EP2654709A2 - Préparations cosmétiques ou dermatologiques à teneur élevée en huile de silicone, contenant une combinaison d'épaississants de polyacrylate et de polyacrylamide - Google Patents

Préparations cosmétiques ou dermatologiques à teneur élevée en huile de silicone, contenant une combinaison d'épaississants de polyacrylate et de polyacrylamide

Info

Publication number
EP2654709A2
EP2654709A2 EP11801678.1A EP11801678A EP2654709A2 EP 2654709 A2 EP2654709 A2 EP 2654709A2 EP 11801678 A EP11801678 A EP 11801678A EP 2654709 A2 EP2654709 A2 EP 2654709A2
Authority
EP
European Patent Office
Prior art keywords
thickeners
cosmetic
preparation
preparation according
polyacrylate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP11801678.1A
Other languages
German (de)
English (en)
Inventor
Dara HUN
Frauke Koch
Andreas Bleckmann
Anja Eitrich
Christopher Mummert
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beiersdorf AG
Original Assignee
Beiersdorf AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beiersdorf AG filed Critical Beiersdorf AG
Publication of EP2654709A2 publication Critical patent/EP2654709A2/fr
Withdrawn legal-status Critical Current

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/89Polysiloxanes
    • A61K8/891Polysiloxanes saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone
    • A61K8/892Polysiloxanes saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone modified by a hydroxy group, e.g. dimethiconol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/58Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing atoms other than carbon, hydrogen, halogen, oxygen, nitrogen, sulfur or phosphorus
    • A61K8/585Organosilicon compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/81Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
    • A61K8/8141Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
    • A61K8/8152Homopolymers or copolymers of esters, e.g. (meth)acrylic acid esters; Compositions of derivatives of such polymers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/81Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
    • A61K8/8141Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
    • A61K8/8158Homopolymers or copolymers of amides or imides, e.g. (meth) acrylamide; Compositions of derivatives of such polymers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/89Polysiloxanes
    • A61K8/891Polysiloxanes saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/04Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59Mixtures
    • A61K2800/594Mixtures of polymers

Definitions

  • Cosmetic or dermatological preparations with high silicone oil content comprising a combination of polyacrylate and polyacrylamide thickener
  • the invention includes cosmetic or dermatological preparations, in particular sunscreen preparations, comprising a combination of polyacrylate and
  • Polyacrylamidverdicker Despite a high silicone oil content, the preparations have advantageous stability and product sensor technology.
  • UV-B Wavelength in the range of 280 to 320 nm, known as UV-B, causes erythema and skin burns that may be detrimental to the formation of natural tan. The UV-B radiation should therefore be filtered out.
  • UV-A radiation having a wavelength in the range of 320 to 400 nm, which tans the skin, can cause a change in the skin, especially in the case of sensitive skin or skin that is continuously exposed to solar radiation.
  • UV-A radiation causes a loss of elasticity of the skin and the
  • UV-B filters UV-A filters
  • broadband filters which show a filtering effect over the entire range of UV-A and UV-B.
  • the absorbance values can at best provide orientation, since interactions with ingredients of the formulation or of the skin itself can lead to imponderables.
  • Oil-soluble UV filters are better bound to the (lipophilic) surface of the skin or are harder to wash off of it than water-soluble UV filters.
  • sunscreen or the underlying UV filter is usually determined in biological efficacy tests under standardized conditions.
  • the sun protection factor LSF often also called SPF (sun protection factor) indicates the extension of the sun exposure, which is made possible by using the sunscreen. It is the ratio of erythema threshold with sunscreen and erythema threshold without sunscreen.
  • IPD immediate pigment darkening
  • a value is determined which indicates by how much longer the skin protected with the sunscreen can be irradiated with UV-A radiation until the same pigmentation occurs as with the unprotected skin.
  • the SPF (Sun Protection Factor) will be issued in accordance with the regulations of the
  • SPF quotient of minimal erythemal dose (MED) on protected and unprotected skin.
  • the MED is the lowest dose of UV radiation, which causes a slight but noticeable erythema (sunburn, erythema) after 16-24h.
  • Radiation sources are solar simulators, mostly with xenon lamps.
