EP2528821B1 - Machine for filling a plurality of containers, system including such a machine, and related manufacture method - Google Patents

Machine for filling a plurality of containers, system including such a machine, and related manufacture method Download PDF

Info

Publication number
EP2528821B1
EP2528821B1 EP11705929.5A EP11705929A EP2528821B1 EP 2528821 B1 EP2528821 B1 EP 2528821B1 EP 11705929 A EP11705929 A EP 11705929A EP 2528821 B1 EP2528821 B1 EP 2528821B1
Authority
EP
European Patent Office
Prior art keywords
filling
machine
containers
rotation
rack
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Not-in-force
Application number
EP11705929.5A
Other languages
German (de)
French (fr)
Other versions
EP2528821A1 (en
Inventor
Marc Tessier
André Marc SARWA
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SPC ENGINEERING
Original Assignee
SPC ENGINEERING
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SPC ENGINEERING filed Critical SPC ENGINEERING
Publication of EP2528821A1 publication Critical patent/EP2528821A1/en
Application granted granted Critical
Publication of EP2528821B1 publication Critical patent/EP2528821B1/en
Not-in-force legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B65CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65BMACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B1/00Packaging fluent solid material, e.g. powders, granular or loose fibrous material, loose masses of small articles, in individual containers or receptacles, e.g. bags, sacks, boxes, cartons, cans, or jars
    • B65B1/04Methods of, or means for, filling the material into the containers or receptacles
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B65CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65BMACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B3/00Packaging plastic material, semiliquids, liquids or mixed solids and liquids, in individual containers or receptacles, e.g. bags, sacks, boxes, cartons, cans, or jars
    • B65B3/003Filling medical containers such as ampoules, vials, syringes or the like
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B65CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65BMACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B1/00Packaging fluent solid material, e.g. powders, granular or loose fibrous material, loose masses of small articles, in individual containers or receptacles, e.g. bags, sacks, boxes, cartons, cans, or jars
    • B65B1/02Machines characterised by the incorporation of means for making the containers or receptacles
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B65CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65BMACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B7/00Closing containers or receptacles after filling
    • B65B7/16Closing semi-rigid or rigid containers or receptacles not deformed by, or not taking-up shape of, contents, e.g. boxes or cartons
    • B65B7/28Closing semi-rigid or rigid containers or receptacles not deformed by, or not taking-up shape of, contents, e.g. boxes or cartons by applying separate preformed closures, e.g. lids, covers
    • B65B7/2821Closing semi-rigid or rigid containers or receptacles not deformed by, or not taking-up shape of, contents, e.g. boxes or cartons by applying separate preformed closures, e.g. lids, covers applying plugs or threadless stoppers

Definitions

  • the present invention relates to the general technical field of automatic filling of small containers, like syringes, to obtain batches of pre-filled containers, such as pre-filled syringes ready for injection.
  • the present invention more particularly relates to a machine for filling a plurality of containers arranged in a display rack, said machine comprising a rotary dispensing member adapted to transfer a filling substance into the containers.
  • the present invention finally relates to a method of manufacturing a first container containing a filling substance, said method comprising a step of filling said first container, which is part of a plurality of containers arranged in a display, said filling step comprising a transfer of the filling substance into the first container by means of a dispensing member.
  • Such displays are generally in the form of a tray, commonly called “nest ", provided on its surface with tubes arranged in a two-dimensional Cartesian arrangement.
  • a syringe In each tube is intended to be threaded a syringe.
  • the syringes thus threaded into the tubes of the tray are held in predetermined positions, parallel to each other.
  • the display further comprises a tray, commonly called “ tub “, provided to its upper free edge of an inner rim on which the "nest” is intended to rest.
  • the syringes accommodated in the display stand are thus arranged in one of the parallel rows forming a two-dimensional Cartesian arrangement, with their filling orifice (opposite to the injection orifice) facing upwards.
  • New and empty syringes are usually delivered pre-packaged in a nest / tub unit for subsequent filling with a pharmaceutical and then capped.
  • the filling of syringes contained in a "nest" can be done manually, using more or less sophisticated pipettes that are handled directly by an operator.
  • Such manual filling is, however, reserved for very punctual filling operations and is not suitable for large quantities of syringes to be filled.
  • manual filling involves a human presence near and above the syringes to be filled, which introduces an additional risk of contamination, unless taking heavy and complex preventive measures.
  • the filling orifice of the syringes may in certain cases have an extremely small section. It may therefore be difficult for the operator to quickly and accurately introduce the stylet of his pipette into the filling port of the syringe to fill it. There is therefore a risk that the user will miss the orifice of the syringe and / or transfer part of the contents of its contents. Fill pipette outside the syringe to fill, with all the disadvantages that could result.
  • a six-axis universal robot that carries a filling stylet connected to a reservoir containing the drug to be transferred into the syringes.
  • the six-axis robot in question is installed near a reception area designed to accommodate a "nest" containing syringes.
  • the robot then successively positions the filling stylus in correspondence with the filling orifice of each syringe and releases a predetermined dose of drug substance which is transferred into the corresponding syringe.
  • Such a universal robot is however expensive, which reserves its use to important productions that allow to amortize the investment.
  • Such a robot is also a heavy equipment, bulky and irremovable because of its weight.
  • Such a robot is also difficult to integrate in a contamination prevention device such as an isolator or a RABS (acronym for "Restricted Access Barrier System”).
  • a contamination prevention device such as an isolator or a RABS (acronym for "Restricted Access Barrier System”
  • the size of such a six-axis robot is likely to hinder the removal operations and rests " nest”.
  • the implementation of such a six-axis robot for filling syringes contained in a "nest” generates the presence of moving parts (belonging to the robot) above the syringes which increases the risk of contamination.
  • SCARA type ancronym for " Selective Compliance Articulated Robot Arm "
  • SCARA-type robot offers specifically dedicated to the medical-pharmaceutical sector and taking into account the particular constraints of this field.
  • SCARA-type robots at satisfactory economic conditions, especially for small productions adapted to costly and / or toxic products requiring confinement as an insulator or RABS ( clinical lots).
  • the cleaning of SCARA-type robots generally relatively complicated, which is of great disadvantage in the context of a pharmaceutical application. The weight of this robot is also relatively important.
  • Cartesian robots however, prove extremely poorly adapted to pharmaceutical conditions, insofar as they implement moving parts near and above the syringes to be filled, that is to say in a highly sensitive area which must meet draconian cleanliness requirements.
  • Cartesian robots three axes have a large footprint, especially when they are in their configuration allowing the removal / rests " nest ".
  • the object assigned to the invention is therefore to remedy the disadvantages listed above and to propose a new machine and system for filling a plurality of containers arranged in a display rack Cartesian arrangement, the kind " nest ", which are inexpensive , reliable, easily integrated in an insulator or RABS, lightweight, removable, meeting high regulatory standards in terms of cleanliness and allowing easy removal / installation of displays.
  • Another object of the invention is to provide a new machine and system for filling a plurality of containers arranged in a display that allow extremely accurate and reliable filling.
  • Another object of the invention is to provide a new machine and system for filling a plurality of containers arranged in a display which are particularly simple and space-saving design.
  • Another object of the invention is to propose a new machine and system for filling a plurality of containers arranged in a display unit which, while being extremely simple in construction, very significantly limit the risk of contamination or pollution of the containers.
  • Another object of the invention is to provide a new machine and system for filling a plurality of containers arranged in a display which are based on an extremely simple, compact and robust construction.
  • Another object of the invention is to provide a new machine and system for filling a plurality of containers arranged in a display unit which use a minimum of moving parts and different types of movements.
  • Another object of the invention is to provide a new machine and system for filling a plurality of containers arranged in a display that allow automatic closure of containers particularly simple, effective and clean.
  • Another object of the invention is to propose a new machine and system for filling a plurality of containers arranged in a display rack which are particularly adapted to cooperate with conventional type of display.
  • a complementary object of the invention is to provide a novel method of manufacturing a container containing a filler, which is cheap, accurate, reliable, and particularly safe.
  • the objects assigned to the invention are achieved by means of a machine for filling a plurality of containers arranged in a display rack, said machine comprising a rotary distribution member according to a first axis of rotation designed to transfer a filling substance in the containers, said dispensing member comprising a filling stylet, said machine comprising a means for driving the display rack in rotation along a second axis of rotation so that the combination of the rotational movements of the dispenser member and the display unit allows the matching the dispensing member with each of the containers to fill them, said machine being characterized in that the trajectory the filling stylus imparted by the rotation of the dispensing member substantially crosses said second axis of rotation.
  • the objects assigned to the invention are also achieved by means of a method of manufacturing a first container containing a filling substance, said method comprising a step of filling said first container, which is part of a plurality of containers arranged in a display, said filling step comprising a transfer of the filling substance into the first container by means of a dispensing member comprising a filling stylet, the filling step including, prior to said transfer of the filling substance in the first container, a matching of the dispensing member and the first container by rotating the dispensing member and the display unit respectively according to a first and a second axis of rotation, said method being characterized in that the trajectory of the filling stylus imparted by the rotation of the dispensing member crosses sensi said second axis of rotation.
  • the invention relates to a machine 1 for filling a plurality of containers 2 arranged in a display rack 3.
  • the machine 1 constitutes a filling machine for containers 2 packaged per group in a display unit 3.
  • the machine 1 according to the invention is designed to fill a plurality of containers 2 arranged in rows in a display unit 3 of the "nest" type, as illustrated in FIGS. Figures 1 to 3 .
  • Type displays "Nest" are well known as such in the medical and pharmaceutical sector.
  • the display 3 thus advantageously comprises a plate of substantially rectangular or square shape through which are perforations regularly distributed over substantially the entire surface of the tray. Each perforation is extended by a holding tube for receiving a container, preferably tubular.
  • the machine 1 is specifically designed to fill tubular containers 2, preferably formed by syringe bodies.
  • a syringe body is conventionally in the form of a tube provided at one of its ends with an injection orifice, of reduced section, to which a needle is intended to abut, and at the opposite end a filling port, in which is intended to be threaded the plunger of the syringe.
  • the syringe body is further provided with a collar located at the filling orifice.
  • the type displays " Nest” such as the display 3 illustrated in the figures, thus accommodate a plurality of syringe bodies arranged vertically parallel to each other, so that their filling port is turned upwards.
  • the collar which is provided with each syringe body is intended to abut against the corresponding holding tube of the " nest ", which makes it possible to position all the filling orifices of the syringe bodies accommodated by the " nest” to a single and same altitude.
  • the syringe bodies are thus advantageously arranged in the rack 3 in rows, preferably parallel, so that their filling orifices are substantially all set in the same horizontal plane.
  • the invention is of course not limited to a machine for filling syringe bodies. It is for example quite possible that the containers 2 consist not of syringe bodies, as in the preferred embodiment, but by any other container of small capacity (at most a few tens of milliliters for example), such as test tubes used for diagnostic purposes in biomedical analysis laboratories, or in the pharmaceutical or biotechnological industry.
  • the machine 1 also comprises a rotary dispensing member 4 designed to transfer a filling substance in the containers 2 while the latter are arranged in the display 3, as previously described and as illustrated in FIGS.
  • the filling substance advantageously has a fluid character with an ability to flow.
  • the filling substance is liquid, it being understood that it is quite possible alternatively that it has a pulverulent or pasty character, without departing from the scope of the invention.
  • the filling substance is advantageously constituted by a medicament intended to be injected into the body of a patient.
  • the invention is however not limited to this specific application, and it is for example quite possible that the filling substance is constituted for example of an analyte, to ingest, to coat or to mix.
  • the dispensing member 4 is designed to be pivotable and is in this respect preferably rotatably mounted along a first axis of rotation X-X '.
  • the machine 1 comprises and a frame 5 on which is mounted the dispensing member 4 with at least one degree of freedom in rotation.
  • the dispensing member 4 comprises a filling stylet 6, connected, for example by a flexible hose 60, to a source of the filling substance.
  • the filling stylet 6 is preferably designed to fill one container 2 at a time.
  • the filling stylet 6 is in the form of a cylindrical duct, constituted for example by a needle, whose section is less than or equal to, and preferably less than, at the section of the filling orifice of each container 2, so as to allow the stylet 6 to enter the container 2 through the filling opening of the latter and thus ensure optimal filling, without risk of inadvertent loss of substance filling.
  • the dispensing member 4 comprises not a single filling stylet 6 designed to fill a container 2 at a time, but a group of filling stylets for filling simultaneously a plurality of containers 2.
  • the machine 1 according to the invention is based on the implementation of a sequential filling of the containers 2, that is to say that the dispensing member 4 is anyway not designed to fill all the containers 2 arranged in the rack 3 simultaneously, but is designed to ensure a sequential filling of the containers 2 in question. Such sequential filling can be ensured by filling one by one, one after another, the containers 2.
  • the dispensing member 4 successively fill groups of containers 2, the number of containers 2 in each group representing a fraction of the total number of containers 2 arranged in the display rack 3.
  • the frame 5 comprises a first column 8 on which the filling arm 7 is mounted by means of a sliding pivot connection of axis X-X '.
  • the first column 8 rises on the frame 5 coaxially with the first axis of rotation X-X ', and even more preferably said first column 8 extends along the first axis of rotation X-X'.
  • the first column 8 preferably extends predominantly vertically while the filling arm 7 extends predominantly substantially horizontally from the free end of the first column 8.
  • the sliding pivot connection between the filling arm 7 and the first column 8 is for example made using a first sleeve 9 which is attached to the first end 7A of the arm filling 7 and which covers the first column 8 while having with respect to the latter a dual translational faculty along the first axis XX 'and rotation along the same first axis X-X'.
  • the rotational and translational movements of the filling arm 7 along the first axis XX ' are advantageously controlled by appropriate actuators of electrical or hydraulic type, for example.
  • the filling machine 1 further comprises a drive means 10 of the display 3 rotating so that the combination of the rotational movements of the dispensing member 4 and the display 3 allows the matching of the distribution member 4 with each of the containers 2 for the purpose of filling the latter.
  • the invention is based in particular on the idea of performing a sequential filling containers 2 arranged in a display 3 by combining only a rotational movement of the display 3 and the dispensing member 4 to put the filling pen 6 successively facing each of the containers 2 arranged in the display 3.
  • the drive means 10 of the display unit 3 is designed to drive the display unit 3 in rotation along a second axis of rotation YY ', said first axis XX' and second axis YY 'of rotation being substantially collinear, or in other words parallel as illustrated in the figures.
  • the invention thus makes it possible, by combining only rotational movements (respectively of the dispensing member 4 and the display 3) to successively fill all the containers 2 arranged in the display stand 3.
  • the idea of rotating the display 3 relative to the frame 5 significantly simplifies and simplifies the dispensing member 4 which only requires a degree of freedom in rotation to ensure a sequential filling of all containers 2, insofar as the rotational movement of the dispenser member 4 is combined with a rotational movement of the display unit 3.
  • the invention avoids the presence of parts in relative movement overhanging the filling ports 2A of the containers 2.
  • the invention makes it possible to implement a first axis of rotation XX 'which is offset relative to in the display 3, which is overhung by the filling arm 7 which advantageously has an invariable length and is not provided with any articulation, unlike the arm of the robots used in the prior art.
  • the invention thus makes it possible, by acting directly on the display 3, to obtain an extremely simple and clean kinematic system, which is therefore particularly suitable for use in constraining environments (for example in a RABS or in an insulator).
  • the drive means 10 of the display 3 advantageously comprises a first turntable 11 on which the display 3 is intended to rest.
  • the first turntable 11 thus comprises a substantially planar receiving surface 11 A of the display unit 3 on which the latter is intended to rest stably, as illustrated in the figures.
  • the receiving surface 11A of the display unit 3 advantageously extends substantially perpendicular to the second axis of rotation Y-Y ', which is advantageously parallel to the first axis of rotation X-X' as mentioned previously.
  • the filling arm 7 is of invariable length.
  • the trajectory of the filling stylet 6 imparted by the rotation of the dispensing member 4 substantially intersects said second axis of rotation Y-Y ', that is to say, in the variant illustrated in the figures, that the trajectory of the filling stylet 6 imparted by the rotation of the filling arm 7 crosses the second axis of rotation YY '.
  • a control means preferably digital, well known as such and therefore does not need to be further described here.
  • the machine 1 further comprises a closure device 12 of the containers 2, once the latter filled, using a plurality of plugs 13 disposed on a plate 14.
  • the plugs 13 are arranged in a matrix manner on the plate 14, in the same way that the containers 2 are placed on the display 3.
  • the plate 14 is thus advantageously provided with orifices intended to receive within them the plugs 13, said orifices having a slightly smaller than the nominal diameter of the plugs 13 so as to maintain the latter in a state of radial compression when they are accommodated in the corresponding orifice of the plate 14.
  • the plate 14 when the display 3 is a "nest” type display allowing a two-dimensional Cartesian arrangement of the containers 2, the plate 14 is also of " nest” type and allows a Cartesian distribution bi-dimensi Onnel of the plugs 13, the plate 14 and its plugs 13 forming from this point of view a " mirror” assembly of the plate 3 with its receptacles 2, each plug 13 corresponding to a receptacle 2.
  • the manipulation member 15 is advantageously designed for one side to cooperate with the drive means 16 of the plate 14 in rotation to successively grasp the plugs 13 one after the other and another side to cooperate with the drive means 10 of the display 3 in rotation to successively close each container 2 with the plugs 13 recovered one by one on the plate 14 by the manipulation member 15.
  • the manipulation member 15 comprises an arm 17 for transferring plugs 13 rotatably mounted along a third axis of rotation ZZ 'which is preferably distinct from and parallel to the first and second axes X-X', YY '. last.
  • the plug transfer arm 17 extends between a first end towards which it is pivotally mounted on the frame 5 and a second end to which it is provided with means 18 for transferring plugs 13.
  • the device capping 12 comprises a second column 19 on which is mounted the transfer arm 17 of the plugs 13 via a sliding pivot connection whose axis corresponds to the third axis Z-Z '.
  • the matching of the transfer means 18 with a specific plug 13 is performed by combining the rotational movement of the plate 14 and the rotational movement of the transfer arm 17, in the same way as the matching of the organ 4 with a specific container 2 is made by combining the rotational movements of the dispensing member 4 and the rotational movement of the display 3.
  • the plug transfer arm 17 is, on the one hand, of invariable length and, on the other hand, designed so that the trajectory of the transfer means 18 imparted by the rotation of the plug transfer arm 13 crosses at once.
  • the drive means 10 of the display 3 rotating is preferably designed to accommodate centrally on the second axis YY 'the display 3, such that said second axis YY 'passes through the center of the display 3.
  • the driving means 16 of the rotating plate 14 is preferably designed to receive centrally on the fourth axis WW' the plate 14, of such so that said fourth axis WW 'passes through the center of the plate 14.
  • the first, second, third and fourth axes X-X ', Y-Y', Z-Z 'and W-W' are advantageously all parallel to one another and parallel to the vertical direction.
  • the transfer means 18 comprises a tube 18A whose diameter is slightly smaller than that of the upper opening 2A of the containers 2.
  • the internal diameter of the tube 18A forming the transfer means 18 is slightly lower than that of the plugs 13, which are preferably made of a flexible material, of the elastomer or rubber type, capable of being compressed radially.
  • the closure device 12 also comprises a thrust arm 21 preferably mounted to rotate on the frame 5 along a fifth axis V-V '.
  • the fifth axis VV ' coincides with the third axis Z-Z', while in the embodiment corresponding to the figure 3 , the fifth axis VV 'is distinct from the first, second, third and fourth axis X-X', Y-Y ', Z-Z', WW 'but is parallel thereto.
  • the thrust arm 21 is also advantageously mounted in translation relative to the frame 5, preferably along the axis V-V '. In the embodiment of the figure 1 , the thrust arm 21 is thus mounted on the second column 19 via a pivot-sliding connection whose axis corresponds to the third axis Z-Z '.
  • the closure device 12 comprises in this case a second sleeve 17A from which the transfer arm 17 extends. Said transfer arm 17 is thus fixed to the second sleeve 17A, which cap the second column 19 while being able to slide and rotate along the third axis Z-Z '.
  • the closure device 12 also comprises a third sleeve 21 A which covers the second sleeve 17A and from which extends the thrust arm 21, the latter being fixed to the third sleeve 21 A.
  • the third sleeve 21 A is also capable of slide and rotate along the third axis Z-Z '.
  • the thrust arm 21 is provided towards its free end with a sinking-plug rod 22 whose diameter is smaller than that of the inside diameter of the tube 18A forming the transfer means 18.
  • the thrust arm 21 is not slidably and rotationally mounted on the second column 19, but on a third column 23 which is distinct from the second column 19 while being substantially parallel and disposed in the immediate vicinity of the latter; as shown in the figure 3 .
  • the third column 23 extends along the fifth axis VV 'which is distinct and extends parallel to the third axis Z-Z'.
  • the closure device 12 advantageously comprises a third sleeve 21 B which is attached to the thrust arm 21. This third sleeve 21 B caps the third column 23 and is pivotally mounted sliding on the latter along the fifth axis V-V '.
  • the machine 1 itself has a high height, which is generally not compatible with its installation on a table or on another machine.
  • the machine 1 must therefore have a structure that stands by itself, with a self-supporting frame 5.
  • Machine 1 of the figure 3 is therefore much easier to integrate in a constraining environment (with the presence of an insulator or a RABS for example), and does not require that its frame 5 is self-supporting.
  • the thrust arm 21 is advantageously permanently arranged above the transfer arm 17, so that the plug-in rod 22 can be threaded into the tube 18A forming a transfer means 18 and be extracted out of this last by vertical sliding along the axis VV 'of the thrust arm 21.
  • the thrust arm 21 is advantageously designed in a manner similar to the transfer arm 17, that is to say that it is advantageously on the one hand of invariable length, and on the other hand designed so that the trajectory of the needle-plug 22 imparted by the rotation of the thrust arm 21 crosses both the second axis of rotation YY 'and the fourth axis of rotation WW' according to which the plate 14 is rotated by the drive means 16, to allow vertical alignment of the plug-in rod 22, the tube 18A forming a transfer means 18, each of the plugs 13 on board 14 and each of the receptacles 2 on the display stand 3.
  • the invention also relates as such to a method of manufacturing a first container 2 containing a filling substance.
  • the manufacturing method aims at obtaining a first container 2 pre-filled with a predetermined dose of filling substance.
  • the process according to the invention is advantageously carried out using the machine 1 according to the invention, and preferably according to the preceding description.
  • the first container 2 in question is a syringe body intended to be filled with a pharmaceutical liquid in order to obtain a pre-filled syringe.
  • the method according to the invention comprises a step of filling the first container 20, which is part of a plurality of containers 2, preferably all identical, arranged in a display 3 according to the above description.
  • the display unit 3 is advantageously a "nest" type display unit which allows a two-dimensional Cartesian distribution of the containers 2 to which the first container 20 belongs, as explained above.
  • the filling step comprises a transfer of the filling substance into the first container 20 by means of a dispensing member 4, preferably in accordance with the foregoing description.
  • the filling step includes, prior to the transfer of the filling substance into the first container 20, a matching of the dispenser member 4 and the display unit 3.
  • the combined rotational movements of the dispenser member 4 and the display stand 3 allow the dispensing member 4 to be matched with a predetermined container 2, in this case the first container 20.
  • the actual filling of the first container 20 is performed, for example in the manner previously described with the aid of a filling stylus 6.
  • the trajectory of the filling stylet 6 imparted by the rotation of the dispensing member 4 substantially intersects said second axis of rotation Y-Y ', which allows the stylus 6 to be matched with all the containers 2 of the display 3, one after the other, only through a combination of rotational movements (the display 3 and the stylus 6).
  • the first container 20 thus filled can then be plugged as described in detail in the foregoing.
  • the invention finds its industrial application in the design, manufacture and use of machines for filling containers.

