EP2570800B1 - Test strip cassette with analytical test strip - Google Patents
Test strip cassette with analytical test strip Download PDFInfo
- Publication number
- EP2570800B1 EP2570800B1 EP11181718.5A EP11181718A EP2570800B1 EP 2570800 B1 EP2570800 B1 EP 2570800B1 EP 11181718 A EP11181718 A EP 11181718A EP 2570800 B1 EP2570800 B1 EP 2570800B1
- Authority
- EP
- European Patent Office
- Prior art keywords
- test
- tape
- test tape
- guide path
- cassette
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Links
- 238000012360 testing method Methods 0.000 title claims description 72
- 238000004458 analytical method Methods 0.000 title claims description 8
- 239000004744 fabric Substances 0.000 claims description 31
- 238000003892 spreading Methods 0.000 claims description 30
- 230000007480 spreading Effects 0.000 claims description 30
- 239000003153 chemical reaction reagent Substances 0.000 claims description 14
- 239000008280 blood Substances 0.000 claims description 13
- 210000004369 blood Anatomy 0.000 claims description 13
- 210000001124 body fluid Anatomy 0.000 claims description 7
- 239000010839 body fluid Substances 0.000 claims description 7
- 238000005259 measurement Methods 0.000 claims description 7
- 230000003287 optical effect Effects 0.000 claims description 4
- 239000012491 analyte Substances 0.000 claims description 3
- 238000003780 insertion Methods 0.000 claims description 2
- 230000037431 insertion Effects 0.000 claims description 2
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- 239000007924 injection Substances 0.000 claims 1
- 239000010410 layer Substances 0.000 description 13
- 239000000126 substance Substances 0.000 description 13
- 230000015572 biosynthetic process Effects 0.000 description 8
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 3
- 239000000853 adhesive Substances 0.000 description 3
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- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
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- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000004877 Insulin Human genes 0.000 description 1
- 108090001061 Insulin Proteins 0.000 description 1
- 208000031737 Tissue Adhesions Diseases 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
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Images
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/66—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood sugars, e.g. galactose
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00009—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with a sample supporting tape, e.g. with absorbent zones
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/84—Systems specially adapted for particular applications
- G01N21/8483—Investigating reagent band
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/4875—Details of handling test elements, e.g. dispensing or storage, not specific to a particular test method
- G01N33/48764—Test tape taken off a spool
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00009—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with a sample supporting tape, e.g. with absorbent zones
- G01N2035/00019—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with a sample supporting tape, e.g. with absorbent zones cassette structures
Description
Die Erfindung betrifft eine Testbandkassette zum Einsetzen in ein Handgerät, insbesondere für Blutzuckertests, mit einem Kassettengehäuse zur Lagerung von Bandspulen, einem mittels der Bandspulen vorspulbaren analytischen Testband, einer Vielzahl von auf dem Testband bevorrateten analytischen Testelementen, welche ein Spreitgewebe zur Applikation von Körperflüssigkeit und eine darunter liegende Reagenzschicht zum Nachweis eines Analyten in der Körperflüssigkeit aufweisen, wobei das Kassettengehäuse eine das Testband umlenkende Applikationsspitze zur Bereitstellung der Testelemente besitzt. Solche Kassetten sind aus
Die Erfindung betrifft weiter ein analytisches Testband insbesondere zum Einsatz in einer solchen Testbandkassette.The invention further relates to an analytical test tape, in particular for use in such a test tape cassette.
Bei einer aus der
Insbesondere wurde festgestellt, dass eine solche Spaltbildung die Neigung zu einer "Entnetzung", d.h. einer Migration der Blutprobe aus den benetzten Gewebemaschen und die Empfindlichkeit gegenüber Verunreinigungen (z.B. Glucose) auf der Haut des Probanden verstärkt. Der letztgenannte Effekt kann sich dadurch ergeben, dass das durch einen Hauteinstich gewonnene Kapillarblut einen Blutstropfen an der Einstichstelle bildet, der zunächst in seinem im Hautkontakt stehenden Randbereich mit Verschmutzungen aufkonzentriert wird. Das "native" Blut wird dann aufgrund der Spaltbildung im Spreitgewebe zunächst in die Randbereiche des Chemieträgers verteilt, während das nachströmende verschmutzte Blut dann auf den zentralen Messfleck gelangt, wodurch die Messperformance beeinträchtigt werden kann.In particular, it was found that such a gap formation increases the tendency to "dewetting", ie migration of the blood sample from the wetted tissue mesh and the sensitivity to impurities (eg glucose) on the subject's skin. The last-mentioned effect can result from the fact that the capillary blood obtained through a skin puncture forms a drop of blood at the puncture site, which is initially concentrated with dirt in the edge area in contact with the skin. The "native" blood is then initially distributed into the edge areas of the chemical carrier due to the formation of a gap in the spreading tissue, while the contaminated blood flowing in then reaches the central measuring spot, which can impair the measuring performance.
