EP2577341B1 - Relaxométrie par rmn à cyclage de champ - Google Patents
Relaxométrie par rmn à cyclage de champ Download PDFInfo
- Publication number
- EP2577341B1 EP2577341B1 EP11729365.4A EP11729365A EP2577341B1 EP 2577341 B1 EP2577341 B1 EP 2577341B1 EP 11729365 A EP11729365 A EP 11729365A EP 2577341 B1 EP2577341 B1 EP 2577341B1
- Authority
- EP
- European Patent Office
- Prior art keywords
- magnetic field
- evolution
- polarization
- field strength
- field
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 238000000679 relaxometry Methods 0.000 title claims description 21
- 230000001351 cycling effect Effects 0.000 title description 2
- 230000010287 polarization Effects 0.000 claims description 60
- 230000005415 magnetization Effects 0.000 claims description 35
- 238000000034 method Methods 0.000 claims description 31
- 238000005259 measurement Methods 0.000 claims description 29
- 238000001514 detection method Methods 0.000 claims description 27
- 230000010355 oscillation Effects 0.000 claims description 24
- 238000005481 NMR spectroscopy Methods 0.000 claims description 17
- 230000008859 change Effects 0.000 claims description 7
- 230000003068 static effect Effects 0.000 claims description 7
- 230000033001 locomotion Effects 0.000 claims description 5
- 230000006698 induction Effects 0.000 claims description 3
- 238000001208 nuclear magnetic resonance pulse sequence Methods 0.000 claims description 3
- 239000000523 sample Substances 0.000 description 25
- 230000008569 process Effects 0.000 description 9
- 230000006399 behavior Effects 0.000 description 8
- 230000006870 function Effects 0.000 description 7
- 238000012937 correction Methods 0.000 description 6
- 238000002474 experimental method Methods 0.000 description 4
- 238000012545 processing Methods 0.000 description 3
- 230000008901 benefit Effects 0.000 description 2
- 230000001419 dependent effect Effects 0.000 description 2
- 238000011065 in-situ storage Methods 0.000 description 2
- 238000004611 spectroscopical analysis Methods 0.000 description 2
- 230000036962 time dependent Effects 0.000 description 2
- 238000000685 Carr-Purcell-Meiboom-Gill pulse sequence Methods 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 230000002238 attenuated effect Effects 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 238000005529 exchange spectroscopy Methods 0.000 description 1
- 239000000446 fuel Substances 0.000 description 1
- 230000005358 geomagnetic field Effects 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 239000004973 liquid crystal related substance Substances 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 239000004530 micro-emulsion Substances 0.000 description 1
- 238000000244 nuclear magnetic resonance diffusometry Methods 0.000 description 1
- 238000000655 nuclear magnetic resonance spectrum Methods 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 238000001860 quasi-elastic neutron scattering Methods 0.000 description 1
- 239000004065 semiconductor Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000000264 spin echo pulse sequence Methods 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 230000009897 systematic effect Effects 0.000 description 1
- 230000002123 temporal effect Effects 0.000 description 1
Images
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
- G01R33/448—Relaxometry, i.e. quantification of relaxation times or spin density
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
- G01R33/445—MR involving a non-standard magnetic field B0, e.g. of low magnitude as in the earth's magnetic field or in nanoTesla spectroscopy, comprising a polarizing magnetic field for pre-polarisation, B0 with a temporal variation of its magnitude or direction such as field cycling of B0 or rotation of the direction of B0, or spatially inhomogeneous B0 like in fringe-field MR or in stray-field imaging
Definitions
- the invention relates to a Kernspinrelaxometrie Kunststoff according to the preamble of claim 1.
- Field-Cycling NMR Nuclear Magnetic Resonance
- Relaxometry is a well-known method by which measurements of the magnetic field (B 0 field) dependent longitudinal (spin-lattice) relaxation time (T 1 ) over a field strength range of over six decades, ie between 10 - 6 T to about 1 T, can be performed. It is of particular interest to measure nuclear spin relaxation in the smallest possible magnetic fields in order to obtain information about, for example, slow dynamic processes in samples of interest.
