EP2416751A1 - Use of a device for reducing adipose overloads for treating physiological disorders - Google Patents

Use of a device for reducing adipose overloads for treating physiological disorders

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Publication number
EP2416751A1
EP2416751A1 EP09784184A EP09784184A EP2416751A1 EP 2416751 A1 EP2416751 A1 EP 2416751A1 EP 09784184 A EP09784184 A EP 09784184A EP 09784184 A EP09784184 A EP 09784184A EP 2416751 A1 EP2416751 A1 EP 2416751A1
Authority
EP
European Patent Office
Prior art keywords
straps
treatment
boots
fat
frequency electromagnetic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP09784184A
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German (de)
French (fr)
Inventor
Daniel Greff
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Biopass SA
Original Assignee
Biopass SA
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Filing date
Publication date
Application filed by Biopass SA filed Critical Biopass SA
Publication of EP2416751A1 publication Critical patent/EP2416751A1/en
Withdrawn legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
    • A61H9/00—Pneumatic or hydraulic massage
    • A61H9/005—Pneumatic massage
    • A61H9/0078—Pneumatic massage with intermittent or alternately inflated bladders or cuffs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
    • A61H2201/00—Characteristics of apparatus not provided for in the preceding codes
    • A61H2201/02—Characteristics of apparatus not provided for in the preceding codes heated or cooled
    • A61H2201/0207—Characteristics of apparatus not provided for in the preceding codes heated or cooled heated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
    • A61H2201/00—Characteristics of apparatus not provided for in the preceding codes
    • A61H2201/02—Characteristics of apparatus not provided for in the preceding codes heated or cooled
    • A61H2201/0221—Mechanism for heating or cooling
    • A61H2201/0228—Mechanism for heating or cooling heated by an electric resistance element
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
    • A61H2201/00—Characteristics of apparatus not provided for in the preceding codes
    • A61H2201/10—Characteristics of apparatus not provided for in the preceding codes with further special therapeutic means, e.g. electrotherapy, magneto therapy or radiation therapy, chromo therapy, infrared or ultraviolet therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/40—Applying electric fields by inductive or capacitive coupling ; Applying radio-frequency signals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N2/00—Magnetotherapy
    • A61N2/002—Magnetotherapy in combination with another treatment

Definitions

  • This device is that described in WO 2008/043907, and is an apparatus for reducing fat overloads comprising a generator of low frequency electromagnetic waves, insulating straps for wrapping fat areas of the body, equipped with a conductor folded into successive strands, arranged alternately in one direction and then in the other, and a dual pressure gradient pressotherapy apparatus comprise two boots and an abdominal belt, and superimposed on said straps. It is stated in this document that this device allows a slimming process and a specific reduction of body fat.
  • an apparatus for the reduction of fat overloads comprising: a generator of low frequency electromagnetic waves; o insulating straps for wrapping fat areas of the body, equipped with a folded conductor in successive strands arranged alternately in one direction and then in the other; o a pressure gradient pressotherapy apparatus comprising two boots and an abdominal belt, and superimposed on said straps, for use in the treatment of stress.
  • This fertility-positive gene induction concerns the same patients as those who showed a redistribution of cholesterol on lipid metabolism, as well as a reduction in the HOMA index, and also correspond to persons whose waist circumference has decreased significantly, there is almost perfect correlation of all these results.

Landscapes

  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rehabilitation Therapy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The invention relates to a device for reducing adipose overloads, comprising: a low-frequency electromagnetic wave generator; insulating straps for surrounding the adipose areas of the body, provided with a conductor folded into consecutive strands arranged alternately in one direction and then in the other; a pressure therapy device with a double pressure gradient, comprising two boots and an abdominal belt and placed over said straps, to be used in treating metabolic syndrome, in treating ovogenetic, ovulatory and spermatogenetic disorders, and to be used in treating stress.

