EP2627509A1

EP2627509A1 - Laminate having improved water retention characteristics

Info

Publication number: EP2627509A1
Application number: EP11776693.1A
Authority: EP
Inventors: Iris Schnitzler; Christian Hausen; Tobias Kleudgen; Christina Klein
Original assignee: LTS Lohmann Therapie Systeme AG
Current assignee: LTS Lohmann Therapie Systeme AG
Priority date: 2010-10-15
Filing date: 2011-10-06
Publication date: 2013-08-21
Also published as: DE102010048408A1; WO2012048816A1; CN103153613A; US20130255713A1; BR112013008626A2; JP2013544671A; CA2813683A1

Abstract

The invention relates to a laminate that has at least two layers, wherein at least one layer of the laminate is a water-soluble polymer film containing active substances (= "water-soluble polymer film containing active substances"), wherein the polymer is a water-soluble polymer, and at least one second layer of the laminate is a nonwoven fabric, knitted fabric, woven fabric or a foam film (= "water retention layer") consisting of a water-soluble polymer, wherein the water-soluble polymers of the two layers are identical or different. The invention further relates to the production of such a laminate and to the use thereof.

Description

Laminate with improved water retention behavior

The invention relates to a laminate of at least one active ingredient-containing, water-soluble polymer film (= "active substance-containing, water-soluble polymer layer") and a flat support with water absorption capacity (= "water retention layer").

Active substance-containing, water-soluble polymer films are known (for example from EP-A-0 450 141, WO 98/026764, WO 00/018365, US-A-2001/006677, WO 02/002085, WO 04/060298 or WO 05 / 009386). To produce such films, active ingredients are dissolved or dispersed in a polymer or a polymer solution, and this solution or dispersion is formed into films with or without the aid of a flat support, then dried and separated from the optionally used support and formulated into salable products. Known polymer films of this type are z. As oral hygiene strips (Listerine ^® strips), dental whitening strips (Crest Whitestrips ^® ) or pharmaceuticals, eg. B. against cough, cold, cold (Theraflu ^® Cold / Cough Nighttime strips, thin strips Triaminic ^®). The range of active ingredients that can be used in such films is large and ranges from inorganic solids such as peroxides to complex organic compounds (pharmaceuticals) or natural products.

As long as the active ingredients dissolve easily and quickly in water and can develop their activity directly after dissolution in aqueous media, the technology described can be used advantageously. However, problems arise when the contact with water is sufficient in terms of quantity, but due to the dissolution speed of the polymer or active ingredient, is insufficient in time to completely dissolve the polymer and the active substance (for example, if the strips only briefly with water be overflowed). In the case of known active ingredient-containing, water-soluble polymer films, the combination of active ingredient and polymer is not able to store a sufficient quantity of water for the overall dissolution or to make it available for a sufficient amount of time. Further complications arise when the active substance (in dissolved or solid form), for example, has yet to be activated before use (eg carbonates for generating carbon dioxide, for example for foaming), especially if this activation is not left to the user without risk but may already be provided in the ready-to-use drug-containing polymer film in any form. Examples of these are: persulfates (for example for hair bleaching) which have to be activated with carbamide peroxide or hydrogen peroxide. Here it can not be left to the user to spray the polymer-film-bound persulfate before application, for example, with a carbamide peroxide solution; The risk of injury to the inexperienced user when handling these substances would be too great (eye injuries, mucosal irritations, skin irritations). In such a case, the activator should expediently already be provided with the active ingredient in "kit form", so that it only has to be triggered by the user.

It was therefore the task, a

to provide active ingredient-containing, water-soluble polymer film which is capable of

a sufficient at least for the dissolution of the active ingredient

amount of water

- to save and / or

- to provide long enough

and optional

contains an activator for the active ingredient, if necessary, prevents the activator reacts prematurely with the drug.

This object is achieved by a laminate having at least two layers, wherein at least one layer of the laminate is an active substance-containing, water-soluble polymer film (1) (= "active substance-containing, water-soluble polymer layer")

and at least one second layer of the laminate is a fleece, knitted fabric, woven fabric or a foam sheet which consists of a water-soluble polymer (= "water retention layer" (2)). definitions

laminate

A "laminate" is the composite of two or more flat, ie two-dimensional films (referred to above and below as "layer") with only small thickness, usually in each case 10 to 5000 pm (preferably 50 to 1000 μιτι, particularly preferably 100 to 800 μιη) understood, wherein the composite of the films is such that it does not delaminate under product-typical treatment (eg., When kinking or opening) (delamination> 5 N / mm in the 180 ° T-Peeltest [15 mm Laminate width, 1 cm / s peel rate].) Such laminates are produced, for example, by coextrusion through a multi-layer die, by combining two or more pre-produced film webs with or without adhesion promoter (eg adhesive) between two or more webs or by coating For example, extrusion coating on one or both surfaces of a pre-produced film web, or by any combination of the methods described.

layer

A layer is a film-like constituent of the laminate according to the invention (see definition: laminate, above).