Landscapes

  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Basic Packing Technique (AREA)

Abstract

The invention relates to a machine (1) for filling a plurality of containers (2) that are arranged in a display (3), said machine (1) including a rotatable dispensing member (4) that is designed for transferring a filling substance into the containers (2). Said machine is also characterized in that it includes a means (10) for rotating a display (3) so that the combination of the rotational movements of the dispensing member (4) and the display (3) makes it possible to correlate the dispensing member (4) with each container (2), with a view to filling the latter. The invention also relates to filling machines.

Description

DOMAINE TECHNIQUETECHNICAL AREA

La présente invention se rapporte au domaine technique général du remplissage automatique de récipients de petites tailles, du genre seringues, afin d'obtenir des lots de récipients pré-remplis, comme par exemple des seringues pré-remplies prêtes à l'injection.The present invention relates to the general technical field of automatic filling of small containers, like syringes, to obtain batches of pre-filled containers, such as pre-filled syringes ready for injection.

La présente invention concerne plus particulièrement une machine pour remplir une pluralité de récipients disposés dans un présentoir, ladite machine comprenant un organe de distribution rotatif conçu pour transférer une substance de remplissage dans les récipients.The present invention more particularly relates to a machine for filling a plurality of containers arranged in a display rack, said machine comprising a rotary dispensing member adapted to transfer a filling substance into the containers.

La présente invention concerne également un système comprenant :

  • une machine pour remplir une pluralité de récipients disposés dans un présentoir, ladite machine comprenant un organe de distribution rotatif conçu pour transférer une substance de remplissage dans les récipients,
  • un présentoir de type « nest »,
  • et une pluralité de récipients, du genre seringues, disposées par rangées dans ledit présentoir.
The present invention also relates to a system comprising:
  • a machine for filling a plurality of containers arranged in a display, said machine comprising a rotational dispensing member adapted to transfer a filling substance into the containers,
  • a "nest " type display ,
  • and a plurality of containers, like syringes, arranged in rows in said display.

La présente invention concerne enfin un procédé de fabrication d'un premier récipient contenant une substance de remplissage, ledit procédé comprenant une étape de remplissage dudit premier récipient, lequel fait partie d'une pluralité de récipients disposés dans un présentoir, ladite étape de remplissage comprenant un transfert de la substance de remplissage dans le premier récipient à l'aide d'un organe de distribution.The present invention finally relates to a method of manufacturing a first container containing a filling substance, said method comprising a step of filling said first container, which is part of a plurality of containers arranged in a display, said filling step comprising a transfer of the filling substance into the first container by means of a dispensing member.

TECHNIQUE ANTERIEUREPRIOR ART

Il est bien connu de conditionner des seringues, destinées à être ultérieurement remplies par un produit pharmaceutique, dans des présentoirs permettant d'accueillir une pluralité de seringues réparties selon un arrangement cartésien bi-dimensionnel.It is well known to package syringes, intended to be subsequently filled with a pharmaceutical product, in displays to accommodate a plurality of syringes distributed in a two-dimensional Cartesian arrangement.

De tels présentoirs se présentent généralement sous la forme d'un plateau, communément appelé « nest », pourvu à sa surface de tubes disposés selon un arrangement cartésien bi-dimensionnel. Dans chaque tube est destinée à être enfilée une seringue. Les seringues ainsi enfilées dans les tubes du plateau sont maintenues dans des positions-prédéterminées, parallèlement les unes aux autres. Le présentoir comprend en outre un bac, communément appelé « tub », muni vers son bord supérieur libre d'un rebord interne sur lequel le « nest » est destiné à reposer. Les seringues accueillies dans le présentoir sont ainsi disposées selon un des rangées parallèles formant un arrangement cartésien bi-dimensionnel, avec leur orifice de remplissage (opposé à l'orifice de l'injection) tourné vers le haut.Such displays are generally in the form of a tray, commonly called "nest ", provided on its surface with tubes arranged in a two-dimensional Cartesian arrangement. In each tube is intended to be threaded a syringe. The syringes thus threaded into the tubes of the tray are held in predetermined positions, parallel to each other. The display further comprises a tray, commonly called " tub ", provided to its upper free edge of an inner rim on which the "nest" is intended to rest. The syringes accommodated in the display stand are thus arranged in one of the parallel rows forming a two-dimensional Cartesian arrangement, with their filling orifice (opposite to the injection orifice) facing upwards.

Les seringues neuves et vides, en particulier lorsqu'elles sont en verre, sont habituellement livrées pré-conditionnées dans une unité nest/tub en vue d'être ensuite remplies par un produit pharmaceutique puis bouchées.New and empty syringes, especially when made of glass, are usually delivered pre-packaged in a nest / tub unit for subsequent filling with a pharmaceutical and then capped.

