EP2483665A4 - Multiphoton luminescence imaging of protein crystals - Google Patents

Multiphoton luminescence imaging of protein crystals

Info

Publication number
EP2483665A4
EP2483665A4 EP10819608.0A EP10819608A EP2483665A4 EP 2483665 A4 EP2483665 A4 EP 2483665A4 EP 10819608 A EP10819608 A EP 10819608A EP 2483665 A4 EP2483665 A4 EP 2483665A4
Authority
EP
European Patent Office
Prior art keywords
protein crystals
luminescence imaging
multiphoton luminescence
multiphoton
imaging
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP10819608.0A
Other languages
German (de)
French (fr)
Other versions
EP2483665B1 (en
EP2483665A1 (en
Inventor
Garth J Simpson
Ellen J Gualtieri
David J Kissick
Jeremy Madden
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Purdue Research Foundation
Original Assignee
Purdue Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Purdue Research Foundation filed Critical Purdue Research Foundation
Priority to EP16193716.4A priority Critical patent/EP3163289A3/en
Publication of EP2483665A1 publication Critical patent/EP2483665A1/en
Publication of EP2483665A4 publication Critical patent/EP2483665A4/en
Application granted granted Critical
Publication of EP2483665B1 publication Critical patent/EP2483665B1/en
Not-in-force legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6486—Measuring fluorescence of biological material, e.g. DNA, RNA, cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6402—Atomic fluorescence; Laser induced fluorescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6456—Spatial resolved fluorescence measurements; Imaging
    • G01N21/6458—Fluorescence microscopy

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Optics & Photonics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
EP10819608.0A 2009-09-28 2010-09-27 Multiphoton luminescence imaging of protein crystals Not-in-force EP2483665B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP16193716.4A EP3163289A3 (en) 2009-09-28 2010-09-27 Multiphoton luminescence imaging of protein crystals

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24633409P 2009-09-28 2009-09-28
PCT/US2010/050409 WO2011038349A1 (en) 2009-09-28 2010-09-27 Multiphoton luminescence imaging of protein crystals

Related Child Applications (2)

Application Number Title Priority Date Filing Date
EP16193716.4A Division EP3163289A3 (en) 2009-09-28 2010-09-27 Multiphoton luminescence imaging of protein crystals
EP16193716.4A Division-Into EP3163289A3 (en) 2009-09-28 2010-09-27 Multiphoton luminescence imaging of protein crystals

Publications (3)

Publication Number Publication Date
EP2483665A1 EP2483665A1 (en) 2012-08-08
EP2483665A4 true EP2483665A4 (en) 2013-08-21
EP2483665B1 EP2483665B1 (en) 2017-04-05

Family

ID=43796257

Family Applications (2)

Application Number Title Priority Date Filing Date
EP16193716.4A Withdrawn EP3163289A3 (en) 2009-09-28 2010-09-27 Multiphoton luminescence imaging of protein crystals
EP10819608.0A Not-in-force EP2483665B1 (en) 2009-09-28 2010-09-27 Multiphoton luminescence imaging of protein crystals

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EP16193716.4A Withdrawn EP3163289A3 (en) 2009-09-28 2010-09-27 Multiphoton luminescence imaging of protein crystals

Country Status (3)

Country Link
US (1) US8946655B2 (en)
EP (2) EP3163289A3 (en)
WO (1) WO2011038349A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3265826A4 (en) * 2015-03-06 2018-08-08 Purdue Research Foundation Methods for second harmonic generation imaging of protein crystals

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0735687A (en) * 1993-07-22 1995-02-07 Fujitsu Ltd Retrieving method of crystal of biopolymer
US20050237522A1 (en) * 2004-04-27 2005-10-27 Swift Kerry M Methods for visualizing crystals and distinguishing crystals from other matter within a biological sample
US20060266954A1 (en) * 2003-08-18 2006-11-30 Rigaku Corporation Specific macromolecule crystal evaluator
JP2007254415A (en) * 2006-03-24 2007-10-04 Gunma Univ Macromolecule crystal, method for producing the same and production apparatus therefor

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4162851A (en) * 1978-03-29 1979-07-31 Akiyoshi Wada Simultaneous photometering method and assembly for multi-dimensional measurements concerning biologically related materials
JP4113063B2 (en) * 2003-08-18 2008-07-02 株式会社リガク Method for detecting specific polymer crystals
US7256894B2 (en) * 2003-10-20 2007-08-14 The Regents Of The University Of California Method and apparatus for performing second harmonic optical coherence tomography
US7545495B2 (en) * 2004-04-27 2009-06-09 Abbott Laboratories Methods for visualizing crystals and distinguishing crystals from other matter within a biological sample
JP4869734B2 (en) * 2005-04-25 2012-02-08 オリンパス株式会社 Multi-photon excitation scanning laser microscope
US7663750B2 (en) * 2005-06-30 2010-02-16 Applied Biosystems, Llc Two-dimensional spectral imaging system

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0735687A (en) * 1993-07-22 1995-02-07 Fujitsu Ltd Retrieving method of crystal of biopolymer
US20060266954A1 (en) * 2003-08-18 2006-11-30 Rigaku Corporation Specific macromolecule crystal evaluator
US20050237522A1 (en) * 2004-04-27 2005-10-27 Swift Kerry M Methods for visualizing crystals and distinguishing crystals from other matter within a biological sample
JP2007254415A (en) * 2006-03-24 2007-10-04 Gunma Univ Macromolecule crystal, method for producing the same and production apparatus therefor

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
MALKIN A J ET AL: "Growth and disorder of macromolecular crystals: insights from atomic force microscopy and X-ray diffraction studies", METHODS : A COMPANION TO METHODS IN ENZYMOLOGY, ACADEMIC PRESS INC., NEW YORK, NY, US, vol. 34, no. 3, 1 November 2004 (2004-11-01), pages 273 - 299, XP004528289, ISSN: 1046-2023, DOI: 10.1016/J.YMETH.2004.03.020 *
RONALD D. WAMPLER ET AL: "Selective Detection of Protein Crystals by Second Harmonic Microscopy", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 130, no. 43, 29 October 2008 (2008-10-29), pages 14076 - 14077, XP055071282, ISSN: 0002-7863, DOI: 10.1021/ja805983b *
See also references of WO2011038349A1 *

Also Published As

Publication number Publication date
EP3163289A2 (en) 2017-05-03
EP2483665B1 (en) 2017-04-05
EP3163289A3 (en) 2017-07-19
US20120241647A1 (en) 2012-09-27
WO2011038349A1 (en) 2011-03-31
EP2483665A1 (en) 2012-08-08
US8946655B2 (en) 2015-02-03

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