EP2644614A3 - Solid state forms of 5-azacytidine and processes for preparation thereof - Google Patents
Solid state forms of 5-azacytidine and processes for preparation thereof Download PDFInfo
- Publication number
- EP2644614A3 EP2644614A3 EP13157868.4A EP13157868A EP2644614A3 EP 2644614 A3 EP2644614 A3 EP 2644614A3 EP 13157868 A EP13157868 A EP 13157868A EP 2644614 A3 EP2644614 A3 EP 2644614A3
- Authority
- EP
- European Patent Office
- Prior art keywords
- preparation
- azacytidine
- processes
- solid state
- state forms
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/12—Triazine radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Abstract
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US88018207P | 2007-01-11 | 2007-01-11 | |
US88081007P | 2007-01-16 | 2007-01-16 | |
US93347407P | 2007-06-05 | 2007-06-05 | |
US99833807P | 2007-10-09 | 2007-10-09 | |
EP08705588A EP2118117A2 (en) | 2007-01-11 | 2008-01-11 | Solid state forms of 5-azacytidine and processes for preparation thereof |
Related Parent Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP08705588A Division EP2118117A2 (en) | 2007-01-11 | 2008-01-11 | Solid state forms of 5-azacytidine and processes for preparation thereof |
EP08705588.5 Division | 2008-01-11 |
Publications (2)
Publication Number | Publication Date |
---|---|
EP2644614A2 EP2644614A2 (en) | 2013-10-02 |
EP2644614A3 true EP2644614A3 (en) | 2014-02-26 |
Family
ID=39272400
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP13157868.4A Withdrawn EP2644614A3 (en) | 2007-01-11 | 2008-01-11 | Solid state forms of 5-azacytidine and processes for preparation thereof |
EP08705588A Withdrawn EP2118117A2 (en) | 2007-01-11 | 2008-01-11 | Solid state forms of 5-azacytidine and processes for preparation thereof |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP08705588A Withdrawn EP2118117A2 (en) | 2007-01-11 | 2008-01-11 | Solid state forms of 5-azacytidine and processes for preparation thereof |
Country Status (3)
Country | Link |
---|---|
US (1) | US7759481B2 (en) |
EP (2) | EP2644614A3 (en) |
WO (1) | WO2008088779A2 (en) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6943249B2 (en) | 2003-03-17 | 2005-09-13 | Ash Stevens, Inc. | Methods for isolating crystalline Form I of 5-azacytidine |
US6887855B2 (en) * | 2003-03-17 | 2005-05-03 | Pharmion Corporation | Forms of 5-azacytidine |
BRPI0912717A2 (en) | 2008-05-15 | 2014-12-23 | Celgene Corp | PHARMACEUTICAL COMPOSITION, AND, USE OF 5-AZACYTIDINE |
ES2400779T3 (en) * | 2008-08-06 | 2013-04-12 | Sicor, Inc. | Process to prepare an intermediate product of azacitidine |
JP2014503597A (en) | 2011-01-31 | 2014-02-13 | セルジーン コーポレイション | Pharmaceutical composition of cytidine analogue and method of use thereof |
BR112013025167A2 (en) | 2011-03-31 | 2019-09-24 | Celgene Int Sarl | process for preparing 5-azacitidine, or a salt, solvate, hydrate, or polymorph thereof, 5-azacitidine, 5-azacitidine salt, or a salt, solvate, hydrate, or polymorph |
WO2014076616A2 (en) * | 2012-11-19 | 2014-05-22 | Shilpa Medicare Limited | Formulations of 5-azacytidine |
US9765108B2 (en) * | 2012-11-19 | 2017-09-19 | Shilpa Medicare Limited | Formulation of 5-azacytidine |
WO2014160698A1 (en) * | 2013-03-26 | 2014-10-02 | Celgene Corporation | SOLID FORMS COMPRISING 4-AMINO-I-β-D-RIBOFURANOSYL-1,3,5-TRIAZIN-2(1H)-ONE AND A COFORMER, COMPOSITIONS AND METHODS OF USE THEREOF |
CN109988207B (en) * | 2017-12-29 | 2022-01-04 | 江苏豪森药业集团有限公司 | Preparation method of azacitidine crystal form |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6887855B2 (en) * | 2003-03-17 | 2005-05-03 | Pharmion Corporation | Forms of 5-azacytidine |
US6943249B2 (en) * | 2003-03-17 | 2005-09-13 | Ash Stevens, Inc. | Methods for isolating crystalline Form I of 5-azacytidine |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6028107A (en) * | 1997-02-27 | 2000-02-22 | Waugh; William Howard | Orthomolecular medical use of L-citrulline for vasoprotection, relaxative smooth muscle tone and cell protection |
GB2381451A (en) * | 2001-11-01 | 2003-05-07 | New Technology Res Ltd | Pharmaco-dietary preparation having nutrition-supplementing and nutrition-enhancing effect |
GB0225399D0 (en) | 2002-10-31 | 2002-12-11 | Merck Sharp & Dohme | Therapeutic agents |
-
2008
- 2008-01-11 WO PCT/US2008/000462 patent/WO2008088779A2/en active Application Filing
- 2008-01-11 EP EP13157868.4A patent/EP2644614A3/en not_active Withdrawn
- 2008-01-11 US US12/008,702 patent/US7759481B2/en active Active
- 2008-01-11 EP EP08705588A patent/EP2118117A2/en not_active Withdrawn
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6887855B2 (en) * | 2003-03-17 | 2005-05-03 | Pharmion Corporation | Forms of 5-azacytidine |
US6943249B2 (en) * | 2003-03-17 | 2005-09-13 | Ash Stevens, Inc. | Methods for isolating crystalline Form I of 5-azacytidine |
US7078518B2 (en) * | 2003-03-17 | 2006-07-18 | Pharmion Corporation | Forms of 5-Azacytidine |
US20060247189A1 (en) * | 2003-03-17 | 2006-11-02 | Pharmion Corporation | Forms of 5-Azacytidine |
Also Published As
Publication number | Publication date |
---|---|
EP2118117A2 (en) | 2009-11-18 |
US20080287378A1 (en) | 2008-11-20 |
EP2644614A2 (en) | 2013-10-02 |
WO2008088779A3 (en) | 2009-05-14 |
US7759481B2 (en) | 2010-07-20 |
WO2008088779A2 (en) | 2008-07-24 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
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AC | Divisional application: reference to earlier application |
Ref document number: 2118117 Country of ref document: EP Kind code of ref document: P |
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AK | Designated contracting states |
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PUAL | Search report despatched |
Free format text: ORIGINAL CODE: 0009013 |
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AK | Designated contracting states |
Kind code of ref document: A3 Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT RO SE SI SK TR |
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RIC1 | Information provided on ipc code assigned before grant |
Ipc: A61P 35/00 20060101ALI20140122BHEP Ipc: A61K 31/706 20060101ALI20140122BHEP Ipc: C07H 19/12 20060101AFI20140122BHEP |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20140827 |