active substance

In the present invention, an active substance is understood as meaning a substance which causes a cosmetic or pharmaceutical action in humans or animals, or which as a result of a chemical reaction undergoes a chemical or physical change to itself (for example the release of a gas) or with the substance Active substance in contact medium (eg skin, enamel, hair) causes (eg pH change, oxidation). Examples include: surfactants, detergents, skin care products, bleaching agents, pH regulators, dietary supplements, but also pharmaceutical agents.

activator

The activator also belongs to the category of active ingredients, but in its function is tuned to the "active substance" to be activated and causes it to develop its activity. Exemplary "drug-activator pairs" are: carbonates (acids), peroxides-water, polymer cross-linkers, monomer initiators, enzyme prodrugs etc.

Water-soluble polymer film

According to the invention, water-soluble polymer films are films (= films) of film-forming water-soluble polymers (for example PVA, PVP, polysaccharides, etc.) and optionally excipients such as plasticizers, surface-active substances, dyes, perfumes, sweeteners, flavorings, flavoring agents, disintegrants and the like. a. Understood.

Such water-soluble polymer films and their preparation are described, for example, in DE-A-196 46 392, to which reference is expressly made at this point.

"Water-soluble polymers" according to the invention dissolve in water to at least 90% by weight, preferably 95% by weight (measurement conditions: 10 g of polymer in particle form [d ₅ o: between 500 and 5000 μm] in 200 ml of H ₂ 0, 25 ° C with stirring [200-1000 rpm], 30 min, filtration through white band filter (filter group 2), determination of the residue by differential weighing.) The possibly present residue is usually undissolved, swollen polymer.

Fleece, knitted fabric, fabric, foam sheet

Nonwovens, knitted fabrics and woven fabrics are made of polymer fibers according to methods familiar to the person skilled in the art, the fiber polymer being a water-soluble polymer (eg, PVA, PVP, polysaccharides, etc.). The foam sheets of the present invention are also made from water-soluble polymers, usually by first dissolving the polymer in water and then introducing a gas into the polymer solution, the solution foaming. Subsequently, the air bubble-containing mass (the foam) is spread on a suitable substrate as a film or layer and subsequently dried. By solvent removal, the foam solidifies during drying to form an airgel, the resulting cavities receive a permanent structure. Such foams and their preparation are described, for example, in DE-A-100 32 456, to which reference is expressly made at this point.

detailed description

Active substance-containing, water-soluble polymer film

The active ingredient-containing, water-soluble polymer film of the present invention contains as essential constituents a water-soluble polymer or a combination of water-soluble polymers and an active ingredient and optionally one or more plasticizers and / or surfactants. Such films are described for example in DE-A-196 46 392, to which reference is expressly made at this point.

The polymers used for the film include hydrophilic and / or water-soluble polymers such as cellulose derivatives, hydroxypropylmethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, carboxymethylcellulose, polyvinylpyrrolidone, polyvinyl alcohol, sodium alginate, polyethylene glycol, natural gums such as xanthan gum, tragacanth, guar gum, acacia gum, gum arabic, water dispersible Polyacrylates such as polyacrylic acid, Methylmethacrylatcopolymere, Carb oxyvinylcopolymere. Preferred polymers are polyvinyl pyrrolidone and polyvinyl alcohol. The concentration of the water-soluble polymer in the finished film is typically between 2 and 70% by weight, preferably between 5 and 50% by weight. A particularly preferred concentration is about 20 wt .-%. The surfactants (= surfactants) optionally used for the water-soluble polymer film may comprise one or more nonionic surfactants. Such surfactants having an HLB of 5.0 and greater are preferred. For the definition of the HLB value, explicit reference is made to the statements in Hugo Janistyn, Handbuch der Kosmetika und Riechstoffe, III. Volume: The personal care products, 2nd edition, Dr. med. Alfred Hüthig Verlag Heidelberg, 1973, pages 68-78, and Hugo Janistyn, Paperback of modern perfumery and cosmetics, 4th edition, Scientific Verlagsgesellschaft mbH Stuttgart, 1974, pages 466-474, as well as the original works cited reference.

Particularly preferred non-ionic surface-active substances are substances that are commercially available as solids or liquids in pure form because of their ease of processing. The definition of purity in this context does not refer to chemically pure compounds. Rather, especially when it comes to natural-based products, mixtures of different homologs can be used, for example with different alkyl chain lengths, as obtained in products based on natural fats and oils. Even with alkoxylated products, mixtures of different degrees of alkoxylation are usually present. The term purity in this context refers rather to the fact that the selected substances should preferably be free from solvents, adjuvants and other impurities. Preferred nonionic surfactants are:

