EP2459520A1 - Crystalline forms of fesoterodine fumarate and fesoterodine base - Google Patents

Crystalline forms of fesoterodine fumarate and fesoterodine base

Info

Publication number
EP2459520A1
EP2459520A1 EP10755268A EP10755268A EP2459520A1 EP 2459520 A1 EP2459520 A1 EP 2459520A1 EP 10755268 A EP10755268 A EP 10755268A EP 10755268 A EP10755268 A EP 10755268A EP 2459520 A1 EP2459520 A1 EP 2459520A1
Authority
EP
European Patent Office
Prior art keywords
fesoterodine fumarate
crystalline
crystalline fesoterodine
ppm
polymorphically pure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP10755268A
Other languages
German (de)
French (fr)
Inventor
Peter Kerekes
Csilla Nemethne Racz
Janos Hajko
Judith Aronhime
Csaba Szabo
Tivadar Tamas
Ales Gavenda
Adrienne Kovacsne Mezei
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teva Pharmaceutical Works PLC
Original Assignee
Teva Pharmaceutical Works PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teva Pharmaceutical Works PLC filed Critical Teva Pharmaceutical Works PLC
Publication of EP2459520A1 publication Critical patent/EP2459520A1/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C219/26—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C219/28—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton having amino groups bound to acyclic carbon atoms of the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/222—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having aromatic groups, e.g. dipivefrine, ibopamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
    • C07C57/13—Dicarboxylic acids
    • C07C57/15—Fumaric acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Definitions