- the basic principle of nuclear spin relaxometry is that the nuclear spin system of a sample is first pre-polarized by means of a polarization magnetic field. Subsequently, this polarization magnetic field is quickly switched to a defined other value (evolution magnetic field). The nuclear spin polarization now relaxes to the thermal equilibrium value prevailing in this evolutionary magnetic field. After the (variable) evolution time is switched to a detection magnetic field in which by means of suitable radio frequency pulses, the instantaneous nuclear spin polarization is measured as a function of the evolution time. From this dependence, the spin-lattice relaxation time (longitudinal relaxation time) in the selected evolutionary magnetic field can then be determined directly.
- the object of the invention is to provide an improved MRI method.
- Kernspinrelaxometrie Kunststoff is achieved by a Kernspinrelaxometrie Kunststoff according to claim 1.
- the decisive factor here is that the evolution magnetic field direction differs from the polarization magnetic field direction.
- a damped precession of the nuclear magnetization around the axis of the evolutionary magnetic field with the strength of the evolutionary magnetic field corresponding Larmor frequency is deliberately brought about.
- This precession is measured simultaneously with the nuclear spin lattice relaxation time. Since the same nuclear spins perform both the Larmor precession and the spin-lattice relaxation, an assignment of the measured relaxation time or the relaxation time distribution to a magnetic field strength of the evolutionary magnetic field is possible, excluding all systematic error sources.
- the size of the magnetic fields of the evolutionary magnetic field down to fractions of a microticla ( ⁇ T) can be measured.
- the measurement of field strength is perfectly in-situ, i. performed by the examined nuclear spins themselves.
- the change in the polarization field strength to the evolution field strength is nonadiabatically fast. This means that during the switching of the magnetic field from the polarization field strength to the evolution field strength no thermal exchange of the nuclear spin system with the environment (the grid) takes place, wherein no change of direction of the magnetization vector of the nuclear spins takes place when switching the magnetic field. This makes it possible to actually assign the measured nuclear spin relaxation to the evolution field.
- the polarization magnetic field is generated by a first magnet arrangement and the evolution magnetic field by a second magnet arrangement, wherein the spatial position of the sample during the implementation of the method relative to the first and second magnet arrangement is constant over time.
- the change of the polarization field strength to the evolution field strength is effected only by switching the respective magnet arrangements, whereby the sample itself is not moved during the measurement.
- the first and the second magnet arrangement can also be one and the same arrangement, which is energized differently in order to produce the polarization field or the evolution field.
- the change of the polarization field strength to the evolution field strength is effected by a relative movement of sample, polarization magnetic field and evolutionary magnetic field (mechanical field cycling).
- the sample is moved spatially from the polarization magnetic field into the evolutionary magnetic field.
- the measurement of the field strength takes place simultaneously with the relaxometry experiment. This ensures that the relaxometry data can be unambiguously assigned to the evolutionary magnetic field prevailing at the time of the relaxometry measurement. A temporal variation due to, for example, temperature fluctuations and / or magnetic field strength fluctuations thus remains irrelevant. In addition, the total measurement time can be reduced in such an approach.
- the measured polarization as a function of the evolution time describes a damped oscillation curve
- the determination of the evolution field strength comprises a determination of the curve of the damped oscillation curve, specifically the determination of the oscillation frequency.
- the measurement curve obtained in the method according to the invention (polarization as a function of the evolution time) has an oscillating component and also shows an exponential profile of the polarization with increasing evolution time corresponding to the longitudinal relaxation.
- the oscillation frequency of the said oscillation curve corresponds to the Larmor frequency of the nuclear spins, with which the nuclear spins precess at the sample location due to the evolutionary magnetic field.
- the Larmor frequency and thus the magnetic field strength of the evolutionary magnetic field can be determined directly from said oscillation curve.
- the polarization field strength is equal to the detection field strength and the polarization magnetic field direction is equal to the detection magnetic field direction.
- the use of a polarization field strength equal to the detection field strength is merely an optional possibility of said nuclear spin relaxometry method.