Le remplissage des seringues contenues dans un « nest » peut s'effectuer de façon manuelle, à l'aide de pipettes plus ou moins perfectionnées qui sont manipulées directement par un opérateur. Un tel remplissage manuel est toutefois réservé à des opérations de remplissages très ponctuelles et ne convient absolument pas pour des quantités importantes de seringues à remplir. En outre, un tel remplissage manuel implique une présence humaine à proximité et au-dessus des seringues à remplir, ce qui introduit un risque supplémentaire de contamination, sauf à prendre des mesures préventives lourdes et complexes. Enfin, l'orifice de remplissage des seringues peut dans certains cas présenter une section extrêmement réduite. Il peut donc être difficile, pour l'opérateur, d'introduire rapidement et précisément le stylet de sa pipette dans l'orifice de remplissage de la seringue en vue de la remplir. Il existe donc un risque de voir l'utilisateur rater l'orifice de la seringue et/ou transférer une partie du contenu de sa pipette de remplissage en dehors de la seringue à remplir, avec tous les inconvénients qui pourraient en résulter.The filling of syringes contained in a "nest" can be done manually, using more or less sophisticated pipettes that are handled directly by an operator. Such manual filling is, however, reserved for very punctual filling operations and is not suitable for large quantities of syringes to be filled. In addition, such manual filling involves a human presence near and above the syringes to be filled, which introduces an additional risk of contamination, unless taking heavy and complex preventive measures. Finally, the filling orifice of the syringes may in certain cases have an extremely small section. It may therefore be difficult for the operator to quickly and accurately introduce the stylet of his pipette into the filling port of the syringe to fill it. There is therefore a risk that the user will miss the orifice of the syringe and / or transfer part of the contents of its contents. Fill pipette outside the syringe to fill, with all the disadvantages that could result.

Afin de répondre à ces inconvénients, il est connu de recourir à un remplissage semi-tiret automatique réalisé à l'aide d'un robot.In order to meet these drawbacks, it is known to use an automatic semi-dash filling made using a robot.

Par exemple, il est connu de recourir à un robot universel six axes qui porte un stylet de remplissage relié à un réservoir contenant la substance médicamenteuse à transférer dans les seringues. Le robot six axes en question est installé à proximité d'une zone de réception conçue pour accueillir un « nest » renfermant des seringues. Le robot positionne ensuite successivement le stylet de remplissage en correspondance avec l'orifice de remplissage de chaque seringue et libère une dose prédéterminée de substance médicamenteuse qui est transférée dans la seringue correspondante. Un tel robot universel s'avère cependant coûteux, ce qui réserve son usage à des productions importantes qui permettent d'en amortir l'investissement. Un tel robot constitue en outre un matériel lourd, encombrant et inamovible du fait de son poids. Un tel robot s'avère également difficile à intégrer dans un dispositif de prévention de contamination tel qu'un isolateur ou un RABS (acronyme anglais de « Restricted Access Barrier System »). En particulier, l'encombrement d'un tel robot six axes est susceptible de gêner les opérations de dépose et repose des « nest ». De plus, la mise en oeuvre d'un tel robot six axes pour remplir des seringues contenues dans un « nest » engendre la présence de pièces mobiles (appartenant au robot) au-dessus des seringues ce qui augmente le risque de contamination.For example, it is known to use a six-axis universal robot that carries a filling stylet connected to a reservoir containing the drug to be transferred into the syringes. The six-axis robot in question is installed near a reception area designed to accommodate a "nest" containing syringes. The robot then successively positions the filling stylus in correspondence with the filling orifice of each syringe and releases a predetermined dose of drug substance which is transferred into the corresponding syringe. Such a universal robot is however expensive, which reserves its use to important productions that allow to amortize the investment. Such a robot is also a heavy equipment, bulky and irremovable because of its weight. Such a robot is also difficult to integrate in a contamination prevention device such as an isolator or a RABS (acronym for "Restricted Access Barrier System"). In particular, the size of such a six-axis robot is likely to hinder the removal operations and rests "nest". In addition, the implementation of such a six-axis robot for filling syringes contained in a "nest" generates the presence of moving parts (belonging to the robot) above the syringes which increases the risk of contamination.

On connaît également des robots à trois ou quatre axes, de type SCARA (acronyme anglais de « Selective Compliance Articulated Robot Arm »). De tels robots sont utilisés dans des applications (industrie des semi-conducteurs) qui n'ont rien à voir avec le secteur médico-pharmaceutique. Ainsi, il n'existe pas d'offre en matière de robot de type SCARA spécifiquement dédiée au secteur médico-pharmaceutique et tenant compte des contraintes particulières de ce domaine. Ceci implique notamment qu'il n'existe pas, en matière de robot de type SCARA, d'offres à des conditions économiques satisfaisantes, notamment pour des petites productions adaptées à des produits coûteux et/ou toxiques nécessitant le confinement en isolateur ou RABS (lots cliniques). En outre, le nettoyage des robots de type SCARA s'avère généralement relativement compliqué, ce qui est d'un désavantage important dans le cadre d'une application pharmaceutique. Le poids de ce robot reste également relativement important.Also known are three-axis or four-axis robots, SCARA type (acronym for " Selective Compliance Articulated Robot Arm "). Such robots are used in applications (semiconductor industry) that have nothing to do with the medical-pharmaceutical sector. Thus, there is no SCARA-type robot offer specifically dedicated to the medical-pharmaceutical sector and taking into account the particular constraints of this field. This implies in particular that there is no offer, in terms of SCARA-type robots, at satisfactory economic conditions, especially for small productions adapted to costly and / or toxic products requiring confinement as an insulator or RABS ( clinical lots). In addition, the cleaning of SCARA-type robots generally relatively complicated, which is of great disadvantage in the context of a pharmaceutical application. The weight of this robot is also relatively important.

Enfin, on connaît également des robots cartésiens trois axes qui sont beaucoup plus économiques que les robots six axes et SCARA.Finally, we also know Cartesian robots three axes which are much more economical than six-axis robots and SCARA.

Ces robots cartésiens s'avèrent cependant extrêmement mal adaptés aux conditions pharmaceutiques, dans la mesure où ils mettent en oeuvre des pièces mobiles à proximité et au-dessus des seringues à remplir, c'est-à-dire dans une zone hautement sensible qui doit répondre à des exigences de propreté draconiennes. En outre, les robots cartésiens trois axes présentent un encombrement important, en particulier lorsqu'ils se trouvent dans leur configuration permettant la dépose/repose des « nest ».These Cartesian robots, however, prove extremely poorly adapted to pharmaceutical conditions, insofar as they implement moving parts near and above the syringes to be filled, that is to say in a highly sensitive area which must meet draconian cleanliness requirements. In addition, Cartesian robots three axes have a large footprint, especially when they are in their configuration allowing the removal / rests " nest ".

Les documents US-2,894,542 , DE-1673152 , CH-286 706 et US-2,493,382 décrivent des machines de remplissage.The documents US 2894542 , DE-1673152 , CH-286 706 and US 2493382 describe filling machines.

Il n'existe donc pas à ce jour de solutions techniques pleinement satisfaisantes pour traiter en particulier les petites productions adaptées à des produits coûteux et/ou toxiques nécessitant le confinement en isolateur ou RABS, tel que les lots cliniques.So far, there are no fully satisfactory technical solutions to deal in particular with small productions adapted to costly and / or toxic products requiring confinement as an isolator or RABS, such as clinical batches.

EXPOSE DE L'INVENTIONSUMMARY OF THE INVENTION

L'objet assigné à l'invention vise en conséquence à porter remède aux inconvénients énumérés précédemment et à proposer de nouveaux machine et système pour remplir une pluralité de récipients disposés dans un présentoir à agencement cartésien, du genre « nest », qui soient bon marché, fiable, facilement intégrable dans un isolateur ou un RABS, légère, amovible, satisfaisant à des niveaux réglementaires élevés en matière de propreté et permettant une dépose/repose aisée des présentoirs.The object assigned to the invention is therefore to remedy the disadvantages listed above and to propose a new machine and system for filling a plurality of containers arranged in a display rack Cartesian arrangement, the kind " nest ", which are inexpensive , reliable, easily integrated in an insulator or RABS, lightweight, removable, meeting high regulatory standards in terms of cleanliness and allowing easy removal / installation of displays.

Un autre objet de l'invention vise à proposer de nouveaux machine et système pour remplir une pluralité de récipients disposés dans un présentoir qui permettent un remplissage extrêmement précis et fiable.Another object of the invention is to provide a new machine and system for filling a plurality of containers arranged in a display that allow extremely accurate and reliable filling.

Un autre objet de l'invention vise à proposer de nouveaux machine et système pour remplir une pluralité de récipients disposés dans un présentoir qui soient de conception particulièrement simple et peu encombrante.Another object of the invention is to provide a new machine and system for filling a plurality of containers arranged in a display which are particularly simple and space-saving design.

Un autre objet de l'invention vise à proposer de nouveaux machine et système pour remplir une pluralité de récipients disposés dans un présentoir qui tout en étant de construction extrêmement simple limitent très significativement les risques de contamination ou de pollution des récipients.Another object of the invention is to propose a new machine and system for filling a plurality of containers arranged in a display unit which, while being extremely simple in construction, very significantly limit the risk of contamination or pollution of the containers.

Un autre objet de l'invention vise à proposer de nouveaux machine et système pour remplir une pluralité de récipients disposés dans un présentoir qui reposent sur une construction extrêmement simple, compacte et robuste.Another object of the invention is to provide a new machine and system for filling a plurality of containers arranged in a display which are based on an extremely simple, compact and robust construction.

Un autre objet de l'invention vise à proposer de nouveaux machine et système pour remplir une pluralité de récipients disposés dans un présentoir qui mettent en oeuvre un minimum de pièces mobiles et de types de mouvements différents.Another object of the invention is to provide a new machine and system for filling a plurality of containers arranged in a display unit which use a minimum of moving parts and different types of movements.

Un autre objet de l'invention vise à proposer de nouveaux machine et système pour remplir une pluralité de récipients disposés dans un présentoir qui permettent un bouchage automatique des récipients particulièrement simple, efficace et propre.Another object of the invention is to provide a new machine and system for filling a plurality of containers arranged in a display that allow automatic closure of containers particularly simple, effective and clean.

Un autre objet de l'invention vise à proposer de nouveaux machine et système pour remplir une pluralité de récipients disposés dans un présentoir qui soient particulièrement adaptée à coopérer avec des présentoirs de type classique.Another object of the invention is to propose a new machine and system for filling a plurality of containers arranged in a display rack which are particularly adapted to cooperate with conventional type of display.

Un objet complémentaire de l'invention vise à proposer un nouveau procédé de fabrication d'un récipient contenant une substance de remplissage, qui soit bon marché, précis, fiable, et particulièrement sûr.A complementary object of the invention is to provide a novel method of manufacturing a container containing a filler, which is cheap, accurate, reliable, and particularly safe.

Les objets assignés à l'invention sont atteints à l'aide d'une machine pour remplir une pluralité de récipients disposés dans un présentoir, ladite machine comprenant un organe de distribution rotatif selon un premier axe de rotation conçu pour transférer une substance de remplissage dans les récipients, ledit organe de distribution comprenant un stylet de remplissage, ladite machine comprenant un moyen d'entraînement du présentoir en rotation selon un deuxième axe de rotation pour que la combinaison des mouvements de rotation de l'organe de distribution et du présentoir permette la mise en correspondance de l'organe de distribution avec chacun des récipients en vue du remplissage de ces derniers, ladite machine étant caractérisée en ce que la trajectoire du stylet de remplissage impartie par la rotation de l'organe de distribution croise sensiblement ledit deuxième axe de rotation.The objects assigned to the invention are achieved by means of a machine for filling a plurality of containers arranged in a display rack, said machine comprising a rotary distribution member according to a first axis of rotation designed to transfer a filling substance in the containers, said dispensing member comprising a filling stylet, said machine comprising a means for driving the display rack in rotation along a second axis of rotation so that the combination of the rotational movements of the dispenser member and the display unit allows the matching the dispensing member with each of the containers to fill them, said machine being characterized in that the trajectory the filling stylus imparted by the rotation of the dispensing member substantially crosses said second axis of rotation.

Les objets assignés à l'invention sont également atteints à l'aide d'un système comprenant :

  • une machine pour remplir une pluralité de récipients disposés dans un présentoir, ladite machine comprenant un organe de distribution rotatif selon un premier axe de rotation conçu pour transférer une substance de remplissage dans les récipients, ledit organe de distribution comprenant un stylet de remplissage, ladite machine comprenant un moyen d'entraînement du présentoir en rotation selon un deuxième axe de rotation pour que la combinaison des mouvements de rotation de l'organe de distribution et du présentoir permette la mise en correspondance de l'organe de distribution avec chacun des récipients en vue du remplissage de ces derniers, ladite machine étant caractérisée en ce que la trajectoire du stylet de remplissage impartie par la rotation de l'organe de distribution croise sensiblement ledit deuxième axe de rotation,
  • un présentoir de type « nest »,
  • une pluralité de récipients, du genre seringue, disposés par rangées dans ledit présentoir.
The objects assigned to the invention are also achieved by means of a system comprising:
  • a machine for filling a plurality of containers arranged in a display rack, said machine comprising a rotational dispensing member according to a first axis of rotation adapted to transfer a filling substance into the containers, said dispensing member comprising a filling stylet, said machine comprising means for driving the display rack in rotation along a second axis of rotation so that the combination of the rotational movements of the dispensing member and the display unit enables the dispenser member to be brought into correspondence with each of the containers in order to filling the latter, said machine being characterized in that the trajectory of the filling stylet imparted by the rotation of the dispensing member substantially crosses said second axis of rotation,
  • a " nest " type display,
  • a plurality of containers, like syringe, arranged in rows in said display.