Ausgehend hiervon liegt der Erfindung die Aufgabe zugrunde, die im Stand der Technik bekannten Testbandsysteme und darin eingesetzten disposiblen Testmittel zu optimieren und eine weiter verbesserte Zuverlässigkeit und Genauigkeit der Messung sicherzustellen.Proceeding from this, the invention is based on the object of optimizing the test tape systems known in the prior art and disposable test means used therein and of ensuring a further improved reliability and accuracy of the measurement.
Zur Lösung dieser Aufgabe wird die in den unabhängigen Patentansprüchen angegebene Merkmalskombination vorgeschlagen. Vorteilhafte Ausgestaltungen und Weiterbildungen der Erfindung ergeben sich aus den abhängigen Ansprüchen.To solve this problem, the combination of features specified in the independent claims is proposed. Advantageous refinements and developments of the invention result from the dependent claims.
Die Erfindung geht von dem Gedanken aus, die Bandführungsgeometrie bzw. den Testfeldaufbau so zu gestalten, dass eine Spaltbildung zwischen Spreitgewebe und Chemieträger unter Einsatzbedingungen weitgehend minimiert wird. Dementsprechend wird gemäß einem ersten Aspekt der Erfindung vorgeschlagen, dass die Applikationsspitze eine längs des Testbandes (bzw. in Bandlaufrichtung) bogenförmig verlaufende und quer dazu ungekrümmte Führungsbahn zur knickfreien Abstützung des Testbands aufweist, und dass die Führungsbahn in ihrem Scheitelbereich einen zentralen Durchbruch als Messfenster für eine optische Messung an den Testelementen begrenzt. Durch die bogenförmige Längskrümmung der Führungsbahn bzw. Lauffläche kann der Biegesteifigkeit der Testelemente und insbesondere des Spreitgewebes durch einen gleichmäßig abstützenden mechanischen Unterbau Rechnung getragen werden, so dass scharfe Bandknicke und damit eine Spaltbildung vermieden werden. Um Verschiebungen in dem Mehrschichtaufbau zu vermeiden, erfolgt die Bandkrümmung nur eindimensional, während in Bandquerrichtung eine ungekrümmte Abstützung erreicht wird. Zugleich kann durch die Bogenform der Führungsbahn eine gezielte Probenaufnahme auch kleinster Probenmengen im Scheitelpunkt sichergestellt werden, wobei durch das dort positionierte, als lichte Öffnung ausgebildete Messfenster auch eine Reduzierung der erforderlichen Testfeldfläche möglich ist.The invention is based on the idea of designing the tape guide geometry or the test field structure in such a way that the formation of a gap between the spreading fabric and the chemical carrier is largely minimized under operating conditions. Accordingly, according to a first aspect of the invention, it is proposed that the application tip has a guide track that runs in an arc along the test tape (or in the direction of tape travel) and is not curved at right angles to it for kink-free support of the test tape, and that the guide track has a central opening in its apex area as a measuring window for an optical measurement on the test elements is limited. Due to the arcuate longitudinal curvature of the guide track or running surface, the flexural rigidity of the test elements and in particular of the spreading fabric can be taken into account by a uniformly supporting mechanical substructure, so that sharp belt kinks and thus gap formation can be avoided. In order to avoid shifts in the multilayer structure, the band is only curved one-dimensionally, while an uncurved support is achieved in the transverse direction of the band. At the same time, the arched shape of the guideway ensures that even the smallest sample quantities can be picked up at the apex, whereby the measuring window positioned there and designed as a clear opening also enables the required test field area to be reduced.