  • the present invention relates to crystalline forms of fesoterodine fumarate and fesoterodine base.
  • Fesoterodine fumarate is a selective M3 antimuscarinic agent indicated for the treatment of overactive bladder syndrome with symptoms of urgency, urinary incontinence and increased urinary frequency.
  • Fesoterodine fumarate is isobutyric acid 2-(3-(diiso- propylamino)-l-(R)-phenylpropyl)-4-(hydroxymethyl) phenyl ester hydrogenfumarate, having the following structure:
  • Fesoterodine fumarate is marketed under the trade name TOVIAZ® by Pfizer.
  • Polymorphism the occurrence of different crystal forms, is a property of some molecules and molecular complexes.
  • a single molecule may give rise to a variety of polymorphs having distinct crystal structures and physical properties like melting point, thermal behaviors (e.g. measured by thermo gravimetric analysis - "TGA”, or differential scanning calorimetry - “DSC”), x-ray diffraction pattern, infrared absorption spectrum, and solid state NMR spectrum.
  • TGA thermo gravimetric analysis -
  • DSC differential scanning calorimetry -
  • Discovering new polymorphic forms and solvates of a pharmaceutical product can provide materials having desirable processing properties, such as ease of handling, ease of processing, storage stability, and ease of purification or as desirable intermediate crystal forms that facilitate conversion to other polymorphic forms.
  • New polymorphic forms and solvates of a pharmaceutically useful compound or salts thereof can also provide an opportunity to improve the performance characteristics of a pharmaceutical product. It enlarges the repertoire of materials that a formulation scientist has available for formulation optimization, for example by providing a product with different properties, e.g., better processing or handling characteristics, improved dissolution profile, or improved shelf-life.
  • the invention comprises polymorphically pure crystalline fesoterodine fumarate denoted Form A characterized by data selected from: an X- ray powder diffraction having peaks at 11.5 and 11.8 (doublet), 14.9 and 15.1 (doublet), 24.1, 27.0 and 27.7 ⁇ 0.2 degrees two-theta; an X-ray powder diffraction pattern substantially as depicted in figure 1; a solid-state 13 C NMR spectrum having characteristic peaks at 18.0, 127.1 and 140.5, ⁇ 0.2 ppm; a solid state 13 C NMR spectrum having chemical shift differences between said characteristic peaks and a peak at 122.3 ⁇ 0.2 ppm of -104.3, 4.8 and 18.2 ⁇ 0.1 ppm, respectively; a solid-state 13 C NMR spectrum substantially as depicted in figure 8 and 9 and combinations thereof; wherein said polymorphically pure form contains up to 10% by weight of crystalline fesoterodine fumarate Form B as determined
  • the present invention comprises crystalline fesoterodine fumarate denoted Form B, characterized by data selected from: an X-ray powder diffraction pattern having peaks at 9.7, 12.2, 14.5, 18.6 and 19.5 ⁇ 0.2 degrees two- theta; an X-ray powder diffraction pattern substantially as depicted in figure 3; a solid-state 13 C NMR spectrum having characteristic peaks at 18.9, 34.9, 48.0, 53.6, 122.5, 127.4, 135.4, and 148.8 ppm ⁇ 0.2 ppm; a solid state 13 C NMR spectrum having chemical shifts differences between said characteristic peaks and a peak at 122.5 ⁇ 0.2 ppm of -103.6, -87.6, -74.5, -68.9, 4.9, 12.9, and 26.3 ⁇ 0.1 ppm, respectively; a solid-state 13 C NMR spectrum substantially as depicted in figure 12 and 13 and combinations thereof; wherein said polymorphically pure form contains
  • the present invention comprises polymorphically pure crystalline fesoterodine fumarate denoted form I characterized by data selected from: an X-ray powder diffraction (XRPD) pattern having peaks at 11.8, 14.9, 16.2 and 27.4 ⁇ 0.2 degrees two-theta; an XRPD pattern substantially as depicted in figure 17; a solid-state 13C NMR spectrum having characteristic peaks at 19.2, 58.0, 122.4, 135.2, 168.3 and 170.9 ppm ⁇ 0.2 ppm; a solid state 13C NMR spectrum having chemical shifts differences between said characteristic peaks and a peak at 122.4 ⁇ 0.2 ppm of -103.2, -64.4, 12.8, 45.9 and 48.5 ⁇ 0.1 ppm, respectively; a solid-state 13C NMR spectrum substantially as depicted in figure 18 and 19, and combinations thereof; wherein said polymorphically pure form contains up to 10% by weight of crystalline fesoterodine fuma
  • a crystalline form of fesoterodine fumarate is characterized by data selected from: a single crystal XRD with the following data: monoclinic crystal system; space group P2i; unit cell parameters: a, b, c: 22.332(2), 9.3990(6), 23.0310(16) [A], respectively, and alpha, beta, gamma: 90°, 116.493(10)°, 90°, [deg], respectively, and volume of: 4326.5(7) [A 3 ], Z of 6; a theoretical XRPD pattern calculated from single crystal data as depicted in figure 16.
  • the present invention comprises the use of any of the above described crystalline forms of fesoterodine fumarate of the present invention for the preparation of a formulation.
  • the present invention comprises a pharmaceutical composition comprising any one, or a combination, of the above described crystalline forms of fesoterodine fumarate of the present invention and at least one pharmaceutically acceptable excipient.
  • the present invention comprises the use of any of the above crystalline forms as a medicament and the use of any of these crystalline forms in the manufacture of a medicament to treat overactive bladder syndrome with symptoms of urgency, urinary incontinence and increased urinary frequency.
  • the present invention comprises a crystalline form of fesoterodine base, characterized by data selected from: an X-ray powder diffraction pattern having peaks at 8.8, 10.8, 19.0, 22.5 and 25.0 ⁇ 0.2 degrees two-theta; an XRPD pattern substantially as depicted in Figure 5; an FTIR spectrum substantially as depicted in Figure 6, and combinations thereof.
  • the present invention comprises the use of the above described polymorph of fesoterodine base to prepare fesoterodine fumarate.
  • the present invention comprises a process for preparing fesoterodine fumarate comprising preparing the above described polymorph of fesoterodine base by the process of the present invention and converting it to fesoterodine fumarate.
  • Figure 1 depicts a characteristic X-ray powder diffraction (XRPD) pattern of crystalline Fesoterodine fumarate polymorphically pure Form A according to ex.2.
  • Figure 2 depicts a characteristic X-ray powder diffraction (XRPD) pattern of crystalline Fesoterodine fumarate Form B according to ex.5.
  • XRPD characteristic X-ray powder diffraction
  • Figure 3 depicts a characteristic X-ray powder diffraction (XRPD) pattern of crystalline Fesoterodine fumarate polymorphically pure Form B according to ex.13.
  • Figure 4 depicts a characteristic X-ray powder diffraction (XRPD) pattern of crystalline Fesoterodine fumarate polymorphically pure Form I (polymorphically pure from Form B) according to ex.12.
  • XRPD characteristic X-ray powder diffraction
  • Figure 5 depicts a characteristic X-ray powder diffraction (XRPD) pattern of fesoterodine base according to ex.1.
  • Figure 6 depicts a FT-IR spectrum of crystalline fesoterodine base according to ex.1.
  • Figure 7 depicts a powder XRD pattern of Form A calculated from single crystal XRD data.
  • Figure 8 depicts a solid-state 13 C NMR spectrum of crystalline Fesoterodine fumarate polymorphically pure Form A according to ex.2.
  • Figure 9 depicts a solid-state 13 C NMR spectrum of crystalline Fesoterodine fumarate polymorphically pure Form A according to ex.2 in the range between 100-180 ppm.
  • Figure 10 depicts a solid-state 13C NMR spectrum of crystalline Fesoterodine fumarate Form B according to ex.5.
  • Figure 11 depicts a solid-state C NMR spectrum of crystalline Fesoterodine fumarate Form B according to ex.5, in the range between 100-180 ppm.
  • Figure 12 depicts a solid-state 13 C NMR spectrum of crystalline Fesoterodine fumarate polymorphically pure Form B according to ex.13.
  • Figure 13 depicts a solid-state 13C NMR spectrum of crystalline Fesoterodine fumarate polymorphically pure Form B according to ex. 13 in the range between 100-180 ppm.
  • Figure 14 depicts a solid-state 13 C NMR spectrum of crystalline Fesoterodine fumarate pure Form I (polymorphically pure from Form B) according to ex.12.
  • Figure 15 depicts a solid-state 13 C NMR spectrum of crystalline Fesoterodine fumarate pure Form I (polymorphically pure from Form B) according to ex.12 in the range between 100-180 ppm.
  • Figure 16 depicts a powder XRD pattern of Form C according to ex.9 calculated from single crystal XRD data.
  • Figure 17 depicts a characteristic X-ray powder diffraction (XRPD) pattern of polymorphically pure crystalline Fesoterodine fumarate Form I (polymorphically pure from Form A and B) according to ex.14.
  • XRPD X-ray powder diffraction