Les objets assignés à l'invention sont également atteints à l'aide d'un procédé de fabrication d'un premier récipient contenant une substance de remplissage, ledit procédé comprenant une étape de remplissage dudit premier récipient, lequel fait partie d'une pluralité de récipients disposés dans un présentoir, ladite étape de remplissage comprenant un transfert de la substance de remplissage dans le premier récipient à l'aide d'un organe de distribution comprenant un stylet de remplissage, l'étape de remplissage incluant, préalablement audit transfert de la substance de remplissage dans le premier récipient, une mise en correspondance de l'organe de distribution et du premier récipient par mise en rotation de l'organe de distribution et du présentoir selon respectivement un premier et un deuxième axe de rotation, ledit procédé étant caractérisé en ce que la trajectoire du stylet de remplissage impartie par la rotation de l'organe de distribution croise sensiblement ledit deuxième axe de rotation.The objects assigned to the invention are also achieved by means of a method of manufacturing a first container containing a filling substance, said method comprising a step of filling said first container, which is part of a plurality of containers arranged in a display, said filling step comprising a transfer of the filling substance into the first container by means of a dispensing member comprising a filling stylet, the filling step including, prior to said transfer of the filling substance in the first container, a matching of the dispensing member and the first container by rotating the dispensing member and the display unit respectively according to a first and a second axis of rotation, said method being characterized in that the trajectory of the filling stylus imparted by the rotation of the dispensing member crosses sensi said second axis of rotation.

DESCRIPTIF SOMMAIRE DES DESSINSSUMMARY DESCRIPTION OF THE DRAWINGS

D'autres objets, caractéristiques et avantages de l'invention apparaîtront mieux à la lecture de la description ci-après, ainsi qu'à l'aide des dessins annexés, donnés à titre purement illustratif et non limitatif, parmi lesquels :

  • La figure 1 représente une vue d'ensemble schématique en perspective d'une première variante de machine conforme à l'invention.
  • La figure 2 illustre, selon une vue schématique de dessus, le principe cinématique sur lequel repose l'invention.
  • La figure 3 illustre, selon une vue schématique en perspective, une deuxième variante de réalisation d'une machine conforme à l'invention.
Other objects, features and advantages of the invention will appear better on reading the following description, as well as with the aid of the accompanying drawings, given purely by way of illustration and without limitation, among which:
  • The figure 1 is a schematic perspective view of a first variant of the machine according to the invention.
  • The figure 2 illustrates, in a schematic view from above, the kinematic principle on which the invention is based.
  • The figure 3 illustrates, in a schematic perspective view, a second alternative embodiment of a machine according to the invention.

MEILLEURE MANIERE DE REALISER L'INVENTIONBEST MODE OF REALIZING THE INVENTION

L'invention concerne une machine 1 pour remplir une pluralité de récipients 2 disposés dans un présentoir 3. En d'autres termes, la machine 1 constitue une machine de remplissage pour des récipients 2 conditionnés par groupe dans un présentoir 3. De préférence, la machine 1 conforme à l'invention est conçue pour remplir une pluralité de récipients 2 disposés par rangées dans un présentoir 3 de type « nest », comme illustré aux figures 1 à 3. Les présentoirs de type « nest » sont bien connus en tant que tels dans le secteur médico-pharmaceutique.The invention relates to a machine 1 for filling a plurality of containers 2 arranged in a display rack 3. In other words, the machine 1 constitutes a filling machine for containers 2 packaged per group in a display unit 3. Preferably, the machine 1 according to the invention is designed to fill a plurality of containers 2 arranged in rows in a display unit 3 of the "nest" type, as illustrated in FIGS. Figures 1 to 3 . Type displays "Nest" are well known as such in the medical and pharmaceutical sector.

Le présentoir 3 comprend ainsi avantageusement un plateau de forme sensiblement rectangulaire ou carrée à travers lequel sont pratiqués des perforations distribuées de façon régulière sur sensiblement toute la surface du plateau. Chaque perforation est prolongée par un tube de maintien destiné à accueillir un récipient, de préférence tubulaire. Ainsi, la machine 1 est spécifiquement conçue pour assurer le remplissage de récipients 2 tubulaires, formé de préférence par des corps de seringues. Un corps de seringue se présente classiquement sous la forme d'un tube pourvu à l'une de ses extrémités d'un orifice d'injection, de section réduite, auquel une aiguille est destinée à s'aboucher, et à l'extrémité opposée d'un orifice de remplissage, dans lequel est destiné à être enfilé le piston de la seringue. Le corps de seringue est pourvu en outre d'une collerette située au niveau de l'orifice de remplissage. Les présentoirs de type « nest », tel que le présentoir 3 illustré aux figures, permettent ainsi d'accueillir une pluralité de corps de seringues disposés verticalement, parallèlement les uns aux autres, de manière à ce que leur orifice de remplissage soit tourné vers le haut. La collerette dont est pourvu chaque corps de seringue est destinée à venir en butée contre le tube de maintien correspondant du « nest », ce qui permet de positionner tous les orifices de remplissage des corps de seringues accueillies par le « nest » à une seule et même altitude. Les corps de seringues sont ainsi avantageusement disposés dans le présentoir 3 par rangées, de préférence parallèles, de telle sorte que leurs orifices de remplissage soient sensiblement tous inscris dans un même plan horizontal.The display 3 thus advantageously comprises a plate of substantially rectangular or square shape through which are perforations regularly distributed over substantially the entire surface of the tray. Each perforation is extended by a holding tube for receiving a container, preferably tubular. Thus, the machine 1 is specifically designed to fill tubular containers 2, preferably formed by syringe bodies. A syringe body is conventionally in the form of a tube provided at one of its ends with an injection orifice, of reduced section, to which a needle is intended to abut, and at the opposite end a filling port, in which is intended to be threaded the plunger of the syringe. The syringe body is further provided with a collar located at the filling orifice. The type displays " Nest ", such as the display 3 illustrated in the figures, thus accommodate a plurality of syringe bodies arranged vertically parallel to each other, so that their filling port is turned upwards. The collar which is provided with each syringe body is intended to abut against the corresponding holding tube of the " nest ", which makes it possible to position all the filling orifices of the syringe bodies accommodated by the "nest" to a single and same altitude. The syringe bodies are thus advantageously arranged in the rack 3 in rows, preferably parallel, so that their filling orifices are substantially all set in the same horizontal plane.

L'invention n'est bien entendu pas limitée à une machine pour remplir des corps de seringues. Il est par exemple tout à fait envisageable que les récipients 2 soient constitués non pas de corps de seringues, comme dans l'exemple préférentiel de réalisation, mais par tout autre récipient de petite capacité (au maximum quelques dizaines de millilitres par exemple), tel que des tubes à essais utilisés à des fins de diagnostic dans des laboratoires d'analyses biomédicales, ou dans l'industrie pharmaceutique ou biotechnologique.The invention is of course not limited to a machine for filling syringe bodies. It is for example quite possible that the containers 2 consist not of syringe bodies, as in the preferred embodiment, but by any other container of small capacity (at most a few tens of milliliters for example), such as test tubes used for diagnostic purposes in biomedical analysis laboratories, or in the pharmaceutical or biotechnological industry.

La machine 1 conforme à l'invention comprend par ailleurs un organe de distribution 4 rotatif conçu pour transférer une substance de remplissage dans les récipients 2 alors que ces derniers sont disposés dans le présentoir 3, comme exposé précédemment et comme illustré aux figures.The machine 1 according to the invention also comprises a rotary dispensing member 4 designed to transfer a filling substance in the containers 2 while the latter are arranged in the display 3, as previously described and as illustrated in FIGS.

La substance de remplissage présente avantageusement un caractère fluide, avec une capacité à s'écouler. De préférence, la substance de remplissage est liquide, étant entendu qu'il est tout à fait envisageable à titre alternatif qu'elle présente plutôt un caractère pulvérulent ou pâteux, sans pour autant que l'on sorte du cadre de l'invention. La substance de remplissage est avantageusement constituée d'un médicament destiné à être injecté dans le corps d'un patient. L'invention n'est cependant pas limitée à cette application spécifique, et il est par exemple tout à fait envisageable que la substance de remplissage soit constituée par exemple d'une substance à analyser, à ingérer, à enduire ou à mélanger. Comme exposé précédemment, l'organe de distribution 4 est conçu pour pouvoir pivoter et est à cet égard de préférence monté en rotation selon un premier axe de rotation X-X'. De préférence, la machine 1 comprend ainsi un bâti 5 sur lequel est monté l'organe de distribution 4 avec au moins un degré de liberté en rotation.The filling substance advantageously has a fluid character with an ability to flow. Preferably, the filling substance is liquid, it being understood that it is quite possible alternatively that it has a pulverulent or pasty character, without departing from the scope of the invention. The filling substance is advantageously constituted by a medicament intended to be injected into the body of a patient. The invention is however not limited to this specific application, and it is for example quite possible that the filling substance is constituted for example of an analyte, to ingest, to coat or to mix. As explained above, the dispensing member 4 is designed to be pivotable and is in this respect preferably rotatably mounted along a first axis of rotation X-X '. Preferably, the machine 1 comprises and a frame 5 on which is mounted the dispensing member 4 with at least one degree of freedom in rotation.

Avantageusement, l'organe de distribution 4 comprend un stylet de remplissage 6, relié, par exemple par un tuyau flexible 60, à une source de la substance de remplissage. Le stylet de remplissage 6 est de préférence conçu pour remplir un récipient 2 à la fois. En d'autres termes, dans ce mode préférentiel de réalisation, le stylet de remplissage 6 se présente sous la forme d'un conduit cylindrique, constitué par exemple par une aiguille, dont la section est inférieure ou égale, et de préférence strictement inférieure, à la section de l'orifice de remplissage de chaque récipient 2, de manière à permettre au stylet 6 de pénétrer dans le récipient 2 par l'orifice de remplissage de ce dernier et ainsi assurer un remplissage optimal, sans risque de perte intempestive de substance de remplissage. Il est cependant tout à fait envisageable que l'organe de distribution 4 comprenne non pas un unique stylet de remplissage 6 conçu pour remplir un récipient 2 à la fois, mais un groupe de stylet de remplissage permettant le remplissage simultané d'une pluralité de récipients 2. De préférence, la machine 1 conforme à l'invention repose sur la mise en oeuvre d'un remplissage séquentiel des récipients 2, c'est-à-dire que l'organe de distribution 4 n'est quoiqu'il en soit pas conçu pour remplir tous les récipients 2 disposés dans le présentoir 3 de manière simultanée, mais est conçu pour assurer un remplissage séquentiel des récipients 2 en question. Un tel remplissage séquentiel peut être assuré en remplissant un par un, les uns après les autres, les récipients 2. A titre alternatif, il est envisageable que l'organe de distribution 4 remplisse successivement des groupes de récipients 2, le nombre de récipient 2 dans chaque groupe représentant une fraction du nombre total de récipients 2 disposés dans le présentoir 3.Advantageously, the dispensing member 4 comprises a filling stylet 6, connected, for example by a flexible hose 60, to a source of the filling substance. The filling stylet 6 is preferably designed to fill one container 2 at a time. In other words, in this preferred embodiment, the filling stylet 6 is in the form of a cylindrical duct, constituted for example by a needle, whose section is less than or equal to, and preferably less than, at the section of the filling orifice of each container 2, so as to allow the stylet 6 to enter the container 2 through the filling opening of the latter and thus ensure optimal filling, without risk of inadvertent loss of substance filling. It is however quite conceivable that the dispensing member 4 comprises not a single filling stylet 6 designed to fill a container 2 at a time, but a group of filling stylets for filling simultaneously a plurality of containers 2. Preferably, the machine 1 according to the invention is based on the implementation of a sequential filling of the containers 2, that is to say that the dispensing member 4 is anyway not designed to fill all the containers 2 arranged in the rack 3 simultaneously, but is designed to ensure a sequential filling of the containers 2 in question. Such sequential filling can be ensured by filling one by one, one after another, the containers 2. As an alternative, it is conceivable that the dispensing member 4 successively fill groups of containers 2, the number of containers 2 in each group representing a fraction of the total number of containers 2 arranged in the display rack 3.

Avantageusement, l'organe de distribution 4 comprend un bras de remplissage 7 qui s'étend entre une première extrémité 7A vers laquelle, et de préférence au niveau de laquelle, le bras de remplissage 7 est monté à pivotement sur le bâti 5, et une deuxième extrémité 7B vers laquelle, et de préférence, au niveau de laquelle, le stylet de remplissage 6 est monté sur le bras de remplissage 7. De préférence, le bras de remplissage 7 est conçu pour pivoter dans un plan sensiblement parallèle au plan dans lequel s'inscrivent les orifices de remplissage des récipients 2, lorsqu'ils sont disposés dans le présentoir 3, ledit plan étant de préférence parallèle au plan horizontal. Dans ce mode de réalisation préférentiel, le premier axe de rotation X-X' est donc sensiblement vertical. Ainsi, une partie au moins du bras de remplissage 7 surplombe les récipients 2 disposés dans le présentoir 3, ce dernier occupant une position prédéterminée dans la machine 1. Avantageusement, l'organe de distribution 4 rotatif est également conçu pour pouvoir se déplacer en translation, de façon à pouvoir se rapprocher et s'éloigner de chaque récipient 2 avec lequel il est mis en correspondance pour en assurer le remplissage. De façon avantageuse, l'organe de distribution 4 est conçu pour se déplacer en translation selon le premier axe de rotation X-X'. De cette façon, l'organe de distribution 4 peut assurer la séquence fonctionnelle suivante :

  • rotation de l'organe de distribution 4 autour de l'axe X-X' pour positionner le stylet de remplissage 6 en regard (c'est-à-dire au droit) et au dessus d'un récipient 2 ;
  • translation verticale descendante, selon l'axe X-X' de l'organe de remplissage 4 (ou tout simplement du stylet de remplissage 6) pour faire pénétrer le stylet de remplissage 6 dans le récipient 2 par l'orifice de remplissage de ce dernier ;
  • transfert d'une quantité prédéterminée de la substance de remplissage dans le récipient 2 par l'intermédiaire du tuyau 60 et du stylet de remplissage 6 ; de préférence, le stylet de remplissage 6 est conçu pour descendre sensiblement jusqu'au fond du récipient 2 pour remonter ensuite progressivement pendant que la substance de remplissage est transféré dans le récipient 2, au fur et à mesure que le niveau monte dans le récipient 2.
  • translation verticale ascendante de l'organe de distribution 4 (ou seulement du stylet de remplissage 6) pour extraire complètement le stylet de remplissage 6 du récipient 2.
Advantageously, the dispensing member 4 comprises a filling arm 7 which extends between a first end 7A to which, and preferably at which, the filling arm 7 is pivotally mounted on the frame 5, and a second end 7B towards which, and preferably at which level, the filling stylet 6 is mounted on the filling arm 7. Preferably, the filling arm 7 is adapted to pivot in a plane substantially parallel to the plane in which the filling orifices of the receptacles 2 are inscribed when they are arranged in the display stand 3, said plane preferably being parallel to the horizontal plane. In this preferential embodiment, the first axis of rotation XX 'is therefore substantially vertical. Thus, at least a portion of the filling arm 7 overhangs the containers 2 arranged in the rack 3, the latter occupying a predetermined position in the machine 1. Advantageously, the rotary dispensing member 4 is also designed to be able to move in translation. , so as to be closer to and away from each container 2 with which it is matched to ensure the filling. Advantageously, the dispensing member 4 is designed to move in translation along the first axis of rotation X-X '. In this way, the dispensing member 4 can provide the following functional sequence:
  • rotating the dispensing member 4 around the axis XX 'to position the filling stylus 6 facing (that is to say right) and above a container 2;
  • downward vertical translation, along the axis XX 'of the filling member 4 (or simply the filling pen 6) to make penetrate the filling pen 6 in the container 2 by the filling opening of the latter;
  • transferring a predetermined quantity of the filling substance into the container 2 via the hose 60 and the filling stylet 6; preferably, the filling stylet 6 is adapted to descend substantially to the bottom of the container 2 to then gradually rise while the filling substance is transferred into the container 2, as the level rises in the container 2 .
  • upward vertical translation of the dispensing member 4 (or only of the filling stylus 6) to completely extract the filling stylus 6 from the container 2.