- the choice of the polarization field strength equal to the detection field strength further simplifies the determination of the evolutionary magnetic field and also of the relaxation behavior of the nuclear spins.
- the measurement of the polarization of the nuclear spins of the sample takes place via a radio frequency readout pulse and a subsequent free induction decay or via a suitable readout pulse sequence (e.g., spin echo or CPMG).
- a radio frequency readout pulse and a subsequent free induction decay or via a suitable readout pulse sequence (e.g., spin echo or CPMG).
- spin echo or CPMG a suitable readout pulse sequence
- the resulting evolutionary-dependent polarization of the nuclear spins exhibits an easy-to-analyze and characteristic behavior in the form of an exponential curve in combination with an oscillation.
- FIG. 1 illustrates the time course of a field-cycling NMR relaxometry experiment.
- the method begins with the pre-polarization of nuclear spins of a sample in a large magnetic field, the so-called polarization magnetic field.
- This polarization magnetic field has an order of magnitude of up to one Tesla.
- the nuclear spin magnetization After the nuclear spin magnetization has reached a saturation state after a period of 100, a sufficient (non-adiabatic) fast switching of the magnetic field to a small, adjustable in its orientation evolution magnetic field such that the nuclear spins can not follow.
- the polarization magnetic field direction of the polarization magnetic field was the B z direction 106, so that the magnetization of the nuclear spins also points in the direction 106.
- the magnetic field is again switched to a detection magnetic field, the z-component of the magnetization being registered in the detection magnetic field over a period of time 104.
- the registration of the z component of the magnetization takes place, for example, via a radio frequency read pulse and a free induction decay or via a spin echo pulse sequence during the period 104.
- the in FIG. 1 explain the method shown so that the polarization magnetic field is nonadiabatically downshifted to a tilted evolution magnetic field, wherein the observation of (due to transverse relaxation, T 2 , T 2 *) attenuated precession to the direction of the evolutionary magnetic field B ev and the relaxation-induced decrease of the magnetization in Evolution magnetic field based on the nuclear spin signal in the detection magnetic field after irradiation, for example, a 90 ° radio frequency pulse as a function of the evolution period 102 takes place.
- the FIG. 2 shows the measurement result of a 1 H NMR measurement in an aqueous CuSO 4 solution.
- the direction of the polarization field is in the direction 106 (z-direction), whereas the direction of the evolution magnetic field is in direction 108, ie tilted by about 45 ° with respect to the z-direction.
- this leads to a precession of the magnetization M by B ev .
- the detection of the z component of the magnetization in the detection magnetic field as a function of the evolution time duration ⁇ results in a signal oscillation 202 which oscillates approximately symmetrically about a center line 204.
- the determination of the oscillation frequency, the amplitude ratios and the offset 200 of the centerline 204 relative to the baseline of the Oscillation curve allows the complete determination of the evolutionary magnetic field.
- FIG. 3 shows another example of 1 H NMR measurement in an aqueous CuSO 4 solution.
- the direction of the evolution magnetic field 108 in the vicinity of the Z axis, that is, the evolution magnetic field direction differs only slightly from the polarization magnetic field direction 106.
- an oscillation behavior 300 of the magnetization arises as a function of the evolution period 102, with the oscillation amplitude of the oscillation 300 only marginally an average 302 varies.
- the oscillation field can be completely determined.
- the precession frequency is only 200 Hz, whereby the z-component of the evolution field is about 5 ⁇ T and the x-component is 1 - 2 ⁇ T.
- the measurement shown here demonstrates the procedure for a simultaneous measurement of the evolutionary magnetic field and the spin-lattice relaxation time:
- An evolutionary magnetic field that is slightly tilted to the z-axis is approached nonadiabatically rapidly.
- the nuclear spins precess in their Larmor frequency and thus provide the desired information about the evolution field strength.
- the precession corresponds to the oscillation 400 of the magnetization curve.
- the oscillation 400 is damped due to the transverse relaxation.
- Another disintegration component 402 of the magnetization provides the spin-lattice relaxation time T 1 in the evolution field.
- the FIG. 5 shows a schematic view of a nuclear spin relaxometry device, a so-called field-cycling NMR relaxometer.
