EP2673039A1 - Zweistufiges system und verfahren zur sauerstoffanreicherung und entfernung von kohlendioxid aus einer physiologischen flüssigkeit - Google Patents
Zweistufiges system und verfahren zur sauerstoffanreicherung und entfernung von kohlendioxid aus einer physiologischen flüssigkeitInfo
- Publication number
- EP2673039A1 EP2673039A1 EP11858232.9A EP11858232A EP2673039A1 EP 2673039 A1 EP2673039 A1 EP 2673039A1 EP 11858232 A EP11858232 A EP 11858232A EP 2673039 A1 EP2673039 A1 EP 2673039A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- oxygen
- carbon dioxide
- carrier fluid
- fluid
- exchange module
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000012530 fluid Substances 0.000 title claims abstract description 275
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 title claims abstract description 254
- 229910002092 carbon dioxide Inorganic materials 0.000 title claims abstract description 127
- 239000001569 carbon dioxide Substances 0.000 title claims abstract description 127
- 230000001706 oxygenating effect Effects 0.000 title claims abstract description 12
- 238000000034 method Methods 0.000 title claims description 18
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims abstract description 148
- 229910052760 oxygen Inorganic materials 0.000 claims abstract description 148
- 239000001301 oxygen Substances 0.000 claims abstract description 148
- 239000007789 gas Substances 0.000 claims abstract description 72
- 238000012546 transfer Methods 0.000 claims abstract description 61
- 239000012510 hollow fiber Substances 0.000 claims description 33
- 210000004072 lung Anatomy 0.000 claims description 29
- 238000004891 communication Methods 0.000 claims description 19
- 230000002792 vascular Effects 0.000 claims description 18
- 239000000463 material Substances 0.000 claims description 11
- 239000000835 fiber Substances 0.000 claims description 10
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 claims description 3
- 239000012080 ambient air Substances 0.000 claims description 3
- 239000000560 biocompatible material Substances 0.000 claims description 3
- 229910001882 dioxygen Inorganic materials 0.000 claims description 3
- 230000002209 hydrophobic effect Effects 0.000 claims description 3
- 241000237509 Patinopecten sp. Species 0.000 claims description 2
- 235000020637 scallop Nutrition 0.000 claims description 2
- 230000000087 stabilizing effect Effects 0.000 claims description 2
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- 206010062016 Immunosuppression Diseases 0.000 description 4
- 230000001684 chronic effect Effects 0.000 description 4
- 230000001506 immunosuppresive effect Effects 0.000 description 4
- 201000009794 Idiopathic Pulmonary Fibrosis Diseases 0.000 description 3
- 230000004913 activation Effects 0.000 description 3
- 208000036971 interstitial lung disease 2 Diseases 0.000 description 3
- 210000000056 organ Anatomy 0.000 description 3
- 208000002815 pulmonary hypertension Diseases 0.000 description 3
- 238000001356 surgical procedure Methods 0.000 description 3
- 238000002689 xenotransplantation Methods 0.000 description 3
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 description 2
- 241000237858 Gastropoda Species 0.000 description 2
- 206010058467 Lung neoplasm malignant Diseases 0.000 description 2
- 208000004756 Respiratory Insufficiency Diseases 0.000 description 2
- 210000001015 abdomen Anatomy 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
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- 238000005192 partition Methods 0.000 description 2
- -1 polytetra- fluoroethylene Polymers 0.000 description 2
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- 201000004193 respiratory failure Diseases 0.000 description 2
- 206010001052 Acute respiratory distress syndrome Diseases 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 102000001554 Hemoglobins Human genes 0.000 description 1
- 108010054147 Hemoglobins Proteins 0.000 description 1
- 208000004852 Lung Injury Diseases 0.000 description 1
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- 206010028980 Neoplasm Diseases 0.000 description 1
- 239000004697 Polyetherimide Substances 0.000 description 1
- 241000288906 Primates Species 0.000 description 1
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- 230000002427 irreversible effect Effects 0.000 description 1
- 230000004199 lung function Effects 0.000 description 1
- 231100000515 lung injury Toxicity 0.000 description 1
- 238000005399 mechanical ventilation Methods 0.000 description 1
- 238000006213 oxygenation reaction Methods 0.000 description 1
- 229950011087 perflunafene Drugs 0.000 description 1
- UWEYRJFJVCLAGH-IJWZVTFUSA-N perfluorodecalin Chemical compound FC1(F)C(F)(F)C(F)(F)C(F)(F)[C@@]2(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)[C@@]21F UWEYRJFJVCLAGH-IJWZVTFUSA-N 0.000 description 1
- 239000004417 polycarbonate Substances 0.000 description 1
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- 229920001601 polyetherimide Polymers 0.000 description 1
- 229920002338 polyhydroxyethylmethacrylate Polymers 0.000 description 1
- 229940058401 polytetrafluoroethylene Drugs 0.000 description 1