Alkoxylated fatty alcohols having 8 to 22, in particular 10 to 16, carbon atoms in the fatty alkyl group and 1 to 30, in particular 1 to 15, ethylene oxide and / or propylene oxide units. Preferred fatty alkyl groups are, for example, lauryl, myristyl, cetyl, but also stearyl, isostearyl and oleyl groups. Particularly preferred compounds of this class are, for example, lauryl alcohol with 2 to 4 ethylene oxide units, oleyl and Cetyl alcohol having in each case 5 to 10 ethylene oxide units, cetyl and stearyl alcohol and mixtures thereof with 10 to 30 ethylene oxide units and the commercial product Aethoxal ^® B (Henkel), a lauryl alcohol with 5 ethylene oxide and 3 propylene oxide units. In addition to the usual alkoxylated fatty alcohols, it is also possible to use so-called "end-capped" compounds according to the invention In these compounds, the alkoxy group has no OH group at the end but is closed in the form of an ether, in particular a C 1 -C 4 -alkyl ether ". An example of such a compound is the commercially available product ^® Dehypon LT 054, a C12 -18- Fettalkoholol + 4,5-ethylene-butyl ether.

Alkoxylated fatty acids having 8 to 22, in particular 10 to 16, carbon atoms in the fatty acid group and 1 to 30, in particular 1 to 15, ethylene oxide and / or propylene oxide units. Preferred fatty acids are, for example, lauric, myristic, palmitic, stearic, isostearic and oleic acids.

Alkoxylated, preferably propoxylated and in particular ethoxylated, mono-, di- and triglycerides. Examples of preferred compounds are glyceryl monolaurate + 20 ethylene oxide and glycerol monostearate + 20 ethylene oxide.

Polyglycerol esters and alkoxylated polyglycerol esters. Preferred compounds of this class are for example poly (3) glycerol diisostearate (commercial product: Lameform ^® TGI (Henkel)) and poly (2) glycerinpolyhydroxystearat (commercial product: Dehymuls ^® PGPH (Henkel)).

Sorbitan fatty acid esters and alkoxylated sorbitan fatty acid esters such as sorbitan monolaurate and sorbitan monolaurate + 20 ethylene oxide (EO). Alkylphenols and alkylphenol alkoxylates having 6 to 21, in particular 6 to 15, carbon atoms in the alkyl chain and 0 to 30 ethylene oxide and / or propylene oxide units. Preferred representatives of this class are, for example, nonylphenol + 4 EO, nonylphenol + 9 EO, octylphenol + 3 EO and octylphenol + 8 EO.

Particularly preferred classes of nonionic surfactants are the alkoxylated fatty alcohols, the alkoxylated fatty acids and the alkylphenols and alkylphenol alkoxylates. The total concentration of surfactants in the final film depends on the properties of the other ingredients, but is desirably between 0.1 and 5% by weight.

Softeners which can be used according to the invention are in particular polyalcohols. Examples of polyhydric alcohols include glycerol, polyethylene glycol, propylene glycol, glycerol monoesters with fatty acids or other pharmaceutically used polyhydric alcohols and also dexpanthenol, a trihydroxyamide. The concentration of the optionally present plasticizer in the dry mass of the film is usually 0.1 to 15 wt .-%.

Useful therapeutic agents include: hypnotics, sedatives, anti-epileptics, weckamines, psychoneurotropics, neuro-muscle blockers, antispasmodics, antihistaminics, antiallergics, cardiotonics, antiarrhythmics, diuretics, hypotensives, vasopressors, antitussives, expectorants, thyroid hormones, sex hormones, anti-diabetics , Antitumor drugs, antibiotics and chemotherapeutica and narcotics. The amount of active ingredient to be incorporated in the film depends on its nature and is usually between 0.01 and 20 wt .-%, but it may, if necessary to achieve the desired effect, higher or lower.

Cosmetic agents include skin care agents such as dexpanthenol, hair care products such as shampoos, breath fresheners such as menthol, other flavorings, fragrances or fragrances commonly used for oral hygiene, and / or oral care and / or oral hygiene ingredients such as quaternary ammonium bases. The effect of flavorings and flavors can be enhanced by flavor enhancers such as tartaric acid, citric acid, vanillin or the like. Other cosmetic active ingredients are bleaching agents such as carbamide peroxide, as used in dental hygiene, or persulfates for bleaching hair. As a further additive, the active ingredient-containing, water-soluble polymer film may contain one or more alkalizing agents, optionally in the form of coated particles. The alkalizing agent is used to adjust an alkaline pH. Alkaliating agents such as ammonium, alkali metal and alkaline earth metal hydroxides, carbonates, bicarbonates, silicates, in particular metasilicates and alkali metal phosphates can be used according to the invention. Short-chain amines such as monoethanolamine, 3-amino-2-methylpropanol or alkaline-reacting amino acids such as arginine, ornithine and lysine can also be used.

In a preferred embodiment, the particulate alkalizing agents comprise particles having a particulate core of solid alkalizing agents selected from alkali metal carbonates, phosphates and / or silicates. Particularly preferred alkalizing agents according to the invention are alkali metal silicates, in particular metasilicates.

In a further preferred embodiment, the active ingredient-containing, water-soluble polymer films according to the invention comprise at least two different alkalizing agents. In this case, mixtures of, for example, a metasilicate and a hydroxycarbonate may be preferred.