Eine weitere Verbesserung in dieser Hinsicht lässt sich dadurch erreichen, dass die kreisbogenförmige Führungsbahn einen festen Krümmungsradius vorzugsweise im Bereich von 3 bis 5 mm aufweist, und dass die Führungsbahn eine Längserstreckung in Bandtransportrichtung im Bereich von 5 bis 8 mm aufweist. Dabei ist es günstig, wenn die Längserstreckung der Führungsbahn gleich oder kleiner als die vorzugsweise im Bereich von 5 bis 15 mm liegende Länge der Testelemente ist.A further improvement in this regard can be achieved in that the circular arc-shaped guide track has a fixed radius of curvature, preferably in the range of 3 to 5 mm, and that the guide track has a longitudinal extension in the tape transport direction in the range of 5 to 8 mm. It is advantageous if the longitudinal extension of the guide track is equal to or smaller than the length of the test elements, which is preferably in the range from 5 to 15 mm.
Die Einsatzbedingungen und insbesondere die Bandzugkraft sollten so angepasst sein, dass das Testband unter Zugspannung flächig auf der Führungsbahn abgestützt ist, so dass das Spreitgewebe im Wesentlichen spaltfrei auf der Reagenzschicht anliegt.The conditions of use and, in particular, the tensile strength of the tape should be adapted in such a way that the test tape is supported flatly on the guideway under tensile stress so that the spreading fabric rests on the reagent layer essentially without gaps.
Um eine Spaltbildung unter dem unverklebten Zentralbereich des Spreitgewebes zu vermeiden, ist es vorteilhaft, wenn die Reagenzschicht in Bandquerrichtung gesehen schmaler als das Testband und breiter als das Messfenster ist.In order to avoid the formation of a gap under the non-glued central area of the spreading fabric, it is advantageous to when the reagent layer, viewed in the transverse direction of the tape, is narrower than the test tape and wider than the measuring window.
Für eine optimierte rückseitige optische Messwerterfassung ist es von Vorteil, wenn eine die Führungsbahn bildende Gehäusewand der Applikationsspitze rückseitig zu dem Messfenster hin abgeschrägt ist.For an optimized rear-side optical measurement value acquisition, it is advantageous if a housing wall of the application tip that forms the guideway is beveled on the rear side towards the measuring window.
Um Gebrauchs- und Herstellungsvorteile zu erreichen, ist es vorteilhaft, wenn die Applikationsspitze vorzugsweise als Spritzgusspartie einstückig an dem Kassettengehäuse angeformt ist und im Gebrauchszustand zum punktuellen Applizieren von Körperflüssigkeit aus dem Handgerät herausragt.In order to achieve usage and manufacturing advantages, it is advantageous if the application tip is formed in one piece on the cassette housing, preferably as an injection-molded part, and protrudes from the hand-held device in the state of use for the selective application of body fluid.
Im Folgenden wird die Erfindung anhand der in der Zeichnung schematisch dargestellten Ausführungsbeispiele näher erläutert. Es zeigen
- Fig. 1
- ein Handgerät für Blutzuckertests mit einer als Verbrauchsmittel eingesetzten Testbandkassette in einer teilweise aufgebrochenen Seitenansicht;
- Fig. 2
- einen Ausschnitt eines Testbands der Testbandkassette mit einem analytischen Testelement in einer perspektivischen Darstellung;
- Fig. 3
- ein Gehäuseteil der Testbandkassette in einer perspektivischen Darstellung;
- Fig. 4
- eine Applikationsspitze der Testbandkassette in der Draufsicht, im Längsschnitt und im Querschnitt;
- Fig. 5 und 6
- einen Schnitt entlang der Linie 5 - 5 und 6 - 6 in
Fig. 4 ; - Fig. 7
- ein Spreitgewebe für ein analytisches Testelement mit Schwächungsstellen in einer ausschnittsweisen Draufsicht;
- Fig. 8
- eine weitere Ausführungsform eines modifizierten Spreitgewebes;
- Fig. 9
- ein Testfeld auf einer Applikationsspitze gemäß dem Stand der Technik in geschnittener perspektivischer Darstellung.
