EP2427543A4 - System and method for monitoring cardiomyocyte beating, viability and morphology and for screening for pharmacological agents which may induce cardiotoxicity or modulate cardiomyocyte function - Google Patents

System and method for monitoring cardiomyocyte beating, viability and morphology and for screening for pharmacological agents which may induce cardiotoxicity or modulate cardiomyocyte function Download PDF

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Publication number
EP2427543A4
EP2427543A4 EP10772804.0A EP10772804A EP2427543A4 EP 2427543 A4 EP2427543 A4 EP 2427543A4 EP 10772804 A EP10772804 A EP 10772804A EP 2427543 A4 EP2427543 A4 EP 2427543A4
Authority
EP
European Patent Office
Prior art keywords
cardiomyocyte
viability
morphology
screening
pharmacological agents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP10772804.0A
Other languages
German (de)
French (fr)
Other versions
EP2427543A1 (en
Inventor
Xiaobo Wang
Wei Ouyang
Nan Li
Biao Xi
Yama A. Abassi
Xiao Xu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Agilent Technologies Inc
Original Assignee
Acea Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Acea Biosciences Inc filed Critical Acea Biosciences Inc
Publication of EP2427543A1 publication Critical patent/EP2427543A1/en
Publication of EP2427543A4 publication Critical patent/EP2427543A4/en
Pending legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/48707—Physical analysis of biological material of liquid biological material by electrical means
    • G01N33/48728—Investigating individual cells, e.g. by patch clamp, voltage clamp

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
EP10772804.0A 2009-05-05 2010-05-05 System and method for monitoring cardiomyocyte beating, viability and morphology and for screening for pharmacological agents which may induce cardiotoxicity or modulate cardiomyocyte function Pending EP2427543A4 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US17556609P 2009-05-05 2009-05-05
US31055710P 2010-03-04 2010-03-04
US32378210P 2010-04-13 2010-04-13
PCT/US2010/033801 WO2010129725A1 (en) 2009-05-05 2010-05-05 System and method for monitoring cardiomyocyte beating, viability and morphology and for screening for pharmacological agents which may induce cardiotoxicity or modulate cardiomyocyte function

Publications (2)

Publication Number Publication Date
EP2427543A1 EP2427543A1 (en) 2012-03-14
EP2427543A4 true EP2427543A4 (en) 2017-11-29

Family

ID=43050454

Family Applications (1)

Application Number Title Priority Date Filing Date
EP10772804.0A Pending EP2427543A4 (en) 2009-05-05 2010-05-05 System and method for monitoring cardiomyocyte beating, viability and morphology and for screening for pharmacological agents which may induce cardiotoxicity or modulate cardiomyocyte function

Country Status (3)