- the device 500 which allows a simultaneous measurement of the evolution magnetic field, consists of a fast switchable main coil 504, an also quickly switchable auxiliary coil 506 and fast switching correction coils, for example, for the x, y and z direction.
- These correction coils are in the FIG. 5 generally designated by reference numeral 502 and include, for example, Helmholtz coil pairs.
- the correction coils 502 are initially used to compensate for stray magnetic fields and the geomagnetic fields at the location of the sample 508.
- the coil 504 is used in this example both for generating the polarization magnetic field and the detection magnetic field in the direction 106th In the FIG. 5 it is assumed that the detection magnetic field is identical to the polarization magnetic field.
- the required tilted evolution magnetic field in the direction 108 is in the embodiment of the Fig. 5 is generated by the three correction coils 502, wherein the auxiliary coil 506 is needed to prevent zero crossings of the magnetic field by magnetic field overshoot during rapid downshifting of the main coil 504 by briefly applying an additional field.
- small z-magnetic fields can be well realized thereby.
- the coils 506, 504 and 502 are supplied via a corresponding power supply 510 with electrical energy in the desired manner.
- the control of the power supply and thus the coils 502, 504 and 506 via a data processing system 512 which for this purpose has a processor 514 and a memory 516.
- the memory 516 has instructions executable by the processor 514 for carrying out the method according to the invention.
- An interface 518 of the data processing system 512 is used to transmit control signals to the power supply 510.
- FIG. 5 Field-cycling relaxometer shown allows the determination of the magnetic field strength of the evolutionary magnetic field 506 at the sample location 508 in-situ by the examined nuclear spins of the sample 508 itself.
- the field strength is measured simultaneously with the relaxometry experiment, the size of the magnetic fields to fractions of a Microtesla is measurable.
Landscapes
- Physics & Mathematics (AREA)
- High Energy & Nuclear Physics (AREA)
- Condensed Matter Physics & Semiconductors (AREA)
- General Physics & Mathematics (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
Claims (5)
- Procédé de relaxométrie de spin nucléaire pour la détermination du comportement de relaxation longitudinale de spins nucléaires d'un échantillon, comprenant les étapes suivantes :- exposer l'échantillon à un champ magnétique de polarisation statique pour la polarisation de saturation des spins nucléaires, dans lequel le champ magnétique de polarisation présente une intensité de champ de polarisation et une direction de champ magnétique de polarisation (106) prédéterminée de sorte que la polarisation des spins nucléaires est dirigée dans la direction z ;- modifier l'intensité du champ de polarisation pour obtenir une intensité de champ d'évolution en exposant l'échantillon à un champ magnétique d'évolution statique, dans lequel la modification de l'intensité du champ de polarisation pour obtenir l'intensité du champ d'évolution s'effectue de manière non adiabatique, dans lequel l'échantillon est exposé à l'intensité du champ d'évolution au cours d'une période d'évolution prédéterminée (102), dans lequel le champ magnétique d'évolution présente une direction de champ magnétique d'évolution (108) prédéterminée, dans lequel l'intensité du champ d'évolution est inférieure à l'intensité du champ de polarisation,- exposer l'échantillon à un champ magnétique de détection statique et mesurer la composante z de la magnétisation des spins nucléaires dans le champ magnétique de détection, dans lequel le champ magnétique de détection présente une intensité de champ de détection et une direction de champ magnétique de détection prédéterminée, dans lequel l'intensité du champ de détection est supérieure à l'intensité du champ d'évolution, dans lequel la mesure de la magnétisation des spins nucléaires est effectuée par une séquence d'impulsions de lecture,- répéter les étapes précédentes pour différentes périodes d'évolution et déterminer le comportement de relaxation longitudinale des spins nucléaires à partir de la composante z mesurée de la magnétisation en fonction de la durée respective des différentes périodes d'évolution,caractérisé en ce que la direction du champ magnétique d'évolution (108) est différente de la direction du champ magnétique de polarisation (106), dans lequel l'intensité du champ d'évolution est également déterminée à partir de la composante z mesurée de la magnétisation en fonction de la durée respective des différentes périodes d'évolution, dans lequel la composante z mesurée de la magnétisation décrit une courbe d'oscillation amortie (202 ; 300 ; 400) en fonction de la durée respective des différentes périodes d'évolution, dans lequel la détermination de l'intensité du champ d'évolution comprend une détermination de la fréquence d'oscillation de la courbe d'oscillation (202 ; 300 ; 400).