The active substance-containing, water-soluble polymer films according to the invention contain alkalizing agents (calculated as uncoated alkalizing agent) preferably in amounts of from 1 to 50% by weight, in particular from 15 to 35% by weight, based in each case on the layer of the active substance-containing, water-soluble polymer film.

In a preferred embodiment of the invention, the laminate according to the invention is used as a bleaching film for bleaching hair. In this case, a layer of the laminate, preferably the active ingredient-containing, water-soluble polymer film, contains a bleaching agent. Blonding agents preferably contain a peroxo compound. The selection of this peroxo compound is in principle not limited. Preferred peroxo compounds are hydrogen peroxide (H ₂ O ₂ ), for example in the form of an aqueous solution or in the form of an H ₂ O ₂ adduct to solid supports, with urea perhydrate or sodium carbonate peroxohydrate ("sodium percarbonate") being of particular importance In addition to or in place of hydrogen peroxide, other peroxo compounds may also be included in laminate layers.

Typical peroxo compounds known to the person skilled in the art are, for example, ammonium peroxodisulfate, potassium peroxodisulfate, sodium peroxodisulfate, ammonium persulfate, potassium persulfate, sodium persulfate, potassium peroxydiphosphate, percarbonates such as magnesium percarbonate, peroxides such as barium peroxide and perborates, urea peroxide and melamine peroxide. Among these peroxo compounds, which can also be used in combination, the inorganic compounds are preferred according to the invention. Particularly preferred are the peroxodisulfates, in particular combinations of at least two peroxodisulfates.

Preferred laminate layers are therefore characterized in that they additionally contain a solid peroxo compound, which is preferably selected from hydrogen peroxide addition compounds to solid supports, ammonium and alkali metal persulfates and peroxodisulfates, with particularly preferred layers containing at least two different peroxodisulfates.

The peroxo compounds are present in the laminate layer according to the invention, in particular the active substance-containing, water-soluble polymer film, preferably in amounts of from 2 to 80% by weight, in particular in amounts of from 20 to 45% by weight.

Furthermore, the above-mentioned Blondiermittel other active, auxiliary and

Additives such as

nonionic polymers such as vinylpyrrolidinone A inyl acrylate copolymers, polyvinylpyrrolidinone and vinylpyrrolidinone / vinyl acetate copolymers and polysiloxanes,

cationic polymers such as quaternized cellulose ethers, polysiloxanes with quaternary groups, dimethyldiallylammonium chloride polymers, acrylamide Dimethyldiallyl-ammonium chloride copolymers, diethyl sulfate-quaternized dimethylamino-ethyl methacrylate-vinylpyrrolidone copolymers, vinylpyrrolidinone-imidazolinium methochloride copolymers and quaternized polyvinyl alcohol,

zwitterionic and amphoteric polymers, for example acrylamidopropyltrimethylammonium chloride / acrylate copolymers and octylacrylamide / methyl methacrylate / tert-butylaminoethyl methacrylate / 2-hydroxypropyl methacrylate copolymers,

anionic polymers such as, for example, polyacrylic acids, crosslinked polyacrylic acids, vinyl acetate / crotonic acid copolymers, vinylpyrrolidone nonA inyl acrylate copolymers, vinyl acetate / butyl maleate / isobornyl acrylate copolymers, methyl vinyl ether / maleic anhydride copolymers and acrylic acid / Ethyl acrylate / N-tert-butyl acrylamide terpolymers,

Thickeners such as agar-agar, guar gum, alginates, xanthan gum, gum arabic, karaya gum, locust bean gum, linseed gums, dextrans, cellulose derivatives, e.g. For example, methylcellulose, hydroxyalkylcellulose and carboxymethylcellulose, starch fractions and derivatives such as amylose, amylopectin and dextrins, clays such. As bentonite or fully synthetic hydrocolloids such. For example, polyvinyl alcohol,

Structurants such as glucose, maleic acid and lactic acid,

hair-conditioning compounds such as phospholipids, for example soya lecithin, egg lecithin and kephaine, and also silicone oils

Protein hydrolysates, in particular elastin, collagen, Kerstin, milk protein, soy protein and wheat protein hydrolysates, their condensation products with fatty acids and quaternized protein hydrolysates,

Perfume oils, dimethylisosorbide and cyclodextrins,

Solvents and mediators such as ethanol, isopropanol, ethylene glycol, propylene glycol, glycerol and diethylene glycol,

fiber-structure-improving active ingredients, in particular mono-, di- and oligosaccharides such as, for example, glucose, galactose, fructose, fructose and lactose,

Active ingredients such as panthenol, pantothenic acid, allantoin, pyrrolidonecarboxylic acids and their salts,

quaternized amines such as methyl-1-alkylamidoethyl-2-alkylimidazolinium methosulfate

