EP2615168A4 - Process for producing reveromycin a or a synthetic intermediate thereof, process for producing compounds containing a spiroketal ring and novel antineoplastics, fungicides and therapeutic agents for bone disorders - Google Patents
Process for producing reveromycin a or a synthetic intermediate thereof, process for producing compounds containing a spiroketal ring and novel antineoplastics, fungicides and therapeutic agents for bone disordersInfo
- Publication number
- EP2615168A4 EP2615168A4 EP11821826.2A EP11821826A EP2615168A4 EP 2615168 A4 EP2615168 A4 EP 2615168A4 EP 11821826 A EP11821826 A EP 11821826A EP 2615168 A4 EP2615168 A4 EP 2615168A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- producing
- antineoplastics
- fungicides
- novel
- therapeutic agents
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/36—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Actinomyces; from Streptomyces (G)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/02—Oxygen as only ring hetero atoms
- C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
- C12P17/181—Heterocyclic compounds containing oxygen atoms as the only ring heteroatoms in the condensed system, e.g. Salinomycin, Septamycin
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Biophysics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Oncology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Communicable Diseases (AREA)
- Rheumatology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2010194222 | 2010-08-31 | ||
PCT/JP2011/069660 WO2012029811A1 (en) | 2010-08-31 | 2011-08-30 | Process for producing reveromycin a or a synthetic intermediate thereof, process for producing compounds containing a spiroketal ring and novel antineoplastics, fungicides and therapeutic agents for bone disorders |
Publications (3)
Publication Number | Publication Date |
---|---|
EP2615168A1 EP2615168A1 (en) | 2013-07-17 |
EP2615168A4 true EP2615168A4 (en) | 2014-03-19 |
EP2615168B1 EP2615168B1 (en) | 2017-07-19 |
Family
ID=45772891
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP11821826.2A Not-in-force EP2615168B1 (en) | 2010-08-31 | 2011-08-30 | Process for producing reveromycin a or a synthetic intermediate thereof, process for producing compounds containing a spiroketal ring and novel antineoplastics, fungicides and therapeutic agents for bone disorders |
Country Status (4)
Country | Link |
---|---|
US (1) | US8980587B2 (en) |
EP (1) | EP2615168B1 (en) |
JP (2) | JP5854515B2 (en) |
WO (1) | WO2012029811A1 (en) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2015087176A (en) * | 2013-10-29 | 2015-05-07 | シスメックス株式会社 | Urine specimen analyzer and analysis method |
JP6228085B2 (en) * | 2014-08-27 | 2017-11-08 | シスメックス株式会社 | Sample analyzer and sample analysis method |
CN106202901A (en) * | 2016-07-04 | 2016-12-07 | 奥美之路(北京)健康科技股份有限公司 | Stone age remote online interpreting system |
CN108085273B (en) * | 2017-12-11 | 2022-01-21 | 暨南大学 | Antifungal streptomyces and metabolite thereof, preparation method and application of metabolite |
CN111514128A (en) * | 2020-04-30 | 2020-08-11 | 广州中医药大学第一附属医院 | Application of hydroxysafflor yellow A in preparation of medicine for treating osteoporosis |
WO2024074637A1 (en) * | 2022-10-07 | 2024-04-11 | Syngenta Crop Protection Ag | Means and methods for controlling pathogens and pests in plants |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0491956A1 (en) * | 1990-06-14 | 1992-07-01 | Rikagaku Kenkyusho | Reveromycin a, production thereof, and antitumor drug and fungicide |
