EP2615168A4 - Process for producing reveromycin a or a synthetic intermediate thereof, process for producing compounds containing a spiroketal ring and novel antineoplastics, fungicides and therapeutic agents for bone disorders - Google Patents

Process for producing reveromycin a or a synthetic intermediate thereof, process for producing compounds containing a spiroketal ring and novel antineoplastics, fungicides and therapeutic agents for bone disorders

Info

Publication number
EP2615168A4
EP2615168A4 EP11821826.2A EP11821826A EP2615168A4 EP 2615168 A4 EP2615168 A4 EP 2615168A4 EP 11821826 A EP11821826 A EP 11821826A EP 2615168 A4 EP2615168 A4 EP 2615168A4
Authority
EP
European Patent Office
Prior art keywords
producing
antineoplastics
fungicides
novel
therapeutic agents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP11821826.2A
Other languages
German (de)
French (fr)
Other versions
EP2615168B1 (en
EP2615168A1 (en
Inventor
Hiroyuki Osada
Shunji Takahashi
Makoto Kawatani
Yoshiyuki Sanaki
Atsushi Toyoda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
RIKEN Institute of Physical and Chemical Research
Original Assignee
RIKEN Institute of Physical and Chemical Research
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by RIKEN Institute of Physical and Chemical Research filed Critical RIKEN Institute of Physical and Chemical Research
Publication of EP2615168A1 publication Critical patent/EP2615168A1/en
Publication of EP2615168A4 publication Critical patent/EP2615168A4/en
Application granted granted Critical
Publication of EP2615168B1 publication Critical patent/EP2615168B1/en
Not-in-force legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/36—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Actinomyces; from Streptomyces (G)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/181—Heterocyclic compounds containing oxygen atoms as the only ring heteroatoms in the condensed system, e.g. Salinomycin, Septamycin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Oncology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP11821826.2A 2010-08-31 2011-08-30 Process for producing reveromycin a or a synthetic intermediate thereof, process for producing compounds containing a spiroketal ring and novel antineoplastics, fungicides and therapeutic agents for bone disorders Not-in-force EP2615168B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2010194222 2010-08-31
PCT/JP2011/069660 WO2012029811A1 (en) 2010-08-31 2011-08-30 Process for producing reveromycin a or a synthetic intermediate thereof, process for producing compounds containing a spiroketal ring and novel antineoplastics, fungicides and therapeutic agents for bone disorders

Publications (3)

Publication Number Publication Date
EP2615168A1 EP2615168A1 (en) 2013-07-17
EP2615168A4 true EP2615168A4 (en) 2014-03-19
EP2615168B1 EP2615168B1 (en) 2017-07-19

Family

ID=45772891

Family Applications (1)

Application Number Title Priority Date Filing Date
EP11821826.2A Not-in-force EP2615168B1 (en) 2010-08-31 2011-08-30 Process for producing reveromycin a or a synthetic intermediate thereof, process for producing compounds containing a spiroketal ring and novel antineoplastics, fungicides and therapeutic agents for bone disorders

Country Status (4)

Country Link
US (1) US8980587B2 (en)
EP (1) EP2615168B1 (en)
JP (2) JP5854515B2 (en)
WO (1) WO2012029811A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015087176A (en) * 2013-10-29 2015-05-07 シスメックス株式会社 Urine specimen analyzer and analysis method
JP6228085B2 (en) * 2014-08-27 2017-11-08 シスメックス株式会社 Sample analyzer and sample analysis method
CN106202901A (en) * 2016-07-04 2016-12-07 奥美之路(北京)健康科技股份有限公司 Stone age remote online interpreting system
CN108085273B (en) * 2017-12-11 2022-01-21 暨南大学 Antifungal streptomyces and metabolite thereof, preparation method and application of metabolite
CN111514128A (en) * 2020-04-30 2020-08-11 广州中医药大学第一附属医院 Application of hydroxysafflor yellow A in preparation of medicine for treating osteoporosis
WO2024074638A1 (en) * 2022-10-07 2024-04-11 Syngenta Crop Protection Ag Fungicidal mixture comprising cyclothiazomycin c and malonomicin

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0491956A1 (en) * 1990-06-14 1992-07-01 Rikagaku Kenkyusho Reveromycin a, production thereof, and antitumor drug and fungicide
EP1650210A1 (en) * 2003-07-15 2006-04-26 Riken Therapeutic agent for hyperpotassemia and bone disease

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0764851B2 (en) * 1992-01-17 1995-07-12 理化学研究所 Reveromycin B, C, and D, production method thereof, and antitumor agent and antifungal agent
JPH07223945A (en) 1994-02-10 1995-08-22 Snow Brand Milk Prod Co Ltd Therapeutic agent for bone disease

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0491956A1 (en) * 1990-06-14 1992-07-01 Rikagaku Kenkyusho Reveromycin a, production thereof, and antitumor drug and fungicide
EP1650210A1 (en) * 2003-07-15 2006-04-26 Riken Therapeutic agent for hyperpotassemia and bone disease

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
GALM ET AL: "Natural Product Drug Discovery: The Times Have Never Been Better", CHEMISTRY AND BIOLOGY, CURRENT BIOLOGY, LONDON, GB, vol. 14, no. 10, 26 October 2007 (2007-10-26), pages 1098 - 1104, XP022309115, ISSN: 1074-5521, DOI: 10.1016/J.CHEMBIOL.2007.10.004 *
See also references of WO2012029811A1 *
SHANNON D. ZANATTA ET AL: "Total Synthesis of the Proposed Structure for Spirofungin B:? A Reassignment of the Stereochemistry", ORGANIC LETTERS, vol. 6, no. 6, 1 March 2004 (2004-03-01), pages 1041 - 1044, XP055100587, ISSN: 1523-7060, DOI: 10.1021/ol049873e *
SHIMIZU T ET AL: "Chemical modification of reveromycin A and its biological activities", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON, AMSTERDAM, NL, vol. 12, no. 23, 1 January 2002 (2002-01-01), pages 3363 - 3366, XP002981347, ISSN: 0960-894X, DOI: 10.1016/S0960-894X(02)00782-5 *
SHUNJI TAKAHASHI ET AL: "Reveromycin A biosynthesis uses RevG and RevJ for stereospecific spiroacetal formation", NATURE CHEMICAL BIOLOGY, vol. 7, no. 7, 5 June 2011 (2011-06-05), pages 461 - 468, XP055099143, ISSN: 1552-4450, DOI: 10.1038/nchembio.583 *
TAKESHI SHIMIZU ET AL: "Asymmetric Total Synthesis of (-)-Spirofungin A and (+)-Spirofungin B", ORGANIC LETTERS, vol. 7, no. 25, 1 December 2005 (2005-12-01), pages 5573 - 5576, XP055100588, ISSN: 1523-7060, DOI: 10.1021/ol052039k *
TAKESHI SHIMIZU ET AL: "Total Synthesis of Reveromycin A", ORGANIC LETTERS, vol. 2, no. 14, 1 July 2000 (2000-07-01), pages 2153 - 2156, XP055100461, ISSN: 1523-7060, DOI: 10.1021/ol0060634 *

Also Published As

Publication number Publication date
JP6066439B2 (en) 2017-01-25
JP5854515B2 (en) 2016-02-09
US8980587B2 (en) 2015-03-17
EP2615168B1 (en) 2017-07-19
JPWO2012029811A1 (en) 2013-10-31
US20130177950A1 (en) 2013-07-11
EP2615168A1 (en) 2013-07-17
JP2016040318A (en) 2016-03-24
WO2012029811A1 (en) 2012-03-08

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