Avantageusement, le bâti 5 comprend une première colonne 8 sur laquelle est monté le bras de remplissage 7 par l'intermédiaire d'une liaison pivot glissant d'axe X-X'.Advantageously, the frame 5 comprises a first column 8 on which the filling arm 7 is mounted by means of a sliding pivot connection of axis X-X '.

De préférence, la première colonne 8 s'élève sur le bâti 5 coaxialement au premier axe de rotation X-X', et de façon encore plus préférentielle ladite première colonne 8 s'étend selon le premier axe de rotation X-X'. Ainsi, comme illustré aux figures, la première colonne 8 s'étend de préférence majoritairement verticalement tandis que le bras de remplissage 7 s'étend majoritairement sensiblement horizontalement à partir de l'extrémité libre de la première colonne 8. La liaison pivot glissant entre le bras de remplissage 7 et la première colonne 8 est par exemple réalisée à l'aide d'un premier manchon 9 qui est attaché à la première extrémité 7A du bras de remplissage 7 et qui coiffe la première colonne 8 tout en présentant par rapport à cette dernière une double faculté de translation selon le premier axe X-X' et de rotation selon ce même premier axe X-X'. Les mouvements de rotation et de translation du bras de remplissage 7 selon le premier axe X-X' sont avantageusement contrôlés par des actionneurs appropriés de type électrique ou hydraulique par exemple.Preferably, the first column 8 rises on the frame 5 coaxially with the first axis of rotation X-X ', and even more preferably said first column 8 extends along the first axis of rotation X-X'. Thus, as illustrated in the figures, the first column 8 preferably extends predominantly vertically while the filling arm 7 extends predominantly substantially horizontally from the free end of the first column 8. The sliding pivot connection between the filling arm 7 and the first column 8 is for example made using a first sleeve 9 which is attached to the first end 7A of the arm filling 7 and which covers the first column 8 while having with respect to the latter a dual translational faculty along the first axis XX 'and rotation along the same first axis X-X'. The rotational and translational movements of the filling arm 7 along the first axis XX 'are advantageously controlled by appropriate actuators of electrical or hydraulic type, for example.

La machine 1 de remplissage conforme à l'invention comprend par ailleurs un moyen d'entraînement 10 du présentoir 3 en rotation pour que la combinaison des mouvements de rotation de l'organe de distribution 4 et du présentoir 3 permette la mise en correspondance de l'organe de distribution 4 avec chacun des récipients 2 en vue du remplissage de ces derniers.The filling machine 1 according to the invention further comprises a drive means 10 of the display 3 rotating so that the combination of the rotational movements of the dispensing member 4 and the display 3 allows the matching of the distribution member 4 with each of the containers 2 for the purpose of filling the latter.

Ainsi, l'invention repose en particulier sur l'idée d'opérer un remplissage séquentiel de récipients 2 disposés dans un présentoir 3 en combinant uniquement un mouvement de rotation du présentoir 3 et de l'organe de distribution 4 pour mettre le stylet de remplissage 6 successivement en regard de chacun des récipients 2 disposés dans le présentoir 3.Thus, the invention is based in particular on the idea of performing a sequential filling containers 2 arranged in a display 3 by combining only a rotational movement of the display 3 and the dispensing member 4 to put the filling pen 6 successively facing each of the containers 2 arranged in the display 3.

Comme illustré aux figures, le moyen d'entraînement 10 du présentoir 3 est conçu pour entraîner le présentoir 3 en rotation selon un deuxième axe de rotation Y-Y', lesdits premier axe X-X' et deuxième axe Y-Y' de rotation étant sensiblement colinéaires, ou en d'autres termes parallèles comme illustré aux figures.As illustrated in the figures, the drive means 10 of the display unit 3 is designed to drive the display unit 3 in rotation along a second axis of rotation YY ', said first axis XX' and second axis YY 'of rotation being substantially collinear, or in other words parallel as illustrated in the figures.

L'invention permet ainsi, en combinant uniquement des mouvements de rotation (respectivement de l'organe de distribution 4 et du présentoir 3) de remplir successivement tous les récipients 2 disposés dans le présentoir 3.The invention thus makes it possible, by combining only rotational movements (respectively of the dispensing member 4 and the display 3) to successively fill all the containers 2 arranged in the display stand 3.

En particulier, l'idée de faire tourner le présentoir 3 relativement au bâti 5 permet d'alléger et de simplifier considérablement l'organe de distribution 4 qui n'a besoin que d'un degré de liberté en rotation pour assurer un remplissage séquentiel de tous les récipients 2, dans la mesure où le mouvement de rotation de l'organe de distribution 4 est combiné avec un mouvement de rotation du présentoir 3.In particular, the idea of rotating the display 3 relative to the frame 5 significantly simplifies and simplifies the dispensing member 4 which only requires a degree of freedom in rotation to ensure a sequential filling of all containers 2, insofar as the rotational movement of the dispenser member 4 is combined with a rotational movement of the display unit 3.

Grâce à ce concept général, l'invention évite la présence de pièces en mouvement relatif surplombant les orifices de remplissage 2A des récipients 2. Au contraire, l'invention permet de mettre en oeuvre un premier axe de rotation X-X' qui est déporté par rapport au présentoir 3, lequel est surplombé par le bras de remplissage 7 qui présente avantageusement une longueur invariable et n'est munie d'aucune articulation, contrairement au bras des robots utilisés dans l'art antérieur. L'invention permet ainsi, en agissant directement sur le présentoir 3, d'obtenir un système cinématique extrêmement simple et propre, qui se prête donc particulièrement bien à une utilisation dans des environnements contraignants (par exemple dans un RABS ou dans un isolateur).With this general concept, the invention avoids the presence of parts in relative movement overhanging the filling ports 2A of the containers 2. On the contrary, the invention makes it possible to implement a first axis of rotation XX 'which is offset relative to in the display 3, which is overhung by the filling arm 7 which advantageously has an invariable length and is not provided with any articulation, unlike the arm of the robots used in the prior art. The invention thus makes it possible, by acting directly on the display 3, to obtain an extremely simple and clean kinematic system, which is therefore particularly suitable for use in constraining environments (for example in a RABS or in an insulator).

Le moyen d'entraînement 10 du présentoir 3 comprend avantageusement une première table tournante 11 sur laquelle le présentoir 3 est destiné à reposer. La première table tournante 11 comprend ainsi une surface 11 A sensiblement plane de réception du présentoir 3 sur laquelle ce dernier est destiné à reposer de façon stable, comme illustré aux figures. La surface 11A de réception du présentoir 3 s'étend avantageusement sensiblement perpendiculairement au deuxième axe de rotation Y-Y', lequel est avantageusement parallèle au premier axe de rotation X-X' comme évoqué précédemment.The drive means 10 of the display 3 advantageously comprises a first turntable 11 on which the display 3 is intended to rest. The first turntable 11 thus comprises a substantially planar receiving surface 11 A of the display unit 3 on which the latter is intended to rest stably, as illustrated in the figures. The receiving surface 11A of the display unit 3 advantageously extends substantially perpendicular to the second axis of rotation Y-Y ', which is advantageously parallel to the first axis of rotation X-X' as mentioned previously.

Avantageusement, le bras de remplissage 7 est de longueur invariable. Afin de permettre le remplissage de tout les récipients 2 disposés dans le présentoir 3 (y compris lorsque ce dernier est un présentoir de type « nest » auquel cas les récipients 2 sont uniformément répartis par rangées, de préférence parallèle entre elles, sur une surface rectangulaire ou carrée), la trajectoire du stylet de remplissage 6 impartie par la rotation de l'organe de distribution 4 croise sensiblement ledit deuxième axe de rotation Y-Y', c'est-à-dire, dans la variante illustrée aux figures, que la trajectoire du stylet de remplissage 6 impartie par la rotation du bras de remplissage 7 croise le deuxième axe de rotation Y-Y'.Advantageously, the filling arm 7 is of invariable length. In order to allow the filling of all the containers 2 arranged in the display 3 (including when the latter is a "nest" type display in which case the containers 2 are uniformly distributed in rows, preferably parallel to each other, on a rectangular surface or square), the trajectory of the filling stylet 6 imparted by the rotation of the dispensing member 4 substantially intersects said second axis of rotation Y-Y ', that is to say, in the variant illustrated in the figures, that the trajectory of the filling stylet 6 imparted by the rotation of the filling arm 7 crosses the second axis of rotation YY '.

Grâce à cette caractéristique, selon laquelle le stylet de remplissage 6 se déplace sur une trajectoire circulaire qui passe au droit du centre de rotation du moyen d'entraînement 10, la combinaison des mouvements de rotation dudit moyen d'entraînement 10 et du bras d'entraînement 7 permet au stylet 6 d'atteindre l'un après l'autre chacun des récipients 2 disposés dans le plateau 3 de type « nest ».With this feature, according to which the filling stylus 6 moves in a circular path which passes to the right of the center of rotation of the driving means 10, the combination of the rotational movements of said drive means 10 and the arm of drive 7 allows the stylus 6 to reach one after the other each of the containers 2 arranged in the tray 3 of type " nest ".

Afin d'assurer un remplissage séquentiel précis et rapide, les mouvements de l'organe de distribution 4 et du moyen d'entraînement 10 du présentoir 3 en rotation sont pilotés de manière coordonnée grâce à un moyen de commande, de préférence numérique, bien connu en tant que tel et qui ne nécessite donc pas être décrit plus avant ici.In order to ensure a precise and rapid sequential filling, the movements of the dispenser member 4 and the drive means 10 of the rotating display stand 3 are controlled in a coordinated manner by means of a control means, preferably digital, well known as such and therefore does not need to be further described here.

Avantageusement, la machine 1 conforme à l'invention comprend par ailleurs un dispositif de bouchage 12 des récipients 2, une fois ces derniers remplis, à l'aide d'une pluralité de bouchons 13 disposés sur un plateau 14. De préférence, les bouchons 13 sont disposés de manière matricielle sur le plateau 14, de la même façon que les récipients 2 sont disposés sur le présentoir 3. Le plateau 14 est ainsi avantageusement pourvu d'orifices destinés à accueillir en leur sein les bouchons 13, lesdits orifices présentant un diamètre légèrement inférieur au diamètre nominal des bouchons 13 de façon à maintenir ces derniers dans un état de compression radiale lorsqu'ils sont logés dans l'orifice correspondant du plateau 14. En particulier, lorsque le présentoir 3 est un présentoir de type « nest » permettant un agencement cartésien bi-dimensionnel des récipients 2, le plateau 14 est également de type « nest » et autorise une distribution cartésienne bi-dimensionnelle des bouchons 13, le plateau 14 et ses bouchons 13 formant de ce point de vue un ensemble « miroir » du plateau 3 avec ses récipients 2, chaque bouchon 13 correspondant à un récipient 2.Advantageously, the machine 1 according to the invention further comprises a closure device 12 of the containers 2, once the latter filled, using a plurality of plugs 13 disposed on a plate 14. Preferably, the plugs 13 are arranged in a matrix manner on the plate 14, in the same way that the containers 2 are placed on the display 3. The plate 14 is thus advantageously provided with orifices intended to receive within them the plugs 13, said orifices having a slightly smaller than the nominal diameter of the plugs 13 so as to maintain the latter in a state of radial compression when they are accommodated in the corresponding orifice of the plate 14. In particular, when the display 3 is a "nest" type display allowing a two-dimensional Cartesian arrangement of the containers 2, the plate 14 is also of "nest" type and allows a Cartesian distribution bi-dimensi Onnel of the plugs 13, the plate 14 and its plugs 13 forming from this point of view a "mirror" assembly of the plate 3 with its receptacles 2, each plug 13 corresponding to a receptacle 2.

Avantageusement, le dispositif de bouchage 12 comprend un organe 15 rotatif de manipulation des bouchons 13 et un moyen d'entraînement 16 du plateau 14 en rotation pour :

  • d'une part que la combinaison des mouvements de rotation de l'organe de manipulation 15 et du plateau 14 permette la mise en correspondance de l'organe de manipulation 15 avec chacun des bouchons 13 en vue de leur saisie par l'organe de manipulation 15
  • et d'autre part que la combinaison des mouvements de rotation de l'organe de manipulation 15 et du présentoir 3 permette la mise en correspondance de l'organe de manipulation 15 avec chacun des récipients 2 en vue de leur bouchage.
Advantageously, the closure device 12 comprises a rotatable member 15 for handling the plugs 13 and a drive means 16 for the plate 14 in rotation for:
  • on the one hand that the combination of the rotational movements of the handling member 15 and the plate 14 allows the matching of the manipulation member 15 with each of the plugs 13 for their input by the manipulator 15
  • and secondly that the combination of the rotational movements of the manipulator 15 and the display 3 allows the matching of the manipulation member 15 with each of the containers 2 for their closure.