  • UV radiation of different frequency / wavelength penetrates the tissue at different depths. Therefore, the type of damage is wavelength dependent.
  • the UV-A protection is of particular importance here, since this UV radiation (UV-A (wavelength 315-400 nm), is essentially responsible for skin aging
  • UVA filters are among the chemical sunscreen filters. They penetrate the skin, absorb the high-energy UV radiation there and convert it into heat or light energy, which can no longer cause any damage. Although it is for the determination of UVA protection currently has no recognized test method (in contrast to the COLI PA method for UVB filters), in practice the so-called UVA / UVB protection balance should apply.
  • UVA protection In order to provide information on the UVA protection performance of a sunscreen product, various experimental models, both in vivo and in vitro, are used and derived statements are made on the packaging (UVA protection according to
  • UVA / UVB balance is the basis of the method discussed there. It is modified to include a pre-irradiation with UV light to include some special UV filter systems. So far, the products have been tested without pre-irradiation. As a result, no information could be provided as to whether the protective effect of the product under real conditions is given by sun exposure. This advanced measurement method is called "COLIPA Ratio".
  • UVA filters are used in relation of 1: 3 to UVB filters and thus the UVA protection is raised with increasing light protection.
  • the EU recommendation provides 1/3 UVA protection in relation to UVB protection. This measurement method is called "COLIPA Ratio.”
  • the COLIPA ratio must be according to the formula
  • the COLIPA ratio is the standard for determining UVA protection. With regard to the stabilization and achievement of a high UV protection, there are various disclosures in the prior art.
  • EP 887069 A2 discloses a UV-A boosting by synthetic beeswax or natural beeswax.
  • Boosting herein means an increase in performance over preparations without beeswax.
  • EP 1965871 A2 discloses cosmetic preparations with a UV-A balance of greater than 35 containing one or more merocyanines.
  • UV filter substances This increased proportion of UV filter substances in turn leads to skin-friendlier preparations that feel dull and sticky, are difficult to rub, more problematic to formulate and, above all, are not long-term stable.
  • Thickeners are auxiliaries for establishing a suitable product consistency and a suitable flow behavior of cosmetic or dermatological preparations. They are preferably used in emulsions and surfactant-containing cleaning products.
  • the substance group of the thickeners can be roughly into the natural thickeners, such as starch, gelatin, alginates, the modified natural substances, such as cellulose ethers or
  • Hydroxyethyl cellulose and the fully synthetic polymers, such as. As polyacrylates, divide.
  • Known natural or modified thickeners include polysaccharides, xanthan gum, cellulose ethers and other cellulose derivatives such as carboxymethylcellulose, hydroxyethylcellulose, gelatin, starch and starch derivatives, sodium alginates,
  • Fatty acid polyethylene glycol ester Fatty acid polyethylene glycol ester, agar-agar, tragacanth or dextrins and mixtures it. Further thickeners are known on the basis of silicates or modified clays such as bentonites or hectorites or their derivatives.
  • polyacrylate thickeners examples are polyacrylates from the group of the so-called carbopols, for example Carbopols of the types 980, 981, 1382, 2020, 2984, 3128, 5984 and permulenes TR1, TR2, in each case individually or in combination.
  • carbopols for example Carbopols of the types 980, 981, 1382, 2020, 2984, 3128, 5984 and permulenes TR1, TR2, in each case individually or in combination.
  • Carbopol 3128 is an acrylates / C 10-30 alkyl acrylate crosspolymer, a copolymer of C10-30 alkyl acrylate and one or more monomers of acrylic acid, methacrylic acid and their simple ester branched with an allyl ether of sucrose or an allyl ether of pentaerythritol.
  • the preferred gel and structure formers mentioned are permulenes TR 1 and Carbopol 3128, which, on the one hand, have very good emulsifying properties but, on the other hand, also lead to a high shear-thinning, rheological behavior. That they form a strong structure, which spontaneously collapses under shear.
  • polyacrylamide thickener are also used as anionic or cationic modified products (anionic and cationic polyacrylamides), the z.
  • Example be obtained by copolymerization of acrylamide with sodium acrylate or quaternary ammonium acrylates according to the following structure
  • Known polyacrylamides are the crosslinked copolymer with the trade name Sepigel 305 (CTFA name: polyacrylamide / C13-14 isoparaffin / Laureth 7) or Simulgel 600 (CTFA name: acrylamide / sodium acryloyldimethyltaurate copolymer / isohexadecane / polysorbate 80) from SEPPIC.