- Fig. 1
- a hand-held device for blood sugar tests with a test tape cassette used as a consumable in a partially broken side view;
- Fig. 2
- a section of a test tape of the test tape cassette with an analytical test element in a perspective view;
- Fig. 3
- a housing part of the test tape cassette in a perspective view;
- Fig. 4
- an application tip of the test tape cassette in plan view, in longitudinal section and in cross section;
- Figures 5 and 6
- a section along lines 5-5 and 6-6 in
Fig. 4 ; - Fig. 7
- a spreading fabric for an analytical test element with weakening points in a partial plan view;
- Fig. 8
- another embodiment of a modified spreading fabric;
- Fig. 9
- a test field on an application tip according to the prior art in a sectional perspective illustration.
Das in
Die mehrlagigen Testelemente 24 weisen als im Umriss rechteckförmige etikettenartige Flächengebilde einen auf das Transportband 22 aufgeklebten doppelseitigen Klebestreifen 26, einen darauf aufgebrachten Chemieträger 28 und ein den Chemieträger 28 an der von dem Transportband 22 abgewandten Oberseite überspannendes Spreitgewebe 30 für eine flächige Verteilung einer von oben auf das Spreitgewebe aufgetragenen Blutprobe auf. Seitlich neben dem Chemieträger 28 sind Abstandshalter 32 vorgesehen, um das Spreitgewebe 30 eben bzw. stufenfrei vollflächig abzustützen.The
Der Chemieträger 28 umfasst eine lichtdurchlässige Trägerfolie 34 und eine darauf aufgebrachte Reagenzschicht 36, die aus einer oberen Pigmentschicht mit darunter liegendem Trockenchemiefilm in an sich bekannter Weise aufgebaut ist.The
Die Abstandshalter 32 bestehen aus einem auf der oberen Klebeschicht 38 des doppelseitigen Klebestreifens 26 haftenden Basisstreifen 40 und einer darauf befindlichen Klebeschicht 42 zur seitlichen Fixierung des Spreitgewebes 30.The
Das in
Dabei wird durch den einseitigen Verschluss der Gewebeöffnungen mit dem Klebematerial der flankierenden Klebeschichten 42 eine Art von Wabenstruktur über den Abstandshaltern 32 gebildet, die einen Blutfluss zu den Seitenkanten des Testelements 24 verhindert. Somit erfolgt die Flüssigkeitsverteilung bzw. -spreitung gezielt in dem nicht verklebten Zentralbereich des Gewebes 30 über der Reagenzschicht 36, so dass auf die nach dem Stand der Technik beispielsweise als Wachsstreifen mittels Thermotransferdruck eigens aufgebrachten hydrophoben Randstreifen ohne Nachteil verzichtet werden kann.The one-sided closure of the tissue openings with the adhesive material of the flanking
Die Reagenzschicht 36 spricht mit ihrem Trockenchemiefilm insbesondere auf Enzymbasis auf einen Analyten (Glucose) durch Farbumschlag an, so dass eine reflexionsphotometrische Erfassung durch den transparenten Folienverbund 22, 26, 34 hindurch von der Rückseite des Testbands 20 her erfolgen kann.The
Die Testfelder 24 lassen sich somit durch Vorspulen des Transportbandes 22 an Applikationsspitze 18 nacheinander zum Einsatz bringen, um gezielt eine geringe Probenmenge auftragen zu können. Aufgrund der dabei ausgeübten Zugkraft ist der mehrlagige Bandaufbau richtungsabhängigen Dehnungen bzw. Kontraktionen insbesondere im Bereich von engen Umlenkstellen unterworfen.The test fields 24 can thus be used one after the other by fast-winding the
Beim Stand der Technik, wie er in
Um die vorstehend beschriebene Spaltbildung zu vermeiden, ist gemäß
Zur Ein- und Ausleitung des Testbands 20 an der Applikationsspitze 18 schließen sich an die Führungsbahn 68 endseitig Führungsschrägen 72 an, die einen spitzen Winkel einschließen. In diesem Bereich sind auch Seitenbegrenzungen 74 vorgesehen, die das Testband 20 gegen Querverschiebung sichern, während die Führungsbahn 68 frei von solchen Seitenbegrenzungen bleibt.For the introduction and discharge of the
Wie am besten aus
Wie in
Als weitere Maßnahme zur Vermeidung bzw. Reduzierung einer Spaltbildung zwischen dem Spreitgewebe 30 und der Reagenzschicht 36 ist die Biegesteifigkeit des Spreitgewebes 30 bereichsweise bzw. lokal entsprechend modifiziert.As a further measure to avoid or reduce the formation of a gap between the spreading
Allgemein lässt sich die Biegesteifigkeit einer Gewebeprobe nach dem Freiträgerverfahren (Cantilever-Verfahren) bestimmen. Hierbei wird das Biegeverhalten aufgrund des Eigengewichts dadurch ermittelt, dass eine Biegelänge erfasst wird, bei der die Gewebeprobe unter ihrem Eigengewicht um einen definierten Winkel nach unten gebogen wird.In general, the flexural rigidity of a tissue sample can be determined using the cantilever method. In this case, the bending behavior is determined based on its own weight in that a bending length is recorded at which the tissue sample is bent downwards by a defined angle under its own weight.