- Procédé selon l'une des revendications précédentes, dans lequel le champ magnétique de polarisation est généré par un premier dispositif magnétique et le champ magnétique d'évolution est généré par un deuxième dispositif magnétique, dans lequel la position spatiale de l'échantillon est constante dans le temps pendant l'exécution du procédé par rapport aux premier et deuxième dispositifs magnétiques.
- Procédé selon l'une des revendications précédentes, dans lequel la modification de l'intensité du champ de polarisation pour obtenir l'intensité du champ d'évolution est provoquée par un mouvement de l'échantillon par rapport au champ magnétique de polarisation et au champ magnétique d'évolution.
- Procédé selon l'une des revendications précédentes, dans lequel l'intensité du champ de polarisation est égale à l'intensité du champ de détection et la direction du champ magnétique de polarisation (106) est identique à la direction du champ magnétique de détection.
- Procédé selon l'une des revendications précédentes, dans lequel la mesure de la polarisation des spins nucléaires de l'échantillon est effectuée par l'intermédiaire d'une impulsion de lecture radiofréquence et d'une désintégration par induction libre.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE201010022385 DE102010022385B9 (de) | 2010-06-01 | 2010-06-01 | Fieldcycling-Kernspinrelaxometrieverfahren und -vorrichtung sowie Computerprogrammprodukt |
PCT/EP2011/002662 WO2011151049A1 (fr) | 2010-06-01 | 2011-05-30 | Relaxométrie rmn à champ cyclé |
Publications (3)
Publication Number | Publication Date |
---|---|
EP2577341A1 EP2577341A1 (fr) | 2013-04-10 |
EP2577341B1 true EP2577341B1 (fr) | 2018-12-19 |
EP2577341B8 EP2577341B8 (fr) | 2019-03-13 |
Family
ID=44508415
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP11729365.4A Active EP2577341B8 (fr) | 2010-06-01 | 2011-05-30 | Relaxométrie par rmn à cyclage de champ |
Country Status (3)
Country | Link |
---|---|
EP (1) | EP2577341B8 (fr) |
DE (1) | DE102010022385B9 (fr) |
WO (1) | WO2011151049A1 (fr) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2018187217A1 (fr) * | 2017-04-02 | 2018-10-11 | Imagion Biosystems Inc. | Procédés et appareils relatifs à des mesures de relaxométrie magnétique en présence d'une réponse environnementale à une excitation magnétique |
CN111965719B (zh) * | 2020-07-21 | 2024-03-15 | 中海油田服务股份有限公司 | 一种弛豫时间测量方法和装置 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9808333D0 (en) * | 1998-04-18 | 1998-06-17 | Inst Of Food Research | A cyclic field-cycling spectrometer |
ITMI20070847A1 (it) * | 2007-04-23 | 2008-10-24 | Stelar S R L | Metodo per l'acquisizione e l'accumulo di un segnale di risonanza magnetica nucleare in presenza di instabilita' di campo magnetico ed in particolare per le procedure di acquisizione e trattamento di segnali nmr utilizzati per lo studio dei tempi di |
-
2010
- 2010-06-01 DE DE201010022385 patent/DE102010022385B9/de not_active Expired - Fee Related
-
2011
- 2011-05-30 EP EP11729365.4A patent/EP2577341B8/fr active Active
- 2011-05-30 WO PCT/EP2011/002662 patent/WO2011151049A1/fr active Application Filing
Non-Patent Citations (1)
Title |
---|
None * |
Also Published As
Publication number | Publication date |
---|---|
DE102010022385B4 (de) | 2012-11-29 |
EP2577341B8 (fr) | 2019-03-13 |
WO2011151049A1 (fr) | 2011-12-08 |
DE102010022385B9 (de) | 2013-05-29 |
EP2577341A1 (fr) | 2013-04-10 |
DE102010022385A1 (de) | 2011-12-01 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EP0074022B1 (fr) | Dispositif de tomographie à spin nucléaire | |
DE102011078680B3 (de) | Magnetfeldunempfindliche CEST-Bildgebung | |
DE2921253C2 (fr) | ||
DE2921252C2 (fr) | ||
DE19511791C1 (de) | Verfahren zur Shimmung eines Magnetsystems eines Kernspintomographen und Vorrichtung zur Durchführung des Verfahrens | |
DE102008014060B4 (de) | Verfahren zur Bestimmung einer Phasenlage einer Magnetisierung und Magnetresonanzanlage | |
DE19750637A9 (de) | Verfahren zur Messung und Kompensation von durch Wirbelströme induzierten sich örtlich und zeitlich ändernden Magnetfeldern | |
DE102015221888B4 (de) | Gleichzeitige MRT-Mehrschichtmessung | |
DE10354941B4 (de) | Bestimmung der B1-Feldstärke bei MR-Messungen | |
DE102011087210B4 (de) | Verfahren zur Ermittlung einer Ansteuerungssequenz beim parallelen Senden | |
DE112012005359T5 (de) | Verwendung von gradientenspulen zum korrigieren von b0-feldinhomogenitäten höherer ordnung bei mr-bildgebung | |