  • Figure 18 depicts a solid-state 13 C NMR spectrum of polymorphically pure crystalline Fesoterodine fumarate Form I (polymorphically pure from Form A and B) according to ex.14.
  • Figure 19 depicts a solid-state 13 C NMR spectrum of polymorphically pure crystalline Fesoterodine fumarate Form I (polymorphically pure from Form A and B) according to ex.14 in the range between 100-180 ppm.
  • the present invention encompasses crystalline forms of fesoterodine fumarate and fesoterodine base.
  • a crystal form may be referred to herein as being characterized by graphical data "as depicted in" a Figure.
  • Such data include, for example, powder X-ray diffractograms and solid state NMR spectra.
  • the skilled person will understand that such graphical representations of data may be subject to small variations, e.g., in peak relative intensities and peak positions due to factors such as variations in instrument response and variations in sample concentration and purity, which are well known to the skilled person. Nonetheless, the skilled person would readily be capable of comparing the graphical data in the Figures herein with graphical data generated for an unknown crystal form and confirm whether the two sets of graphical data are characterizing the same crystal form or two different crystal forms.
  • the present invention relates to polymorphically pure forms of fesoterodine fumarate, preferably wherein the forms are substantially free of any other polymorph forms.
  • Polymorphically pure therefore means 10% or less, more preferably 5% or less, most preferably 2% or less, particularly 0.2%> or less. For example, between 0.2%> and 10%>, between 0.2%> and 5% or between 0.2%> and 2%.
  • the present invention encompasses a polymorphically pure crystalline form of fesoterodine fumarate, denoted herein as pure Form A.
  • the polymorphically pure Form A can contain up to 10%), preferably up to 5%, and more preferably up to 2% by weight of crystalline fesoterodine fumarate Form B as determined by powder X-ray diffraction, and can contain up to 10%), preferably up to 5%, and more preferably up to 2% by weight by weight of crystalline fesoterodine fumarate Form I as determined by solid state 13 C NMR.
  • polymorphically pure crystalline form A of fesoterodine fumarate can contain between 0.2% and 10%, between 0.2% and 5% or between 0.2% and 2% by weight of crystalline fesoterodine fumarate denoted Form B and/or of crystalline fesoterodine fumarate denoted Form I.
  • the polymorphically pure crystalline fesoterodine fumarate Form A can be characterized by data selected from: an X-ray powder diffraction having peaks at 11.5 and 11.8 (doublet), 14.9 and 15.1 (doublet), 24.1, 27.0 and 27.7 ⁇ 0.2 degrees two-theta; an X-ray powder diffraction pattern substantially as depicted in figure 1; a solid-state C NMR spectrum having characteristic peaks at 18.0, 127.1 and 140.5, ⁇ 0.2 ppm; a solid state 13 C NMR spectrum having chemical shift differences between said characteristic peaks and a peak at 122.3 ⁇ 0.2 ppm of -104.3, 4.8 and 18.2 ⁇ 0.1 ppm, respectively; a solid-state 13 C NMR spectrum substantially as depicted in figure 8 and 9 and combinations thereof.
  • the presence and amount of crystalline fesoterodine fumarate Form B present as a polymorphic impurity can be determined using one or more XRD peaks selected from 9.7, 12.2, 14.5, 18.6 and 19.5 ⁇ 0.2 degrees two-theta.
  • the presence and amount of crystalline fesoterodine fumarate Form I present as a polymorphic impurity can be determined using one or more solid-state 13 C NMR peaks selected from 19.2, 58.0, 135.2, 168.3 and 170.9 ⁇ 0.2 ppm.
  • the polymorphically pure crystalline fesoterodine fumarate Form A may further characterized by additional X-ray diffraction peaks at 10.4, 12.8, 18.0, 18.9 and 20.8 ⁇ 0.2 degrees two-theta and by additional solid state 13 C NMR peaks at 122.3, 134.9, 138.6, 148.6 and 168.6 ⁇ 0.2 ppm; and by the solid state 13 C NMR chemical shifts differences between said additional 13 C NMR peaks and the 13 C NMR peak at 122.3 ⁇ 0.2 ppm of 12.6, 16.3, 26.3 and 46.3 ⁇ 0.1 ppm, respectively.
  • crystalline fesoterodine fumarate Form A can be characterized by a crystal structure corresponding to fesoterodine fumarate salt having a 1 : 1 ratio of fesoterodine to fumaric acid, i.e., one molecule of fesoterodine cation and one fumarate anion in the independent part of the unit cell.
  • the polymorphically pure crystalline fesoterodine fumarate Form A may be characterized by data selected from: a single crystal XRD with the following data: monoclinic crystal system; space group P2i; unit cell parameters: a, b, c: 7.6709(9), 9.3896(14), 20.099(4) [A], respectively, and alpha, beta, gamma: 90°, 96.321(15)°, 90° [deg], respectively, and volume of: 1438.9(4) [A 3 ], Z of 2 and a theoretical XRPD pattern calculated from single crystal data as depicted in figure 7.
  • a single crystal XRD with the following data: monoclinic crystal system; space group P2i; unit cell parameters: a, b, c: 7.6709(9), 9.3896(14), 20.099(4) [A], respectively, and alpha, beta, gamma: 90°, 96.321(15)°, 90° [deg], respectively, and volume of: 1438.9
  • the polymorphically pure crystalline fesoterodine fumarate Form A can be characterized by its melting point of 109°C (DSC onset measured at 105.6°C, and DSC peak measured at 109.6°C)
  • the present invention encompasses a polymorphically pure crystalline fesoterodine fumarate, denoted herein as pure Form B.
  • the polymorphically pure Form B can contain up to 10%, preferably up to 5%, and more preferably up to 2% by weight of crystalline fesoterodine fumarate Form A, and can contain up to 10%, preferably up to 5%, and more preferably up to 2% by weight by weight of crystalline fesoterodine fumarate Form I as determined by powder X-ray diffraction.
  • polymorphically pure crystalline form B of fesoterodine fumarate can contain between 0.2% and 10%, between 0.2% and 5% or between 0.2% and 2% by weight of crystalline fesoterodine fumarate denoted Form A and/or of crystalline fesoterodine fumarate denoted Form I.
  • the polymorphically pure crystalline fesoterodine fumarate Form B can be characterized by data selected from: an X-ray powder diffraction pattern having peaks at 9.7, 12.2, 14.5, 18.6 and 19.5 ⁇ 0.2 degrees two-theta; an X-ray powder diffraction pattern substantially as depicted in figure 3; a solid-state 13 C NMR spectrum having characteristic peaks at 18.9, 34.9, 48.0, 53.6, 122.5, 127.4, 135.4, and 148.8 ppm ⁇ 0.2 ppm; a solid state 13 C NMR spectrum having chemical shifts differences between said characteristic peaks and a peak at 122.5 ⁇ 0.2 ppm of -103.6, -87.6, -74.5, -68.9, 4.9, 12.9, and 26.3 ⁇ 0.1 ppm, respectively; a solid-state 13 C NMR spectrum substantially as depicted in figure 12 and 13 and combinations thereof.
  • the presence and amount of crystalline fesoterodine fumarate Forms A and I, present as polymorphic impurities, can be determined using one or more XRD peaks selected from 12.8, 18.0 and 20.8 ⁇ 0.2 degrees two-theta, an XRPD diffraction pattern substantially as depicted in figures 1, 4 and 17, and combinations thereof.
  • the polymorphically pure crystalline fesoterodine fumarate Form B may further characterized by additional X-ray peaks at 10.4, 17.6, 20.0, 21.4 and 26.0 ⁇ 0.2 degrees two-theta.
  • the present invention encompasses polymorphically pure crystalline fesoterodine fumarate denoted herein as pure Form I.
  • the polymorphically pure Form I can contain up to 10%), preferably up to 5%, and more preferably up to 2% by weight of crystalline fesoterodine fumarate Form A as determined by powder X-ray diffraction or solid state C NMR, and can contain up to 10%, preferably up to 5%, and more preferably up to 2% by weight by weight of crystalline fesoterodine fumarate Form B as determined by solid state 13 C NMR.
  • polymorphically pure crystalline form I of fesoterodine fumarate can contain between 0.2% and 10%>, between 0.2%> and 5% or between 0.2%> and 2% by weight of crystalline fesoterodine fumarate denoted Form A and/or of crystalline
  • fesoterodine fumarate denoted Form B.
  • polymorphically pure crystalline fesoterodine fumarate Form I that is pure from Form B.
  • polymorphically pure crystalline fesoterodine fumarate Form I that is pure from Form A and Form B.
  • the polymorphically pure crystalline fesoterodine fumarate Form I can be characterized by data selected from: an X-ray powder diffraction (XRPD) pattern having peaks at 11.8, 14.9, 16.2 and 27.4 ⁇ 0.2 degrees two-theta; an XRPD pattern substantially as depicted in figure 17; a solid-state 13 C NMR spectrum having characteristic peaks at 19.2, 58.0, 122.4, 135.2, 168.3 and 170.9 ppm ⁇ 0.2 ppm; a solid state 13 C NMR spectrum having chemical shifts differences between said characteristic peaks and a peak at 122.4 ⁇ 0.2 ppm of -103.2, -64.4, 12.8, 45.9 and 48.5 ⁇ 0.1 ppm, respectively; a solid-state 13 C NMR spectrum substantially as depicted in figure 18 and 19, and combinations thereof.