Beispielsweise kann eine hohe Biegesteifigkeit in Bandquerrichtung vorgesehen sein, um eine benötigte Planlage des Spreitgewebes sicherzustellen. Es kann aber auch eine niedrige Biegesteifigkeit in Bandlängsrichtung notwendig sein, um das Spreitgewebe umlenken zu können, ohne dass es zu ungewollten Aufwölbungen oder einer Delaminierung weiterer Teile des gesamten Testelementaufbaus kommt.For example, high flexural rigidity can be provided in the transverse direction of the tape in order to ensure that the spreading fabric is flat. However, a low flexural rigidity in the longitudinal direction of the tape can also be necessary in order to be able to deflect the spreading fabric without undesired bulges or delamination of further parts of the entire test element structure.
Ein isotropes Gewebe mit einheitlichen Schuss- und Kettfäden kann je nach Fadenstärke bzw. Gewebedicke nur eine in Bezug auf die gewünschte Testelementarchitektur gleichmäßig hohe oder niedrige Biegesteifigkeit besitzen.An isotropic fabric with uniform warp and weft threads can only have a uniformly high or low flexural rigidity in relation to the desired test element architecture, depending on the thread size or fabric thickness.
Um ein für die Testfunktion ausreichend dickes Spreitgewebe mit Bereichen hoher Biegesteifigkeit und zugleich mit Bereichen geringer Biegesteifigkeit zu erhalten, bestehen folgende Möglichkeiten, die Biegesteifigkeit bereichsweise bzw. lokal zu modifizieren:
- der Einsatz unterschiedlich starker Fäden in entsprechenden Bereichen des Gewebes;
- das Herauslösen einzelner Fäden in bestimmten Bereichen;
- die zusätzliche Beschichtung in bestimmten Bereichen;
- die Verdünnung oder lokale Schwächung von einem oder mehreren Fäden;
- der Einsatz unterschiedlicher Fadenmaterialien;
- der Einsatz unterschiedlicher Fadenbeschaffenheiten (z.B. multifile Fäden).
- the use of threads of different strengths in corresponding areas of the fabric;
- the loosening of individual threads in certain areas;
- the additional coating in certain areas;
- the thinning or local weakening of one or more threads;
- the use of different thread materials;
- the use of different thread properties (e.g. multifilament threads).
Claims (6)
- Test tape cassette for insertion into a hand-held device (12), in particular for blood sugar tests, comprising a cassette housing (50) for storing tape spools (54, 58), an analytical test tape (20) that can be wound forwards by means of the tape spools (54, 58), a plurality of analytical test elements (24) stored on the test tape (20) which have a spreading fabric (30) for applying body fluid and an underlying reagent layer (36) for detecting an analyte in the body fluid, wherein the cassette housing (50) has an application tip (18) that deflects the test tape (20) in order to provide the test elements (24),
characterized in that the application tip (18) has a guide path (68) which extends in an arch shape longitudinally to the test tape (20) and is uncurved at right angles thereto for supporting the test tape in a kink-free manner, that the apex area of the guide path (68) delimits a central opening as a measuring window (70) for an optical measurement on the test elements (24) and that the test tape (20) under tension is supported in a planar fashion on the guide path (68) such that the spreading fabric (30) lies gap-free on the reagent layer (36), wherein a housing wall (76) of the application tip (18) forming the guide path (68) is bevelled on the rear side towards the measuring window (70). - Test tape cassette according to claim 1, characterized in that the arc-shaped guide path (68) has a fixed radius of curvature preferably in the range of 3 to 5 mm.
