EP2531860A4 - Measuring multi-analyte samples using an in-line flow cell - Google Patents

Measuring multi-analyte samples using an in-line flow cell

Info

Publication number
EP2531860A4
EP2531860A4 EP11740432.7A EP11740432A EP2531860A4 EP 2531860 A4 EP2531860 A4 EP 2531860A4 EP 11740432 A EP11740432 A EP 11740432A EP 2531860 A4 EP2531860 A4 EP 2531860A4
Authority
EP
European Patent Office
Prior art keywords
flow cell
line flow
analyte samples
measuring multi
measuring
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP11740432.7A
Other languages
German (de)
French (fr)
Other versions
EP2531860B1 (en
EP2531860A1 (en
Inventor
Robert K Likuski
Anthony F Prestigiacomo
Tong Le
Kurt D Kramer
Don Bartling
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bio Rad Laboratories Inc
Original Assignee
Bio Rad Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bio Rad Laboratories Inc filed Critical Bio Rad Laboratories Inc
Publication of EP2531860A1 publication Critical patent/EP2531860A1/en
Publication of EP2531860A4 publication Critical patent/EP2531860A4/en
Application granted granted Critical
Publication of EP2531860B1 publication Critical patent/EP2531860B1/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/49—Blood
    • G01N33/4915—Blood using flow cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/06—Investigating concentration of particle suspensions
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6486—Measuring fluorescence of biological material, e.g. DNA, RNA, cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/04—Preparation or injection of sample to be analysed
    • G01N30/06—Preparation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1095—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices for supplying the samples to flow-through analysers
    • G01N15/075—
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1095—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices for supplying the samples to flow-through analysers
    • G01N35/1097—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices for supplying the samples to flow-through analysers characterised by the valves
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/2575—Volumetric liquid transfer
EP11740432.7A 2010-02-04 2011-02-04 Measuring multi-analyte samples using an in-line flow cell Active EP2531860B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12/700,653 US8790592B2 (en) 2010-02-04 2010-02-04 Measuring multi-analyte samples using an in-line flow cell
PCT/US2011/023760 WO2011097489A1 (en) 2010-02-04 2011-02-04 Measuring multi-analyte samples using an in-line flow cell

Publications (3)

Publication Number Publication Date
EP2531860A1 EP2531860A1 (en) 2012-12-12
EP2531860A4 true EP2531860A4 (en) 2014-07-02
EP2531860B1 EP2531860B1 (en) 2018-04-11

Family

ID=44342030

Family Applications (1)

Application Number Title Priority Date Filing Date
EP11740432.7A Active EP2531860B1 (en) 2010-02-04 2011-02-04 Measuring multi-analyte samples using an in-line flow cell

Country Status (6)

Country Link
US (2) US8790592B2 (en)
EP (1) EP2531860B1 (en)
JP (1) JP5819858B2 (en)
AU (1) AU2011212806B2 (en)
CA (1) CA2788077A1 (en)
WO (1) WO2011097489A1 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5711564B2 (en) * 2011-02-17 2015-05-07 ベックマン コールター， インコーポレイテッド Automatic analyzer
JP2013255447A (en) * 2012-06-12 2013-12-26 Nippon Koden Corp Cell isolation apparatus
EP2991747B1 (en) 2013-05-03 2020-06-24 Bio-rad Laboratories, Inc. Ultrasonically cleaned low-pressure filter
CN105745535B (en) * 2013-07-17 2017-07-28 积水医疗株式会社 Gradient liquid transporting apparatus for sample analyser
CN104730182A (en) * 2013-12-18 2015-06-24 北京普源精电科技有限公司 Automatic threshold acquisition method and chromatographic work station having automatic threshold acquisition function
CN114923837A (en) 2015-02-09 2022-08-19 弹弓生物科学公司 Hydrogel particles with tunable optical properties and methods of using the same
US10960393B2 (en) 2017-08-22 2021-03-30 Idex Health And Science Llc Apparatus and methods for bioprocesses and other processes
US10711237B2 (en) 2017-08-22 2020-07-14 Idex Health & Science Llc Apparatus and methods for bioprocesses and other processes
US11054364B2 (en) * 2018-12-17 2021-07-06 Thermo Finnigan Llc Apparatus and methods for handling and spectrophotometry of small liquid samples
JP7368308B2 (en) 2019-06-21 2023-10-24 アークレイ株式会社 Stable A1c measurement method
US11315776B2 (en) * 2019-10-01 2022-04-26 Elemental Scientific, Inc. Automated inline preparation and degassing of volatile samples for inline analysis
CN113945444A (en) * 2021-10-28 2022-01-18 科正检测(苏州)有限公司 Solvent extraction method for hydrocarbon substances in trace rock sample

