EP2498608A4 - Benzene sulfonamide thiazole and oxazole compounds - Google Patents

Benzene sulfonamide thiazole and oxazole compounds

Info

Publication number
EP2498608A4
EP2498608A4 EP10830388.4A EP10830388A EP2498608A4 EP 2498608 A4 EP2498608 A4 EP 2498608A4 EP 10830388 A EP10830388 A EP 10830388A EP 2498608 A4 EP2498608 A4 EP 2498608A4
Authority
EP
European Patent Office
Prior art keywords
benzene sulfonamide
oxazole compounds
sulfonamide thiazole
thiazole
oxazole
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP10830388.4A
Other languages
German (de)
French (fr)
Other versions
EP2498608A1 (en
Inventor
Jerry Leroy Adams
Thomas Faitg
Jiri Kasparec
Xin Peng
Jeffrey Ralph
Tara Renae Rheault
Alex Gregory Waterson
Kimberly Petrov
David Edward Uehling
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GlaxoSmithKline LLC
Original Assignee
GlaxoSmithKline LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GlaxoSmithKline LLC filed Critical GlaxoSmithKline LLC
Publication of EP2498608A1 publication Critical patent/EP2498608A1/en
Publication of EP2498608A4 publication Critical patent/EP2498608A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP10830388.4A 2009-11-10 2010-10-08 Benzene sulfonamide thiazole and oxazole compounds Withdrawn EP2498608A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25976809P 2009-11-10 2009-11-10
PCT/US2010/051890 WO2011059610A1 (en) 2009-11-10 2010-10-08 Benzene sulfonamide thiazole and oxazole compounds

Publications (2)

Publication Number Publication Date
EP2498608A1 EP2498608A1 (en) 2012-09-19
EP2498608A4 true EP2498608A4 (en) 2013-04-24

Family

ID=43991933

Family Applications (1)

Application Number Title Priority Date Filing Date
EP10830388.4A Withdrawn EP2498608A4 (en) 2009-11-10 2010-10-08 Benzene sulfonamide thiazole and oxazole compounds

Country Status (2)

Country Link
EP (1) EP2498608A4 (en)
WO (1) WO2011059610A1 (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20130048293A (en) * 2010-06-25 2013-05-09 노파르티스 아게 Heteroaryl compounds and compositions as protein kinase inhibitors
CN103403002B (en) 2011-02-24 2016-06-22 内尔维阿诺医学科学有限公司 Thiazolylphenyl-benzderivativesido derivativesido as inhibitors of kinases
US9242969B2 (en) 2013-03-14 2016-01-26 Novartis Ag Biaryl amide compounds as kinase inhibitors
CN105228983A (en) 2013-05-30 2016-01-06 普莱希科公司 The compound regulated for kinases and indication thereof
UY36294A (en) 2014-09-12 2016-04-29 Novartis Ag COMPOUNDS AND COMPOSITIONS AS QUINASA INHIBITORS
AU2017329090B9 (en) 2016-09-19 2019-09-05 Novartis Ag Therapeutic combinations comprising a RAF inhibitor and a ERK inhibitor
WO2018055097A1 (en) 2016-09-23 2018-03-29 Cellipse Lim kinase inhibitors, pharmaceutical composition and method of use in limk-mediated diseases
JP7309614B2 (en) 2017-05-02 2023-07-18 ノバルティス アーゲー combination therapy
WO2020124397A1 (en) * 2018-12-19 2020-06-25 Inventisbio Shanghai Ltd. C-terminal src kinase inhibitors
CN114746419B (en) * 2019-12-05 2023-10-24 国家医疗保健研究所 N- (3- (5- (pyrimidin-4-yl) thiazol-4-yl) phenyl) sulfonamide compounds and their use as BRAF inhibitors
CN111320548B (en) * 2020-04-24 2022-10-18 浦拉司科技（上海）有限责任公司 Synthesis method of anticancer drug intermediate 2-fluoro-3-methyl aminobenzoate
CN114560774A (en) * 2020-11-27 2022-05-31 瑞博(杭州)医药科技有限公司 Synthetic method of 2-fluoro-3-nitrobenzoic acid
WO2023070076A1 (en) * 2021-10-22 2023-04-27 The Board Of Trustees Of The University Of Illinois Compounds for cancers driven by braf mutation
CN115850103B (en) * 2023-01-19 2023-04-28 北京颖泰嘉和生物科技股份有限公司 Preparation method of 3-amino-2-fluorobenzoic acid methyl ester

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005116025A2 (en) * 2004-05-26 2005-12-08 Cyclacel Limited 2-substituted-4-heteroaryl-pyrimidines useful for the treatment of proliferative disorders
WO2009137391A2 (en) * 2008-05-06 2009-11-12 Smithkline Beecham Corporation Benzene sulfonamide thiazole and oxazole compounds

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011506454A (en) * 2007-12-13 2011-03-03 グラクソスミスクライン エルエルシー Thiazole and oxazole kinase inhibitors

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005116025A2 (en) * 2004-05-26 2005-12-08 Cyclacel Limited 2-substituted-4-heteroaryl-pyrimidines useful for the treatment of proliferative disorders
WO2009137391A2 (en) * 2008-05-06 2009-11-12 Smithkline Beecham Corporation Benzene sulfonamide thiazole and oxazole compounds

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO2011059610A1 *

Also Published As

Publication number Publication date
EP2498608A1 (en) 2012-09-19
WO2011059610A1 (en) 2011-05-19

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Legal Events

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PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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DAX Request for extension of the european patent (deleted)
A4 Supplementary search report drawn up and despatched

Effective date: 20130327

RIC1 Information provided on ipc code assigned before grant

Ipc: A01N 43/78 20060101AFI20130321BHEP

Ipc: C07D 417/14 20060101ALI20130321BHEP

Ipc: C07D 413/04 20060101ALI20130321BHEP

Ipc: A61K 31/425 20060101ALI20130321BHEP

Ipc: C07D 417/04 20060101ALI20130321BHEP

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