  • CFA name polyacrylamide / C13-14 isoparaffin / Laureth 7
  • Simulgel 600 CTFA name: acrylamide / sodium acryloyldimethyltaurate copolymer / isohexadecane / polysorbate 80
  • SEPI PLUS 265 an acrylamide / ammonium acrylate copolymer in admixture with polyisobutenes and polysorbate 20, the company SEPPIC.
  • Cosmetic preparations comprising Sepiplus 265 are known, for example, as an anti-age product Nutri 35/50 comprising glycerol at 2% by weight, polyglyceryl-4 stearates at 3% by weight and further customary cosmetic constituents, and from US 20070237735.
  • the cosmetic specialist is often faced with the problem of ensuring the stability of the preparation and taking into account sensory aspects.
  • Formulations that are also used in combination with high silicone contents (> 5%) and high sunscreen levels (> 10%) over a period of 6 to 24 months
  • the invention is a cosmetic or dermatological preparation comprising a. ) one or more thickeners based on polyacrylate,
  • the preparations according to the invention have an improved stability of the preparation compared to preparations with the same UV filter content. Improved stability is particularly evident in improved storage stability.
  • Stress tests are carried out under different environmental conditions (heat, cold and room temperature) over a storage period of up to 360 days.
  • the preparations according to the invention have a good product sensor technology compared to the prior art and the UV light protection performance is not restricted.
  • polyacrylate-based thickeners in particular acrylates and acrylate crosspolymers are understood.
  • Carbopol The chemical nature of these acrylates, trade name Carbopol, is generically referred to as "carbomers" according to USP-NF (U.S.A. Pharmacopeia), European Pharmacopoeia, British Pharmacopoeia, United States Adopted Names Council (USAN), and International Nomenclature for Cosmetic Ingredients (INCI).
  • the Japanese Pharmacopoeia designates Carbopol homopolymers as "carboxyvinyl polymer” and "carboxy polymethylene.”
  • the Italian Pharmacopoeia identifies Carbopol 934P as “carboxy polymethylene” and the German Pharmacopoeia called Carbopol 980NF as "polyacrylic acid.”
  • Carbopol copolymers such as Carbopol 1342 NF and 1382, are referred to by the USP-NF as “carbomers”, which are also named “Acrylates / C10-C30 Alkyl Acrylates Cross Polymers” according to INCI
  • the acrylate crosspolymers commercially available under the names Pemulen TR1 and TR2, Carbopol 1342, 1382, ETD 2020, Ultrez 21 (Lubrizol Advanced Materials) as well as the commercial acrylates designated Carbopol 954, 5984, 980, 981, and 7 or Carbopol 2984 preferably to choose as polyacrylate-based thickener.
  • the acrylate / C 10-30 alkyl acrylate crosspolymer to be used as the polyacrylate thickener as Carbomer 3128 or Pemulen TR1, to choose.
  • the proportion of polyacrylate thickeners is preferably in a proportion of 0.01 wt.% To 1, 0 wt, preferably in the range of 0.2 to 0.7 wt.%, Based chosen on the total mass of the preparation.
  • Preferred polyacrylamide thickeners acrylamide / ammonium acrylate copolymers are selected.
  • Such a preferred polyacrylamide-based thickener commercially available as Sepiplus 265 is commercially available.
  • the acrylamide / ammonium acrylate copolymer is offered in the mixture with polyisubutylene, polysorbate 20, sorbitan isostearate and water.
  • polyamide thickeners are available, for example, under the names Sepiplus 250 (with mineral oil and polysorbate 20) from Seppic and the Bozepole CV from Clariant.
  • polyacrylamide-based thickeners are often only available in mixtures with the listed solvents PIB, etc. in order to improve their handling, for example to prevent the formation of dust.
  • the proportion of polyacrylamide thickeners is preferably chosen to a proportion of 0.1 to 4 wt.%, In particular in the range of 0.3 to 2 wt.%, Based on the total mass of the preparation. Preference is given to combining a combination of a polyacrylamide thickener, in particular acrylamide / ammonium acrylate copolymer (Sepiplus 265), and one or two different thickeners from the group of the polyacrylates, more particularly the acrylate crosspolymers.