- Test tape cassette according to claim 1 or 2, characterized in that that the guide path (68) has a longitudinal extension in the direction of tape transport in the range of 5 to 8 mm.
- Test tape cassette according to one of the claims 1 to 3, characterized in that the longitudinal extension of the guide path (68) is the same or less than the length of the test elements (24) which is preferably in the range of 5 to 15 mm.
- Test tape cassette according to one of the claims 1 to 4, characterized in that the reagent layer (36) viewed in the tape transverse direction is narrower than the test tape (20) and wider than the measuring window (70).
- Test tape cassette according to one of the claims 1 to 5, characterized in the application tip (18) is moulded in one piece preferably as an injection moulded part on the cassette housing (50) and projects from the hand-held device (12) in the operating state in order to punctually apply body fluid.
Priority Applications (28)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PT111817185T PT2570800T (en) | 2011-09-16 | 2011-09-16 | Test strip cassette and analytical test strip for same |
EP11181718.5A EP2570800B1 (en) | 2011-09-16 | 2011-09-16 | Test strip cassette with analytical test strip |
ARP120103354A AR087846A1 (en) | 2011-09-16 | 2012-09-13 | TEST TAPE CASSETTE AND ANALYTIC TEST TAPE FOR THE SAME |
CA2845148A CA2845148C (en) | 2011-09-16 | 2012-09-14 | Test tape cassette and analytical test tape therefor |
MX2014002410A MX343655B (en) | 2011-09-16 | 2012-09-14 | Test tape cassette and analytical test tape therefor. |
AU2012307335A AU2012307335A1 (en) | 2011-09-16 | 2012-09-14 | Test tape cassette and analytical test tape therefor |
TW103146177A TWI542876B (en) | 2011-09-16 | 2012-09-14 | Test tape cassette and analytical test tape therefor |
KR1020157034814A KR101895663B1 (en) | 2011-09-16 | 2012-09-14 | Test tape cassette and analytical test tape therefor |
KR1020187024924A KR101940970B1 (en) | 2011-09-16 | 2012-09-14 | Test tape cassette and analytical test tape therefor |
TW101133878A TWI472764B (en) | 2011-09-16 | 2012-09-14 | Test tape cassette and analytical test tape therefor |
KR1020147006952A KR20140049601A (en) | 2011-09-16 | 2012-09-14 | Test tape cassette and analytical test tape therefor |
RU2014114868/28A RU2573704C2 (en) | 2011-09-16 | 2012-09-14 | Cassette for control tape in set with analytical control tape |
BR112014004003A BR112014004003A2 (en) | 2011-09-16 | 2012-09-14 | test analytical tape and test tape cassette for insertion into a portable device |
PCT/EP2012/068145 WO2013037969A1 (en) | 2011-09-16 | 2012-09-14 | Test tape cassette and analytical test tape therefor |
CN201280044837.5A CN103814290B (en) | 2011-09-16 | 2012-09-14 | Test tape drum and the analysis calibration tape for described test tape drum |
EP12761954.2A EP2756288B1 (en) | 2011-09-16 | 2012-09-14 | Analytical test tape for a test tape cassette |
SG2014006498A SG2014006498A (en) | 2011-09-16 | 2012-09-14 | Test tape cassette and analytical test tape therefor |
PL12761954.2T PL2756288T3 (en) | 2011-09-16 | 2012-09-14 | Analytical test tape for a test tape cassette |
HUE12761954A HUE063061T2 (en) | 2011-09-16 | 2012-09-14 | Analytical test tape for a test tape cassette |
JP2014530244A JP6138134B2 (en) | 2011-09-16 | 2012-09-14 | Test tape cassette and test tape for analysis for test tape cassette |
SG10201607238XA SG10201607238XA (en) | 2011-09-16 | 2012-09-14 | Test tape cassette and analytical test tape therefor |
