EP2579870A4 - Trkb agonists and methods of use - Google Patents

Trkb agonists and methods of use

Info

Publication number
EP2579870A4
EP2579870A4 EP11793086.7A EP11793086A EP2579870A4 EP 2579870 A4 EP2579870 A4 EP 2579870A4 EP 11793086 A EP11793086 A EP 11793086A EP 2579870 A4 EP2579870 A4 EP 2579870A4
Authority
EP
European Patent Office
Prior art keywords
methods
trkb agonists
trkb
agonists
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP11793086.7A
Other languages
German (de)
French (fr)
Other versions
EP2579870A2 (en
EP2579870B1 (en
Inventor
Keqiang Ye
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Emory University
Original Assignee
Emory University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Emory University filed Critical Emory University
Publication of EP2579870A2 publication Critical patent/EP2579870A2/en
Publication of EP2579870A4 publication Critical patent/EP2579870A4/en
Application granted granted Critical
Publication of EP2579870B1 publication Critical patent/EP2579870B1/en
Not-in-force legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
    • C07D311/28—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only
    • C07D311/30—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only not hydrogenated in the hetero ring, e.g. flavones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
    • A61K31/37—Coumarins, e.g. psoralen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP11793086.7A 2010-06-09 2011-06-08 Trkb agonists and methods of use Not-in-force EP2579870B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US35299110P 2010-06-09 2010-06-09
PCT/US2011/039614 WO2011156479A2 (en) 2010-06-09 2011-06-08 Trkb agonists and methods of use

Publications (3)

Publication Number Publication Date
EP2579870A2 EP2579870A2 (en) 2013-04-17
EP2579870A4 true EP2579870A4 (en) 2013-11-27
EP2579870B1 EP2579870B1 (en) 2018-02-14

Family

ID=45098643

Family Applications (1)

Application Number Title Priority Date Filing Date
EP11793086.7A Not-in-force EP2579870B1 (en) 2010-06-09 2011-06-08 Trkb agonists and methods of use

Country Status (6)

Country Link
US (2) US9029561B2 (en)
EP (1) EP2579870B1 (en)
CN (2) CN103108633B (en)
AU (1) AU2011264917B2 (en)
CA (1) CA2801415A1 (en)
WO (1) WO2011156479A2 (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2011264917B2 (en) 2010-06-09 2015-08-06 Emory University TrkB agonists and methods of use
US9593125B2 (en) 2012-07-27 2017-03-14 Emory University Heterocyclic flavone derivatives, compositions, and methods related thereto
US9682948B2 (en) * 2012-11-05 2017-06-20 Emory University 7,8-dihydoxyflavone and 7,8-substituted flavone derivatives, compositions, and methods related thereto
CN106928207A (en) * 2017-03-17 2017-07-07 南华大学 Double target spot inhibitor of the α of tumour tubulin HIF 1 and preparation method thereof
CN106946864A (en) * 2017-03-17 2017-07-14 南华大学 Suppress the α of HIF 1 antitumor drug candidate and preparation method
US10793634B2 (en) 2017-06-09 2020-10-06 Boehringer Ingelheim International Gmbh Anti-TrkB antibodies
EP3831821A4 (en) * 2018-08-01 2022-05-11 Shaanxi Micot Technology Limited Company Compound for treating nervous system diseases and use thereof
EP3833343B1 (en) 2018-08-07 2024-02-21 Emory University Heterocyclic flavone derivatives, compositions, and methods related thereto
WO2021108855A1 (en) * 2019-12-06 2021-06-10 Gretals Australia Pty Ltd Neurologically active flavonoid compositions and methods of use thereof
GB202101728D0 (en) * 2021-02-08 2021-03-24 Floratek Pharma Ag Compounds and their use treating cancer
GB202104122D0 (en) * 2021-03-24 2021-05-05 Floratek Pharma Ag Compounds and their use
WO2023227881A1 (en) 2022-05-24 2023-11-30 Ontrack Therapeutics Limited Compounds for use in the treatment of diseases and conditions associated with neurodegenerative dysfunction
WO2023227882A1 (en) 2022-05-24 2023-11-30 Ontrack Therapeutics Limited 4-(6-oxo-2-(trifluoromethyl)-3,6-dihydrochromeno[7,8-d]imidazol-8-yl)benzonitril e for the treatment of diseases and conditions associated with movement disorders