Description

Utilisation d'un appareil pour la réduction des surcharges adipeuses pour le traitement de troubles physiologiques. Use of a device for the reduction of fat overloads for the treatment of physiological disorders.
L'invention concerne l'utilisation d'un appareil pour la réduction des surcharges adipeuses pour le traitement de divers troubles physiologiques, en particulier l'infertilité chez l'être humain ou en cas d'obésité abdominale et de syndrome métabolique.The invention relates to the use of an apparatus for the reduction of fat overload for the treatment of various physiological disorders, in particular infertility in humans or in cases of abdominal obesity and metabolic syndrome.
On sait que l'une des causes d'une infertilité féminine peut être l'obésité abdominale et le traitement d'une telle infertilité comporte généralement un amaigrissement de la femme particulièrement au niveau de la ceinture abdominale. Cet amaigrissement peut être obtenu par un régime, une activité sportive et/ou des techniques appropriées. Le traitement est toutefois aléatoire et dans tous les cas relativement long.It is known that one of the causes of female infertility may be abdominal obesity and the treatment of such infertility usually involves a slimming of the woman particularly at the level of the abdominal belt. This weight loss can be achieved through diet, sports activity and / or appropriate techniques. The treatment is however random and in all cases relatively long.
Or, on a découvert de manière surprenante que l'utilisation d'ondes électromagnétiques basse fréquence au moyen d'un appareil d'un type particulier permet d'obtenir des résultats sur l'infertilité de manière efficace et rapide. Cet appareil est celui décrit dans WO 2008/043907, et est un appareil pour la réduction des surcharges adipeuses comprenant un générateur d'ondes électromagnétiques à basse fréquence, des sangles isolantes pour l'enveloppement des zones adipeuses du corps, équipées d'un conducteur replié en brins successifs, disposés alternativement dans un sens puis dans l'autre, et un appareil de pressothérapie à double gradient de pression comportent deux bottes et une ceinture abdominale, et superposé auxdites sangles. Il est indiqué dans ce document que cet appareil permet un processus d'amaigrissement et une réduction spécifique de la masse grasse corporelle.Surprisingly, it has been discovered that the use of low frequency electromagnetic waves by means of an apparatus of a particular type makes it possible to obtain infertility results efficiently and rapidly. This device is that described in WO 2008/043907, and is an apparatus for reducing fat overloads comprising a generator of low frequency electromagnetic waves, insulating straps for wrapping fat areas of the body, equipped with a conductor folded into successive strands, arranged alternately in one direction and then in the other, and a dual pressure gradient pressotherapy apparatus comprise two boots and an abdominal belt, and superimposed on said straps. It is stated in this document that this device allows a slimming process and a specific reduction of body fat.
Sans vouloir se lier à une quelconque théorie, il semble que l'action de cet appareil provoque une stimulation de nombreux gènes codant pour des protéines qui jouent un rôle dans le fonctionnement des canaux calciques et on a constaté à l'heure actuelle que les améliorations constatées sont de trois types : amélioration de la fertilité humaine dans certains cas d'obésité abdominale, amélioration de quatre des cinq critères du syndrome métabolique (métabolisme lipidique : cholestérol et triglycérides, résistance à l'insuline, diminution du tour de taille).Without wishing to be bound by any theory, it appears that the action of this device causes stimulation of many genes encoding proteins that play a role in the functioning of calcium channels and it has now been found that improvements There are three types of findings: improvement of human fertility in some cases of abdominal obesity, improvement of four of the five criteria of the metabolic syndrome (lipid metabolism: cholesterol and triglycerides, insulin resistance, reduced waist circumference).
Amélioration dans le traitement du stress. L'invention a donc pour objet : - un appareil pour la réduction des surcharges adipeuses, comportant : o un générateur d'ondes électromagnétiques à basse fréquence ; o des sangles isolantes pour l'enveloppement des zones adipeuses du corps, équipées d'un conducteur replié en brins successifs disposés alternativement dans un sens puis dans l'autre ; o un appareil de pressothérapie à double gradient de pression comportant deux bottes et une ceinture abdominale, et superposé auxdites sangles, pour utilisation dans le traitement du syndrome métabolique. un appareil pour la réduction des surcharges adipeuses, comportant : o un générateur d'ondes électromagnétiques à basse fréquence ; o des sangles isolantes pour l'enveloppement des zones adipeuses du corps, équipées d'un conducteur replié en brins successifs disposés alternativement dans un sens puis dans l'autre ; o un appareil de pressothérapie à double gradient de pressions comportant deux bottes et une ceinture abdominale, et superposé auxdites sangles, pour utilisation dans le traitement des troubles de l'ovulation, l'ovogenèse et de la spermatogenèse. un appareil pour la réduction des surcharges adipeuses, comportant : o un générateur d'ondes électromagnétiques à basse fréquence ; o des sangles isolantes pour l'enveloppement des zones adipeuses du corps, équipées d'un conducteur replié en brins successifs disposés alternativement dans un sens puis dans l'autre ; o un appareil de pressothérapie à double gradient de