EP1650210A1 (en) * | 2003-07-15 | 2006-04-26 | Riken | Therapeutic agent for hyperpotassemia and bone disease |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0764851B2 (en) * | 1992-01-17 | 1995-07-12 | 理化学研究所 | Reveromycin B, C, and D, production method thereof, and antitumor agent and antifungal agent |
JPH07223945A (en) | 1994-02-10 | 1995-08-22 | Snow Brand Milk Prod Co Ltd | Therapeutic agent for bone disease |
-
2011
- 2011-08-30 US US13/819,959 patent/US8980587B2/en not_active Expired - Fee Related
- 2011-08-30 EP EP11821826.2A patent/EP2615168B1/en not_active Not-in-force
- 2011-08-30 JP JP2012531904A patent/JP5854515B2/en active Active
- 2011-08-30 WO PCT/JP2011/069660 patent/WO2012029811A1/en active Application Filing
-
2015
- 2015-12-04 JP JP2015237319A patent/JP6066439B2/en active Active
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0491956A1 (en) * | 1990-06-14 | 1992-07-01 | Rikagaku Kenkyusho | Reveromycin a, production thereof, and antitumor drug and fungicide |
EP1650210A1 (en) * | 2003-07-15 | 2006-04-26 | Riken | Therapeutic agent for hyperpotassemia and bone disease |
Non-Patent Citations (7)
Title |
---|
GALM ET AL: "Natural Product Drug Discovery: The Times Have Never Been Better", CHEMISTRY AND BIOLOGY, CURRENT BIOLOGY, LONDON, GB, vol. 14, no. 10, 26 October 2007 (2007-10-26), pages 1098 - 1104, XP022309115, ISSN: 1074-5521, DOI: 10.1016/J.CHEMBIOL.2007.10.004 * |
See also references of WO2012029811A1 * |
SHANNON D. ZANATTA ET AL: "Total Synthesis of the Proposed Structure for Spirofungin B:? A Reassignment of the Stereochemistry", ORGANIC LETTERS, vol. 6, no. 6, 1 March 2004 (2004-03-01), pages 1041 - 1044, XP055100587, ISSN: 1523-7060, DOI: 10.1021/ol049873e * |
SHIMIZU T ET AL: "Chemical modification of reveromycin A and its biological activities", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON, AMSTERDAM, NL, vol. 12, no. 23, 1 January 2002 (2002-01-01), pages 3363 - 3366, XP002981347, ISSN: 0960-894X, DOI: 10.1016/S0960-894X(02)00782-5 * |
SHUNJI TAKAHASHI ET AL: "Reveromycin A biosynthesis uses RevG and RevJ for stereospecific spiroacetal formation", NATURE CHEMICAL BIOLOGY, vol. 7, no. 7, 5 June 2011 (2011-06-05), pages 461 - 468, XP055099143, ISSN: 1552-4450, DOI: 10.1038/nchembio.583 * |
TAKESHI SHIMIZU ET AL: "Asymmetric Total Synthesis of (-)-Spirofungin A and (+)-Spirofungin B", ORGANIC LETTERS, vol. 7, no. 25, 1 December 2005 (2005-12-01), pages 5573 - 5576, XP055100588, ISSN: 1523-7060, DOI: 10.1021/ol052039k * |
TAKESHI SHIMIZU ET AL: "Total Synthesis of Reveromycin A", ORGANIC LETTERS, vol. 2, no. 14, 1 July 2000 (2000-07-01), pages 2153 - 2156, XP055100461, ISSN: 1523-7060, DOI: 10.1021/ol0060634 * |
Also Published As
Publication number | Publication date |
---|---|
EP2615168A1 (en) | 2013-07-17 |
JP2016040318A (en) | 2016-03-24 |
WO2012029811A1 (en) | 2012-03-08 |
JP5854515B2 (en) | 2016-02-09 |
US20130177950A1 (en) | 2013-07-11 |
JPWO2012029811A1 (en) | 2013-10-31 |
JP6066439B2 (en) | 2017-01-25 |
US8980587B2 (en) | 2015-03-17 |
EP2615168B1 (en) | 2017-07-19 |
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Legal Events
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Inventor name: OSADA, HIROYUKI Inventor name: TOYODA, ATSUSHI Inventor name: TAKAHASHI, SHUNJI Inventor name: SANAKI, YOSHIYUKI Inventor name: KAWATANI, MAKOTO |
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Inventor name: SAKAKI, YOSHIYUKI Inventor name: TAKAHASHI, SHUNJI Inventor name: TOYODA, ATSUSHI Inventor name: OSADA, HIROYUKI Inventor name: KAWATANI, MAKOTO |
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