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001003681A2 (en) * 1999-07-08 2001-01-18 Prendergast Patrick T Use of flavones, coumarins and related compounds to treat infections
WO2006001665A1 (en) * 2004-06-28 2006-01-05 Seoul National University Industry Foundation Composition for preventing or treating acute or chronic degenerative brain diseases including flavonoid derivatives
WO2008011538A2 (en) * 2006-07-19 2008-01-24 The Salk Institute For Biological Studies Methods of using flavonoids to enhance memory
WO2009003147A1 (en) * 2007-06-26 2008-12-31 Parkinson's Institute Methods and compositions for the treatment of neurological disorders

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9317071D0 (en) 1993-08-17 1993-09-29 Univ Strathclyde Flavonoids
AUPO203996A0 (en) 1996-08-30 1996-09-26 Novogen Research Pty Ltd Therapeutic uses
US20020160983A1 (en) * 2001-03-16 2002-10-31 Alberto Bargiotti Substituted benzopyranones as telomerase inhibitors
US20030125264A1 (en) * 2001-12-29 2003-07-03 Kimberly-Clark Worldwide, Inc. Methods For Treating Wounds
AU2003282999A1 (en) 2002-10-22 2004-05-13 Jenken Biosciences, Inc. Chromones and chromone derivatives and uses thereof
US7547794B2 (en) 2003-04-03 2009-06-16 Vertex Pharmaceuticals Incorporated Compositions useful as inhibitors of protein kinases
US20060025337A1 (en) 2003-07-01 2006-02-02 President And Fellows Of Harvard College Sirtuin related therapeutics and diagnostics for neurodegenerative diseases
US8017634B2 (en) 2003-12-29 2011-09-13 President And Fellows Of Harvard College Compositions for treating obesity and insulin resistance disorders
WO2008091710A2 (en) 2007-01-26 2008-07-31 Washington University Methods and compositions for treating neuropathies
CA2731849C (en) * 2008-07-25 2017-07-11 Emory University Use of 7,8-dihydroxyflavone and derivatives thereof as neuroprotectants and antidepressants
US8203009B2 (en) 2008-07-28 2012-06-19 Emory University Neurotrophic activity of deoxygedunin
AU2011264917B2 (en) 2010-06-09 2015-08-06 Emory University TrkB agonists and methods of use

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001003681A2 (en) * 1999-07-08 2001-01-18 Prendergast Patrick T Use of flavones, coumarins and related compounds to treat infections
WO2006001665A1 (en) * 2004-06-28 2006-01-05 Seoul National University Industry Foundation Composition for preventing or treating acute or chronic degenerative brain diseases including flavonoid derivatives
WO2008011538A2 (en) * 2006-07-19 2008-01-24 The Salk Institute For Biological Studies Methods of using flavonoids to enhance memory
WO2009003147A1 (en) * 2007-06-26 2008-12-31 Parkinson's Institute Methods and compositions for the treatment of neurological disorders

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
S.-W. JANG ET AL: "A selective TrkB agonist with potent neurotrophic activities by 7,8-dihydroxyflavone", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, vol. 107, no. 6, 9 February 2010 (2010-02-09), pages 2687 - 2692, XP055084207, ISSN: 0027-8424, DOI: 10.1073/pnas.0913572107 *
See also references of WO2011156479A2 *
XIA LIU ET AL: "A Synthetic 7,8-Dihydroxyflavone Derivative Promotes Neurogenesis and Exhibits Potent Antidepressant Effect", JOURNAL OF MEDICINAL CHEMISTRY, vol. 53, no. 23, 9 December 2010 (2010-12-09), pages 8274 - 8286, XP055084240, ISSN: 0022-2623, DOI: 10.1021/jm101206p *

Also Published As

Publication number Publication date
CA2801415A1 (en) 2011-12-15
US9029561B2 (en) 2015-05-12
AU2011264917B2 (en) 2015-08-06
WO2011156479A2 (en) 2011-12-15
WO2011156479A3 (en) 2012-04-12
EP2579870A2 (en) 2013-04-17
CN103108633B (en) 2016-01-27
US9504674B2 (en) 2016-11-29
WO2011156479A9 (en) 2012-05-31
EP2579870B1 (en) 2018-02-14
CN103108633A (en) 2013-05-15
AU2011264917A1 (en) 2013-01-10
US20130040947A1 (en) 2013-02-14
CN105566272A (en) 2016-05-11
US20150174107A1 (en) 2015-06-25

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