  • the preparations furthermore advantageously comprise one or more powder raw materials.
  • a powder is a very finely ground, dry solid that is used in cosmetics.
  • the powder carriers exist depending on the application
  • Silicates talc and kaolin
  • carbonates magnesium or calcium carbonate
  • oxides zinc oxide, titanium dioxide
  • organic zinc and magnesium salts stearates, laurates and undecanates
  • sugar derivatives stearates, laurates and undecanates
  • the powder raw materials from the group of sugar derivatives are, for example, starch and / or starch derivatives or cyclodextrins and / or
  • starch powders are, for example, distarch phosphate, tapioca starch, acetyl or adipic acid substituted starch, hydroxypropylated starch, starch substituted with N-octenyl succinate, corn starch, 2-hydropropyl ether modified starch and
  • Tapioca or tapioca starch is an almost tasteless starch, which is made from the processed and dried cassava root (cassava).
  • Preferred powder raw materials are methyl methacrylate crosspolymer
  • the powder methyl methacrylate crosspolymer is also a polymer, it has no thickening properties due to its chemical structure.
  • the purder raw material (s) are preferably to be selected in a proportion in the range from 0.5% by weight to 4% by weight, based on the total mass of the preparation.
  • methyl methacrylate crosspolymer polymethylsilsesquioxane, tapioca starch and distarch phosphates.
  • These powder raw materials are used in particular to a proportion of 0.5 to 3 wt.%, Based on the total mass of the preparation
  • methyl methacrylate crosspolymer and / or
  • Polymethylsilsesquioxane particularly advantageous to use as a powder raw material.
  • the total proportion of powder raw materials is preferably still to be selected in the stated range of shares or only the preferably mentioned powder raw materials are present in the preparation in the stated range of proportions.
  • Lipids are fats and fat-like substances. For cosmetics, they are of importance, above all, as emollient ingredients and as skin-specific lipids of the horny layer, which are stored between the horny cells. They enable the skin to store moisture. In addition to the nourishing aspect, lipids become the cosmetic
  • Preparations added to ensure better distribution on the skin and to improve the sensory properties of the preparations.
  • cyclomethicone / decacyclopentasiloxane D5
  • cyclomethicone / dodecamethylcyclohexasiloxane D6
  • the mixtures can be used on their own or in appropriate formulations as volatile silicone compounds (Cosmet. Toiletries 107, No. 5, 27 [1992]).
  • Silicone containing oils include the high molecular weight polydiorganosiloxanes known as silicone gums. Silicone gums are described for example in US 4152416. High molecular weight means a molecular weight of about 200,000 to 1,000,000 g / mol.
  • Known silicone gums are polymeric polydimethylsiloxanes (INCI name:
  • Dimethicone e.g. As the products sold under the name DC 200 by Dow Corning products, polyphenylmethylsiloxanes (INCI name: Phenyl Trimethicone), z.
  • the commercial product DC 556 fluid from Dow Corning silicone-glycol copolymers (INCI Name: dimethicone copolyol), e.g.
  • the commercial products DC 190 and DC 193 Dow Corning esters and partial esters of silicone glycol copolymers, such as those sold by Fanning under the trade name Fancorsil LIM (INCI name: Dimethicone Copolyol Meadowfoamate), dimethylsiloxanes with hydroxy - end groups (INCI name: dimethiconol), z.
  • the commercial products DC 1401 and Q2-1403 from Dow Coming are examples of Dow Coming.
  • silicone gums are, for example, SE 30, SE 33, SE 54 and SE 76 from General Electric.
  • silicone gums from Dow Corning with the name Dow Corning® 1501 fluid (cyclopentasiloxanes, dimethiconol); Dow Corning® 1503 Fluid (dimethicone, dimethiconol), Dow Corning® CB 1556 fluid (phenyl trimethicone,
  • silicone fluids and volatile silicone oils such as cyclomethicones, and silicone gums are also known in cosmetic preparations.
  • the silicones to be used according to the invention preferably consist of light, e.g.