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4586190A (en) * 1982-11-19 1986-04-29 Shimadzu Corporation Blood cell discriminator and counter utilizing transmitted and scattered light
EP0275409A2 (en) * 1986-05-28 1988-07-27 Sumitomo Electric Industries Limited Particle analyzer and a system utilizing the same
US5365559A (en) * 1992-01-30 1994-11-15 Hitachi, Ltd. Particle counting apparatus for a total counting of particles contained in a liquid sample
EP1054250A1 (en) * 1999-01-25 2000-11-22 Laboratory of Molecular Biophotonics Pipette adaptor, pipette for absorbance measurement, tip, and method and apparatus for absorbance measurement
WO2005121780A2 (en) * 2003-12-09 2005-12-22 Board Of Regents, The University Of Texas System Methods and apparatus for characterizing, measuring, and dispensing fluids
US20060027490A1 (en) * 2004-02-25 2006-02-09 Analogix, Inc. Chromatography system and method
JP3941391B2 (en) * 1998-06-04 2007-07-04 東洋鋼鈑株式会社 Immobilized DNA library production apparatus, gene amplification apparatus, gene amplification product analysis, gene diagnosis apparatus, and control method of these apparatuses

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5299141A (en) * 1989-12-22 1994-03-29 American Sigma, Inc. Automatic fluid monitoring and sampling apparatus and method
US6277257B1 (en) * 1997-06-25 2001-08-21 Sandia Corporation Electrokinetic high pressure hydraulic system
US6641783B1 (en) * 1999-02-08 2003-11-04 Charles Pidgeon Chromatographic systems with pre-detector eluent switching
JP4635138B2 (en) * 1999-09-10 2011-02-16 アークレイ株式会社 Analysis method of specific components
DE10016568A1 (en) * 2000-04-03 2001-10-04 Basf Ag Device and method for performing preparation and NMR measurement of samples
WO2006080761A1 (en) * 2004-10-13 2006-08-03 Centennial Technology Company Automatic chlorophyll analyzer and analytical method
WO2006121510A2 (en) * 2005-05-09 2006-11-16 Theranos, Inc. Point-of-care fluidic systems and uses thereof
US7986399B2 (en) * 2007-10-23 2011-07-26 Los Alamos National Security, Llc Portable sample preparation and analysis system for micron and sub-micron particle characterization using light scattering and absorption spectroscopy
JP5044454B2 (en) * 2008-03-13 2012-10-10 積水化学工業株式会社 Liquid chromatograph apparatus and liquid chromatography
JP4985556B2 (en) * 2008-06-24 2012-07-25 株式会社島津製作所 Preparative liquid chromatograph apparatus and preparative purification method using the apparatus

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4586190A (en) * 1982-11-19 1986-04-29 Shimadzu Corporation Blood cell discriminator and counter utilizing transmitted and scattered light
EP0275409A2 (en) * 1986-05-28 1988-07-27 Sumitomo Electric Industries Limited Particle analyzer and a system utilizing the same
US5365559A (en) * 1992-01-30 1994-11-15 Hitachi, Ltd. Particle counting apparatus for a total counting of particles contained in a liquid sample
JP3941391B2 (en) * 1998-06-04 2007-07-04 東洋鋼鈑株式会社 Immobilized DNA library production apparatus, gene amplification apparatus, gene amplification product analysis, gene diagnosis apparatus, and control method of these apparatuses
EP1054250A1 (en) * 1999-01-25 2000-11-22 Laboratory of Molecular Biophotonics Pipette adaptor, pipette for absorbance measurement, tip, and method and apparatus for absorbance measurement
WO2005121780A2 (en) * 2003-12-09 2005-12-22 Board Of Regents, The University Of Texas System Methods and apparatus for characterizing, measuring, and dispensing fluids
US20060027490A1 (en) * 2004-02-25 2006-02-09 Analogix, Inc. Chromatography system and method

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO2011097489A1 *

Also Published As

Publication number Publication date
US8790592B2 (en) 2014-07-29
AU2011212806B2 (en) 2014-09-11
EP2531860B1 (en) 2018-04-11
JP5819858B2 (en) 2015-11-24
JP2013519093A (en) 2013-05-23
CA2788077A1 (en) 2011-08-11
AU2011212806A1 (en) 2012-08-16
US9110050B2 (en) 2015-08-18
EP2531860A1 (en) 2012-12-12
US20150027207A1 (en) 2015-01-29
WO2011097489A1 (en) 2011-08-11
US20110189715A1 (en) 2011-08-04

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