En d'autres termes, l'organe de manipulation 15 est avantageusement conçu pour d'un côté coopérer avec le moyen d'entraînement 16 du plateau 14 en rotation pour venir saisir successivement les bouchons 13 les uns après les autres et d'un autre côté pour coopérer avec le moyen d'entraînement 10 du présentoir 3 en rotation pour venir boucher successivement chaque récipient 2 avec les bouchons 13 récupérés un par un sur le plateau 14 par l'organe de manipulation 15.In other words, the manipulation member 15 is advantageously designed for one side to cooperate with the drive means 16 of the plate 14 in rotation to successively grasp the plugs 13 one after the other and another side to cooperate with the drive means 10 of the display 3 in rotation to successively close each container 2 with the plugs 13 recovered one by one on the plate 14 by the manipulation member 15.

De préférence, l'organe de manipulation 15 comprend un bras 17 de transfert des bouchons 13 montés en rotation selon un troisième axe de rotation Z-Z' qui est de préférence distinct des premier et deuxième axes X-X', Y-Y' et parallèle à ces derniers. Le bras 17 de transfert des bouchons 13 s'étend entre une première extrémité vers laquelle il est monté à pivotement sur le bâti 5 et une deuxième extrémité vers laquelle il est pourvu d'un moyen 18 de transfert des bouchons 13. Avantageusement, le dispositif de bouchage 12 comprend une deuxième colonne 19 sur laquelle est monté le bras 17 de transfert des bouchons 13 par l'intermédiaire d'une liaison pivot glissant dont l'axe correspond au troisième axe Z-Z'.Preferably, the manipulation member 15 comprises an arm 17 for transferring plugs 13 rotatably mounted along a third axis of rotation ZZ 'which is preferably distinct from and parallel to the first and second axes X-X', YY '. last. The plug transfer arm 17 extends between a first end towards which it is pivotally mounted on the frame 5 and a second end to which it is provided with means 18 for transferring plugs 13. Advantageously, the device capping 12 comprises a second column 19 on which is mounted the transfer arm 17 of the plugs 13 via a sliding pivot connection whose axis corresponds to the third axis Z-Z '.

La mise en correspondance du moyen de transfert 18 avec un bouchon 13 spécifique s'effectue par combinaison du mouvement de rotation du plateau 14 et du mouvement de rotation du bras de transfert 17, de la même façon que la mise en correspondance de l'organe de distribution 4 avec un récipient 2 spécifique s'effectue par combinaison des mouvements de rotation de l'organe de distribution 4 et du mouvement de rotation du présentoir 3.The matching of the transfer means 18 with a specific plug 13 is performed by combining the rotational movement of the plate 14 and the rotational movement of the transfer arm 17, in the same way as the matching of the organ 4 with a specific container 2 is made by combining the rotational movements of the dispensing member 4 and the rotational movement of the display 3.

De préférence, le bras 17 de transfert de bouchons 13 est d'une part de longueur invariable et d'autre part conçu pour que la trajectoire du moyen de transfert 18 impartie par la rotation du bras 17 de transfert de bouchons 13 croise à la fois le deuxième axe de rotation Y-Y' et un quatrième axe de rotation W-W' selon lequel le plateau 14 est mis en rotation par le moyen d'entraînement 16. Ceci permet aux bras de remplissage 7 et de transfert 17 d'atteindre respectivement chacun des récipients 2 et des bouchons 13. A cette fin, le moyen d'entraînement 10 du présentoir 3 en rotation est préférentiellement conçu pour accueillir de façon centrée sur le deuxième axe Y-Y' le présentoir 3, de telle sorte que ledit deuxième axe Y-Y' passe par le centre du présentoir 3. De même, le moyen d'entraînement 16 du plateau 14 en rotation est préférentiellement conçu pour accueillir de façon centrée sur le quatrième axe W-W' le plateau 14, de telle sorte que ledit quatrième axe W-W' passe par le centre du plateau 14.Preferably, the plug transfer arm 17 is, on the one hand, of invariable length and, on the other hand, designed so that the trajectory of the transfer means 18 imparted by the rotation of the plug transfer arm 13 crosses at once. the second axis of rotation YY 'and a fourth axis of rotation WW' in which the plate 14 is rotated by the drive means 16. This allows the filling arms 7 and each of the containers 2 and the plugs 13 to reach respectively. For this purpose, the drive means 10 of the display 3 rotating is preferably designed to accommodate centrally on the second axis YY 'the display 3, such that said second axis YY 'passes through the center of the display 3. Similarly, the driving means 16 of the rotating plate 14 is preferably designed to receive centrally on the fourth axis WW' the plate 14, of such so that said fourth axis WW 'passes through the center of the plate 14.

Les premier, deuxième, troisième et quatrième axes X-X', Y-Y', Z-Z' et W-W' sont avantageusement tous parallèles les uns aux autres et parallèles à la direction verticale.The first, second, third and fourth axes X-X ', Y-Y', Z-Z 'and W-W' are advantageously all parallel to one another and parallel to the vertical direction.

Avantageusement, le moyen de transfert 18 comprend un tube 18A dont le diamètre est légèrement inférieur à celui de l'ouverture supérieure 2A des récipients 2. Le diamètre interne du tube 18A formant le moyen de transfert 18 est quant à lui légèrement inférieur à celui des bouchons 13, lesquels sont de préférence réalisés en un matériau souple, du genre élastomère ou caoutchouc, capable d'être comprimé radialement.Advantageously, the transfer means 18 comprises a tube 18A whose diameter is slightly smaller than that of the upper opening 2A of the containers 2. The internal diameter of the tube 18A forming the transfer means 18 is slightly lower than that of the plugs 13, which are preferably made of a flexible material, of the elastomer or rubber type, capable of being compressed radially.

Avantageusement, le dispositif de bouchage 12 comprend également un bras 21 de poussée monté de préférence à rotation sur le bâti 5 selon un cinquième axe V-V'. Dans le mode de réalisation de la figure 1, le cinquième axe V-V' est confondu avec le troisième axe Z-Z', tandis que dans le mode de réalisation correspondant à la figure 3, le cinquième axe V-V' est distinct du premier, du deuxième, du troisième et du quatrième axe X-X', Y-Y', Z-Z', W-W' mais est parallèle à ces derniers.Advantageously, the closure device 12 also comprises a thrust arm 21 preferably mounted to rotate on the frame 5 along a fifth axis V-V '. In the embodiment of the figure 1 , the fifth axis VV 'coincides with the third axis Z-Z', while in the embodiment corresponding to the figure 3 , the fifth axis VV 'is distinct from the first, second, third and fourth axis X-X', Y-Y ', Z-Z', WW 'but is parallel thereto.

Le bras de poussée 21 est également avantageusement monté à translation par rapport au bâti 5, de préférence selon l'axe V-V'. Dans le mode de réalisation de la figure 1, le bras de poussée 21 est ainsi monté sur la deuxième colonne 19 par l'intermédiaire d'une liaison pivot-glissant dont l'axe correspond au troisième axe Z-Z'.The thrust arm 21 is also advantageously mounted in translation relative to the frame 5, preferably along the axis V-V '. In the embodiment of the figure 1 , the thrust arm 21 is thus mounted on the second column 19 via a pivot-sliding connection whose axis corresponds to the third axis Z-Z '.

Plus précisément, le dispositif de bouchage 12 comprend dans ce cas un deuxième manchon 17A à partir duquel s'étend le bras 17 de transfert. Ledit bras 17 de transfert est ainsi fixé au deuxième manchon 17A, lequel coiffe la deuxième colonne 19 tout en pouvant coulisser et tourner selon le troisième axe Z-Z'.More specifically, the closure device 12 comprises in this case a second sleeve 17A from which the transfer arm 17 extends. Said transfer arm 17 is thus fixed to the second sleeve 17A, which cap the second column 19 while being able to slide and rotate along the third axis Z-Z '.

Le dispositif de bouchage 12 comprend également un troisième manchon 21 A qui coiffe le deuxième manchon 17A et à partir duquel s'étend le bras de poussée 21, ce dernier étant fixé au troisième manchon 21 A. Le troisième manchon 21 A est également capable de coulisser et de tourner selon le troisième axe Z-Z'.The closure device 12 also comprises a third sleeve 21 A which covers the second sleeve 17A and from which extends the thrust arm 21, the latter being fixed to the third sleeve 21 A. The third sleeve 21 A is also capable of slide and rotate along the third axis Z-Z '.

Avantageusement, le bras de poussée 21 est pourvu vers son extrémité libre d'une tige enfonce-bouchon 22 dont le diamètre est inférieur à celui du diamètre intérieur du tube 18A formant le moyen de transfert 18.Advantageously, the thrust arm 21 is provided towards its free end with a sinking-plug rod 22 whose diameter is smaller than that of the inside diameter of the tube 18A forming the transfer means 18.

Dans le mode préférentiel de réalisation illustré,à la figure 3, le bras de poussée 21 n'est pas monté à coulissement et à rotation sur la deuxième colonne 19, mais sur une troisième colonne 23 qui est distincte de la deuxième colonne 19 tout en étant sensiblement parallèle et disposée au voisinage immédiat de cette dernière, comme illustré à la figure 3. Dans ce cas, la troisième colonne 23 s'étend selon le cinquième axe V-V' qui est distinct et s'étend parallèlement au troisième axe Z-Z'. Dans ce mode de réalisation illustré à la figure 3, le dispositif de bouchage 12 comprend avantageusement un troisième manchon 21 B auquel est fixé le bras de poussée 21. Ce troisième manchon 21 B coiffe la troisième colonne 23 et est monté à pivot glissant sur cette dernière selon le cinquième axe V-V'. L'intérêt principal de recourir à des bras de transfert 17 et de poussée 21 montés à rotation autour d'axes de rotation respectifs Z-Z', V-V' différents est de limiter l'encombrement vertical de la machine 1. En effet, dans le cas de la variante de la figure 1, les courses en translation verticale du bras de transfert 17 et du bras de poussée 21 s'additionnent, ce qui nécessite avec les moyens classiquement utilisés (vis sans fin par exemple) de prévoir un espace de dégagement vertical important sous la deuxième colonne 19.In the preferred embodiment illustrated, at the figure 3 the thrust arm 21 is not slidably and rotationally mounted on the second column 19, but on a third column 23 which is distinct from the second column 19 while being substantially parallel and disposed in the immediate vicinity of the latter; as shown in the figure 3 . In this case, the third column 23 extends along the fifth axis VV 'which is distinct and extends parallel to the third axis Z-Z'. In this embodiment illustrated in figure 3 , the closure device 12 advantageously comprises a third sleeve 21 B which is attached to the thrust arm 21. This third sleeve 21 B caps the third column 23 and is pivotally mounted sliding on the latter along the fifth axis V-V '. The main advantage of using transfer arms 17 and thrust 21 rotatably mounted about respective axes of rotation Z-Z ', VV' is to limit the vertical size of the machine 1. In fact, in the case of the variant of the figure 1 the travel in vertical translation of the transfer arm 17 and the thrust arm 21 add up, which requires with the means conventionally used (endless screw for example) to provide a large vertical clearance space under the second column 19.

Ceci implique que la machine 1 présente elle-même une hauteur importante, qui n'est généralement pas compatible avec son installation sur une table ou sur une autre machine. Dans ce mode de réalisation, la machine 1 doit donc présenter une structure qui se tient par elle-même, avec un bâti 5 autoporteur.This implies that the machine 1 itself has a high height, which is generally not compatible with its installation on a table or on another machine. In this embodiment, the machine 1 must therefore have a structure that stands by itself, with a self-supporting frame 5.

Au contraire, dans le mode de réalisation de la figure 3, les courses verticales des bras de transfert 17 et de poussée 21 ne s'additionnent pas puisque ces bras 17, 21 se déplacent verticalement l'un parallèlement à l'autre. De ce fait, l'encombrement vertical de la machine 1 est moindre ce qui permet à cette dernière d'être plus aisément posée sur une table ou d'être installée sur une autre machine par exemple.On the contrary, in the embodiment of the figure 3 the vertical strokes of the transfer arms 17 and thrust 21 do not add up since these arms 17, 21 move vertically one parallel to the other. As a result, vertical clutter of the machine 1 is less which allows the latter to be more easily placed on a table or to be installed on another machine for example.

La machine 1 de la figure 3 est donc beaucoup plus facilement intégrable dans un environnement contraignant (avec présence d'un isolateur ou d'un RABS par exemple), et ne nécessite pas que son bâti 5 soit autoporteur.Machine 1 of the figure 3 is therefore much easier to integrate in a constraining environment (with the presence of an insulator or a RABS for example), and does not require that its frame 5 is self-supporting.

Comme illustré aux figures, le bras de poussée 21 est disposé avantageusement en permanence au dessus du bras de transfert 17, de façon que la tige enfonce-bouchon 22 puisse être enfilée dans le tube 18A formant moyen de transfert 18 et être extraite hors de ce dernier par coulissement vertical, selon l'axe V-V' du bras de poussée 21.As illustrated in the figures, the thrust arm 21 is advantageously permanently arranged above the transfer arm 17, so that the plug-in rod 22 can be threaded into the tube 18A forming a transfer means 18 and be extracted out of this last by vertical sliding along the axis VV 'of the thrust arm 21.