NZ620214A NZ620214B2 (en) | 2011-09-16 | 2012-09-14 | Test tape cassette and analytical test tape therefor |
CN201610735498.5A CN106248949B (en) | 2011-09-16 | 2012-09-14 | Test tape drum and the analysis calibration tape for the test tape drum |
ES12761954T ES2952695T3 (en) | 2011-09-16 | 2012-09-14 | Cassette for test tapes and analytical test tape for the same |
ZA2014/01598A ZA201401598B (en) | 2011-09-16 | 2014-03-03 | Test tape cassette and analytical test tape therefor |
US14/200,805 US9335333B2 (en) | 2011-09-16 | 2014-03-07 | Test tape cassette and analytical test tape therefor |
HK14111658.4A HK1198206A1 (en) | 2011-09-16 | 2014-11-19 | Test tape cassette and analytical test tape therefor |
JP2017050076A JP6325708B2 (en) | 2011-09-16 | 2017-03-15 | Test tape for analysis |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP11181718.5A EP2570800B1 (en) | 2011-09-16 | 2011-09-16 | Test strip cassette with analytical test strip |
Publications (2)
Publication Number | Publication Date |
---|---|
EP2570800A1 EP2570800A1 (en) | 2013-03-20 |
EP2570800B1 true EP2570800B1 (en) | 2021-01-27 |
Family
ID=46888421
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP11181718.5A Active EP2570800B1 (en) | 2011-09-16 | 2011-09-16 | Test strip cassette with analytical test strip |
EP12761954.2A Active EP2756288B1 (en) | 2011-09-16 | 2012-09-14 | Analytical test tape for a test tape cassette |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP12761954.2A Active EP2756288B1 (en) | 2011-09-16 | 2012-09-14 | Analytical test tape for a test tape cassette |
Country Status (20)
Country | Link |
---|---|
US (1) | US9335333B2 (en) |
EP (2) | EP2570800B1 (en) |
JP (2) | JP6138134B2 (en) |
KR (3) | KR101940970B1 (en) |
CN (2) | CN103814290B (en) |
AR (1) | AR087846A1 (en) |
AU (1) | AU2012307335A1 (en) |
BR (1) | BR112014004003A2 (en) |
CA (1) | CA2845148C (en) |
ES (1) | ES2952695T3 (en) |
HK (1) | HK1198206A1 (en) |
HU (1) | HUE063061T2 (en) |
MX (1) | MX343655B (en) |
PL (1) | PL2756288T3 (en) |
PT (1) | PT2570800T (en) |
RU (1) | RU2573704C2 (en) |
SG (2) | SG10201607238XA (en) |
TW (2) | TWI472764B (en) |
WO (1) | WO2013037969A1 (en) |
ZA (1) | ZA201401598B (en) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2019013544A (en) * | 2017-07-07 | 2019-01-31 | 株式会社三洋物産 | Game machine |
JP2019013543A (en) * | 2017-07-07 | 2019-01-31 | 株式会社三洋物産 | Game machine |
JP7032454B2 (en) * | 2017-08-02 | 2022-03-08 | エフ.ホフマン-ラ ロシュ アーゲー | Glucose test arrangement and method |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1878379A1 (en) * | 2006-07-11 | 2008-01-16 | F.Hoffmann-La Roche Ag | Test tape unit, in particular for blood sugar analysis |
Family Cites Families (16)
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US4218421A (en) * | 1978-08-18 | 1980-08-19 | Honeywell Inc. | Disposable container for a continuous band of test strips |
JPS63313063A (en) * | 1987-06-16 | 1988-12-21 | Fuji Photo Film Co Ltd | Instrument and method for chemical analysis |
JP2002034779A (en) * | 2000-07-21 | 2002-02-05 | Yonezawa Bussan:Kk | Lengthwise flexible core fabric for curtain, and device and method for producing the same |
EP1424040A1 (en) * | 2002-11-26 | 2004-06-02 | Roche Diagnostics GmbH | Body fluid testing device |
US7731900B2 (en) * | 2002-11-26 | 2010-06-08 | Roche Diagnostics Operations, Inc. | Body fluid testing device |