Defoamers like silicones,

Dyes for staining the agent,

Antidandruff active ingredients such as Piroctone olamine, zinc omadine and climbazole, light stabilizers, in particular derivatized benzophenones, cinnamic acid derivatives and triazines,

Substances for adjusting the pH, such as conventional acids, in particular edible acids and bases,

Active ingredients such as allantoin, pyrrolidonecarboxylic acids and their salts, and bisabolol,

Vitamins, provitamins and vitamin precursors, in particular those of groups A, B3, B5, B6, C, E, F and H,

Plant extracts such as extracts of green tea, oak bark, nettle, witch hazel, hops, chamomile, burdock root, horsetail, hawthorn, lime blossom, almond, aloe vera, spruce needle, horse chestnut, sandalwood, juniper, coconut, mango, apricot, lime, wheat, kiwi , Melon, orange, grapefruit, sage, rosemary, birch, mallow, meadowfoam, quenelle, yarrow, thyme, melissa, toadstool, coltsfoot, marshmallow, meristem, ginseng and ginger root,

Cholesterol,

Bodying agents such as sugar esters, polyol esters or polyol alkyl ethers,

Fats and waxes such as spermaceti, beeswax, montan wax and paraffins,

Fatty alcohols and fatty acid esters,

fatty acid,

Complexing agents such as EDTA, NTA, β-alaninediacetic acid and phosphonic acids, swelling and penetrating substances such as glycerol, propylene glycol monoethyl ether, carbonates, bicarbonates, guanidines, ureas and primary, secondary and tertiary phosphates,

Opacifiers such as latex, styrene / PVP and styrene / acrylamide copolymers, pearlescing agents such as ethylene glycol mono- and distearate and PEG-3-distearate, pigments

Stabilizers for hydrogen peroxide and other oxidizing agents, propellants such as propane-butane mixtures, N ₂ U, dimethyl ether, CO ₂ and air, antioxidants,

- dyes,

Odorants and

explosives

contain. The said substances, which may optionally be admixed to the film, must be safe in terms of toxicity and should be approved for use in cosmetics, medical devices and pharmaceutical products by the competent authorities. FIG. 1 shows the structure of the laminate according to the invention of the active substance-containing, water-soluble polymer layer (1), the water retention layer (2) and the optionally present carrier layer (3).

The active substance-containing, water-soluble film (1) can be prepared as follows:

The active ingredient as well as optional surfactants, optional plasticizers, disintegrants and other optional ingredients other than the water-soluble polymer (s) are dissolved or dispersed with a sufficient amount of a compatible solvent. Examples of a compatible solvent include water, alcohols such as ethyl alcohol, esters such as ethyl acetate, ketones such as acetone, ethers such as diethyl ether, tetrahydrofuran (THF), dimethylformamide (DMF), dimethylsulfoxide DMSO or mixtures thereof. After forming a solution or suspension, the water-soluble polymer or mixture of water-soluble polymers is slowly added with stirring and, if necessary, heat until a homogeneous solution or a homogeneous pasty mass is formed. Alternatively, and provided that used starting materials, the mass can also be prepared without the use of solvents.

The mass obtained is then conveniently applied to a support (3) and dried to a film. The support material must have a surface tension which allows the polymer solution or mass to be distributed uniformly over the intended coating width without the solution / mass being sucked in, thus creating a destructive bond between the support and the coating. Examples of suitable materials include metal foils such as aluminum foils, non-siliconized polyethylene terephthalate films, non-siliconized kraft paper, polyethylene-impregnated kraft paper, or non-siliconized polyethylene film.

The order of the solution or mass on the carrier material (3) can be performed with any conventional device. A particularly preferred application technique relates to a roll doctor coating machine. The thickness of the resulting film layer depends on the concentration of the solids in the coating solution or mass and on the gap width of the coating machine and can vary between 5 and 5000 μm. The drying of the film is z. B. in a hot air bath using a drying oven, drying tunnel, vacuum dryer or other suitable drying devices that do not adversely affect the effect of the drug. Subsequently, the film - including carrier film or after separation from the carrier film - further processed or cut or made easier to better ease of use directly into pieces of suitable size and shape.

Fleece, knitted fabric, fabric, foam film (= water retention layer (2))

The second layer (2) of the laminate according to the invention consists of a water-soluble polymer, wherein the layer of this polymer is designed so that it has an increased water retention capacity. This can be done, for example, by constructing the layer of staple fibers of the water-soluble polymer in the form of a nonwoven or corresponding fibers of the water-soluble polymer to corresponding knitted fabrics or fabrics are processed.

The thicknesses of the nonwovens, knitted fabrics or fabrics used according to the invention vary between 5 and 1000 μm, preferably 10 to 500 μm and particularly preferably 20 to 200 μm. They have expediently basis weights of 5 to 1000 g / m ² , preferably 10 to 500 g / m ² , particularly preferably 20 to 200 g / m ² .

Preferred are nonwovens, particularly from PVA, such as those from the company Freudenberg (Weinheim, Germany) under the name Vilene ^® (DO DO 101 or 102) are sold.