Le déplacement des bras de transfert 17 et de poussée 21 est avantageusement contrôlé par un système de commande, de préférence numérique, conçu pour opérer au moins les opérations suivantes :

  • translation verticale descendante du bras de transfert 17 de façon à amener ce dernier à une altitude inférieure à celle des bouchons 13 contenue dans le plateau 14 ;
  • rotation du bras de transfert 17 autour du troisième axe Z-Z' pour positionner le tube 18A formant moyen de transfert 18 sous un bouchon 13 donné, au droit de ce dernier ;
  • translation verticale ascendante du bras de transfert 17 de manière à ce que le tube 18A vienne affleurer le bouchon 13 ;
  • rotation du bras de poussée 21 autour du cinquième axe V-V' de façon à positionner la tige enfonce-bouchon 22 au dessus et au droit du bouchon 13 en question, ce dernier étant ainsi interposé entre la tige enfonce-bouchon 22 au-dessus et le tube 18A au-dessous et étant aligné avec ces derniers ;
  • translation verticale descendante du bras de poussée 21 selon le cinquième axe V-V' de manière à repousser, à l'aide de la tige enfonce-bouchon 22, le bouchon 13 dans le tube 18A, le bouchon 13 restant coincé dans le tube 18A par expansion radiale (retour élastique radial centrifuge) ;
  • positionnement du bras de transfert 17, par translation et rotation de ce dernier selon le troisième axe Z-Z', en regard et au dessus d'un récipient 2 à boucher ;
  • translation verticale descendante du bras de transfert 17 de manière à faire pénétrer très légèrement l'extrémité inférieure du tube 18A contenant le bouchon 13 dans l'ouverture 2A du récipient 2 à boucher ;
  • positionnement de la tige enfonce-bouchon 22 sur et contre le bouchon 13 contenu dans le tube 18A ;
  • translation verticale ascendante du bras de transfert 17, ce qui entraîne la mise en butée du bouchon 13 contre la tige enfonce-bouchon 22, laquelle reste stationnaire ce qui permet le bouchage du récipient 2 concerné ;
The displacement of the transfer and thrust arms 21 is advantageously controlled by a control system, preferably digital, designed to operate at least the following operations:
  • descending vertical translation of the transfer arm 17 so as to bring the latter to an altitude lower than that of the plugs 13 contained in the plate 14;
  • rotation of the transfer arm 17 about the third axis ZZ 'to position the tube 18A forming a transfer means 18 under a cap 13 given to the right of the latter;
  • upward vertical translation of the transfer arm 17 so that the tube 18A comes flush with the plug 13;
  • rotation of the thrust arm 21 around the fifth axis VV 'so as to position the cap-push rod 22 above and to the right of the cap 13 in question, the latter being thus interposed between the sinking-cap rod 22 above and the tube 18A below and aligned with them;
  • descending vertical translation of the thrust arm 21 along the fifth axis VV 'so as to push, with the aid of the push-in rod 22, the plug 13 into the tube 18A, the plug 13 remaining wedged in the tube 18A by expansion radial (centrifugal radial spring return);
  • positioning of the transfer arm 17, by translation and rotation of the latter along the third axis Z-Z ', opposite and above a container 2 to be closed;
  • vertical downward translation of the transfer arm 17 so as to penetrate very slightly the lower end of the tube 18A containing the plug 13 in the opening 2A of the container 2 to be plugged;
  • positioning of the sinking-cap rod 22 on and against the plug 13 contained in the tube 18A;
  • upward vertical translation of the transfer arm 17, which causes the abutment of the stopper 13 against the push rod-plug 22, which remains stationary which allows the closure of the container 2 concerned;

Le bras de poussée 21 est avantageusement conçu de manière similaire au bras de transfert 17, c'est-à-dire qu'il est avantageusement d'une part de longueur invariable, et d'autre part conçu pour que la trajectoire de l'aiguille enfonce-bouchon 22 impartie par la rotation du bras de poussée 21 croise à la fois le deuxième axe de rotation Y-Y' et le quatrième axe de rotation W-W' selon lequel le plateau 14 est mis en rotation par le moyen d'entraînement 16, afin de permettre un alignement vertical de la tige enfonce-bouchon 22, du tube 18A formant moyen de transfert 18, de chacun des bouchons 13 embarqués sur le plateau 14 et de chacun des récipients 2 embarqués sur le présentoir 3.The thrust arm 21 is advantageously designed in a manner similar to the transfer arm 17, that is to say that it is advantageously on the one hand of invariable length, and on the other hand designed so that the trajectory of the needle-plug 22 imparted by the rotation of the thrust arm 21 crosses both the second axis of rotation YY 'and the fourth axis of rotation WW' according to which the plate 14 is rotated by the drive means 16, to allow vertical alignment of the plug-in rod 22, the tube 18A forming a transfer means 18, each of the plugs 13 on board 14 and each of the receptacles 2 on the display stand 3.

L'invention concerne par ailleurs en tant que tel un système comprenant :

  • une machine 1 conforme à l'invention et de préférence conforme à la description qui précède,
  • un présentoir 3 de type « nest »,
  • une pluralité de récipients 2, du genre corps de seringues, disposées par rangées dans ledit présentoir 3, selon une répartition cartésienne régulière bi-dimensionnelle.
The invention furthermore relates as such to a system comprising:
  • a machine 1 according to the invention and preferably as described above,
  • a display unit 3 of " nest " type,
  • a plurality of containers 2, of the syringe body type, arranged in rows in said display unit 3, in a regular two-dimensional Cartesian distribution.

L'invention concerne également en tant que tel un procédé de fabrication d'un premier récipient 2 contenant une substance de remplissage.The invention also relates as such to a method of manufacturing a first container 2 containing a filling substance.

En d'autres termes, le procédé de fabrication vise à obtenir un premier récipient 2 pré-rempli avec une dose prédéterminée de substance de remplissage.In other words, the manufacturing method aims at obtaining a first container 2 pre-filled with a predetermined dose of filling substance.

Le procédé conforme à l'invention est avantageusement mis en oeuvre à l'aide de la machine 1 conforme à l'invention, et de préférence conforme à la description qui précède.The process according to the invention is advantageously carried out using the machine 1 according to the invention, and preferably according to the preceding description.

Avantageusement, le premier récipient 2 en question est un corps de seringue destiné à être rempli par un liquide pharmaceutique afin d'obtenir une seringue pré-remplie.Advantageously, the first container 2 in question is a syringe body intended to be filled with a pharmaceutical liquid in order to obtain a pre-filled syringe.

Le procédé conforme à l'invention comprend une étape de remplissage du premier récipient 20, lequel fait partie d'une pluralité de récipients 2, de préférence tous identiques, disposés dans un présentoir 3 conforme à la description qui précède. Le présentoir 3 est avantageusement un présentoir de type « nest » qui permet une répartition cartésienne bi-dimensionnelle des récipients 2 dont fait partie le premier récipient 20, comme exposé précédemment.The method according to the invention comprises a step of filling the first container 20, which is part of a plurality of containers 2, preferably all identical, arranged in a display 3 according to the above description. The display unit 3 is advantageously a "nest" type display unit which allows a two-dimensional Cartesian distribution of the containers 2 to which the first container 20 belongs, as explained above.

L'étape de remplissage comprend un transfert de la substance de remplissage dans le premier récipient 20 à l'aide d'un organe de distribution 4, de préférence conforme à la description qui précède. L'étape de remplissage inclue, préalablement au transfert de la substance de remplissage dans le premier récipient 20, une mise en correspondance de l'organe de distribution 4 et du présentoir 3.The filling step comprises a transfer of the filling substance into the first container 20 by means of a dispensing member 4, preferably in accordance with the foregoing description. The filling step includes, prior to the transfer of the filling substance into the first container 20, a matching of the dispenser member 4 and the display unit 3.

En d'autres termes, et comme cela a été décrit précédemment en relation avec la machine 1 de remplissage conforme à l'invention, les mouvements de rotation combinés de l'organe de distribution 4 et du présentoir 3 permettent à l'organe de distribution 4 d'être mis en correspondance avec un récipient 2 prédéterminé, en l'occurrence le premier récipient 20.In other words, and as previously described in relation to the filling machine 1 according to the invention, the combined rotational movements of the dispenser member 4 and the display stand 3 allow the dispensing member 4 to be matched with a predetermined container 2, in this case the first container 20.

Une fois cette mise en correspondance effectuée, le remplissage proprement dit du premier récipient 20 est réalisé, par exemple de la façon décrite précédemment à l'aide d'un stylet de remplissage 6.Once this mapping is done, the actual filling of the first container 20 is performed, for example in the manner previously described with the aid of a filling stylus 6.

Afin de permettre le remplissage de tout les récipients 2 disposés dans le présentoir 3 (y compris lorsque ce dernier est un présentoir de type « nest » auquel cas les récipients 2 sont uniformément répartis par rangées, de préférence parallèle entre elles, sur une surface rectangulaire ou carrée), la trajectoire du stylet de remplissage 6 impartie par la rotation de l'organe de distribution 4 croise sensiblement ledit deuxième axe de rotation Y-Y', ce qui permet au stylet 6 d'être mis en correspondance avec tous les récipients 2 du présentoir 3, l'un après l'autre, uniquement grâce à une combinaison de mouvements de rotation (du présentoir 3 et du stylet 6).In order to allow the filling of all the containers 2 arranged in the display 3 (including when the latter is a "nest" type display in which case the containers 2 are uniformly distributed in rows, preferably parallel to one another, on a rectangular or square surface), the trajectory of the filling stylet 6 imparted by the rotation of the dispensing member 4 substantially intersects said second axis of rotation Y-Y ', which allows the stylus 6 to be matched with all the containers 2 of the display 3, one after the other, only through a combination of rotational movements (the display 3 and the stylus 6).

Le premier récipient 20 ainsi rempli peut alors être bouché comme décrit en détails dans ce qui précède.The first container 20 thus filled can then be plugged as described in detail in the foregoing.

POSSIBILITE D'APPLICATION INDUSTRIELLEPOSSIBILITY OF INDUSTRIAL APPLICATION

L'invention trouve son application industrielle dans la conception, la fabrication et l'utilisation de machines pour remplir des récipients.The invention finds its industrial application in the design, manufacture and use of machines for filling containers.

Claims (15)

  1. A machine (1) for filling a plurality of containers (2) arranged in a rack (3), said machine (1) comprising a dispensing unit (4) rotatable about a first axis of rotation (X-X'), designed for transferring a filling substance into the containers (2), said dispensing unit (4) comprising a filling stylet (6), said machine (1) comprising a means (10) for driving the rack (3) in rotation about a second axis of rotation (Y-Y') so that the combination of the rotational movements of the dispensing unit (4) and the rack (3) makes possible the placement of the dispensing unit (4) in correspondence with each of the containers (2) in order to fill these latter, said machine being characterized in that the trajectory of the filling stylet (6) imparted by the rotation of the dispensing unit (4) substantially crosses said second axis of rotation (Y-Y').
  2. A machine (1) according to claim 1, characterized in that the rotatable dispensing unit (4) is also designed so as to be movable in translation, in order to be able to move closer to or away from each container (2) with which it is placed in correspondence.
  3. A machine (1) according to claim 1 or 2, characterized in that the filling stylet (6) is designed for filling one container (2) at a time.
  4. A machine (1) according to claim 3, characterized in that it comprises a frame (5) on which said dispensing unit (4) and a means for driving the rack are mounted, the dispensing unit (4) comprising a filling arm (7) that extends between a first end (7A) toward which said filling arm (7) is pivotably mounted on the frame (5) and a second end (7B) toward which the filling stylet (6) is mounted on the filling arm (7).
  5. A machine (1) according to claims 2 and 4, characterized in that said frame comprises a first column (8) on which said filling arm (7) is mounted through a sliding pivot connection.
  6. A machine (1) according to claim 5, characterized in that the first column (8) extends predominantly vertically whereas the filling arm (7) extends predominantly horizontally.
  7. A machine (1) according to one of claims 1 to 6, characterized in that the driving means (10) of the rack (3) comprises a first rotatable table (11), on which the rack (3) is intended to rest.
  8. A machine (1) according to one of claims 1 to 7, characterized in that said first and second axes of rotation (X-X', Y-Y') are substantially collinear to each other.
  9. A machine (1) according to claims 5, 7 and 8, characterized in that said first column (8) extends substantially about the first axis of rotation (X-X'), whereas the first table (11) comprises a substantially planar surface (11A) for receiving the rack (3), which extends substantially perpendicular to the second axis of rotation (Y-Y').
  10. A machine (1) according to claims 4 and 8, characterized in that the filling arm (7) is of invariable length.
  11. A machine (1) according to one of claims 1 to 10, characterized in that it comprises a device (12) for plugging the containers (2), once these latter have been filled, by means of a plurality of plugs (13) arranged on a tray (14), said plugging device (12) comprising a rotatable unit (15) for handling the plugs (13) and a means (16) for rotational driving of the tray (14), so that, on the one hand, the combination of the rotational movements of the handling unit (15) and the tray (14) allows the placement of the handling unit (15) in correspondence with each of the plugs (13) in order for them to be gripped by the handling unit (15), and on the other hand, the combination of the rotational movements of the handling unit (15) and the rack (3) allows the placement of the handling unit (15) in correspondence with each of the containers (2) in order for them to be plugged.
  12. A machine (1) according to one of claims 1 to 11, characterized in that it is designed for filling a plurality of containers (2) arranged into rows in a rack (3) of the nest type.
  13. A machine (1) according to one of claims 1 to 12, characterized in that said containers (2) are tubular containers (2), formed preferably by syringe bodies.
  14. A system comprising:
    - a machine (1) according to one of claims 1 to 13,
    - a rack (3) of the nest type,
    - a plurality of containers (2), such as syringe bodies, arranged into rows in said rack (3).
  15. A method of manufacturing a first container (20) containing a filling substance, said method comprising a step of filling said first container (20), which belongs to a plurality of containers (2) arranged in a rack (3), said filling step comprising a transfer of the filling substance into the first container (20) by means of a dispensing unit (4) comprising a filling stylet (6), the filling step including, before said transfer of the filling substance into the first container, a placement of the dispensing unit (4) and the first container (20) in correspondence with each other by rotating the dispensing unit (4) and the rack (3) about a first and a second axis of rotation (X-X', Y-Y'), respectively, said method being characterized in that the trajectory of the filling stylet (6) imparted by the rotation of the dispensing unit (4) substantially crosses said second axis of rotation (Y-Y').
EP11705929.5A 2010-01-26 2011-01-26 Machine for filling a plurality of containers, system including such a machine, and related manufacture method Not-in-force EP2528821B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR1050517A FR2955563B1 (en) 2010-01-26 2010-01-26 MACHINE FOR FILLING A PLURALITY OF CONTAINERS, SYSTEM INCLUDING SUCH A MACHINE AND PROCESS FOR PRODUCING THE SAME
PCT/FR2011/050147 WO2011092427A1 (en) 2010-01-26 2011-01-26 Machine for filling a plurality of containers, system including such a machine, and related manufacture method

Publications (2)

Publication Number Publication Date
EP2528821A1 EP2528821A1 (en) 2012-12-05
EP2528821B1 true EP2528821B1 (en) 2013-12-18

Family

ID=42797133

Family Applications (1)

Application Number Title Priority Date Filing Date
EP11705929.5A Not-in-force EP2528821B1 (en) 2010-01-26 2011-01-26 Machine for filling a plurality of containers, system including such a machine, and related manufacture method

Country Status (8)