  • Volatile cyclic compounds such as cyclomethicones (D5 / D6) and smaller proportions of heavier linear silicone compounds
  • Dimethicones with siloxane units greater than 20 or so-called silicone gums such as, for example, DC 1501 fluid.
  • the cyclic compounds give the pleasant feeling on the skin, ensure very good spreadability and silky sensory properties directly on the distribution process of the product on the skin.
  • the linear compounds give a silky residue on the skin even after 5 minutes or even longer periods after the last application of the product
  • Preferred concentration ranges for the cyclomethicones according to the invention are from 2.0 to 12.0% by weight, preferably from 4.0 to 7.0% by weight, based on the total weight of the formulation.
  • Silicone compounds are in the range of 0.5 to 2.5 wt.%, Preferably 1, 0 to 2.0 wt.% Based on the total weight of the formulation.
  • the total content of the silicone phase in the formulation is therefore preferably between 3.5 and 12.5% by weight, preferably between 4.0 and 10.0% by weight, more preferably above 5%, in particular between 5.0 and 7.5% by weight, based on the total weight of the preparation.
  • the ratio of cyclomethicones to the long-chain linear silicone compounds should be between 10: 1 and 1: 1, preferably between 5: 1 and 2: 1.
  • a proportion of cyclic compounds which is at least always twice as high in relation to the linear silicones is preferably present in the formula according to the invention.
  • Long-chain means an Si atomic number greater than 20.
  • a measure of the UV protection performance in the context of the present invention is, for example, the sun protection factor (SPF or SPF).
  • the cosmetic and dermatological preparations in the sense of the present invention leave no greasy or sticky impression on the skin, have excellent skin compatibility and are furthermore surprisingly characterized by the fact that they have good stability despite the silicone oil content and despite the UV filter content.
  • UV filter substances based on triazine derivatives which are the structural motif
  • EP-A-775 698 EP-A-0 878 469 and EP-A-1 027 881.
  • Triazine derivatives according to the invention are therefore, for example, those which are described in EP-A-775,698:
  • R 4 and R 5 are selected from the group of branched and unbranched alkyl groups of 1 to 18 carbon atoms. Again, the alkyl groups may in turn be advantageously substituted with silyloxy groups.
  • Ai is advantageously a substituted homo- or heterocyclic aromatic five-membered or six-membered ring.
  • R 6 represents a hydrogen atom or a branched or unbranched alkyl group having 1 to 10 carbon atoms, in particular the 2,4-bis - ⁇ [4- (2-ethylhexyloxy) -2-hydroxy] - phenyl ⁇ -6- (4 -methoxyphenyl) -1, 3,5-triazine (INCI: aniso triazine), which is available under the trade name Tinosorb® S from CIBA-Chemikalien GmbH and characterized by the following structure:
  • dioctylbutylamidotriazone (INCI: dioctylbutamidotriazone), which is available under the trade name UVASORB HEB from Sigma 3V and is characterized by the following structural formula:
  • UV-A filter substance (s) of component (a) of the preparations according to the invention is or are the phenylene-1,4-bis (2-benzimidazyl) -3,3'-5,5'-tetrasulfonic acid
  • salts preferably the corresponding sodium, potassium or triethanolammonium salts, in particular the phenylene-1,4-bis (2-benzimidazyl) -3,3'-5,5'-tetrasulfonic acid bis-sodium salt
  • the at least one UV filter substance of component (a) may include 2,2'-methylenebis (6- (2H-benzotriazol-2-yl) -4- (1,1,3,3-tetramethylbutyl) phenol ) [INCI: bisoctyltriazole], which is represented by the chemical structural formula
  • UV filter substances are used together.
  • Exemplary combinations are:
  • Another embodiment of the present invention contains 2,4-bis - ⁇ [4- (2-ethyl-hexyl-oxy) -2-hydroxy] -phenyl ⁇ -6- (4-methoxyphenyl) -1, 3,5-triazine (Tinosorb® S), phenylene-1,4-bis (2-benzimidazyl) -3,3'-5,5'-tetrasulfonic acid bis-sodium salt (Neo Heliopan® AP) and 2,2'-methylene bis (6- (2H-benzotriazol-2-yl) -4- (1,1,3,3-tetramethylbutyl) -phenol) (Tinosorb® M) together as UV filter substances.
