2012220592A1 (en) |
CA (1) | CA2828443A1 (en) |
WO (1) | WO2012116142A2 (en) |
ZA (1) | ZA201307069B (en) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2717854C (en) | 2008-03-03 | 2019-02-19 | The University Of Miami | Allogeneic cancer cell-based immunotherapy |
EP2274001A4 (en) | 2008-03-20 | 2012-08-01 | Univ Miami | Heat shock protein gp96 vaccination and methods of using same |
WO2016007765A1 (en) | 2014-07-11 | 2016-01-14 | Gilead Sciences, Inc. | Modulators of toll-like receptors for the treatment of hiv |
SG11201705844SA (en) * | 2015-02-06 | 2017-08-30 | Heat Biologics Inc | Vector co-expressing vaccine and costimulatory molecules |
US11666649B2 (en) | 2016-10-11 | 2023-06-06 | University Of Miami | Vectors and vaccine cells for immunity against Zika virus |
WO2018187260A1 (en) | 2017-04-04 | 2018-10-11 | Heat Biologics, Inc. | Intratumoral vaccination |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2010060026A1 (en) * | 2008-11-21 | 2010-05-27 | University Of Miami | Hiv/siv vaccines for the generation of mucosal and systemic immunity |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2001257072A1 (en) * | 2000-04-17 | 2001-10-30 | Qais Al-Awqati | Methods and compositions for heat shock protein mediated immunotherapy of melanoma |
CZ20024154A3 (en) * | 2000-06-26 | 2003-08-13 | Stressgen Biotechnologies Corporation | Use of a composition containing heat shock protein for treating warts, diseases, and states connected with papilloma virus |
DK1363938T3 (en) * | 2000-08-03 | 2014-03-24 | Univ Johns Hopkins | Molecular vaccine that connects an endoplasmic reticulum-chaperonepolypeptid with an antigen |
GB0118367D0 (en) * | 2001-07-27 | 2001-09-19 | Glaxosmithkline Biolog Sa | Novel use |
EP1479689A1 (en) * | 2003-05-21 | 2004-11-24 | Biotech Tools S.A. | Peptide complex |
CN101351223A (en) * | 2005-10-17 | 2009-01-21 | 诺华有限公司 | Multiclade HIV vaccines |
CN101057975B (en) * | 2006-12-13 | 2012-10-10 | 中国科学院微生物研究所 | Cocktail vaccine for anti immune tolerance and immunodeficiency virus and its application |
CN101002949A (en) * | 2006-12-25 | 2007-07-25 | 叶新新 | HIV-Env gene DNA allosterism recombination envelope protein antigen for immunoresponsiveness of anti-HIV test and method |
-
2012
- 2012-02-23 CN CN201280013070.XA patent/CN103501807A/en active Pending
- 2012-02-23 KR KR1020137024712A patent/KR20140045341A/en not_active Application Discontinuation
- 2012-02-23 WO PCT/US2012/026256 patent/WO2012116142A2/en active Application Filing
- 2012-02-23 EP EP12750264.9A patent/EP2678031A4/en not_active Withdrawn
- 2012-02-23 AU AU2012220592A patent/AU2012220592A1/en not_active Abandoned
- 2012-02-23 CA CA2828443A patent/CA2828443A1/en not_active Abandoned
- 2012-02-23 US US14/001,112 patent/US20140286991A1/en not_active Abandoned
- 2012-02-23 JP JP2013555542A patent/JP2014508762A/en active Pending
-
2013
- 2013-09-19 ZA ZA2013/07069A patent/ZA201307069B/en unknown
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2010060026A1 (en) * | 2008-11-21 | 2010-05-27 | University Of Miami | Hiv/siv vaccines for the generation of mucosal and systemic immunity |
Non-Patent Citations (5)
Title |
---|
BELSHE R B ET AL: "NEUTRALIZING ANTIBODIES TO HIV-1 IN SERONEGATIVE VOLUNTEERS IMMUNIZED WITH RECOMBINANT GP120 FROM THE MN STRAIN OF HIV-1", JAMA THE JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, AMERICAN MEDICAL ASSOCIATION, US, vol. 272, no. 6, 10 August 1994 (1994-08-10), pages 475 - 480, XP000197424, ISSN: 0098-7484, DOI: 10.1001/JAMA.272.6.475 * |
DORIA-ROSE N A ET AL: "Human Immunodeficiency Virus Type 1 subtype B Ancestral Envelope Protein Is Functional and Elicits Neutralizing Antibodies in Rabbits Similar to Those Elicited by a Circulating Subtype B Envelope", JOURNAL OF VIROLOGY, THE AMERICAN SOCIETY FOR MICROBIOLOGY, US, vol. 79, no. 17, 1 September 2005 (2005-09-01), pages 11214 - 11224, XP008112620, ISSN: 0022-538X, DOI: 10.1128/JVI.79.17.11214-11224.2005 * |
GEOFFREY J. GORSE ET AL: "HIV-1MN Recombinant Glycoprotein 160 Vaccine-Induced Cellular and Humoral Immunity Boosted by HIV-1MN Recombinant Glycoprotein 120 Vaccine", AIDS RESEARCH AND HUMAN RETROVIRUSES, vol. 15, no. 2, 20 January 1999 (1999-01-20), pages 115 - 132, XP055204334, ISSN: 0889-2229, DOI: 10.1089/088922299311547 * |
MCFARLAND E J ET AL: "Human immunodeficiency virus type 1 (HIV-1) gp120-specific antibodies in neonates receiving an HIV-1 recombinant gp120 vaccine", JOURNAL OF INFECTIOUS DISEASES. JID, UNIVERSITY OF CHICAGO PRESS, CHICAGO, IL, vol. 184, no. 10, 15 November 2001 (2001-11-15), pages 1331 - 1335, XP002391888, ISSN: 0022-1899, DOI: 10.1086/323994 * |
NATASA STRBO ET AL: "Gp96Ig immunization induces potent polyepitope specific, multifunctional memory responses in rectal and vaginal mucosa", VACCINE, ELSEVIER LTD, GB, vol. 29, no. 14, 17 January 2011 (2011-01-17), pages 2619 - 2625, XP028172311, ISSN: 0264-410X, [retrieved on 20110120], DOI: 10.1016/J.VACCINE.2011.01.044 * |
Also Published As
Publication number | Publication date |
---|---|
WO2012116142A3 (en) | 2012-10-26 |
JP2014508762A (en) | 2014-04-10 |
KR20140045341A (en) | 2014-04-16 |
CA2828443A1 (en) | 2012-08-30 |
CN103501807A (en) | 2014-01-08 |
EP2678031A2 (en) | 2014-01-01 |
AU2012220592A1 (en) | 2013-09-12 |
WO2012116142A2 (en) | 2012-08-30 |
ZA201307069B (en) | 2016-01-27 |
US20140286991A1 (en) | 2014-09-25 |
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Legal Events
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Owner name: THE UNITED STATES OF AMERICA, AS REPRESENTED BY TH Owner name: UNIVERSITY OF MIAMI |
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A4 | Supplementary search report drawn up and despatched |
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RIC1 | Information provided on ipc code assigned before grant |
Ipc: A61K 39/00 20060101AFI20150729BHEP Ipc: A61K 39/21 20060101ALI20150729BHEP Ipc: A61K 39/12 20060101ALI20150729BHEP Ipc: A61K 35/17 20150101ALI20150729BHEP |
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