  • XRPD X-ray powder diffraction
  • the presence and amount of Form A that may be present as a polymorphic impurity may be detected by one or more XRD peaks at 1 1.5, 15.1, 24.1, 27.0 27.7 ⁇ 0.2 degrees two-theta or by one or more solid state 13 C NMR peaks at 18.0, 127.1 and 140.5 ⁇ 0.2 ppm.
  • the presence and amount of Form B may be detected by one or more XRD peaks at 9.7, 12.2, 14.5, 18.6 and 19.5 ⁇ 0.2 degrees two-theta; an XRPD pattern substantially as depicted in figure 1 and 2, and 3 and combinations thereof.
  • the present invention encompasses polymorphically pure crystalline fesoterodine fumarate Form I that is pure from Forms A and B.
  • Pure Form I pure from Forms A and B can be characterized by data selected from: an X-ray powder diffraction (XRPD) pattern having typical peaks at 11.8, 14.9, 16.2 and 27.4 ⁇ 0.2 degrees two-theta and absence of diffraction peaks at 11.5, 15.1, 24.1, 27.0 and 27.7 ⁇ 0.2 degrees two-theta; an XRPD pattern substantially as depicted in figure 17; a solid-state 13C NMR spectrum having characteristic peaks at 19.2, 58.0, 122.4, 135.2, 168.3 and 170.9 ppm ⁇ 0.2 ppm; a solid state 13C NMR spectrum having chemical shifts differences between said characteristic peaks and a peak at 122.4 ⁇ 0.2 ppm of -103.2, -64.4, 12.8, 45.9 and 48.5 ⁇ 0.1 pp
  • the present invention further provides a crystalline form of fesoterodine fumarate, denoted Form C.
  • Form C is characterized by data selected from: a single crystal XRD with the following data: monoclinic crystal system; space group P2i; unit cell parameters: a, b, c: 22.332(2), 9.3990(6), 23.0310(16) [A], respectively, and alpha, beta, gamma: 90°, 116.493(10)°, 90°, [deg], respectively, and volume of: 4326.5(7) [A 3 ], Z of 6; a theoretical XRPD pattern calculated from single crystal data as depicted in figure 16.
  • crystalline fesoterodine fumarate Form C can be characterized by a structure of fesoterodine fumarate salt having a ratio of 1 : 1 of fesoterodine to fumaric acid, i.e., three distinct symmetry-independent molecules of the fesoterodine cation and three symmetry independent molecules of the fumarate anion in the independent part of the unit cell.
  • the above crystalline forms of fesoterodine fumarate can be used to prepare formulations by any method known in the art.
  • the present invention also encompasses a pharmaceutical formulation comprising any of the above crystalline forms and at least one pharmaceutically acceptable excipient.
  • any of the above crystalline forms as a medicament and the use of any of these crystalline forms in the manufacture of a medicament to treat overactive bladder syndrome with symptoms of urgency, urinary incontinence and increased urinary frequency.
  • the present invention comprises a crystalline form of fesoterodine base, characterized by data selected from: an X-ray powder diffraction pattern having peaks at 8.8, 10.8, 19.0, 22.5 and 25.0 ⁇ 0.2 degrees two-theta; an XRPD pattern substantially as depicted in Figure 5, and combinations thereof.
  • the above crystalline fesoterodine base can be further characterized by data selected from: an X-ray powder diffraction pattern having additional peaks at 13.7, 15.6, 16.8, 20.3, 21.7 and 23.5 ⁇ 0.2 degrees two-theta; a FT-IR spectrum having peaks at 3595, 2983, 2713, 1741, 1496, 1469, 1387, 1354, 1213, 1177, 1137, 1034, 871, 820 and 700 cm “1 ⁇ 4 cm "1 ; a FT-IR spectrum substantially as depicted in Figure 6, and combinations thereof.
  • the above crystalline fesoterodine base can be used to prepare a fesoterodine salt, preferably, a fesoterodine fumarate salt.
  • a fesoterodine salt can be prepared, for example, by a process comprising preparing the above described polymorph of fesoterodine base by the process of the present invention and converting it to a fesoterodine salt. The conversion can be done, for example, by reacting fesoterodine base polymorph with a suitable acid, such as fumaric acid.
  • USP melting point was measured by BLTCHI B-545 equipment using the following parameters: Heating rate: l°C/min, Scan range 80-120°C.
  • Example 1 Process for preparing fesoterodine base
  • Example 2 Process for preparing polymorphically pure crystalline fesoterodine fumarate Form A
  • Fesoterodine base (199.5 g) was dissolved in 1540 ml of 3-pentanone.
  • Example 3 Process for preparing polymorphically pure crystalline fesoterodine fumarate Form A
  • Example 4 Process for preparing polymorphically pure crystalline fesoterodine fumarate Form A
  • Fesoterodine fumarate (1.0 g) was dissolved in 20 ml of 3-pentanone at 40-
  • Example 5 Process for preparing crystalline fesoterodine fumarate Form B
  • Fesoterodine fumarate (3 g) was dissolved by warming in a mixture of 2- butanone (2.5 ml) and isobutyl-methyl ketone (2.5 ml). Isobutyl-methyl ketone (20 ml) was added to the mixture, and then that mixture was cooled to 20-25°C and stirred for 16 hours. Crystals formed and were filtered off, washed with isobutyl-methyl ketone (5 ml), and air dried for 24 hours to yield 2.42 g (81 % yield) of the product.
  • Example 6 Process for preparing crystalline fesoterodine fumarate Form B
  • Fesoterodine fumarate (0.5 g) was dissolved by warming in isobutyl-methyl ketone (20 ml). The solution was cooled to 20-25°C and stirred for 3 hours. Crystals formed and were filtered off, washed with isobutyl-methyl ketone (5 ml), and air dried for 24 hours to yield 0.2 lg (42 % yield) of the product.
  • Example 7 Process for preparing crystalline fesoterodine fumarate Form B
  • Fesoterodine fumarate 0.5 g was dissolved in DCM (5 ml). Ethyl acetate (10 ml) was added to the solution, and then the DCM was evaporated. The thus-formed slurry was cooled to 20-25°C and stirred for 3 hours. Crystals formed and were filtered off, washed with ethyl acetate (5 ml), and air dried for 24 hours to yield 0.35 g (70 % yield) of the product.
  • Example 8 Process for preparing crystalline fesoterodine fumarate Form B
  • Example 9 Process for preparing a mixture of crystalline fesoterodine fumarate Form A and Form C single crystal
  • Fesoterodine fumarate 150 mg was dissolved in a mixture of isobutyl methyl ketone (7 ml) and acetone (0.9 ml) by heating to 50oC. The solution was allowed to stand in an open glass vial for 5 days. During this period the solvents were partially evaporated. Part of the fesoterodine fumarate precipitated as an oil and some crystals were formed on the interface of the precipitated oil. The crystals were isolated by filtration, and used for the crystal structure determination.
  • Fesoterodine base (appr. 0.2 g) was dissolved in dimethylcarbonate (appr. 0.1 ml).
  • n-Heptane (appr. 2 ml) was added dropwise at room temperature while the mixture was stirred vigorously. The mixture was stirred for further 2 hrs to form a suspension.
  • Fesoterodine base (3.7 g) was dissolved in dimethylcarbonate (15 ml), and n- heptane (15 ml) was added dropwise to the stirred solution at 20-25°C.
  • the mixture was seeded with crystals from the suspension prepared in example 10.
  • the mixture was stirred at 20-25°C for 2 hrs. Additional n-heptane (10 ml) was added, and this mixture was stirred for 20 minutes.
  • the resulting suspension was filtered, and the separated solid was washed with 5 ml of n-heptane.
  • the prepared solid was dried under vacuum at 45°C under nitrogen for 1 day. The obtained dry white solid (0.53 g) was analyzed by XRPD.
  • Example 12 Process for preparing crystalline fesoterodine fumarate pure Form I
  • Fesoterodine base (31.4 g) was dissolved in 82 ml of 2-butanone at 20-25°C.
  • Example 13 Process for preparing crystalline fesoterodine fumarate pure Form B
  • Fesoterodine fumarate (6 g) was dissolved by warming in a mixture of 2- butanone (5.0 ml) and isobutyl-methyl ketone (5.0 ml). Isobutyl-methyl ketone (40 ml) was added to the mixture, and the resulting mixture was cooled to 20-25°C and stirred for 16 hours. Crystals formed and were filtered off, and air dried for 24 hours to yield 5.59 g (93 % yield) of the product.
  • Example 14 Process for preparing crystalline fesoterodine fumarate pure Form I
  • Fesoterodine base (8.0 g) was dissolved in 36 ml acetone. To the stirred solution 2.24 g fumaric acid was added and dissolved at 35-40°C. The clear solution was then evaporated totally. From the obtained residue, 3.2 g was dissolved in 10 ml 2-butanone. The resulting solution was divided into 4 parts. To one stirred part n-heptane (15 ml) was added dropwise while the temperature was set to 0°C by ice/water cooling. The formed mixture was stirred vigorously at 0°C for 4-5 hrs, settled at 2-8°C overnight then stirred vigorously at 0°C for an additional 2-3 hrs. The suspension was then filtered and washed with n-heptane (1-2 ml). The resulting white solid was dried at 40-45°C, to provide 430 mg of dry material.