  • UV filter substances which are used in the preparations according to the invention are mentioned below:
  • Advantageous oil-soluble UV-B filters are z. B .:
  • 4-aminobenzoic acid derivatives preferably (2-ethylhexyl) 4- (dimethylamino) benzoate, 4- (dimethylamino) benzoic acid amyl ester;
  • Esters of cinnamic acid preferably 4-methoxycinnamic acid (2-ethylhexyl) ester, 4-methoxycinnamic acid isopentyl ester;
  • esters of salicylic acid preferably 2-ethylhexyl salicylate, 4-isopropylbenzyl salicylate, homomenthyl salicylate,
  • benzophenone preferably 2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxy-4'-methylbenzophenone, 2,2'-dihydroxy-4-methoxybenzophenone;
  • Esters of benzalmalonic acid preferably 4-methoxybenzalmalonic acid di (2-ethylhexyl ester, Symmetrical triazine derivatives, preferably 4,4 ', 4 "- (1,3,5-triazine-2,4,6-triyltriimino) -tris-benzoic acid tris (2-ethylhexyl ester) with respect to the C 3 axis of the triazine core [INCI: Octyl Triazone], which is marketed by BASF Aktiengesellschaft under the trade name UVINUL® T 150,
  • Benzotriazole derivatives preferably 2,2'-methylenebis (6- (2H-benzotriazol-2-yl) -4- (1,1,3,3-tetramethylbutyl) -phenol)
  • Advantageous water-soluble UV-B filter substances are z. B .:
  • ⁇ sulfonic acid derivatives of 3-benzylidenecamphor such as.
  • UV-A filters which can be used in formulations according to the invention are, for example, derivatives of dibenzoylmethane, in particular 1- (4'-tert-butylphenyl) -3- (4'-methoxyphenyl) propane-1,3-dione and 1-phenyl -3- (4'-isopropylphenyl) propane-1,3-dione.
  • Advantageous UV-A filter substance is also 4- (tert-butyl) -4'-methoxydibenzoylmethane (CAS-Nr. 70356-09-1), marketed by Givaudan under the trade name Parsol ® 1789 and from Merck under the trade name Eusolex ® 9020 is sold.
  • 1,4-di (2-oxo-10-sulfo-3-bomylidenemethyl) benzene and its salts especially the corresponding 10-sulfato compounds, in particular the corresponding sodium, potassium or triethanolammonium salt.
  • benzene-1, 4-di (2-oxo-3-bomylidenemethyl-10-sulfonic acid) is characterized by the following structure:
  • Advantageous filter substances which absorb both UV-A and UV-B radiation are, for example, 2,2'-methylenebis (6- (2H-benzotriazol-2-yl) -4- (1, 1, 3,3-tetramethylbutyl) phenol) or 2- (2H-benzotriazol-2-yl) -4-methyl-6- [2-methyl-3- [1,3,3,3- tetramethyl-1 - [(trimethylsilyl) oxy] disiloxanyl] propyl] phenol (CAS No .: 155633-54-8) with the INCI name Drometrizole Trisiloxane, which is represented by the chemical structural formula
  • a further light protection filter substance according to the invention to be used advantageously is ethylhexyl-2-cyano-3,3-diphenylacrylate (octocrylene), which is under the name Uvinul ® N 539 available from BASF and is characterized by the following structure:
  • the preparations according to the invention if they are in the form of so-called oil-free cosmetic or dermatological preparations, preferably present, which contain a water phase and at least one UV filter substance which is liquid at room temperature as further phase, may contain the following UV filter substances which are liquid at room temperature.
  • UV filter substances which are liquid at room temperature are homomenthyl salicylate, 2-ethylhexyl 2-cyano-3,3-diphenyl acrylate, 2-ethylhexyl 2-hydroxybenzoate and esters of cinnamic acid, preferably 4-methoxycinnamic acid (2-ethylhexyl) ester and 4-methoxycinnamic acid - isopentyl ester.