DE102005040540B4 (de) | Verfahren und Gerät zur Nachweisverbesserung einer schwachsensitiven Atomkernart in der NMR-Spektroskopie | |
DE102005015069B4 (de) | Verfahren zur Vermeidung linearer Phasenfehler in der Magnetresonanz-Spektroskopie | |
DE102019105770A1 (de) | Parallele mr-bildgebung mit spektraler fettunterdrückung | |
DE4024161A1 (de) | Pulssequenz zur schnellen ermittlung von bildern der fett- und wasserverteilung in einem untersuchungsobjekt mittels der kernmagnetischen resonanz | |
DE102012209295B4 (de) | Bestimmung einer objektspezifischen B1-Verteilung eines Untersuchungsobjekts im Messvolumen in der Magnetresonanztechnik | |
DE102013201671B3 (de) | Verfahren zum Erfassen von MR-Daten und zur Bestimmung eines B1-Magnetfelds sowie entsprechend ausgestaltete Magnetresonanzanlage | |
DE3539256C2 (de) | Verfahren zur Darstellung der kernmagnetischen Eigenschaften eines zu untersuchenden Objektes | |
EP2577341B1 (fr) | Relaxométrie par rmn à cyclage de champ | |
DE102011082669B4 (de) | Hyperintense Darstellung von Bereichen im Umfeld von Dipolfeldern mittels MRI | |
DE102014204995B4 (de) | Verfahren und Magnetresonanzanlage zur Fettsättigung | |
DE102013227170B3 (de) | Verfahren und Steuereinrichtung zur Ansteuerung eines Magnetresonanzsystems | |
DE112019001281T5 (de) | Mr-bildgebung mit spiralerfassung | |
DE19747563A9 (de) | Lageerfassungsvorrichtung | |
EP2676151B1 (fr) | Détermination de la forme d'impulsions rf pour l'excitation sélective dans l'imagerie par résonance magnétique |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 20130102 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR |
|
DAX | Request for extension of the european patent (deleted) | ||
17Q | First examination report despatched |
Effective date: 20150206 |
|
GRAP | Despatch of communication of intention to grant a patent |
Free format text: ORIGINAL CODE: EPIDOSNIGR1 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: GRANT OF PATENT IS INTENDED |
|
INTG | Intention to grant announced |
Effective date: 20180626 |
|
GRAS | Grant fee paid |
Free format text: ORIGINAL CODE: EPIDOSNIGR3 |
|
GRAA | (expected) grant |
Free format text: ORIGINAL CODE: 0009210 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE PATENT HAS BEEN GRANTED |
|
RAP1 | Party data changed (applicant data changed or rights of an application transferred) |
Owner name: FUJARA, MARIAN |
|
RIN1 | Information on inventor provided before grant (corrected) |
Inventor name: FUJARA, MARIAN Inventor name: PRIVALOV, ALEXEI Inventor name: GAEDKE, ACHIM Inventor name: FUJARA, FRANZ |
|
AK | Designated contracting states |
Kind code of ref document: B1 Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR |
|
REG | Reference to a national code |
Ref country code: GB Ref legal event code: FG4D Free format text: NOT ENGLISH |
|
REG | Reference to a national code |
Ref country code: CH Ref legal event code: EP |
|
REG | Reference to a national code |
Ref country code: IE Ref legal event code: FG4D Free format text: LANGUAGE OF EP DOCUMENT: GERMAN |
|
REG | Reference to a national code |
Ref country code: DE Ref legal event code: R096 Ref document number: 502011015182 Country of ref document: DE |
|
REG | Reference to a national code |
Ref country code: AT Ref legal event code: REF Ref document number: 1079293 Country of ref document: AT Kind code of ref document: T Effective date: 20190115 |
|
RAP2 | Party data changed (patent owner data changed or rights of a patent transferred) |
Owner name: INNOVENT E.V. |
|
REG | Reference to a national code |
Ref country code: CH Ref legal event code: PK Free format text: BERICHTIGUNG B8 |
|
REG | Reference to a national code |
Ref country code: NL Ref legal event code: MP Effective date: 20181219 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: BG Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20190319 Ref country code: HR Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20181219 Ref country code: LT Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20181219 Ref country code: NO Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20190319 Ref country code: LV Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20181219 Ref country code: FI Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20181219 |
|
REG | Reference to a national code |
