EP2410992A4 - Nanosystèmes liés à l'ascorbate pour administration cérébrale - Google Patents

Nanosystèmes liés à l'ascorbate pour administration cérébrale

Info

Publication number
EP2410992A4
EP2410992A4 EP10756933.7A EP10756933A EP2410992A4 EP 2410992 A4 EP2410992 A4 EP 2410992A4 EP 10756933 A EP10756933 A EP 10756933A EP 2410992 A4 EP2410992 A4 EP 2410992A4
Authority
EP
European Patent Office
Prior art keywords
nanosystems
ascorbate
linked
brain delivery
brain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP10756933.7A
Other languages
German (de)
English (en)
Other versions
EP2410992A1 (fr
Inventor
Vladimir Torchilin
Tiziana Musacchio
Stefano Salmaso
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Universita degli Studi di Padova
Northeastern University Boston
Original Assignee
Universita degli Studi di Padova
Northeastern University Boston
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universita degli Studi di Padova, Northeastern University Boston filed Critical Universita degli Studi di Padova
Publication of EP2410992A1 publication Critical patent/EP2410992A1/fr
Publication of EP2410992A4 publication Critical patent/EP2410992A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0085—Brain, e.g. brain implants; Spinal cord
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6905—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion
    • A61K47/6907—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion the form being a microemulsion, nanoemulsion or micelle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6905—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion
    • A61K47/6911—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion the form being a liposome
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Dispersion Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nanotechnology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Psychology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
EP10756933.7A 2009-03-26 2010-03-26 Nanosystèmes liés à l'ascorbate pour administration cérébrale Withdrawn EP2410992A4 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US16357709P 2009-03-26 2009-03-26
PCT/US2010/028872 WO2010111620A1 (fr) 2009-03-26 2010-03-26 Nanosystèmes liés à l'ascorbate pour administration cérébrale

Publications (2)

Publication Number Publication Date
EP2410992A1 EP2410992A1 (fr) 2012-02-01
EP2410992A4 true EP2410992A4 (fr) 2013-09-11

Family

ID=42781556

Family Applications (1)

Application Number Title Priority Date Filing Date
EP10756933.7A Withdrawn EP2410992A4 (fr) 2009-03-26 2010-03-26 Nanosystèmes liés à l'ascorbate pour administration cérébrale

Country Status (5)

Country Link
EP (1) EP2410992A4 (fr)
CN (1) CN102458365A (fr)
AU (1) AU2010229700A1 (fr)
CA (1) CA2756581A1 (fr)
WO (1) WO2010111620A1 (fr)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001082900A1 (fr) * 2000-04-25 2001-11-08 The Regents Of The University Of California Ciblage génique non effractif du cerveau
WO2008112565A2 (fr) * 2007-03-09 2008-09-18 Anthony Manganaro Méthode et composition pour traiter le cancer

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001082900A1 (fr) * 2000-04-25 2001-11-08 The Regents Of The University Of California Ciblage génique non effractif du cerveau
WO2008112565A2 (fr) * 2007-03-09 2008-09-18 Anthony Manganaro Méthode et composition pour traiter le cancer

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
HARISON-F-E. MAY-J-M.: "vitamin C function in the brain: vital role of the ascorbate transporter SVCT2", FREE RADICAL BIOLOGY & MEDICINE, vol. 46, no. 6, 15 March 2009 (2009-03-15), pages 719 - 730, XP002699940 *
RATNAM D V ET AL: "Role of antioxidants in prophylaxis and therapy: A pharmaceutical perspective", JOURNAL OF CONTROLLED RELEASE, ELSEVIER, AMSTERDAM, NL, vol. 113, no. 3, 20 July 2006 (2006-07-20), pages 189 - 207, XP024957555, ISSN: 0168-3659, [retrieved on 20060720], DOI: 10.1016/J.JCONREL.2006.04.015 *
See also references of WO2010111620A1 *

Also Published As

Publication number Publication date
CN102458365A (zh) 2012-05-16
AU2010229700A1 (en) 2011-10-27
EP2410992A1 (fr) 2012-02-01
WO2010111620A1 (fr) 2010-09-30
CA2756581A1 (fr) 2010-09-30

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Legal Events

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PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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RIC1 Information provided on ipc code assigned before grant

Ipc: A61K 9/00 20060101ALI20130711BHEP

Ipc: A61K 31/375 20060101ALI20130711BHEP

Ipc: A61K 9/127 20060101AFI20130711BHEP

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Effective date: 20151001