A particularly advantageous embodiment of the water retention layer (2) is a foam sheet of water-soluble polymer, as described, for example, in DE-A-100 32 456, to which reference is expressly made at this point. Such foams disintegrate or dissolve rapidly in an aqueous environment and moreover have the advantage that (further) active substances (eg an activator) for release can be provided in the cavities of the foam, which due to their encapsulation in the foam have no contact with materials outside of the surrounding polymer shell of the foam.

The spaces or cavities of the foam can therefore be filled with a gas, a gas mixture, a liquid or a liquid mixture. The polymer of the matrix is a water-soluble polymer as used for the water-soluble films described above, but a polyvinyl alcohol-polyethylene glycol graft copolymer is preferably used.

The spaces or cavities of the foam film (2) can each be present in isolation from one another in the polymer matrix, preferably in the form of solidified bubbles (as are known, for example, from PU or PS foams). The gas or gas mixture in the cavities is preferably air, nitrogen, oxygen, carbon dioxide, helium or any mixture of these gases, more preferably air. However, it can also be advantageous if the spaces or cavities are filled with a liquid or a liquid mixture (for example an oil), wherein these liquids are not miscible with the matrix material and do not dissolve the polymer skeleton of the matrix. The liquid or the liquid mixture may also contain one or more active ingredients.

The thickness of the foam sheet is preferably 0.1 to 5 mm, more preferably 0.5 to 1 mm.

For the production of the foam film (2), for example, first a solution or dispersion is prepared which contains the water-soluble polymer and optionally an active substance. This solution, which may also be a concentrated solution or viscous mass, is then foamed by introducing a gas or gas mixture (eg air). This can be done by means of a disperser or a Schaumaufschlagmaschine, but also by other methods, eg. B. by means of ultrasound, but preferably with the aid of a foam impact machine. This allows the diameter of the bubbles in a wide range, almost arbitrarily set. Thus, the diameter of the bubbles or cavities can be in the range of 0.01 to 50 pm; prefers bubbles / cavities with a diameter between 0.1 and 10 pm. In order to stabilize the foams or bubble-containing (or gas-bubble or active-ingredient-containing) masses thus produced, a foam-stabilizing agent may be added before or during foam production. For this purpose suitable means, for. As surfactants are known in the art and listed by way of example above. Finally, the foam is spread on the active substance-containing, water-soluble polymer layer or, if the foam film is produced separately, on a suitable support as a film or layer and subsequently dried. By solvent removal, the foam solidifies during drying to form an airgel, the resulting cavities receive a permanent structure. The shape, number and size of the generated spaces or cavities can be influenced by means of various process parameters, for. Example by the concentration of the polymer, by the viscosity of the polymer composition, by controlling the foaming process (see above) or by selecting the foam-stabilizing agents.

Further, alternative methods for producing the foam sheet are described in DE-A-100 32 456. Water-soluble laminate

The laminate according to the invention is produced from the active substance-containing polymer film and the water-soluble nonwoven fabric, knitted fabric, woven fabric or the water-soluble foam film. Expediently, the procedure is such that the active substance-containing polymer film and the water-soluble nonwoven fabric, knitted fabric or woven or water-soluble foam film are produced separately, superimposed and then combined to form the laminate according to the invention and rolled up or made up. Alternatively, the water-soluble nonwoven fabric, knitted fabric, woven fabric or the water-soluble foam film can also be used in the process of producing the active ingredient-containing polymer film

- For example, before or after drying - laminated or spread as a mass (or vice versa: the active ingredient-containing polymer film is laminated or painted in the manufacturing process of the water-soluble nonwoven, knitted fabric, or the water-soluble foam sheet on this). Subsequently, the laminate becomes

- Including carrier film or after separation from the carrier film - rolled up and stored or cut into pieces of suitable size and shape and packaged.

The advantage of the laminate according to the invention is that after addition of water, the laminate sucks like a sponge and / or a larger amount remains on the material surface. Here, first, the thin water-soluble cover (2) (for example, the fleece) dissolved before for the subsequent drug release greater amounts of water are available.

The laminates according to the invention are outstandingly suitable for bleaching

Hair. In general, the procedure is as follows:

- moistening the water retention layer of the laminate according to the invention with an aqueous medium, preferably with an aqueous, 2-10% by weight H ₂ 0 ₂ solution or a carbamide peroxide gel; (immediately) thereafter placing a strand of hair on the moistened water retention layer, optionally covering the strand of hair with a sheet-like cover that is impermeable to active substances and possibly additives,

Release of the active ingredients by prolonged contact of the moistened water retention layer with the active substance-containing layer,

Allowing the active ingredients to act on the hair strand for a period of at least 5 minutes, preferably 20 to 120 minutes, bleaching; the "exposure" can be done with additional heat, whereby the contact time can be shortened and / or bleaching can be strengthened,

Removal of the laminate and of the optional layered cover,

- if necessary, rinse the strand of hair with water.

