EP2394996A4 - Phenylimidazole compounds - Google Patents

Phenylimidazole compounds

Info

Publication number
EP2394996A4
EP2394996A4 EP10738531A EP10738531A EP2394996A4 EP 2394996 A4 EP2394996 A4 EP 2394996A4 EP 10738531 A EP10738531 A EP 10738531A EP 10738531 A EP10738531 A EP 10738531A EP 2394996 A4 EP2394996 A4 EP 2394996A4
Authority
EP
European Patent Office
Prior art keywords
phenylimidazole compounds
phenylimidazole
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP10738531A
Other languages
German (de)
French (fr)
Other versions
EP2394996B1 (en
EP2394996A1 (en
EP2394996B8 (en
Inventor
Tadao Shibutani
Koushi Iwata
Satoshi Kido
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Pharmaceutical Co Ltd
Original Assignee
Otsuka Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharmaceutical Co Ltd filed Critical Otsuka Pharmaceutical Co Ltd
Publication of EP2394996A1 publication Critical patent/EP2394996A1/en
Publication of EP2394996A4 publication Critical patent/EP2394996A4/en
Publication of EP2394996B1 publication Critical patent/EP2394996B1/en
Application granted granted Critical
Publication of EP2394996B8 publication Critical patent/EP2394996B8/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Child & Adolescent Psychology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
EP10738531.2A 2009-02-04 2010-02-03 Phenylimidazole compounds Active EP2394996B8 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2009023793 2009-02-04
JP2009255980 2009-11-09
PCT/JP2010/051469 WO2010090200A1 (en) 2009-02-04 2010-02-03 Phenylimidazole compounds

Publications (4)

Publication Number Publication Date
EP2394996A1 EP2394996A1 (en) 2011-12-14
EP2394996A4 true EP2394996A4 (en) 2012-09-12
EP2394996B1 EP2394996B1 (en) 2016-06-22
EP2394996B8 EP2394996B8 (en) 2016-10-19

Family

ID=42542093

Family Applications (1)

Application Number Title Priority Date Filing Date
EP10738531.2A Active EP2394996B8 (en) 2009-02-04 2010-02-03 Phenylimidazole compounds

Country Status (22)

Country Link
US (1) US8329739B2 (en)
EP (1) EP2394996B8 (en)
JP (1) JP5540227B2 (en)
KR (1) KR101676889B1 (en)
CN (1) CN102307861B (en)
AR (1) AR075245A1 (en)
AU (1) AU2010211753B2 (en)
BR (1) BRPI1007902B1 (en)
CA (1) CA2750704C (en)
DK (1) DK2394996T3 (en)
ES (1) ES2587942T3 (en)
HK (1) HK1160123A1 (en)
HU (1) HUE028840T2 (en)
MX (1) MX2011008197A (en)
MY (1) MY156539A (en)
PL (1) PL2394996T3 (en)
PT (1) PT2394996T (en)
RU (1) RU2497811C2 (en)
SG (1) SG172895A1 (en)
TW (1) TWI435871B (en)
WO (1) WO2010090200A1 (en)
ZA (1) ZA201104932B (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2280706T3 (en) * 2008-05-14 2013-02-04 Otsuka Pharma Co Ltd Lipasa activating lipoprotein compositions comprising benzene derivatives
KR20180032686A (en) * 2010-03-24 2018-03-30 아미텍 테러퓨틱 솔루션즈 인크 Heterocyclic compounds useful for kinase inhibition
ES2899757T3 (en) 2014-12-19 2022-03-14 Galderma Res & Dev Heterocyclic compounds, their synthesis procedure and their use in medicine as well as in cosmetics
AU2016378154B2 (en) 2015-12-25 2020-08-13 Otsuka Pharmaceutical Factory, Inc. Phenylimidazole compound
CN106946862B (en) * 2017-03-31 2019-09-03 枣庄学院 1- alkane -6- methyl-5-nitro -1H- benzo [D] glyoxaline compound and preparation method thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008153957A1 (en) * 2007-06-07 2008-12-18 The Trustees Of Columbia University In The City Of New York Uses of rage antagonists for treating obesity and related diseases