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- 150000003180 prostaglandins Chemical class 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
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- 230000002441 reversible effect Effects 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 230000000391 smoking effect Effects 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- TXEYQDLBPFQVAA-UHFFFAOYSA-N tetrafluoromethane Chemical compound FC(F)(F)F TXEYQDLBPFQVAA-UHFFFAOYSA-N 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
- A61M1/1698—Blood oxygenators with or without heat-exchangers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/32—Oxygenators without membranes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D63/00—Apparatus in general for separation processes using semi-permeable membranes
- B01D63/02—Hollow fibre modules
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D63/00—Apparatus in general for separation processes using semi-permeable membranes
- B01D63/02—Hollow fibre modules
- B01D63/028—Microfluidic devices comprising semi-permeable hollow fibre membranes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
- A61M1/1678—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes intracorporal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/02—General characteristics of the apparatus characterised by a particular materials
- A61M2205/0244—Micromachined materials, e.g. made from silicon wafers, microelectromechanical systems [MEMS] or comprising nanotechnology
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/04—General characteristics of the apparatus implanted
Landscapes
- Health & Medical Sciences (AREA)
- Emergency Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Anesthesiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Vascular Medicine (AREA)
- Dispersion Chemistry (AREA)
- External Artificial Organs (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US2011/000236 WO2012108855A1 (en) | 2011-02-10 | 2011-02-10 | A two-stage system and method for oxygenating and removing carbon dioxide from a physiological fluid |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EP2673039A1 true EP2673039A1 (de) | 2013-12-18 |
| EP2673039A4 EP2673039A4 (de) | 2018-03-07 |
Family
ID=46638854
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP11858232.9A Pending EP2673039A4 (de) | 2011-02-10 | 2011-02-10 | Zweistufiges system und verfahren zur sauerstoffanreicherung und entfernung von kohlendioxid aus einer physiologischen flüssigkeit |
Country Status (2)
| Country | Link |
|---|---|
| EP (1) | EP2673039A4 (de) |
| WO (1) | WO2012108855A1 (de) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019079838A1 (en) * | 2017-10-25 | 2019-05-02 | Technische Universität Wien | METHOD AND SYSTEM FOR REGULATING PERMEAT EXCHANGE RATES |
| US11191888B1 (en) | 2020-05-18 | 2021-12-07 | Agitated Solutions Inc. | Syringe-based microbubble generator |
| CN111494741A (zh) * | 2020-05-25 | 2020-08-07 | 清华大学 | 一种用于体外循环的人工肺 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5492109A (en) * | 1993-11-03 | 1996-02-20 | The Regents Of The University Of Michigan | Liquid ventilator with venturi-inducing patient connector |
| DE19804536C2 (de) | 1998-02-05 | 2003-04-10 | Inst Polymerforschung Dresden | Verfahren zur Oxygenation von Blut |
| US20020143397A1 (en) * | 2001-04-02 | 2002-10-03 | Von Segesser Ludwig K. | Compliant artificial lung for extrapulmonary gas transfer |
| US20040009096A1 (en) * | 2002-06-08 | 2004-01-15 | Wellman Parris S. | Substantially inertia free hemodialysis |
| JP4665791B2 (ja) * | 2005-04-15 | 2011-04-06 | ニプロ株式会社 | 酸素運搬体の脱一酸化炭素化方法、脱一酸化炭素化された酸素運搬体、その医薬組成物及び脱一酸化炭素化装置 |
| US20090018484A1 (en) * | 2007-07-11 | 2009-01-15 | Levitov Alexander B | System device and method for oxygenation |
-
2011
- 2011-02-10 WO PCT/US2011/000236 patent/WO2012108855A1/en active Application Filing
- 2011-02-10 EP EP11858232.9A patent/EP2673039A4/de active Pending
Non-Patent Citations (1)
| Title |
|---|
| See references of WO2012108855A1 * |
Also Published As
| Publication number | Publication date |
|---|---|
| EP2673039A4 (de) | 2018-03-07 |
| WO2012108855A1 (en) | 2012-08-16 |
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| PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
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Effective date: 20130829 |
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| DAX | Request for extension of the european patent (deleted) | ||
| RA4 | Supplementary search report drawn up and despatched (corrected) |
Effective date: 20180202 |
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| RIC1 | Information provided on ipc code assigned before grant |
Ipc: B01D 63/02 20060101ALI20180129BHEP Ipc: A61M 1/16 20060101AFI20180129BHEP Ipc: A61M 1/32 20060101ALI20180129BHEP |
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| 19U | Interruption of proceedings before grant |
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| 19W | Proceedings resumed before grant after interruption of proceedings |
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| P01 | Opt-out of the competence of the unified patent court (upc) registered |
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Owner name: VIVONICS, INC. |
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