In the following the invention will be explained in more detail by means of examples.

example 1

With vigorous stirring, 25 g polyvinylpyrrolidone polymer (PVPP) (Kollidon ^® 30, BASF) and 5 g of disintegrant (Kollidon ^® CL-SF, BASF) dissolved in 30 g of ethanol and 6 g of water. Portions of 70 g of carbamide peroxide were added and stirred until the optical homogeneity. The pH was then adjusted to 4 by dropwise addition of phosphoric acid and testing by means of a pH electrode. The resulting paste was applied by hand doctor blade (gap width 1000 pm) on a carrier film (aluminum foil, 40 g / m ^2, Fa. Korff, Switzerland), with a water-soluble nonwoven fabric (VILENE ^® DO 101 of the Fa. Freudenberg, Weinheim, Germany) covered and then allowed to rest for 24 hours at room temperature, so that a dry laminate with a basis weight of about 420 g / m ² resulted (round blank punch 50 cm ² , weighing by means of laboratory fine scale).

The resulting product was separated into sections of 10 * 17 cm each and packed individually in four-edge sealed bags. The packaging material used was a paper / aluminum / PE composite.

Example 2

With vigorous stirring, 20 g of PVPP (Kollidon 30) and then 5 g of disintegrant (Kollidon CL-SF) were added to 35 g of ethanol. 10 g of plasticizer (dexpanthenol 100%) were added to the homogeneous mass and stirred until complete dissolution. Portionwise, 65 g of a solid mixture consisting of components for hair bleaching (alkali silicate (peroxide stabilizer), sodium persulfate (bleach), ammonium persulfate (bleach), disodium EDTA (complexing agent, stabilizer), silica) were added and stirred to optical homogeneity.

The resulting paste was applied by means of a hand doctor blade (gap width 600 pm) on a carrier film, covered with a water-soluble nonwoven (VILENE DO 101 Fa. Freudenberg, Weinheim, Germany) and then allowed to stand for 24 hours at room temperature, so that a dry laminate with A basis weight of about 520 g / m ² resulted (round blank punch 50 cm ² , weighing by means of laboratory fine scale).

The resulting product was separated into sections of 10 x 17 cm each and packed individually in four-edge sealed bags. The packaging material used was a paper / aluminum / PE composite. Example 3

With vigorous stirring, 17 g of PVPP (Kollidon 30) and then 3 g of disintegrant (Kollidon CL-SF) were added to 35 g of ethanol. 12 g of plasticizer (triethyl citrate) were added to the homogeneous mass and stirred until complete dissolution. Portionswise, 70 g of a solid mixture consisting of components for hair bleaching (persulfates, silicates and the like, see Example 2) were added and stirred until they were homogeneous.

The paste obtained was applied by means of a hand doctor blade (gap width 600 μηι) on a carrier film, covered with a water-soluble nonwoven (VILENE DO 101 Fa. Freudenberg, Weinheim, Germany) and then allowed to rest for 24 hours at room temperature, so that a dry laminate with A basis weight of about 490 g / m ² resulted (round blank punch 50 cm ² , weighing by means of laboratory fine scale).

The resulting product was separated into sections of 10 x 17 cm each and packed individually in four-edge sealed bags. The packaging material used was a paper / aluminum / PE composite. Example 4 (application example)

The laminates of Examples 1 to 3 were used for hair bleaching. The procedure was as follows:

The water retention layer of the laminates was treated with an aqueous hydrogen peroxide solution or gel (4-9% by weight). Subsequently, one strand of hair was placed on the moistened water retention layer. By wrapping the strand with the laminate, intensive contact was made between the strand and the active ingredients. After a contact time of 45 minutes without external heat, the laminates were removed and the strands rinsed with water. Description of the result:

The hair treated in this way showed, depending on the thickness of the laminate and the applied mass of hydrogen peroxide, a different degree of color lightening.

Claims

claims

1. At least two-layer laminate, wherein

at least one layer of the laminate is an active ingredient-containing, water-soluble polymer film (= "active substance, water-soluble polymer layer"), wherein the polymer is a water-soluble polymer, and

at least one second layer of the laminate is a nonwoven, knitted fabric, woven fabric or a foam sheet (= "water retention layer") consisting of a water-soluble polymer, the water-soluble polymers of the two layers being identical or different.

2. Laminate according to claim 1, characterized in that the water-soluble polymer is selected from: cellulose derivatives, polyvinylpyrrolidone, polyvinyl alcohol, sodium alginate, polyethylene glycol, natural gums, water-dispersible polyacrylates and mixtures thereof.

3. Laminate according to claim 1 or 2, characterized in that the concentration of the water-soluble polymer in the active substance-containing, water-soluble polymer film is between 2 and 70 wt .-%.