  • Homomenthyl salicylate ICI: ie the following structure:
  • Octyl salicylate INCI: octyl salicylates
  • Neo Heliopan OS is available, for example, from Haarmann & Reimer under the trade name Neo Heliopan OS and is characterized by the following structure:
  • 4-Methoxycinnamate (2-ethylhexyl) ester (2-ethylhexyl-4-methoxycinnamate, INCI: octyl methoxycinnamate) is available, for example, from Hoffmann-La Roche under the trade name Parsol MCX and has the following structure:
  • Isopentyl 4-methoxycinnamate isopentyl-4-methoxycinnamate, INCI: isoamyl p-methoxycinnamate
  • isoamyl p-methoxycinnamate is available, for example, from Haarmann & Reimer under the trade name Neo Heliopan E 1000 and has the following structure:
  • the UV filters determined according to the COLI PA ratio are preferably selected as UVA filters from:
  • UV filters can be selected from the group octocrylene, homosalates, ethylhexyl salicylates (octyl salicylate), butyl methoxydibenzoylmethanes, titanium dioxides, phenylbenzimidazoles sulfonic acid, bis-ethylhexyloxyphenol methoxyphenyl triazines (Tinosorb® S), polysilicone-15, diethylamino hydroxybenzoyl hexyl benzoates and
  • High UV filter content means that the proportion of UV light protection substances comprises more than 10% by weight, based on the total mass of the preparation.
  • the proportion is preferably selected in the range from 15% by weight to 40% by weight, in particular from 20 to 35% by weight.
  • the preparation advantageously comprises a UV filter substance content of 20 to 30% by weight, based on the total mass of the preparation.
  • the preparation advantageously comprises a UV filter substance content of 25 to 35% by weight, based on the total mass of the preparation.
  • dermatological preparations is advantageously selected from the range 15 wt .-% to 40% by weight, preferably from 20 to 35 wt .-%, each based on the total weight of the preparations.
  • the UV filters increase, increase the sunscreen of cosmetic or dermatological preparations. Although the preparations per se have a UV protection due to the UV filter contained, but this sunscreen by the addition of
  • Substances of the invention are referred to as boosters, SPF boosters due to their performance increase and the "increase" of sunscreen performance as a boosting or SPF boosting.
  • Skin moisturizing agent in a proportion of 1 to 10 wt.%, Preferably between 2 and 7.5 wt.%, Particularly preferably between 2.5 and 5 wt.%, Based on the total mass of the preparation.
  • Preferred humectant is glycerol.
  • moisturizers are propylene glycols and butylene glycols.
  • the 1, 2 alkanediols are beneficial skin moisturizer.
  • the latter are preferably used in use concentrations in the range between 0, 1 and 2 wt.%, Preferably 0.2 to 1 wt.%, Particularly preferably 0.3 to 0.75 wt.%, Based on the total mass of the preparation used.
  • Skin moisture is a term from the cosmetics industry. Healthy skin has a natural moisture. Only when the human skin shows anomalies with regard to dryness, does the lack of skin moisture come into play. Apart from pathological causes, the age of the human skin and the pigmentation also play a role. Moisturizing factors such as urea play an important role in the moisture of the skin. These can be supplied to the skin by skin care products. Normally, human skin does not need any natural moisture maintenance tools. However, unhealthy lifestyles, dry air (especially in solariums and heated indoor spaces), environmental stresses, stress and long sunbaths contribute to the removal of moisture. Even long and hot baths and detergent residues in clothing cause the loss of important components of the skin's hydrolipid system. To prevent dehydration of the skin one uses
  • humidifiers can be used to support a healthy skin moisture.
  • Moisturizers also referred to as moisturizers, are substances or mixtures of substances which impart the property to cosmetic or dermatological preparations after application or spreading on the surface of the skin
  • Moisturizing the horny layer also called transepidermal water loss (TEWL) called
  • TEWL transepidermal water loss
  • moisturizers for the purposes of the present invention are, for example, glycerol, lanolin and its esters, lanolin alcohol, sorbitol, lactic acid and salts thereof,
  • humectants are, for example, polymeric moisturizers from the group of water-soluble and / or water-swellable and / or water-gellable polysaccharides.
  • a disadvantage has hitherto been that a high proportion of humectants in emulsions meant that the care emulsions had an unacceptable consistency and a non-desired by the user stickiness.
  • the formulations are formulated on the basis of an emulsion.