Country Link
EP (1) EP2427543A4 (en)
CA (1) CA2760941C (en)
WO (1) WO2010129725A1 (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8263375B2 (en) 2002-12-20 2012-09-11 Acea Biosciences Dynamic monitoring of activation of G-protein coupled receptor (GPCR) and receptor tyrosine kinase (RTK) in living cells using real-time microelectronic cell sensing technology
US11346797B2 (en) 2002-12-20 2022-05-31 Agilent Technologies, Inc. System and method for monitoring cardiomyocyte beating, viability, morphology and electrophysiological properties
US9612234B2 (en) 2008-05-05 2017-04-04 Acea Biosciences, Inc. Data analysis of impedance-based cardiomyocyte-beating signals as detected on real-time cell analysis (RTCA) cardio instruments
US10215748B2 (en) 2002-12-20 2019-02-26 Acea Biosciences, Inc. Using impedance-based cell response profiling to identify putative inhibitors for oncogene addicted targets or pathways
US10539523B2 (en) 2002-12-20 2020-01-21 Acea Biosciences, Inc. System and method for monitoring cardiomyocyte beating, viability, morphology, and electrophysiological properties
US10551371B2 (en) 2003-11-10 2020-02-04 Acea Biosciences, Inc. System and method for monitoring cardiomyocyte beating, viability and morphology and for screening for pharmacological agents which may induce cardiotoxicity or modulate cardiomyocyte function
EP1692258A4 (en) 2003-11-12 2007-03-21 Xiao Xu Real time electronic cell sensing systems and applications for cell-based assays
CA2723223C (en) 2008-05-05 2017-06-06 Acea Biosciences, Inc. Label-free monitoring of excitation-contraction coupling and excitable cells using impedance based systems with millisecond time resolution
WO2012178095A1 (en) * 2011-06-22 2012-12-27 Ifluidics, Inc. Electromotive system for high-throughput screening
EP2929014A4 (en) 2012-12-07 2016-08-03 Univ Toronto Cardiac tissue constructs and methods of fabrication thereof
WO2018161063A1 (en) 2017-03-03 2018-09-07 Acea Biosciences, Inc. METHODS AND SYSTEMS FOR FUNCTIONAL MATURATION OF iPSC AND ESC DERIVED CARDIOMYOCYTES
US11492609B2 (en) 2017-08-16 2022-11-08 Amgen Inc. Adaptive electrode arrangement and method
CN113655102A (en) * 2021-08-25 2021-11-16 深圳市溢鑫科技研发有限公司 Electrochemical measurement microelectrode structure and manufacturing method thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6051422A (en) * 1997-05-30 2000-04-18 Board Of Trustees, Leland Stanford, Jr., University Hybrid biosensors
EP1040345B1 (en) * 1997-12-25 2006-03-22 Matsushita Electric Industrial Co., Ltd. Cell potential measuring electrode and measuring apparatus using the same
US20060121446A1 (en) * 2002-12-20 2006-06-08 Abassi Yama A Device and method for electroporation-based delivery of molecules into cells and dynamic monitoring of cell responses
WO2009038079A1 (en) * 2007-09-18 2009-03-26 Biotec Co., Ltd. Cell measuring vessel, extracellular potential measuring method, and chemical testing method

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60329187D1 (en) * 2002-07-20 2009-10-22 Acea Biosciences Inc IMPEDANCE BASED DEVICES AND METHOD FOR THE ANALYSIS OF CELLS AND PARTICLES
GB0414546D0 (en) * 2004-06-29 2004-08-04 Oxford Biosensors Ltd Electrode for electrochemical sensor

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6051422A (en) * 1997-05-30 2000-04-18 Board Of Trustees, Leland Stanford, Jr., University Hybrid biosensors
EP1040345B1 (en) * 1997-12-25 2006-03-22 Matsushita Electric Industrial Co., Ltd. Cell potential measuring electrode and measuring apparatus using the same
US20060121446A1 (en) * 2002-12-20 2006-06-08 Abassi Yama A Device and method for electroporation-based delivery of molecules into cells and dynamic monitoring of cell responses
WO2009038079A1 (en) * 2007-09-18 2009-03-26 Biotec Co., Ltd. Cell measuring vessel, extracellular potential measuring method, and chemical testing method
EP2213721A1 (en) * 2007-09-18 2010-08-04 Biotec Co., Ltd. Cell measuring vessel, extracellular potential measuring method, and chemical testing method

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CONNOLLY P ET AL: "An Extracellular microelectrode Array for monitoring electrogenic cells in culture", BIOSENSORS AND BIOELECTRONICS, ELSEVIER BV, NL, vol. 5, no. 3, 1 January 1990 (1990-01-01), pages 223 - 234, XP026569182, ISSN: 0956-5663, [retrieved on 19900101], DOI: 10.1016/0956-5663(90)80011-2 *
See also references of WO2010129725A1 *

Also Published As

Publication number Publication date
CA2760941A1 (en) 2010-11-11
EP2427543A1 (en) 2012-03-14
WO2010129725A1 (en) 2010-11-11
CA2760941C (en) 2019-07-23

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