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Polymorphically pure crystalline forms of fesoterodine fumarate and fesoterodine base are described and characterized.

Description

Crystalline Forms of Fesoterodine Fumarate and Fesoterodine Base
CROSS-REFERENCE TO RELATED APPLICATIONS
[0001] This application claims the benefit of U.S. Provisional Patent Application
Serial Nos. 61/239,491, filed September 3, 2009, 61/240,271, filed September 7, 2009, 61/258,321, filed November 5, 2009, 61/286,829, filed December 16, 2009, and 61/333,071, filed May 10, 2010, which are incorporated herein by reference.
FIELD OF THE INVENTION
[0002] The present invention relates to crystalline forms of fesoterodine fumarate and fesoterodine base.
BACKGROUND OF THE INVENTION
[0003] Fesoterodine fumarate is a selective M3 antimuscarinic agent indicated for the treatment of overactive bladder syndrome with symptoms of urgency, urinary incontinence and increased urinary frequency.
[0004] The chemical name of Fesoterodine fumarate is isobutyric acid 2-(3-(diiso- propylamino)-l-(R)-phenylpropyl)-4-(hydroxymethyl) phenyl ester hydrogenfumarate, having the following structure:
Fesoterodine fumarate is marketed under the trade name TOVIAZ® by Pfizer.
[0005] Salts of fesoterodine and their preparation are reported in US 6,858,650 and in patent application WO 2007/140986. Other forms of fesoterodine previously described include fesoterodine base, disclosed in US patent application 2006/0014832, US patent application 2010/0152483, EP 2196452, and amorphous fesoterodine fumarate, disclosed in patent application WO 2009/044278.
[0006] Polymorphism, the occurrence of different crystal forms, is a property of some molecules and molecular complexes. A single molecule may give rise to a variety of polymorphs having distinct crystal structures and physical properties like melting point, thermal behaviors (e.g. measured by thermo gravimetric analysis - "TGA", or differential scanning calorimetry - "DSC"), x-ray diffraction pattern, infrared absorption spectrum, and solid state NMR spectrum. One or more of these techniques may be used to distinguish different polymorphic forms of a compound.
[0007] Discovering new polymorphic forms and solvates of a pharmaceutical product can provide materials having desirable processing properties, such as ease of handling, ease of processing, storage stability, and ease of purification or as desirable intermediate crystal forms that facilitate conversion to other polymorphic forms. New polymorphic forms and solvates of a pharmaceutically useful compound or salts thereof can also provide an opportunity to improve the performance characteristics of a pharmaceutical product. It enlarges the repertoire of materials that a formulation scientist has available for formulation optimization, for example by providing a product with different properties, e.g., better processing or handling characteristics, improved dissolution profile, or improved shelf-life. For at least these reasons, there is a need in the art for additional solid state forms of fesoterodine fumarate and of fesoterodine base and for additional methods for preparing fesoterodine fumarate and fesoterodine base crystal forms that provide fesoterodine efficiently and can be applied on an industrial scale.
SUMMARY OF THE INVENTION
[0008] According to one embodiment the invention comprises polymorphically pure crystalline fesoterodine fumarate denoted Form A characterized by data selected from: an X- ray powder diffraction having peaks at 11.5 and 11.8 (doublet), 14.9 and 15.1 (doublet), 24.1, 27.0 and 27.7 ± 0.2 degrees two-theta; an X-ray powder diffraction pattern substantially as depicted in figure 1; a solid-state 13C NMR spectrum having characteristic peaks at 18.0, 127.1 and 140.5, ± 0.2 ppm; a solid state 13C NMR spectrum having chemical shift differences between said characteristic peaks and a peak at 122.3 ± 0.2 ppm of -104.3, 4.8 and 18.2 ± 0.1 ppm, respectively; a solid-state 13C NMR spectrum substantially as depicted in figure 8 and 9 and combinations thereof; wherein said polymorphically pure form contains up to 10% by weight of crystalline fesoterodine fumarate Form B as determined by using one or more XRD peaks selected from 9.7, 12.2, 14.5, 18.6 and 19.5 ± 0.2 degrees two-theta, and contains up to 10% by weight of crystalline fesoterodine fumarate Form I as determined by using one or more solid-state 13C NMR peaks selected from 19.2, 58.0, 135.2, 168.3 and 170.9 ± 0.2 ppm.
[0009] In another embodiment, the present invention comprises crystalline fesoterodine fumarate denoted Form B, characterized by data selected from: an X-ray powder diffraction pattern having peaks at 9.7, 12.2, 14.5, 18.6 and 19.5 ± 0.2 degrees two- theta; an X-ray powder diffraction pattern substantially as depicted in figure 3; a solid-state 13C NMR spectrum having characteristic peaks at 18.9, 34.9, 48.0, 53.6, 122.5, 127.4, 135.4, and 148.8 ppm ± 0.2 ppm; a solid state 13C NMR spectrum having chemical shifts differences between said characteristic peaks and a peak at 122.5 ± 0.2 ppm of -103.6, -87.6, -74.5, -68.9, 4.9, 12.9, and 26.3 ± 0.1 ppm, respectively; a solid-state 13C NMR spectrum substantially as depicted in figure 12 and 13 and combinations thereof; wherein said polymorphically pure form contains up to 10% by weight of crystalline fesoterodine fumarate Form A up to 10% by weight of crystalline fesoterodine fumarate Form I as determined by using one or more XRD peaks selected from 12.8, 18.0 and 20.8 ± 0.2 degrees two-theta.
[00010] In another embodiment, the present invention comprises polymorphically pure crystalline fesoterodine fumarate denoted form I characterized by data selected from: an X-ray powder diffraction (XRPD) pattern having peaks at 11.8, 14.9, 16.2 and 27.4 ± 0.2 degrees two-theta; an XRPD pattern substantially as depicted in figure 17; a solid-state 13C NMR spectrum having characteristic peaks at 19.2, 58.0, 122.4, 135.2, 168.3 and 170.9 ppm ± 0.2 ppm; a solid state 13C NMR spectrum having chemical shifts differences between said characteristic peaks and a peak at 122.4 ± 0.2 ppm of -103.2, -64.4, 12.8, 45.9 and 48.5 ± 0.1 ppm, respectively; a solid-state 13C NMR spectrum substantially as depicted in figure 18 and 19, and combinations thereof; wherein said polymorphically pure form contains up to 10% by weight of crystalline fesoterodine fumarate Form A as determined by using one or more XRD peaks selected from 11.5, 15.1, 24.1 and 27.7 ± 0.2 degrees two-theta or one or more solid state 13C NMR peaks selected from 18.0, 127.1 and 140.5± 0.2 ppm, and up to 10% by weight of crystalline fesoterodine fumarate Form B as determined by using one or more XRD peaks selected from 9.7, 12.2, 14.5, 18.6 and 19.5 ± 0.2 degrees two-theta.
[00011] A crystalline form of fesoterodine fumarate, denoted Form C, is characterized by data selected from: a single crystal XRD with the following data: monoclinic crystal system; space group P2i; unit cell parameters: a, b, c: 22.332(2), 9.3990(6), 23.0310(16) [A], respectively, and alpha, beta, gamma: 90°, 116.493(10)°, 90°, [deg], respectively, and volume of: 4326.5(7) [A3], Z of 6; a theoretical XRPD pattern calculated from single crystal data as depicted in figure 16.
[00012] In one embodiment, the present invention comprises the use of any of the above described crystalline forms of fesoterodine fumarate of the present invention for the preparation of a formulation.
[00013] In another embodiment, the present invention comprises a pharmaceutical composition comprising any one, or a combination, of the above described crystalline forms of fesoterodine fumarate of the present invention and at least one pharmaceutically acceptable excipient.
[00014] In another embodiment, the present invention comprises the use of any of the above crystalline forms as a medicament and the use of any of these crystalline forms in the manufacture of a medicament to treat overactive bladder syndrome with symptoms of urgency, urinary incontinence and increased urinary frequency.
[00015] In another embodiment, the present invention comprises a crystalline form of fesoterodine base, characterized by data selected from: an X-ray powder diffraction pattern having peaks at 8.8, 10.8, 19.0, 22.5 and 25.0 ± 0.2 degrees two-theta; an XRPD pattern substantially as depicted in Figure 5; an FTIR spectrum substantially as depicted in Figure 6, and combinations thereof.
[00016] In one embodiment, the present invention comprises the use of the above described polymorph of fesoterodine base to prepare fesoterodine fumarate. [00017] In another embodiment, the present invention comprises a process for preparing fesoterodine fumarate comprising preparing the above described polymorph of fesoterodine base by the process of the present invention and converting it to fesoterodine fumarate.
BRIEF DESCRIPTION OF THE FIGURES
[00018] Figure 1 depicts a characteristic X-ray powder diffraction (XRPD) pattern of crystalline Fesoterodine fumarate polymorphically pure Form A according to ex.2.
[00019] Figure 2 depicts a characteristic X-ray powder diffraction (XRPD) pattern of crystalline Fesoterodine fumarate Form B according to ex.5.
[00020] Figure 3 depicts a characteristic X-ray powder diffraction (XRPD) pattern of crystalline Fesoterodine fumarate polymorphically pure Form B according to ex.13.
[00021] Figure 4 depicts a characteristic X-ray powder diffraction (XRPD) pattern of crystalline Fesoterodine fumarate polymorphically pure Form I (polymorphically pure from Form B) according to ex.12.
[00022] Figure 5 depicts a characteristic X-ray powder diffraction (XRPD) pattern of fesoterodine base according to ex.1.
[00023] Figure 6 depicts a FT-IR spectrum of crystalline fesoterodine base according to ex.1.
[00024] Figure 7 depicts a powder XRD pattern of Form A calculated from single crystal XRD data.
[00025] Figure 8 depicts a solid-state 13C NMR spectrum of crystalline Fesoterodine fumarate polymorphically pure Form A according to ex.2.
[00026] Figure 9 depicts a solid-state 13C NMR spectrum of crystalline Fesoterodine fumarate polymorphically pure Form A according to ex.2 in the range between 100-180 ppm.
[00027] Figure 10 depicts a solid-state 13C NMR spectrum of crystalline Fesoterodine fumarate Form B according to ex.5. [00028] Figure 11 depicts a solid-state C NMR spectrum of crystalline Fesoterodine fumarate Form B according to ex.5, in the range between 100-180 ppm.
[00029] Figure 12 depicts a solid-state 13C NMR spectrum of crystalline Fesoterodine fumarate polymorphically pure Form B according to ex.13.
[00030] Figure 13 depicts a solid-state 13C NMR spectrum of crystalline Fesoterodine fumarate polymorphically pure Form B according to ex. 13 in the range between 100-180 ppm.
[00031] Figure 14 depicts a solid-state 13C NMR spectrum of crystalline Fesoterodine fumarate pure Form I (polymorphically pure from Form B) according to ex.12.
[00032] Figure 15 depicts a solid-state 13C NMR spectrum of crystalline Fesoterodine fumarate pure Form I (polymorphically pure from Form B) according to ex.12 in the range between 100-180 ppm.
[00033] Figure 16 depicts a powder XRD pattern of Form C according to ex.9 calculated from single crystal XRD data.
[00034] Figure 17 depicts a characteristic X-ray powder diffraction (XRPD) pattern of polymorphically pure crystalline Fesoterodine fumarate Form I (polymorphically pure from Form A and B) according to ex.14.
[00035] Figure 18 depicts a solid-state 13C NMR spectrum of polymorphically pure crystalline Fesoterodine fumarate Form I (polymorphically pure from Form A and B) according to ex.14.
[00036] Figure 19 depicts a solid-state 13C NMR spectrum of polymorphically pure crystalline Fesoterodine fumarate Form I (polymorphically pure from Form A and B) according to ex.14 in the range between 100-180 ppm.
DETAILED DESCRIPTION OF THE INVENTION