pressions comportant deux bottes et une ceinture abdominale, et superposé auxdites sangles, pour utilisation dans le traitement du stress.Improvement in the treatment of stress. The invention therefore relates to: an apparatus for reducing fat overloads, comprising: a generator of low frequency electromagnetic waves; o insulating straps for wrapping fat areas of the body, equipped with a folded conductor in successive strands arranged alternately in one direction and then in the other; o a double pressure gradient pressotherapy apparatus comprising two boots and an abdominal belt, and superimposed on said straps, for use in the treatment of the metabolic syndrome. an apparatus for the reduction of fat overloads, comprising: a generator of low frequency electromagnetic waves; o insulating straps for wrapping fat areas of the body, equipped with a folded conductor in successive strands arranged alternately in one direction and then in the other; o a double pressure gradient pressotherapy apparatus comprising two boots and an abdominal belt, and superimposed on said straps, for use in the treatment of ovulation disorders, oogenesis and spermatogenesis. an apparatus for the reduction of fat overloads, comprising: a generator of low frequency electromagnetic waves; o insulating straps for wrapping fat areas of the body, equipped with a folded conductor in successive strands arranged alternately in one direction and then in the other; o a pressure gradient pressotherapy apparatus comprising two boots and an abdominal belt, and superimposed on said straps, for use in the treatment of stress.
Des profils d'expression pour la caractérisation des effets transcriptionnels induits dans les cellules du sang total ont été réalisés sur des patients soumis à 12 séances de l'appareil pour la réduction des surcharges adipeuses (ci-après l'appareil).Expression profiles for the characterization of induced transcriptional effects in whole blood cells were performed on patients subjected to 12 sessions of the apparatus for the reduction of fat overload (hereinafter the apparatus).
Des prélèvements sanguins ont été effectués pour chaque patient avant le début des séances, juste avant et juste après la 8eme séance et à la fin de la 12eme séance.Blood samples were taken for each patient before the start of the sessions, just before and after the 8 th meeting and at the end of the 12 th session.
Les résultats ont été obtenus à partir de l'étude du profil d'expression sur puces Agilent Whole Génome Microarray kit 4x44K comportant 43 776 séquences génétiques (hors contrôles). Ces puces ont été hybridées à des sondes correspondant aux échantillons d'ARns extraits à partir de sang total collecté dans des tubes PAXgene.The results were obtained from the study of the Agilent Whole Genome Microarray kit 4x44K expression profile comprising 43,776 genetic sequences (excluding controls). These chips were hybridized to probes corresponding to the ARns samples extracted from whole blood collected in PAXgene tubes.
La qualité et la quantité de l'ensemble des échantillons des ARNs ont été mesurées, respectivement, au moyen du Bioanalyser (Agilent) et par Nanodrop. Un bilan biologique ainsi qu'une mesure de tour de taille ont été réalisés pour l'ensemble des patients.The quality and quantity of all samples of the RNAs were measured, respectively, using the Bioanalyser (Agilent) and Nanodrop. A biological assessment and a measurement of waist circumference were performed for all patients.
Les données ont été soumises à une normalisation intra-puces et inter-puces (méthode quantile) au moyen du logiciel R. Les rapports des intensités : après séance (b,c,d) versus avant première séance (a) ont été calculés pour chaque patient.The data were subjected to intra-chip and inter-chip normalization (quantile method) using software R. The intensity ratios: after session (b, c, d) versus before first session (a) were calculated for each patient.
Il a été effectué une sélection de gènes dont le rapport d'expression est supérieur ou égal à 2 après la 12eme séance de traitement avec l'appareil.A selection of genes whose expression ratio was greater than or equal to 2 after the 12 th treatment session with the apparatus was performed.
Cette analyse a conduit à sélectionner 112 gènes qui ont été soumis à une étude de corrélation au moyen du logiciel PredictSearch. Dans un deuxième temps, les données d'intensités obtenues après normalisation ont été filtrées sur la base : (i) intensité supérieure au bruit de fond pour l'ensemble des échantillons, (ii) rapport d'intensité supérieure à 1,5. Cette sélection a identifié 89 gènes.This analysis led to the selection of 112 genes that were subjected to a correlation study using the PredictSearch software. In a second step, the intensities data obtained after normalization were filtered on the basis of: (i) intensity greater than the background noise for all the samples, (ii) intensity ratio greater than 1.5. This selection identified 89 genes.
Au final l'action de l'appareil semble cibler les cellules musculaires et intègre des gènes associés à la contraction musculaire. Cet effet résulterait d'une modulation de l'expression de gènes codant pour des protéines qui jouent un rôle dans le fonctionnement des canaux calciques.In the end the action of the device seems to target the muscle cells and integrates genes associated with muscle contraction. This effect would result from a modulation of the expression of genes encoding proteins that play a role in the functioning of calcium channels.