  • preparations according to the invention are, for example: solutions, suspensions, emulsions, PIT emulsions, pastes, ointments, gels, creams, lotions, powders, soaps, surfactant-containing cleaning preparations, oils, aerosols and sprays.
  • Other forms of application include sticks, shampoos and shower baths. Any customary carrier substances, adjuvants and optionally further active ingredients can be added to the preparation.
  • Polyacrylamide thickeners in particular acrylamide / ammonium acrylate copolymer, comprising one or more cyclomethicones and one or more linear
  • Silicone compounds is used to stabilize and increase the sunscreen power
  • the present combination is one or more polyacrylate thickeners, especially acrylates / C 10-30 alkyl acrylate crosspolymer, and one or more
  • copolymer Comprising one or more cyclomethicones and one or more linear silicone compounds for improving the product sensory or cosmetic
  • cosmetic or dermatological preparations with regard to their product sensor technology, light protection performance and simultaneous storage stability comprising 0.2 to 0.7% by weight of acrylates / C 10-30 alkyl acrylate crosspolymers, 0.3 to 2% by weight of acrylamide / ammonium acrylate copolymers, one or more UV filters selected from the group octocrylene, homosalates, 2-ethylhexyl salicylates, butyl methoxydibenzoylmethane, titanium dioxides, phenylbenzimidazole sulfonic acid, bis-ethylhexyloxyphenol methoxyphenyl triazines, polysilicone-15, diethylamino hydroxybenzoyl hexyl benzoates and benzophenones-3, as well as a or more powder raw materials selected from the group methyl group
  • Methacrylate Crosspolymer Polymethylsilsesquioxane, Tapioca Starch, Distarch Phosphate, Nylon, Polyamide-5, Aluminum Starch Octenylsuccinate and Acrylonitrile-methacrylonitrile-methyl-methacrylate copolymer and one or more cyclomethicones and one or more linear silicone compounds.
  • Methyl Methacrylate Crosspolymer 1 50 2.00 2.00

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Abstract

L'invention concerne des préparations cosmétiques ou dermatologiques de protection solaire contenant, outre une ou plusieurs cyclométhicones et un ou plusieurs composés silicones linéaires, une combinaison d'épaississants de polyacrylate et de polyacrylamide. Malgré une teneur élevée en filtres UV, ces préparations présentent une stabilité avantageuse et simultanément elles sont plus agréables au toucher pour l'utilisateur.
EP11801678.1A 2010-12-22 2011-12-13 Préparations cosmétiques ou dermatologiques à teneur élevée en huile de silicone, contenant une combinaison d'épaississants de polyacrylate et de polyacrylamide Withdrawn EP2654709A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102010063894A DE102010063894A1 (de) 2010-12-22 2010-12-22 Kosmetische oder dermatologische Lichtschutzzubereitungen mit hohem Silikonölgehalt umfassend eine Kombination aus Polyacrylat- und Polyacrylamidverdicker
PCT/EP2011/072545 WO2012084598A2 (fr) 2010-12-22 2011-12-13 Préparations cosmétiques ou dermatologiques à teneur élevée en huile de silicone, contenant une combinaison d'épaississants de polyacrylate et de polyacrylamide

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EP2654709A2 true EP2654709A2 (fr) 2013-10-30

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EP (1) EP2654709A2 (fr)
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WO (1) WO2012084598A2 (fr)

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KR102582817B1 (ko) 2018-08-23 2023-09-26 더 프록터 앤드 갬블 캄파니 피부 케어 조성물
WO2020062117A1 (fr) * 2018-09-29 2020-04-02 Beiersdorf Daily Chemical (Wuhan) Co. Ltd. Préparation cosmétique ayant des propriétés sensorielles uniques et un aspect attrayant
US20220023190A1 (en) * 2018-11-26 2022-01-27 Dsm Ip Assets B.V. Cosmetic composition comprising specific hyperbranched copolymers and organic uv filters
WO2021101943A1 (fr) * 2019-11-21 2021-05-27 Dow Global Technologies Llc Composition de soins d'hygiène comprenant un polymère en plusieurs étapes

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BR112013016012A2 (pt) 2018-12-11
WO2012084598A3 (fr) 2012-09-07
DE102010063894A1 (de) 2012-06-28
CN103347491A (zh) 2013-10-09

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