[00037] The present invention encompasses crystalline forms of fesoterodine fumarate and fesoterodine base.
[00038] A crystal form may be referred to herein as being characterized by graphical data "as depicted in" a Figure. Such data include, for example, powder X-ray diffractograms and solid state NMR spectra. The skilled person will understand that such graphical representations of data may be subject to small variations, e.g., in peak relative intensities and peak positions due to factors such as variations in instrument response and variations in sample concentration and purity, which are well known to the skilled person. Nonetheless, the skilled person would readily be capable of comparing the graphical data in the Figures herein with graphical data generated for an unknown crystal form and confirm whether the two sets of graphical data are characterizing the same crystal form or two different crystal forms.
[00039] The present invention relates to polymorphically pure forms of fesoterodine fumarate, preferably wherein the forms are substantially free of any other polymorph forms. Polymorphically pure therefore means 10% or less, more preferably 5% or less, most preferably 2% or less, particularly 0.2%> or less. For example, between 0.2%> and 10%>, between 0.2%> and 5% or between 0.2%> and 2%.
[00040] In one embodiment the present invention encompasses a polymorphically pure crystalline form of fesoterodine fumarate, denoted herein as pure Form A.
[00041] According to one embodiment, the polymorphically pure Form A can contain up to 10%), preferably up to 5%, and more preferably up to 2% by weight of crystalline fesoterodine fumarate Form B as determined by powder X-ray diffraction, and can contain up to 10%), preferably up to 5%, and more preferably up to 2% by weight by weight of crystalline fesoterodine fumarate Form I as determined by solid state 13C NMR.
[00042] For example, polymorphically pure crystalline form A of fesoterodine fumarate, can contain between 0.2% and 10%, between 0.2% and 5% or between 0.2% and 2% by weight of crystalline fesoterodine fumarate denoted Form B and/or of crystalline fesoterodine fumarate denoted Form I.
[00043] According to one embodiment, the polymorphically pure crystalline fesoterodine fumarate Form A can be characterized by data selected from: an X-ray powder diffraction having peaks at 11.5 and 11.8 (doublet), 14.9 and 15.1 (doublet), 24.1, 27.0 and 27.7 ± 0.2 degrees two-theta; an X-ray powder diffraction pattern substantially as depicted in figure 1; a solid-state C NMR spectrum having characteristic peaks at 18.0, 127.1 and 140.5, ± 0.2 ppm; a solid state 13C NMR spectrum having chemical shift differences between said characteristic peaks and a peak at 122.3 ± 0.2 ppm of -104.3, 4.8 and 18.2 ± 0.1 ppm, respectively; a solid-state 13C NMR spectrum substantially as depicted in figure 8 and 9 and combinations thereof. The presence and amount of crystalline fesoterodine fumarate Form B present as a polymorphic impurity can be determined using one or more XRD peaks selected from 9.7, 12.2, 14.5, 18.6 and 19.5 ± 0.2 degrees two-theta. The presence and amount of crystalline fesoterodine fumarate Form I present as a polymorphic impurity can be determined using one or more solid-state 13C NMR peaks selected from 19.2, 58.0, 135.2, 168.3 and 170.9 ± 0.2 ppm.
[00044] The polymorphically pure crystalline fesoterodine fumarate Form A, characterized as described above, may further characterized by additional X-ray diffraction peaks at 10.4, 12.8, 18.0, 18.9 and 20.8 ± 0.2 degrees two-theta and by additional solid state 13C NMR peaks at 122.3, 134.9, 138.6, 148.6 and 168.6± 0.2 ppm; and by the solid state 13C NMR chemical shifts differences between said additional 13C NMR peaks and the 13C NMR peak at 122.3 ± 0.2 ppm of 12.6, 16.3, 26.3 and 46.3 ± 0.1 ppm, respectively.
[00045] The data above shows that crystalline fesoterodine fumarate Form A can be characterized by a crystal structure corresponding to fesoterodine fumarate salt having a 1 : 1 ratio of fesoterodine to fumaric acid, i.e., one molecule of fesoterodine cation and one fumarate anion in the independent part of the unit cell.
[00046] According to another embodiment, the polymorphically pure crystalline fesoterodine fumarate Form A may be characterized by data selected from: a single crystal XRD with the following data: monoclinic crystal system; space group P2i; unit cell parameters: a, b, c: 7.6709(9), 9.3896(14), 20.099(4) [A], respectively, and alpha, beta, gamma: 90°, 96.321(15)°, 90° [deg], respectively, and volume of: 1438.9(4) [A3], Z of 2 and a theoretical XRPD pattern calculated from single crystal data as depicted in figure 7.
[00047] According to another embodiment, the polymorphically pure crystalline fesoterodine fumarate Form A can be characterized by its melting point of 109°C (DSC onset measured at 105.6°C, and DSC peak measured at 109.6°C) [00048] In another embodiment, the present invention encompasses a polymorphically pure crystalline fesoterodine fumarate, denoted herein as pure Form B.
[00049] According to one embodiment, the polymorphically pure Form B can contain up to 10%, preferably up to 5%, and more preferably up to 2% by weight of crystalline fesoterodine fumarate Form A, and can contain up to 10%, preferably up to 5%, and more preferably up to 2% by weight by weight of crystalline fesoterodine fumarate Form I as determined by powder X-ray diffraction. For example, polymorphically pure crystalline form B of fesoterodine fumarate, can contain between 0.2% and 10%, between 0.2% and 5% or between 0.2% and 2% by weight of crystalline fesoterodine fumarate denoted Form A and/or of crystalline fesoterodine fumarate denoted Form I.
[00050] The polymorphically pure crystalline fesoterodine fumarate Form B can be characterized by data selected from: an X-ray powder diffraction pattern having peaks at 9.7, 12.2, 14.5, 18.6 and 19.5 ± 0.2 degrees two-theta; an X-ray powder diffraction pattern substantially as depicted in figure 3; a solid-state 13C NMR spectrum having characteristic peaks at 18.9, 34.9, 48.0, 53.6, 122.5, 127.4, 135.4, and 148.8 ppm ± 0.2 ppm; a solid state 13C NMR spectrum having chemical shifts differences between said characteristic peaks and a peak at 122.5 ± 0.2 ppm of -103.6, -87.6, -74.5, -68.9, 4.9, 12.9, and 26.3 ± 0.1 ppm, respectively; a solid-state 13C NMR spectrum substantially as depicted in figure 12 and 13 and combinations thereof. The presence and amount of crystalline fesoterodine fumarate Forms A and I, present as polymorphic impurities, can be determined using one or more XRD peaks selected from 12.8, 18.0 and 20.8 ± 0.2 degrees two-theta, an XRPD diffraction pattern substantially as depicted in figures 1, 4 and 17, and combinations thereof.
[00051] The polymorphically pure crystalline fesoterodine fumarate Form B, characterized as described above, may further characterized by additional X-ray peaks at 10.4, 17.6, 20.0, 21.4 and 26.0± 0.2 degrees two-theta.
[00052] In another embodiment, the present invention encompasses polymorphically pure crystalline fesoterodine fumarate denoted herein as pure Form I.
[00053] According to one embodiment, the polymorphically pure Form I can contain up to 10%), preferably up to 5%, and more preferably up to 2% by weight of crystalline fesoterodine fumarate Form A as determined by powder X-ray diffraction or solid state C NMR, and can contain up to 10%, preferably up to 5%, and more preferably up to 2% by weight by weight of crystalline fesoterodine fumarate Form B as determined by solid state 13C NMR. For example, polymorphically pure crystalline form I of fesoterodine fumarate, can contain between 0.2% and 10%>, between 0.2%> and 5% or between 0.2%> and 2% by weight of crystalline fesoterodine fumarate denoted Form A and/or of crystalline
fesoterodine fumarate denoted Form B. According to another embodiment, there is provided polymorphically pure crystalline fesoterodine fumarate Form I that is pure from Form B. According to yet another embodiment, there is provided polymorphically pure crystalline fesoterodine fumarate Form I that is pure from Form A and Form B.
[00054] The polymorphically pure crystalline fesoterodine fumarate Form I can be characterized by data selected from: an X-ray powder diffraction (XRPD) pattern having peaks at 11.8, 14.9, 16.2 and 27.4 ± 0.2 degrees two-theta; an XRPD pattern substantially as depicted in figure 17; a solid-state 13C NMR spectrum having characteristic peaks at 19.2, 58.0, 122.4, 135.2, 168.3 and 170.9 ppm ± 0.2 ppm; a solid state 13C NMR spectrum having chemical shifts differences between said characteristic peaks and a peak at 122.4 ± 0.2 ppm of -103.2, -64.4, 12.8, 45.9 and 48.5 ± 0.1 ppm, respectively; a solid-state 13C NMR spectrum substantially as depicted in figure 18 and 19, and combinations thereof. The presence and amount of Form A that may be present as a polymorphic impurity may be detected by one or more XRD peaks at 1 1.5, 15.1, 24.1, 27.0 27.7 ± 0.2 degrees two-theta or by one or more solid state 13C NMR peaks at 18.0, 127.1 and 140.5 ± 0.2 ppm. The presence and amount of Form B may be detected by one or more XRD peaks at 9.7, 12.2, 14.5, 18.6 and 19.5 ± 0.2 degrees two-theta; an XRPD pattern substantially as depicted in figure 1 and 2, and 3 and combinations thereof.
[00055] According to another embodiment, the present invention encompasses polymorphically pure crystalline fesoterodine fumarate Form I that is pure from Forms A and B. Pure Form I pure from Forms A and B can be characterized by data selected from: an X-ray powder diffraction (XRPD) pattern having typical peaks at 11.8, 14.9, 16.2 and 27.4 ± 0.2 degrees two-theta and absence of diffraction peaks at 11.5, 15.1, 24.1, 27.0 and 27.7 ± 0.2 degrees two-theta; an XRPD pattern substantially as depicted in figure 17; a solid-state 13C NMR spectrum having characteristic peaks at 19.2, 58.0, 122.4, 135.2, 168.3 and 170.9 ppm ± 0.2 ppm; a solid state 13C NMR spectrum having chemical shifts differences between said characteristic peaks and a peak at 122.4 ± 0.2 ppm of -103.2, -64.4, 12.8, 45.9 and 48.5 ± 0.1 ppm respectively; a solid-state 13C NMR spectrum substantially as depicted in figure 18 and 19, and combinations thereof.
[00056] The present invention further provides a crystalline form of fesoterodine fumarate, denoted Form C. Form C is characterized by data selected from: a single crystal XRD with the following data: monoclinic crystal system; space group P2i; unit cell parameters: a, b, c: 22.332(2), 9.3990(6), 23.0310(16) [A], respectively, and alpha, beta, gamma: 90°, 116.493(10)°, 90°, [deg], respectively, and volume of: 4326.5(7) [A3], Z of 6; a theoretical XRPD pattern calculated from single crystal data as depicted in figure 16.
[00057] The data above shows that crystalline fesoterodine fumarate Form C can be characterized by a structure of fesoterodine fumarate salt having a ratio of 1 : 1 of fesoterodine to fumaric acid, i.e., three distinct symmetry-independent molecules of the fesoterodine cation and three symmetry independent molecules of the fumarate anion in the independent part of the unit cell.
[00058] The above crystalline forms of fesoterodine fumarate can be used to prepare formulations by any method known in the art. The present invention also encompasses a pharmaceutical formulation comprising any of the above crystalline forms and at least one pharmaceutically acceptable excipient.
[00059] Also encompassed by the present invention is the use of any of the above crystalline forms as a medicament and the use of any of these crystalline forms in the manufacture of a medicament to treat overactive bladder syndrome with symptoms of urgency, urinary incontinence and increased urinary frequency.
[00060] In another embodiment, the present invention comprises a crystalline form of fesoterodine base, characterized by data selected from: an X-ray powder diffraction pattern having peaks at 8.8, 10.8, 19.0, 22.5 and 25.0 ± 0.2 degrees two-theta; an XRPD pattern substantially as depicted in Figure 5, and combinations thereof.