Il faut distinguer le syndrome métabolique de l'obésité qui atteint l'ensemble du corps et qui ne comporte pas obligatoirement de risques cardio-vasculaires spécifiques ni de facteurs favorisant l'athérosclérose. Au niveau abdominal, la graisse se révèle bien plus dangereuse, car les adipocytes, en fort excès, libèrent de nombreuses substances toxiques qui exercent des effets néfastes sur les artères, entraînant l'apparition de maladies, telle l'athérosclérose, et des états inflammatoires. Ces adipocytes agissent aussi de façon indirecte sur la sécrétion d'insuline en induisant une insulino- résistance. Le syndrome métabolique est moins spectaculaire que l'obésité, mais son risque médical est plus élevé.The metabolic syndrome must be distinguished from obesity, which affects the whole body and does not necessarily involve specific cardiovascular risks or factors that promote atherosclerosis. In the abdomen, fat is much more dangerous because adipocytes, in large excess, release many toxic substances that have adverse effects on the arteries, leading to the development of diseases, such as atherosclerosis, and inflammatory conditions . These adipocytes also act indirectly on the secretion of insulin by inducing insulin resistance. The metabolic syndrome is less dramatic than obesity, but its medical risk is higher.
Il est déterminant de chercher à diminuer le tour de taille abdominal qui apparaît comme le point de départ du syndrome métabolique, celui-ci est particulièrement en cause dans l'insulino- résistance. Globalement, la réduction du tour de taille observée chez l'ensemble des patients (dans 90% des cas) confirme l'effet bénéfique de l'appareil.It is decisive to try to reduce the abdominal waistline, which appears to be the starting point of the metabolic syndrome, which is particularly implicated in insulin resistance. Overall, the reduction in waist circumference observed in all patients (in 90% of cases) confirms the beneficial effect of the device.
Concernant l'impact d'une redistribution du cholestérol sur le métabolisme lipidique, au regard des variations du taux de cholestérol et de triglycérides donné par les bilans biologiques, il est à signaler que les gènes impliqués dans cette redistribution sont significativement modulés dans près de 70% des cas.Concerning the impact of a redistribution of cholesterol on the lipid metabolism, with regard to the variations of the cholesterol and triglyceride levels given by the biological balance sheets, it is report that the genes involved in this redistribution are significantly modulated in nearly 70% of cases.
Sur un autre plan, la réduction de l'indice HOMA, indice de résistance à l'insuline, chez les patients présentant une activation significative des gènes impliqués dans la restauration d'une réponse à l'insuline a été démontrée.On another level, the reduction of the HOMA index, insulin resistance index, in patients with significant activation of the genes involved in the restoration of an insulin response has been demonstrated.
On retrouve un bon parallèle entre les résultats des indices HOMA et des bilans lipidiques, avec la modulation positive des gènes, dans la mesure où il s'agit des mêmes patients concernés.A good parallel is found between the results of the HOMA indices and lipid balances, with the positive modulation of the genes, insofar as they are the same patients concerned.
Par ailleurs, il faut noter l'induction génique permettant de rendre compte des effets positifs de l'appareil sur la fertilité. En effet on a pu mettre en évidence dans cette étude l'induction de la LHB «luteinizing hormone beta polypeptide», une sous-unité de la luteinizing hormone (LH) connue pour sa capacité à stimuler l'ovulation. La LHB dont l'expression est augmentée par le calcium, active par ailleurs l'ovogenèse et la spermatogenèse.In addition, we must note the gene induction to account for the positive effects of the device on fertility. In fact, it was possible to demonstrate in this study the induction of the LHB "luteinizing hormone beta polypeptide", a subunit of the luteinizing hormone (LH) known for its ability to stimulate ovulation. LHB, whose expression is increased by calcium, also activates oogenesis and spermatogenesis.
Cette induction génique positive, au niveau de la fertilité, concerne les mêmes patients que ceux ayant montré une redistribution du cholestérol sur le métabolisme lipidique, ainsi qu'une réduction de l'indice HOMA, et correspondent également aux personnes dont le tour de taille a diminué de façon significative, il y a donc quasi parfaite corrélation de l'ensemble de ces résultats.This fertility-positive gene induction concerns the same patients as those who showed a redistribution of cholesterol on lipid metabolism, as well as a reduction in the HOMA index, and also correspond to persons whose waist circumference has decreased significantly, there is almost perfect correlation of all these results.
On note que les patients soumis à 12 séances de traitement par l'appareil présentent un stress inférieur à ce qu'il était avant. Les effets de l'appareil se font sentir d'une manière légèrement différente d'une personne à une autre selon ses particularités propres.It is noted that patients subjected to 12 treatment sessions by the device have a lower stress than it was before. The effects of the device are felt in a slightly different way from one person to another according to its own particularities.
Les effets de l'appareil persistent encore 4 à 6 semaines après l'arrêt de la dernière séance de la cure de 12 séances, ce qui semble être une relation directe avec une stimulation génique qui agirait de façon prolongée pour certains gènes. The effects of the device still persist 4 to 6 weeks after stopping the last session of the course of 12 sessions, which seems to be a direct relationship with gene stimulation that would act for a long time for certain genes.