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI57407C (en) * 1971-05-11 1980-08-11 Ciba Geigy Ag ANALOGIFICATION OF THE PHARMACOLOGICAL PROPERTIES OF THE 2-STATIONARY SUBSTITUTES 4 (5) -PYRIDYL-5 (4) -PHENYL-IMIDAZOLE
DE3411997A1 (en) * 1984-03-31 1985-10-17 Boehringer Mannheim Gmbh, 6800 Mannheim NEW REDOX INDICATORS
JP2001226358A (en) 1999-10-12 2001-08-21 Japan Tobacco Inc Lpl potentiator
DK2280706T3 (en) * 2008-05-14 2013-02-04 Otsuka Pharma Co Ltd Lipasa activating lipoprotein compositions comprising benzene derivatives

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008153957A1 (en) * 2007-06-07 2008-12-18 The Trustees Of Columbia University In The City Of New York Uses of rage antagonists for treating obesity and related diseases

Also Published As

Publication number Publication date
AU2010211753A1 (en) 2011-07-28
AU2010211753B2 (en) 2015-11-05
TWI435871B (en) 2014-05-01
JP5540227B2 (en) 2014-07-02
JPWO2010090200A1 (en) 2012-08-09
ZA201104932B (en) 2012-09-26
CN102307861B (en) 2014-10-29
US20110275823A1 (en) 2011-11-10
US8329739B2 (en) 2012-12-11
EP2394996B1 (en) 2016-06-22
PL2394996T3 (en) 2016-12-30
TW201033179A (en) 2010-09-16
CN102307861A (en) 2012-01-04
ES2587942T3 (en) 2016-10-27
BRPI1007902B1 (en) 2022-01-04
KR101676889B1 (en) 2016-11-16
KR20110111300A (en) 2011-10-10
WO2010090200A1 (en) 2010-08-12
HUE028840T2 (en) 2017-01-30
SG172895A1 (en) 2011-08-29
CA2750704A1 (en) 2010-08-12
CA2750704C (en) 2016-11-22
PT2394996T (en) 2016-08-31
BRPI1007902A2 (en) 2020-08-18
HK1160123A1 (en) 2012-08-10
RU2011136719A (en) 2013-03-10
EP2394996A1 (en) 2011-12-14
AR075245A1 (en) 2011-03-16
RU2497811C2 (en) 2013-11-10
DK2394996T3 (en) 2016-08-01
MX2011008197A (en) 2011-08-17
MY156539A (en) 2016-02-26
EP2394996B8 (en) 2016-10-19

Similar Documents

Publication Publication Date Title
GB0907425D0 (en) Compounds
EP2393493A4 (en) Compounds
EP2491025A4 (en) Azaazulene compounds
GB0907515D0 (en) Compounds
GB0914856D0 (en) Compounds
GB0905641D0 (en) Compounds
GB0909671D0 (en) Compounds
HK1160123A1 (en) Phenylimidazole compounds
AP2909A (en) Pyrazinoisoquinoline Compounds
GB0915519D0 (en) Ntithrombotic compounds
GB0911000D0 (en) Compounds
GB0909672D0 (en) Compounds
EP2443115A4 (en) Compounds
GB0904729D0 (en) Compounds
GB0915686D0 (en) Compounds
GB0906853D0 (en) Compounds
GB0908941D0 (en) Compounds
GB0908942D0 (en) Compounds
GB0905054D0 (en) Compounds
GB0902391D0 (en) Compounds
GB0906433D0 (en) Compounds
GB0902259D0 (en) Compounds
GB0906378D0 (en) Compounds
GB0909744D0 (en) Compounds
GB0905060D0 (en) Compounds