[00061] The above crystalline fesoterodine base can be further characterized by data selected from: an X-ray powder diffraction pattern having additional peaks at 13.7, 15.6, 16.8, 20.3, 21.7 and 23.5 ± 0.2 degrees two-theta; a FT-IR spectrum having peaks at 3595, 2983, 2713, 1741, 1496, 1469, 1387, 1354, 1213, 1177, 1137, 1034, 871, 820 and 700 cm"1 ± 4 cm"1; a FT-IR spectrum substantially as depicted in Figure 6, and combinations thereof.
[00062] The above crystalline fesoterodine base can be used to prepare a fesoterodine salt, preferably, a fesoterodine fumarate salt. Such a fesoterodine salt can be prepared, for example, by a process comprising preparing the above described polymorph of fesoterodine base by the process of the present invention and converting it to a fesoterodine salt. The conversion can be done, for example, by reacting fesoterodine base polymorph with a suitable acid, such as fumaric acid.
EXAMPLES
PXRD
[00063] The X-ray powder diffraction patterns were measured with ARL X-ray powder diffractometer model X TRA-030, equipped with Cu irradiation source λ=1.54056 A, Peltier detector, and with a round standard aluminum sample holder with round zero background quartz plate. Scanning parameters: Range: 2-40 deg. 2Θ, continuous Scan, Rate: 3 deg./min. The accuracy of peak positions is defined as +/- 0.2 degrees due to experimental differences like instrumentations, sample preparations.
[00064] The above mentioned peak positions were determined by using silicon powder as an internal standard in an admixture with the sample measured. The position of the silicon (111) peak was corrected to be 28.45 degrees two theta. The positions of measured peaks were corrected respectively. However, no correction was performed on the diffractograms presented as figures 1 and 2.
Single crystal X-ray diffraction
[00065] Data was collected on Xcalibur PX Cu Kal (1.540598 A) using combined φ and ω scans at 150 K. All non-hydrogen atoms were refined anisotropically. Cell parameters were determined at 150 K. References to programs used: Data collection: CrysAlisPro CCD (Oxford Diffraction, 2002); cell refinement: CrysAlisPro RED; data reduction: CrysAlisPro RED; program used to solve structure: Superflip (Palatinus & Chapuis, 2006); program used to refine structure and absolute chirality analysis: CRYSTALS (Betteridge et al, 2003); molecular graphics: Mercury, DS ViewerPro. Data export and void calculation was done by Platon (Spek, 2003).
FT-IR spectroscopy
[00066] Data was collected using a Perkin-Elmer Spectrum One Spectrometer, at 4 cm"1 resolution with 16 scans, in the range of 4000-400 cm"1. Sample was analyzed in KBr pellet. The spectrum was recorded using an empty cell as a background.
Solid-state 13C NMR spectroscopy
[00067] 13C NMR spectra were recorded at 125 MHz using a Bruker Avance 11+ 500 instrument. SB probe using 4mm rotors. Magic angle was set using KBr. Homogeneity of magnetic field was checked using adamantine. Parameters for Cross-polarization were optimized using glycine. Spectral reference set according to glycine as external standard (176.03 ppm) for low field carboxyl signal.
[00068] Scanning parameters: Magic Angle Spinning Rate: 11 kHz
[00069] Pulse program: cp with tppml5 during decoupling
[00070] Delay time: 2s
[00071] Number of scans: 2048
Melting point
[00072] USP melting point was measured by BLTCHI B-545 equipment using the following parameters: Heating rate: l°C/min, Scan range 80-120°C.
Example 1. Process for preparing fesoterodine base
[00073] (R)-Hydroxymethyl-tolterodine (160.0 g, 468.5 mmol) was dissolved in 6400 ml of dichloromethane (DCM) at 20-25°C. To the stirred solution, 13.0 ml of triethylamine was added. The resulting mixture was stirred for 15 min under nitrogen at 20-25°C.
Isobutyryl chloride (51.0 ml dissolved in 1600 ml DCM) was added dropwise over 50 min. The resulting mixture was stirred for an additional one hour at 20-25 °C. Sodium hydrogen- carbonate (79 g in 1600 ml of distilled water) was then added in one portion. This mixture was stirred vigorously for one hour. The stirring was then stopped and the organic phase was separated and concentrated at 25-30°C under 20 mbar, resulting in isolation of 199.5 g of product as a dark yellow oil.
Example 2. Process for preparing polymorphically pure crystalline fesoterodine fumarate Form A
[00074] Fesoterodine base (199.5 g) was dissolved in 1540 ml of 3-pentanone.
Fumaric acid (54.3 g) and distilled water (4.8 ml) were added. The resulting suspension was stirred for 16 hrs at 20-25°C, and then filtered. The separated solid was washed with 150 ml of 3-pentanone. The resulting white solid was dried (100 mbar, 40-45°C) under nitrogen for 50 hrs. The obtained dry white powder (205.3 g, 83% for 2 steps) was analyzed by XRPD.
Example 3. Process for preparing polymorphically pure crystalline fesoterodine fumarate Form A
[00075] To 13.3 g of Fesoterodine base was added 30 ml of acetone and 3.4 g of fumaric acid. The resulting suspension was stirred at 40-45°C for 0.5 hour to form a solution. To the solution was added 96 ml of 3-pentanone. This mixture was concentrated under 100 mbar of vacuum at 40-45°C to evaporate 30 ml of the solvent. The resulting solution was cooled to 20-25°C, and seeded with crystals, which were prepared in the same way as described in Example 1. The resulting suspension was stirred for 20 hrs at 20-25°C, and then filtered. The separated solid was washed with 15 ml of 3-pentanone, and dried (100 mbar, 40-45°C) under nitrogen for 40 hrs. The obtained dry white powder (12.7 g, 74%) was analyzed by XRPD.
Example 4. Process for preparing polymorphically pure crystalline fesoterodine fumarate Form A
[00076] Fesoterodine fumarate (1.0 g) was dissolved in 20 ml of 3-pentanone at 40-
45°C. The resulting solution was cooled to 20-25°C, and stirred overnight. The suspension which formed was filtered and the separated solid was dried at 45°C. The obtained dry white powder (0.59 g, 59 %) was analyzed by XRPD.
Example 5. Process for preparing crystalline fesoterodine fumarate Form B
[00077] Fesoterodine fumarate (3 g) was dissolved by warming in a mixture of 2- butanone (2.5 ml) and isobutyl-methyl ketone (2.5 ml). Isobutyl-methyl ketone (20 ml) was added to the mixture, and then that mixture was cooled to 20-25°C and stirred for 16 hours. Crystals formed and were filtered off, washed with isobutyl-methyl ketone (5 ml), and air dried for 24 hours to yield 2.42 g (81 % yield) of the product.
Example 6. Process for preparing crystalline fesoterodine fumarate Form B
[00078] Fesoterodine fumarate (0.5 g) was dissolved by warming in isobutyl-methyl ketone (20 ml). The solution was cooled to 20-25°C and stirred for 3 hours. Crystals formed and were filtered off, washed with isobutyl-methyl ketone (5 ml), and air dried for 24 hours to yield 0.2 lg (42 % yield) of the product.
Example 7. Process for preparing crystalline fesoterodine fumarate Form B
[00079] Fesoterodine fumarate (0.5 g) was dissolved in DCM (5 ml). Ethyl acetate (10 ml) was added to the solution, and then the DCM was evaporated. The thus-formed slurry was cooled to 20-25°C and stirred for 3 hours. Crystals formed and were filtered off, washed with ethyl acetate (5 ml), and air dried for 24 hours to yield 0.35 g (70 % yield) of the product.
Example 8. Process for preparing crystalline fesoterodine fumarate Form B
[00080] Fesoterodine fumarate (0.5 g) was dissolved in DCM (5 ml). n-Butyl acetate
(5 ml) was added to the solution, and then the DCM was evaporated. The formed slurry was cooled to 20-25°C and stirred for 3 hours. Crystals formed and were filtered off, washed with n-butyl acetate (5 ml), and air dried for 24 hours to yield 0.36 g (72 % yield) of the product.
Example 9. Process for preparing a mixture of crystalline fesoterodine fumarate Form A and Form C single crystal [00081] Fesoterodine fumarate (150 mg) was dissolved in a mixture of isobutyl methyl ketone (7 ml) and acetone (0.9 ml) by heating to 50oC. The solution was allowed to stand in an open glass vial for 5 days. During this period the solvents were partially evaporated. Part of the fesoterodine fumarate precipitated as an oil and some crystals were formed on the interface of the precipitated oil. The crystals were isolated by filtration, and used for the crystal structure determination.
Example 10. Preparation of seeding material to preparation of Fesoterodine base
[00082] Fesoterodine base (appr. 0.2 g) was dissolved in dimethylcarbonate (appr. 0.1 ml). n-Heptane (appr. 2 ml) was added dropwise at room temperature while the mixture was stirred vigorously. The mixture was stirred for further 2 hrs to form a suspension.
Example 11. Preparation of crystalline fesoterodine base
[00083] Fesoterodine base (3.7 g) was dissolved in dimethylcarbonate (15 ml), and n- heptane (15 ml) was added dropwise to the stirred solution at 20-25°C. The mixture was seeded with crystals from the suspension prepared in example 10. The mixture was stirred at 20-25°C for 2 hrs. Additional n-heptane (10 ml) was added, and this mixture was stirred for 20 minutes. The resulting suspension was filtered, and the separated solid was washed with 5 ml of n-heptane. The prepared solid was dried under vacuum at 45°C under nitrogen for 1 day. The obtained dry white solid (0.53 g) was analyzed by XRPD.
Example 12. Process for preparing crystalline fesoterodine fumarate pure Form I
[00084] Fesoterodine base (31.4 g) was dissolved in 82 ml of 2-butanone at 20-25°C.
To the stirred solution was added fumaric acid (8.86 g). The resulting suspension was stirred at 35-40 °C, until complete dissolution. The solution was cooled to 0 °C. To the stirred solution cyclohexane (10+10 ml) was added dropwise. After each 10 ml addition of cyclohexane, seeding crystals were added, which were prepared the same way without seeding. The vessel was allowed to warm up to 20-25 °C, and then 20 ml cyclohexane was added dropwise. The resulting suspension was stirred for 20 minutes. An additional 42 ml of cyclohexane was added. The resulting suspension was stirred at 20-25 °C for 16 hrs. To the stirred suspension was added an additional 82 ml of cyclohexane, and the resulting suspension was stirred for 1 hr. Before filtration the suspension was diluted with an additional 82 ml of cyclohexane. The suspension was filtered through a G3 glass-filter, and the separated solid was washed with cyclohexane (2 x 60 ml). The obtained white solid was dried (40-45 °C, 100 mbar), under nitrogen for 20 hrs. The resulting dry white solid (38.3 g, 95 %) was analyzed by XRPD.
Example 13. Process for preparing crystalline fesoterodine fumarate pure Form B
[00085] Fesoterodine fumarate (6 g) was dissolved by warming in a mixture of 2- butanone (5.0 ml) and isobutyl-methyl ketone (5.0 ml). Isobutyl-methyl ketone (40 ml) was added to the mixture, and the resulting mixture was cooled to 20-25°C and stirred for 16 hours. Crystals formed and were filtered off, and air dried for 24 hours to yield 5.59 g (93 % yield) of the product.
Example 14. Process for preparing crystalline fesoterodine fumarate pure Form I
[00086] Fesoterodine base (8.0 g) was dissolved in 36 ml acetone. To the stirred solution 2.24 g fumaric acid was added and dissolved at 35-40°C. The clear solution was then evaporated totally. From the obtained residue, 3.2 g was dissolved in 10 ml 2-butanone. The resulting solution was divided into 4 parts. To one stirred part n-heptane (15 ml) was added dropwise while the temperature was set to 0°C by ice/water cooling. The formed mixture was stirred vigorously at 0°C for 4-5 hrs, settled at 2-8°C overnight then stirred vigorously at 0°C for an additional 2-3 hrs. The suspension was then filtered and washed with n-heptane (1-2 ml). The resulting white solid was dried at 40-45°C, to provide 430 mg of dry material.