Claims

Revendications claims
1. Appareil pour la réduction des surcharges adipeuses, comportant :Apparatus for reducing fat overload, comprising:
- un générateur d'ondes électromagnétiques à basse fréquence ;- a generator of low frequency electromagnetic waves;
- des sangles isolantes pour l'enveloppement des zones adipeuses du corps, équipées d'un conducteur replié en brins successifs disposés alternativement dans un sens puis dans l'autre ;insulating straps for wrapping fat areas of the body, equipped with a folded conductor in successive strands arranged alternately in one direction and then in the other;
- un appareil de pressothérapie à double gradient de pression comportant deux bottes et une ceinture abdominale, et superposé auxdites sangles, pour utilisation dans le traitement du syndrome métabolique. - A pressurized dual pressure gradient pressure device comprising two boots and an abdominal belt, and superimposed on said straps, for use in the treatment of metabolic syndrome.
2. Appareil pour la réduction des surcharges adipeuses, comportant :2. Apparatus for reducing adipose overload, comprising:
- un générateur d'ondes électromagnétiques à basse fréquence ;- a generator of low frequency electromagnetic waves;
- des sangles isolantes pour l'enveloppement des zones adipeuses du corps, équipées d'un conducteur replié en brins successifs disposés alternativement dans un sens puis dans l'autre ; - un appareil de pressothérapie à double gradient de pression comportant deux bottes et une ceinture abdominale, et superposé auxdites sangles, pour utilisation dans le traitement des troubles de l'ovulation, de l'ovogenèse et de la spermatogenèse.insulating straps for wrapping fat areas of the body, equipped with a folded conductor in successive strands arranged alternately in one direction and then in the other; - A double pressure gradient pressotherapy apparatus comprising two boots and an abdominal belt, and superimposed on said straps, for use in the treatment of disorders of ovulation, oogenesis and spermatogenesis.
3. Appareil pour la réduction des surcharges adipeuses, comportant : - un générateur d'ondes électromagnétiques à basse fréquence ;Apparatus for reducing fat overload, comprising: - a generator of low frequency electromagnetic waves;
- des sangles isolantes pour l'enveloppement des zones adipeuses du corps, équipées d'un conducteur replié en brins successifs disposés alternativement dans un sens puis dans l'autre ;insulating straps for wrapping fat areas of the body, equipped with a folded conductor in successive strands arranged alternately in one direction and then in the other;
- un appareil de pressothérapie à double gradient de pression comportant deux bottes et une ceinture abdominale, et superposé auxdites sangles, pour utilisation dans le traitement du stress. - A pressure gradient pressotherapy apparatus comprising two boots and an abdominal belt, and superimposed on said straps, for use in the treatment of stress.
EP09784184A 2009-04-06 2009-04-06 Use of a device for reducing adipose overloads for treating physiological disorders Withdrawn EP2416751A1 (en)

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PCT/FR2009/000405 WO2010116046A1 (en) 2009-04-06 2009-04-06 Use of a device for reducing adipose overloads for treating physiological disorders

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EP2416751A1 true EP2416751A1 (en) 2012-02-15

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FR2855415B1 (en) * 2003-05-28 2006-01-06 H C A Sa ELECTRICAL DEVICE FOR REDUCING ADDITIONAL OVERLOADS
FR2906727A1 (en) * 2006-10-06 2008-04-11 H C A Sa "METHOD AND APPARATUS FOR REDUCING ADDITIONAL OVERLOADS".

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