Ref country code: LT Ref legal event code: MG4D |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: SE Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20181219 Ref country code: AL Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20181219 Ref country code: RS Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20181219 Ref country code: GR Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20190320 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: NL Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20181219 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: CZ Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20181219 Ref country code: PT Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20190419 Ref country code: ES Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20181219 Ref country code: PL Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20181219 |
|
REG | Reference to a national code |
Ref country code: DE Ref legal event code: R082 Ref document number: 502011015182 Country of ref document: DE Representative=s name: PATENTANWAELTE LIEDTKE & PARTNER, DE |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: EE Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20181219 Ref country code: SK Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20181219 Ref country code: RO Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20181219 Ref country code: IS Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20190419 Ref country code: SM Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20181219 |
|
REG | Reference to a national code |
Ref country code: DE Ref legal event code: R097 Ref document number: 502011015182 Country of ref document: DE |
|
PLBE | No opposition filed within time limit |
Free format text: ORIGINAL CODE: 0009261 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: NO OPPOSITION FILED WITHIN TIME LIMIT |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: DK Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20181219 |
|
26N | No opposition filed |
Effective date: 20190920 |
|
REG | Reference to a national code |
Ref country code: CH Ref legal event code: PL |
|
GBPC | Gb: european patent ceased through non-payment of renewal fee |
Effective date: 20190530 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: LI Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20190531 Ref country code: CH Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20190531 Ref country code: MC Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20181219 |
|
REG | Reference to a national code |
Ref country code: BE Ref legal event code: MM Effective date: 20190531 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: SI Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20181219 Ref country code: LU Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20190530 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: TR Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20181219 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: IE Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20190530 Ref country code: GB Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20190530 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: BE Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20190531 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: FR Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20190531 |
|
REG | Reference to a national code |
Ref country code: AT Ref legal event code: MM01 Ref document number: 1079293 Country of ref document: AT Kind code of ref document: T Effective date: 20190530 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: AT Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20190530 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: CY Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20181219 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: MT Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20181219 Ref country code: HU Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT; INVALID AB INITIO Effective date: 20110530 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: MK Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20181219 |
|
PGFP | Annual fee paid to national office [announced via postgrant information from national office to epo] |
Ref country code: IT Payment date: 20230531 Year of fee payment: 13 |
|
PGFP | Annual fee paid to national office [announced via postgrant information from national office to epo] |
Ref country code: DE Payment date: 20240626 Year of fee payment: 14 |