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20110720

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR

DAX Request for extension of the european patent (deleted)
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 1160123

Country of ref document: HK

A4 Supplementary search report drawn up and despatched

Effective date: 20120816

RIC1 Information provided on ipc code assigned before grant

Ipc: C07D 233/54 20060101ALI20120809BHEP

Ipc: C07D 233/64 20060101AFI20120809BHEP

Ipc: C07D 405/04 20060101ALI20120809BHEP

Ipc: A61P 9/10 20060101ALI20120809BHEP

Ipc: A61P 3/06 20060101ALI20120809BHEP

Ipc: A61P 3/04 20060101ALI20120809BHEP

Ipc: A61K 31/4178 20060101ALI20120809BHEP

Ipc: C07D 409/04 20060101ALI20120809BHEP

Ipc: A61K 31/4164 20060101ALI20120809BHEP

Ipc: A61P 43/00 20060101ALI20120809BHEP

17Q First examination report despatched

Effective date: 20131202

GRAP Despatch of communication of intention to grant a patent

Free format text: ORIGINAL CODE: EPIDOSNIGR1

INTG Intention to grant announced

Effective date: 20151201

GRAS Grant fee paid

Free format text: ORIGINAL CODE: EPIDOSNIGR3

GRAA (expected) grant

Free format text: ORIGINAL CODE: 0009210

AK Designated contracting states

Kind code of ref document: B1

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: OTSUKA PHARMACEUTICAL FACTORY, INC.

REG Reference to a national code

Ref country code: GB

Ref legal event code: FG4D

REG Reference to a national code

Ref country code: CH

Ref legal event code: EP

REG Reference to a national code

Ref country code: IE

Ref legal event code: FG4D

REG Reference to a national code

Ref country code: AT

Ref legal event code: REF

Ref document number: 807580

Country of ref document: AT

Kind code of ref document: T

Effective date: 20160715

RAP2 Party data changed (patent owner data changed or rights of a patent transferred)

Owner name: OTSUKA PHARMACEUTICAL FACTORY, INC.

RIN2 Information on inventor provided after grant (corrected)

Inventor name: IWATA, KOUSHI

Inventor name: KIDO, SATOSHI

Inventor name: SHIBUTANI, TADAO

REG Reference to a national code

Ref country code: DK

Ref legal event code: T3

Effective date: 20160726

REG Reference to a national code

Ref country code: DE

Ref legal event code: R096

Ref document number: 602010034166

Country of ref document: DE

REG Reference to a national code

Ref country code: CH

Ref legal event code: PCOW

Free format text: NEW ADDRESS: 115 AZA KUGUHARA TATEIWA MUYA-CHO, NARUTO-SHI, TOKUSHIMA 7728601 (JP)

REG Reference to a national code

Ref country code: RO

Ref legal event code: EPE

RAP2 Party data changed (patent owner data changed or rights of a patent transferred)

Owner name: OTSUKA PHARMACEUTICAL FACTORY, INC.

REG Reference to a national code

Ref country code: PT

Ref legal event code: SC4A

Ref document number: 2394996

Country of ref document: PT

Date of ref document: 20160831

Kind code of ref document: T

Free format text: AVAILABILITY OF NATIONAL TRANSLATION

Effective date: 20160825

RIN2 Information on inventor provided after grant (corrected)

Inventor name: SHIBUTANI, TADAO

Inventor name: IWATA, KOUSHI

Inventor name: KIDO, SATOSHI

REG Reference to a national code

Ref country code: NL

Ref legal event code: FP

RIN2 Information on inventor provided after grant (corrected)

Inventor name: KIDO, SATOSHI

Inventor name: IWATA, KOUSHI

Inventor name: SHIBUTANI, TADAO

REG Reference to a national code

Ref country code: SE

Ref legal event code: TRGR

REG Reference to a national code

Ref country code: NO

Ref legal event code: T2

Effective date: 20160622

REG Reference to a national code

Ref country code: LT

Ref legal event code: MG4D

REG Reference to a national code

Ref country code: ES

Ref legal event code: FG2A

Ref document number: 2587942

Country of ref document: ES

Kind code of ref document: T3

Effective date: 20161027

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: LT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20160622