Claims

What is claimed is:
1. Polymorphically pure crystalline fesoterodine fumarate Form A.
2. The polymorphically pure Form A according to claim 1; wherein said polymorphically pure form contains up to 10% by weight of crystalline fesoterodine fumarate Form B as determined by powder X-ray diffraction, and contains up to 10% by weight of crystalline fesoterodine fumarate Form I as determined by solid state 13C NMR.
3. The polymorphically pure crystalline fesoterodine fumarate according to claim 2,
characterized by data selected from: an X-ray powder diffraction having peaks at 11.5 and 11.8 (doublet), 14.9 and 15.1 (doublet), 24.1, 27.0 and 27.7 ± 0.2 degrees two-theta; an X-ray powder diffraction pattern substantially as depicted in figure 1; a solid-state 13C NMR spectrum having characteristic peaks at 18.0, 127.1 and 140.5, ± 0.2 ppm; a solid state 13C NMR spectrum having chemical shift differences between said characteristic peaks and a peak at 122.3 ± 0.2 ppm of -104.3, 4.8 and 18.2 ± 0.1 ppm, respectively; a solid-state 13C NMR spectrum substantially as depicted in figure 8 and 9 and
combinations thereof; wherein the amount of crystalline fesoterodine fumarate Form B is determined using one or more XRD peaks selected from 9.7, 12.2, 14.5, 18.6 and 19.5 ± 0.2 degrees two-theta; and the amount of crystalline fesoterodine fumarate Form I is determined using one or more solid-state 13C NMR peaks selected from 19.2, 58.0, 135.2, 168.3 and 170.9 ± 0.2 ppm.
4. The polymorphically pure crystalline fesoterodine fumarate according to claim 2,
characterized by data selected from: a single crystal XRD with the following data:
monoclinic crystal system; space group P2i; unit cell parameters: a, b, c: 7.6709(9), 9.3896(14), 20.099(4) [A], respectively, and alpha, beta, gamma: 90°, 96.321(15)°, 90° [deg], respectively, and volume of: 1438.9(4) [A3], Z of 2 and a theoretical XRPD pattern calculated from single crystal data as depicted in figure 7.
5. The polymorphically pure crystalline fesoterodine fumarate according to claim 3, further characterized by additional X-ray diffraction peaks at 10.4, 12.8, 18.0, 18.9 and 20.8 ± 0.2 degrees two-theta and additional solid state 13C NMR peaks at 122.3, 134.9, 138.6,
148.6 and 168.6± 0.2 ppm; and the solid state C NMR chemical shifts differences between said additional peaks and the peak at 122.3 ± 0.2 ppm of 12.6, 16.3, 26.3 and 46.3 ± 0.1 ppm, respectively.
6. The polymorphically pure crystalline fesoterodine fumarate according to any of claims 1 to 5, having up to 5% of crystalline fesoterodine fumarate denoted Form B, and up to 5% of crystalline fesoterodine fumarate denoted Form I.
7. The polymorphically pure crystalline fesoterodine fumarate according to any of claims 1 to 5, having up to 2% of crystalline fesoterodine fumarate denoted Form B, and up to 2% of crystalline fesoterodine fumarate denoted Form I.
8. The polymorphically pure crystalline fesoterodine fumarate according to claim 2
wherein, the crystalline is a crystalline powder having a melting point of 109°C.
9. Polymorphically pure crystalline fesoterodine fumarate Form B.
10. The polymorphically pure Form B according to claim 9; wherein said polymorphically pure form contains up to 10% by weight of crystalline fesoterodine fumarate Form A, and up to 10% by weight of crystalline fesoterodine fumarate Form I as determined by powder X-ray diffraction.
11. The polymorphically pure crystalline fesoterodine fumarate according to claim 10, characterized by data selected from: an X-ray powder diffraction pattern having peaks at 9.7, 12.2, 14.5, 18.6 and 19.5 ± 0.2 degrees two-theta; an X-ray powder diffraction pattern substantially as depicted in figure 3; a solid-state 13C NMR spectrum having characteristic peaks at 18.9, 34.9, 48.0, 53.6, 122.5, 127.4, 135.4, and 148.8 ppm ± 0.2 ppm; a solid state 13C NMR spectrum having chemical shifts differences between said characteristic peaks and a peak at 122.5 ± 0.2 ppm of -103.6, -87.6, -74.5, -68.9, 4.9, 12.9, and 26.3 ± 0.1 ppm, respectively; a solid-state 13C NMR spectrum substantially as depicted in figure 12 and 13 and combinations thereof; wherein the amount of crystalline fesoterodine fumarate Forms A and I are determined using one or more XRD peaks selected from 12.8, 18.0 and 20.8 ± 0.2 degrees two-theta.
12. The polymorphically pure crystalline fesoterodine fumarate according to claim 11, further characterized by additional X-ray peaks at 10.4, 17.6, 20.0, 21.4 and 26.0 ± 0.2 degrees two-theta.
13. The polymorphically pure crystalline fesoterodine fumarate according to any of claims 9 to 12, having up to 5% of crystalline fesoterodine fumarate denoted Form A, and up to 5% of crystalline fesoterodine fumarate denoted Form I.
14. The polymorphically pure crystalline fesoterodine fumarate according to any of claims 9 to 12, having up to 2% of crystalline fesoterodine fumarate denoted Form A, and up to 2% of crystalline fesoterodine fumarate denoted Form I.
15. Polymorphically pure crystalline fesoterodine fumarate Form I.
16. The polymorphically pure Form I according to claim 15; wherein said polymorphically pure form contains up to 10% by weight of crystalline fesoterodine fumarate Form A as determined by powder X-ray diffraction or by solid state 13C NMR, and up to 10% by weight of crystalline fesoterodine fumarate Form B as determined by powder X-ray diffraction.
17. The polymorphically pure crystalline fesoterodine fumarate according to claim 16, characterized by data selected from: an X-ray powder diffraction (XRPD) pattern having peaks at 11.8, 14.9, 16.2 and 27.4 ± 0.2 degrees two-theta; an XRPD pattern substantially as depicted in figure 17; a solid-state 13C NMR spectrum having characteristic peaks at 19.2, 58.0, 122.4, 135.2, 168.3 and 170.9 ppm ± 0.2 ppm; a solid state 13C NMR spectrum having chemical shift differences between said characteristic peaks and a peak at 122.4 ± 0.2 ppm of -103.2, -64.4, 12.8, 45.9 and 48.5 ± 0.1 ppm, respectively; a solid-state 13C NMR spectrum substantially as depicted in figure 18 and 19, and combinations thereof; wherein the amount of crystalline fesoterodine fumarate Form A is determined using one or more XRD peaks selected from 11.5, 15.1, 24.1 and 27.7 ± 0.2 degrees two-theta or one or more solid state 13C NMR peaks selected from 18.0, 127.1 and 140.5± 0.2 ppm, and the amount of crystalline fesoterodine fumarate Form B is determined using one or more XRD peaks selected from 9.7, 12.2, 14.5, 18.6 and 19.5 ± 0.2 degrees two-theta.
18. The polymorphically pure crystalline fesoterodine fumarate according to any of claims 15 to 17, having up to 5% of crystalline fesoterodine fumarate denoted Form A, and up to 5% of crystalline fesoterodine fumarate denoted Form B.
19. The polymorphically pure crystalline fesoterodine fumarate according to any of claims 15 to 17, having up to 2% of crystalline fesoterodine fumarate denoted Form A, and up to 2% of crystalline fesoterodine fumarate denoted Form B.
20. A pharmaceutical formulation comprising any of the crystalline forms claimed in claims 1 to 19, and at least one pharmaceutically acceptable excipient.
21. The use of any of the crystalline forms claimed in claims 1 to 19 as a medicament.
22. The use of any of the crystalline forms claimed in claims 1 to 19 in the manufacture of a medicament to treat overactive bladder syndrome with symptoms of urgency, urinary incontinence and increased urinary frequency.
23. The crystalline forms claimed in claims 1 to 19 for use in treating overactive bladder syndrome with symptoms of urgency, urinary incontinence and increased urinary frequency.
EP10755268A 2009-09-03 2010-09-03 Crystalline forms of fesoterodine fumarate and fesoterodine base Withdrawn EP2459520A1 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US23949109P 2009-09-03 2009-09-03
US24027109P 2009-09-07 2009-09-07
US25832109P 2009-11-05 2009-11-05
US28682909P 2009-12-16 2009-12-16
US33307110P 2010-05-10 2010-05-10
PCT/US2010/047820 WO2011029005A1 (en) 2009-09-03 2010-09-03 Crystalline forms of fesoterodine fumarate and fesoterodine base

Publications (1)

Publication Number Publication Date
EP2459520A1 true EP2459520A1 (en) 2012-06-06

Family

ID=43027769

Family Applications (1)

Application Number Title Priority Date Filing Date
EP10755268A Withdrawn EP2459520A1 (en) 2009-09-03 2010-09-03 Crystalline forms of fesoterodine fumarate and fesoterodine base

Country Status (4)

Country Link
US (1) US20120220655A1 (en)
EP (1) EP2459520A1 (en)
KR (1) KR20120053027A (en)
WO (1) WO2011029005A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1394219B1 (en) * 2009-05-15 2012-06-01 Chemi Spa METHOD OF PREPARATION OF HIGH PURITY SMOKED FESOTERODINE.
WO2014167578A2 (en) * 2013-03-27 2014-10-16 Msn Laboratories Limited Novel polymorph of isobutyric acid 2-((r)-3-diisopropyl amino-1-phenylpropyl)-4-(hydroxymethyl)phenyl ester hydrochloride and process for preparation thereof
US9751828B2 (en) 2014-07-30 2017-09-05 Dipharma Francis S.R.L. Antimuscarinic compound having a low content of impurities

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19955190A1 (en) 1999-11-16 2001-06-21 Sanol Arznei Schwarz Gmbh Stable salts of novel derivatives of 3,3-diphenylpropylamines
DE10315917A1 (en) 2003-04-08 2004-11-18 Schwarz Pharma Ag Highly pure bases of 3,3-diphenylpropylamine monoesters
DE602007008389D1 (en) 2006-06-09 2010-09-23 Schwarz Pharma Ltd SYNTHESIS OF PHENOLIC ESTERS OF HYDROXYMETHYLPHENOLES
US20100297241A1 (en) 2007-10-01 2010-11-25 Actavis Group Ptc Ehf Amorphous Fesoterodine Fumarate
US20110171274A1 (en) * 2008-07-21 2011-07-14 Actavis Group Ptc Ehf Fesoterodine Substantially Free of Dehydroxy Impurity
IT1392082B1 (en) 2008-12-10 2012-02-09 Chemi Spa NEW SOLID FORMS OF THE SMOKED FESOTERODY

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
See also references of WO2011029005A1 *
Third-party observation re EP2196452 (D3) dated 12.01.2011 *
Third-party observation re EP2196452 (D3) dated 16.04.2012 *

Also Published As

Publication number Publication date
KR20120053027A (en) 2012-05-24
US20120220655A1 (en) 2012-08-30
WO2011029005A1 (en) 2011-03-10

Similar Documents

Publication Publication Date Title
US11149017B2 (en) Solid state forms of apalutamide
WO2016025720A1 (en) Solid state forms of ibrutinib
JP2014530805A (en) Crystal form of azilsartan and its production and use
EP3672968B1 (en) Solid state form of ribociclib succinate
JP2023036708A (en) Salts and crystal forms of gabaa positive allosteric modulator
WO2009120746A2 (en) Crystalline forms of sitagliptin phosphate
WO2017040872A1 (en) Solid state forms of selexipag
EP3692021A1 (en) Solid state forms of eltrombopag choline
EP2855499A1 (en) Solid state forms of fidaxomycin and processes for preparation thereof
EP2468762A1 (en) Optimized synthesis of pure, non-polymorphic, crystalline bile acids with defined particle size
US8183373B2 (en) Solid state forms of sitagliptin salts
KR20100022081A (en) Crystalline rotigotine base and preparation process therefor
WO2011029005A1 (en) Crystalline forms of fesoterodine fumarate and fesoterodine base
WO2012125993A1 (en) Solid state forms of rilpivirine base, and rilipivirine salts
US20220009929A1 (en) Polymorphic forms of ibrutinib
US20050131067A1 (en) Novel polymorphs of tolterodine tartrate
US20220372006A1 (en) Solid state forms of pemafibrate
WO2022081502A1 (en) Solid state forms of lorecivivint
WO2021046014A1 (en) Solid state forms of pamiparib and process for preparation thereof
WO2022200426A1 (en) Preparation method of quinoline derivative compounds
CN117624241A (en) Polymorphic form preparation of TLR agonist or salt thereof
KR101199919B1 (en) Novel crystal forms of atorvastatin hemicalcium and manufacturing method thereof
US20090030207A1 (en) Polymorphs of Dolasetron base and process for preparation thereof
EP2154137A1 (en) Crystalline form of moxifloxacin base
WO2013181384A1 (en) Solid state forms of aleglitazar sodium

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20120302

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR

DAX Request for extension of the european patent (deleted)
TPAC Observations filed by third parties

Free format text: ORIGINAL CODE: EPIDOSNTIPA

17Q First examination report despatched

Effective date: 20140221

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20140401