CA2511179C (en) * | 2002-12-23 | 2009-05-12 | F. Hoffmann-La Roche Ag | Transport device for transporting test strips in an analysis system |
DE10332488A1 (en) | 2003-07-16 | 2005-02-24 | Roche Diagnostics Gmbh | Analyzer and analysis method for body fluids |
DE10343896A1 (en) * | 2003-09-19 | 2005-04-28 | Roche Diagnostics Gmbh | Testing device for the examination of body fluids |
AU2005201576B2 (en) * | 2004-05-07 | 2010-06-24 | F. Hoffmann-La Roche Ag | Process and device for producing an analytical tape for liquid samples |
DE102005013685A1 (en) * | 2005-03-18 | 2006-09-28 | Roche Diagnostics Gmbh | Tape magazine for a hand-held device for examining a body fluid, as well as a hand-held device |
JP4728827B2 (en) * | 2006-02-08 | 2011-07-20 | 旭陽産業株式会社 | Textile adhesive interlining and method for producing the same |
EP1834696B1 (en) * | 2006-03-14 | 2013-02-20 | F. Hoffmann-La Roche AG | Method for producing a multi-layer analysis element |
EP2011630A1 (en) * | 2007-07-03 | 2009-01-07 | F. Hoffmann-La Roche AG | Method for manufacturing an analytical element |
EP2116180A1 (en) * | 2008-05-06 | 2009-11-11 | F.Hoffmann-La Roche Ag | Diagnostic tape unit and measuring system |
EP2151686A1 (en) * | 2008-08-04 | 2010-02-10 | Roche Diagnostics GmbH | Analysis system with encryption detection |
EP2223746A1 (en) * | 2009-02-13 | 2010-09-01 | F. Hoffmann-La Roche AG | Diagnostic test strip for fluid samples |
-
2011
- 2011-09-16 EP EP11181718.5A patent/EP2570800B1/en active Active
- 2011-09-16 PT PT111817185T patent/PT2570800T/en unknown
-
2012
- 2012-09-13 AR ARP120103354A patent/AR087846A1/en active IP Right Grant
- 2012-09-14 MX MX2014002410A patent/MX343655B/en active IP Right Grant
- 2012-09-14 JP JP2014530244A patent/JP6138134B2/en active Active
- 2012-09-14 ES ES12761954T patent/ES2952695T3/en active Active
- 2012-09-14 SG SG10201607238XA patent/SG10201607238XA/en unknown
- 2012-09-14 KR KR1020187024924A patent/KR101940970B1/en active IP Right Grant
- 2012-09-14 WO PCT/EP2012/068145 patent/WO2013037969A1/en active Application Filing
- 2012-09-14 AU AU2012307335A patent/AU2012307335A1/en not_active Abandoned
- 2012-09-14 TW TW101133878A patent/TWI472764B/en active
- 2012-09-14 PL PL12761954.2T patent/PL2756288T3/en unknown
- 2012-09-14 RU RU2014114868/28A patent/RU2573704C2/en active
- 2012-09-14 CN CN201280044837.5A patent/CN103814290B/en active Active
- 2012-09-14 KR KR1020147006952A patent/KR20140049601A/en active Application Filing
- 2012-09-14 EP EP12761954.2A patent/EP2756288B1/en active Active
- 2012-09-14 SG SG2014006498A patent/SG2014006498A/en unknown
- 2012-09-14 CN CN201610735498.5A patent/CN106248949B/en active Active
- 2012-09-14 BR BR112014004003A patent/BR112014004003A2/en active Search and Examination
- 2012-09-14 KR KR1020157034814A patent/KR101895663B1/en active IP Right Grant
- 2012-09-14 TW TW103146177A patent/TWI542876B/en active
- 2012-09-14 CA CA2845148A patent/CA2845148C/en active Active
- 2012-09-14 HU HUE12761954A patent/HUE063061T2/en unknown
-
2014
- 2014-03-03 ZA ZA2014/01598A patent/ZA201401598B/en unknown
- 2014-03-07 US US14/200,805 patent/US9335333B2/en active Active
- 2014-11-19 HK HK14111658.4A patent/HK1198206A1/en unknown
-
2017
- 2017-03-15 JP JP2017050076A patent/JP6325708B2/en active Active
Patent Citations (1)
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EP1878379A1 (en) * | 2006-07-11 | 2008-01-16 | F.Hoffmann-La Roche Ag | Test tape unit, in particular for blood sugar analysis |
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