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: LV

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20160622

Ref country code: HR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20160622

REG Reference to a national code

Ref country code: FR

Ref legal event code: PLFP

Year of fee payment: 8

REG Reference to a national code

Ref country code: HU

Ref legal event code: AG4A

Ref document number: E028840

Country of ref document: HU

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: SK

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20160622

Ref country code: EE

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20160622

Ref country code: IS

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20161022

REG Reference to a national code

Ref country code: GR

Ref legal event code: EP

Ref document number: 20160402062

Country of ref document: GR

Effective date: 20161118

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: SM

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20160622

REG Reference to a national code

Ref country code: DE

Ref legal event code: R097

Ref document number: 602010034166

Country of ref document: DE

REG Reference to a national code

Ref country code: HK

Ref legal event code: GR

Ref document number: 1160123

Country of ref document: HK

PLBE No opposition filed within time limit

Free format text: ORIGINAL CODE: 0009261

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: NO OPPOSITION FILED WITHIN TIME LIMIT

26N No opposition filed

Effective date: 20170323

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: SI

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20160622

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: MC

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20160622

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: LU

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20170203

REG Reference to a national code

Ref country code: FR

Ref legal event code: PLFP

Year of fee payment: 9

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: RO

Payment date: 20180129

Year of fee payment: 9

Ref country code: FI

Payment date: 20180209

Year of fee payment: 9

Ref country code: DK

Payment date: 20180212

Year of fee payment: 9

Ref country code: NO

Payment date: 20180209

Year of fee payment: 9

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: HU

Payment date: 20180126

Year of fee payment: 9

Ref country code: GR

Payment date: 20180129

Year of fee payment: 9

Ref country code: IE

Payment date: 20180212

Year of fee payment: 9

Ref country code: PT

Payment date: 20180117

Year of fee payment: 9

Ref country code: PL

Payment date: 20180130

Year of fee payment: 9

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: MT

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20170203

REG Reference to a national code

Ref country code: AT

Ref legal event code: UEP

Ref document number: 807580

Country of ref document: AT

Kind code of ref document: T

Effective date: 20160622

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: BG

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20160622

REG Reference to a national code

Ref country code: DK

Ref legal event code: EBP

Effective date: 20190228

Ref country code: NO

Ref legal event code: MMEP

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: FI

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20190203

Ref country code: NO

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20190228

Ref country code: PT

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20190805

Ref country code: RO

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20190203

Ref country code: CY

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20160622

REG Reference to a national code

Ref country code: IE

Ref legal event code: MM4A

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: HU

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20190204

Ref country code: GR

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20190904

Ref country code: MK

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20160622

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: IE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20190203

Ref country code: DK

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20190228

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: PL

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20190203

P01 Opt-out of the competence of the unified patent court (upc) registered

Effective date: 20230525

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: NL

Payment date: 20240214

Year of fee payment: 15

Ref country code: ES

Payment date: 20240301

Year of fee payment: 15

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: AT

Payment date: 20240125

Year of fee payment: 15

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: DE

Payment date: 20240130

Year of fee payment: 15

Ref country code: CZ

Payment date: 20240125

Year of fee payment: 15

Ref country code: GB

Payment date: 20240125

Year of fee payment: 15

Ref country code: CH

Payment date: 20240301

Year of fee payment: 15

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: TR

Payment date: 20240129

Year of fee payment: 15

Ref country code: SE

Payment date: 20240130

Year of fee payment: 15

Ref country code: IT

Payment date: 20240126

Year of fee payment: 15

Ref country code: FR

Payment date: 20240213

Year of fee payment: 15

Ref country code: BE

Payment date: 20240216

Year of fee payment: 15