4. Laminate according to one of claims 1 to 3, characterized in that the active ingredient-containing, water-soluble polymer film surfactants (= surfactants) contains, preferably one or more nonionic surfactants, preferably those having an HLB value of 5.0 and greater , more preferably non-ionic surfactants, and most preferably

alkoxylated fatty alcohols having 8 to 22 carbon atoms in the fatty alkyl group and 1 to 30 ethylene oxide and / or propylene oxide units and / or alkoxylated fatty acids having 8 to 22 carbon atoms in the fatty acid group and 1 to 30 ethylene oxide and / or propylene oxide units and / or

alkoxylated mono-, di- and triglycerides and / or

Polyglycerol esters and alkoxylated polyglycerol esters and / or sorbitan fatty acid esters and alkoxylated sorbitan fatty acid esters and / or

Alkylphenols and alkylphenol alkoxylates having 6 to 21 carbon atoms in the alkyl chain and 0 to 30 ethylene oxide and / or propylene oxide units,

wherein the total concentration of surfactants in the active ingredient-containing, water-soluble polymer film is preferably between 0.1 and 5 wt .-%.

5. Laminate according to one of claims 1 to 4, characterized in that the active substance-containing, water-soluble polymer film contains plasticizer, preferably polyalcohols, in particular glycerol, dexpanthenol, polyethylene glycol, propylene glycol and / or glycerol monoesters with fatty acids, wherein the concentration of the plasticizer in the Dry matter of the active ingredient-containing, water-soluble polymer film is preferably 0.1 to 15 wt .-%.

6. Laminate according to one of claims 1 to 5, characterized in that the active ingredient in the active substance-containing, water-soluble polymer film is selected from the group: Hypnotica, sedatives, antiepileptics, weckamine, psychoneurotropica, neuro-muscle blockers, antispasmodica, antihistaminica, antiallergic, cardiotonica , Antiarrhythmics, diuretics, hypotensives, vasopressors, antitussives, expectorants, thyroid hormones, sex hormones, anti-diabetics, antitumor agents, antibiotics, chemotherapeutics, narcotics, skin care products, hair products, breath fresheners, flavorings, flavor enhancers, flavorings, perfumes, dentifrices , Active ingredients for oral hygiene, bleaching agents and mixtures thereof.

7. Laminate according to one of claims 1 to 6, characterized in that the active substance-containing, water-soluble polymer film contains one or more alkalizing optionally in the form of coated particles, preferably at least two different alkalizing agents, wherein the alkalizing (calculated as uncoated alkalizing) preferably in amounts of 1 to 50 wt .-% in the active ingredient-containing, water-soluble polymer film are included.

8. Laminate according to one of claims 1 to 7, characterized in that the laminate, preferably the active ingredient-containing, water-soluble polymer film containing a Blondiermittel, preferably at least one peroxo compound, preferably in amounts of 2 to 80 wt .-%.

Laminate according to any one of Claims 1 to 8, characterized in that the second layer of the laminate is composed of staple fibers of a water-soluble polymer in the form of a non-woven fabric or of corresponding fibers of a water-soluble polymer in the form of a knitted or woven fabric, the thickness of the nonwoven, knitted or woven fabric preferably varies between 5 and 1000 μm and / or their basis weights are between 5 and 1000 g / m ² .

10. Laminate according to one of claims 1 to 8, characterized in that the second layer of the laminate is a foam sheet of a water-soluble polymer, preferably with a thickness of 0.1 to 5 mm.

11. Laminate according to one of claims 1 to 10, characterized in that the laminate contains a third layer (= carrier), which is preferably selected from: metal foils such as aluminum foils, non-siliconized polyethylene terephthalate films, non-siliconized Kraft papers, polyethylene-impregnated Kraft papers and non-siliconized polyethylene films.

12. A method for producing a laminate according to claim 1, characterized in that

the active ingredient-containing polymer film and the water-soluble nonwoven fabric, knitted fabric, woven fabric or the water-soluble foam film are produced separately, superimposed and then combined to form the laminate and rolled up or made up

or the water-soluble nonwoven fabric, knitted fabric, woven fabric or the water-soluble foam film in the manufacturing process of the active substance-containing polymer film, optionally with the aid of a carrier film, laminated on the polymer film or spread as a mass and then the laminate - including optionally present carrier film or after separation from the optionally present carrier film - Rolls up and stores or cuts into pieces of suitable size and shape and packs

or the active substance-containing polymer film in the production process of the water-soluble nonwoven, knitted fabric, fabric or water-soluble foam film, optionally with the aid of a carrier film, laminated or painted onto the water-soluble nonwoven fabric, knitted fabric or water-soluble foam film and then the laminate - including optionally present carrier film or after Separation from the optional carrier film - rolls up and stores or cuts into pieces of suitable size and shape and packaged.

13. Use of a laminate according to claim 1 for the administration of a drug or cosmetic.

14. Use according to claim 3 for hair bleaching.

15. A method of bleaching hair characterized by the steps of:

Moistening the water retention layer of a laminate according to claim 8 with an aqueous medium,

Placing a strand of hair on the moistened water retention layer, Release of the active ingredients by prolonged contact of the moistened water retention layer with the active substance-containing layer,

Applying the active ingredients to the strand of hair and

Remove the laminate.