Country Link
US (1) US20130174520A1 (en)
EP (1) EP2528821B1 (en)
JP (1) JP2013518000A (en)
CN (1) CN102947185B (en)
ES (1) ES2448832T3 (en)
FR (1) FR2955563B1 (en)
HK (1) HK1182678A1 (en)
WO (1) WO2011092427A1 (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITUD20110128A1 (en) * 2011-08-09 2013-02-10 Steelco Spa EQUIPMENT FOR SEMI-AUTOMATIC CAPPING OF LIQUIDS CONTAINERS, SUCH AS BIBERON, POPPATOI, DRINKERS OR OTHER CONTAINERS, FOR FEEDING ANIMALS
JP6336327B2 (en) * 2013-05-08 2018-06-06 エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft Cap supply device for containers containing biological samples
TW201900137A (en) * 2013-08-16 2019-01-01 加拿大商凡爾克斯醫藥系統公司 Method, device and system for filling and lyophilizing drug containers
CN104326421A (en) * 2014-09-25 2015-02-04 河南科技大学第一附属医院 Dosing apparatus
GB201601667D0 (en) 2016-01-29 2016-03-16 Ge Healthcare Bio Sciences Ab Improvements in and relating to liquid fraction collectors
CN206984426U (en) * 2016-06-14 2018-02-09 Jvm有限公司 Drug packages equipment
TW201811292A (en) * 2016-09-13 2018-04-01 加拿大商凡爾克斯醫藥系統公司 Apparatus and method for monitoring and controlling the aseptic filling and sealing of pharmaceutical containers with a pharmaceutical fluid using rotary stage
JP2018176295A (en) * 2017-04-03 2018-11-15 川崎重工業株式会社 Robot and operation method therefor
CN107555385B (en) * 2017-10-16 2024-06-14 南京海涛机械科技有限公司 Material taking equipment for box-packed materials
CN111655593B (en) * 2017-12-22 2022-06-14 西氏医药服务公司 Packaging system for aseptic filling of small-volume bottles
DE102019211568A1 (en) * 2019-08-01 2021-02-04 Syntegon Technology Gmbh Apparatus and method for weighing pharmaceutical containers nested in a carrier
WO2021081275A1 (en) * 2019-10-25 2021-04-29 University Of South Carolina Automatic syringe handling system
US20210171231A1 (en) * 2019-12-09 2021-06-10 Revessel Inc Robotic automated filling and capping system for vape oil cartridges
KR102522803B1 (en) * 2022-11-16 2023-04-18 (주)진스랩 Reagent Tube Production Equipment

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2503147A (en) * 1944-12-21 1950-04-04 Applezweig Norman Carpule filling machine
NL153885B (en) * 1947-09-05 Sumitomo Chemical Co PROCEDURE FOR PREPARING A VINYL CHLORIDE RESIN.
US2493382A (en) * 1948-10-29 1950-01-03 American Cyanamid Co Automatic sample collector
NL178714B (en) * 1953-05-06 Skf Ind Trading & Dev SECURITY GUIDE AND RING.
GB773357A (en) * 1955-09-30 1957-04-24 Lkb Produkter Fabriksaktiebola Improved apparatus for collecting liquid samples
GB1051956A (en) * 1964-04-01
DE1673152B1 (en) * 1964-04-01 1972-10-26 Technicon Instr Sample feeder for continuously working analyzers
DE1598160A1 (en) * 1966-12-15 1970-10-29 Bodenseewerk Perkin Elmer Co Device for the automatic execution of chemical analyzes
US3570555A (en) * 1968-11-12 1971-03-16 Warren E Gilson Fraction collector
US3871426A (en) * 1973-10-15 1975-03-18 Eldex Lab Fraction collecting apparatus
US4077444A (en) * 1975-02-12 1978-03-07 Gilson Warren E Fraction collector
US4235840A (en) * 1979-05-10 1980-11-25 Baxter Travenol Laboratories, Inc. Sample transfer arm assembly
DE3229118A1 (en) * 1981-08-05 1983-03-24 Varian Techtron Proprietary Ltd., 3170 Mulgrave, Victoria DEVICE FOR HANDLING SAMPLES
SE450532B (en) * 1981-09-22 1987-06-29 Pharmacia Ab SAMPLE PROCESSING DEVICE
JPS6441861A (en) * 1987-08-07 1989-02-14 Shimadzu Corp Sample distribution
US5046539A (en) * 1989-05-26 1991-09-10 The Rockefeller University Automatic fluid dispenser for multi-welled dish
US5012630A (en) * 1990-03-01 1991-05-07 Owens-Illinois Closure Inc. Closure application system
US5054260A (en) * 1990-06-13 1991-10-08 Anchor Hocking Packaging Company High speed sealing machine
GB9217616D0 (en) * 1992-08-19 1992-09-30 British Nuclear Fuels Plc Dispensing apparatus
US20060211132A1 (en) * 1998-01-09 2006-09-21 Rico Miledi Method for high throughput drop dispensing of specific patterns
WO2002011787A2 (en) * 2000-08-10 2002-02-14 Baxa Corporation Method, system, and apparatus for handling, labeling, filling, and capping syringes
US6450218B1 (en) * 2001-02-02 2002-09-17 Amersham Pharmacia Biotech Ab Fraction collector
US7017622B2 (en) * 2002-12-03 2006-03-28 Forhealth Technologies, Inc. Automated means for removing, parking and replacing a syringe tip cap from a syringe
US7086431B2 (en) * 2002-12-09 2006-08-08 D'antonio Consultants International, Inc. Injection cartridge filling apparatus
GB0328887D0 (en) * 2003-12-12 2004-01-14 Glaxo Group Ltd Object holding tool and object supporting unit
US7096896B2 (en) * 2004-03-05 2006-08-29 Medical Instill Technologies, Inc. Apparatus and method for needle filling and laser resealing
JP2006343299A (en) * 2005-05-12 2006-12-21 Uniflows Co Ltd Liquid feeder
DE102005026986A1 (en) * 2005-06-10 2006-12-14 Robert Bosch Gmbh Device for filling and closing containers
WO2007136749A2 (en) * 2006-05-19 2007-11-29 Thomas Richard A Polar coordinate positioning system
DE102007042218A1 (en) * 2007-09-05 2009-03-12 Robert Bosch Gmbh Method and device for sterile or aseptic handling of containers
US20090223592A1 (en) * 2008-03-04 2009-09-10 Vanrx Pharmaceuticals, Inc. Robotic filling systems and methods
CN201264898Y (en) * 2008-09-25 2009-07-01 温州科瑞机械有限公司 Semiautomatic microfilling machine
CN101628699A (en) * 2009-07-22 2010-01-20 李成海 Wave spiral multiphase cosmetic filling device and filling method

Also Published As

Publication number Publication date
HK1182678A1 (en) 2014-01-10
JP2013518000A (en) 2013-05-20
FR2955563B1 (en) 2013-09-06
CN102947185A (en) 2013-02-27
FR2955563A1 (en) 2011-07-29
ES2448832T3 (en) 2014-03-17
WO2011092427A1 (en) 2011-08-04
CN102947185B (en) 2014-12-17
EP2528821A1 (en) 2012-12-05
US20130174520A1 (en) 2013-07-11

Similar Documents

Publication Publication Date Title
EP2528821B1 (en) Machine for filling a plurality of containers, system including such a machine, and related manufacture method
EP0263753B1 (en) Device for automatically withdrawing a liquid from a flask
WO2018001316A1 (en) Push-rod type automatic dispensing device for bottled medicaments
FR2987896A1 (en) MEDICAL ANALYSIS AUTOMATE AND CORRESPONDING METHOD
US20140150379A1 (en) Machine and method for the automatic preparation of intravenous medication
EP3440642B1 (en) Device for handling and distributing packages
EP2556512B1 (en) Device for preparing a syringe
WO1997047974A2 (en) Robotized laboratory for sample analysis
FR2961595A1 (en) FLUID DISPENSER INSTALLATION
CN112368211A (en) Device for removing pharmaceutical containers, such as syringes, vials and the like, from a corresponding support element consisting of a basin and a honeycomb
EP3401925B1 (en) Cart for manipulating a container with regard to his connection to an isolator
EP3551538B1 (en) Device for preparing radioactive solutions
CA3201395A1 (en) Method for assembling and filling containers for a needleless injection device
FR2630216A1 (en) Robotised installation for analyses, in particular medical analyses
CN113874303B (en) Device for transporting at least one object, in particular a pharmaceutical container
FR2850015A1 (en) Liquid transferring device for pharmaceutical application, has three internal canals coupling two needles, third needle to inverse side of pipette and fourth needle to pipette suction side, respectively
EP2786102B1 (en) Device for dispensing powder, cap for such a device and workstation comprising such a device
FR3012335A1 (en) POSITION FOR MAKING A MEDICINAL PREPARATION
JP6533313B2 (en) Test apparatus for checking the tightness of a container and method for the same
EP4016046B1 (en) Device for gravimetric dilution of a sample with a predetermined amount of liquid and corresponding method
WO2022024996A1 (en) Packing/plugging device and vessel supplying/collecting mechanism
EP4360668A1 (en) Method for filling syringes
FR3067338A1 (en) IMPROVED SYSTEM FOR PRODUCT PREPARATION
FR2775958A1 (en) Distribution cap for powdered or granular products contained in a flask
EP4196754A1 (en) Fluid product dispensing mechanism intended for a product dispensing machine, and associated machine

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20120823

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: S.P.C. MANUFACTURING

DAX Request for extension of the european patent (deleted)
GRAP Despatch of communication of intention to grant a patent

Free format text: ORIGINAL CODE: EPIDOSNIGR1

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: SPC ENGINEERING

INTG Intention to grant announced

Effective date: 20130701

RIN1 Information on inventor provided before grant (corrected)

Inventor name: SARWA, ANDRE, MARC

Inventor name: TESSIER, MARC

GRAS Grant fee paid

Free format text: ORIGINAL CODE: EPIDOSNIGR3

GRAA (expected) grant

Free format text: ORIGINAL CODE: 0009210

AK Designated contracting states

Kind code of ref document: B1

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

REG Reference to a national code

Ref country code: GB

Ref legal event code: FG4D

Free format text: NOT ENGLISH

REG Reference to a national code

Ref country code: CH

Ref legal event code: EP

REG Reference to a national code

Ref country code: AT

Ref legal event code: REF

Ref document number: 645504

Country of ref document: AT

Kind code of ref document: T

Effective date: 20140115

REG Reference to a national code

Ref country code: IE

Ref legal event code: FG4D

Free format text: LANGUAGE OF EP DOCUMENT: FRENCH

REG Reference to a national code

Ref country code: DE

Ref legal event code: R096

Ref document number: 602011004251

Country of ref document: DE

Effective date: 20140213

REG Reference to a national code

Ref country code: CH

Ref legal event code: NV

Representative=s name: MEYER AND KOLLEGEN, CH

REG Reference to a national code

Ref country code: ES

Ref legal event code: FG2A

Ref document number: 2448832

Country of ref document: ES

Kind code of ref document: T3

Effective date: 20140317

REG Reference to a national code

Ref country code: NL

Ref legal event code: VDEP

Effective date: 20131218

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: FI

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20131218

Ref country code: LT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20131218

Ref country code: NO

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20140318

Ref country code: HR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20131218

Ref country code: SE

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20131218

REG Reference to a national code

Ref country code: AT

Ref legal event code: MK05

Ref document number: 645504

Country of ref document: AT

Kind code of ref document: T

Effective date: 20131218

REG Reference to a national code

Ref country code: LT

Ref legal event code: MG4D

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: LV

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20131218

Ref country code: RS

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20131218

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: EE

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20131218

Ref country code: IS

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20140418

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: AT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20131218

Ref country code: CZ

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20131218

Ref country code: PT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20140418

Ref country code: LU

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20140126

Ref country code: NL

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20131218

Ref country code: SK

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20131218

Ref country code: PL

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20131218

Ref country code: RO

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20131218

Ref country code: CY

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20131218

REG Reference to a national code

Ref country code: DE

Ref legal event code: R097

Ref document number: 602011004251

Country of ref document: DE

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: MC

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20131218

PLBE No opposition filed within time limit

Free format text: ORIGINAL CODE: 0009261

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: NO OPPOSITION FILED WITHIN TIME LIMIT

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: DK

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20131218

REG Reference to a national code

Ref country code: IE

Ref legal event code: MM4A

26N No opposition filed

Effective date: 20140919

REG Reference to a national code

Ref country code: DE

Ref legal event code: R097

Ref document number: 602011004251

Country of ref document: DE

Effective date: 20140919

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: IE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20140126

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: SI

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20131218

REG Reference to a national code

Ref country code: FR

Ref legal event code: PLFP

Year of fee payment: 6

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: MT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20131218

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: SM

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20131218

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: GR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20140319

Ref country code: BG

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20131218

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: HU

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT; INVALID AB INITIO

Effective date: 20110126

Ref country code: TR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20131218

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: BE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20170131

REG Reference to a national code

Ref country code: FR

Ref legal event code: PLFP

Year of fee payment: 7

REG Reference to a national code

Ref country code: FR

Ref legal event code: PLFP

Year of fee payment: 8

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: MK

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20131218

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: AL

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20131218

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: FR

Payment date: 20190129

Year of fee payment: 9

Ref country code: IT

Payment date: 20190125

Year of fee payment: 9

Ref country code: DE

Payment date: 20190211

Year of fee payment: 9

Ref country code: ES

Payment date: 20190321

Year of fee payment: 9

Ref country code: CH

Payment date: 20190218

Year of fee payment: 9

Ref country code: GB

Payment date: 20190215

Year of fee payment: 9

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: BE

Payment date: 20190131

Year of fee payment: 9

REG Reference to a national code

Ref country code: DE

Ref legal event code: R119

Ref document number: 602011004251

Country of ref document: DE

REG Reference to a national code

Ref country code: CH

Ref legal event code: PL

GBPC Gb: european patent ceased through non-payment of renewal fee

Effective date: 20200126

REG Reference to a national code

Ref country code: BE

Ref legal event code: MM

Effective date: 20200131

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: DE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20200801

Ref country code: GB

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20200126

Ref country code: FR

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20200131

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: BE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20200131

Ref country code: CH

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20200131

Ref country code: LI

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20200131

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: IT

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20200126

REG Reference to a national code

Ref country code: ES

Ref legal event code: FD2A

Effective date: 20210604

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: ES

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20200127