EP2384207A1 - Medical injection device with electric motor drive control - Google Patents

Medical injection device with electric motor drive control

Info

Publication number
EP2384207A1
EP2384207A1 EP09796390A EP09796390A EP2384207A1 EP 2384207 A1 EP2384207 A1 EP 2384207A1 EP 09796390 A EP09796390 A EP 09796390A EP 09796390 A EP09796390 A EP 09796390A EP 2384207 A1 EP2384207 A1 EP 2384207A1
Authority
EP
European Patent Office
Prior art keywords
motor
injection device
medicament
drive
control means
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP09796390A
Other languages
German (de)
French (fr)
Other versions
EP2384207B1 (en
Inventor
Ulrich Brüggemann
Scott Preece
Christopher Langley
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis Deutschland GmbH
Original Assignee
Sanofi Aventis Deutschland GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis Deutschland GmbH filed Critical Sanofi Aventis Deutschland GmbH
Priority to EP09796390.4A priority Critical patent/EP2384207B1/en
Priority to DK17162265.7T priority patent/DK3216471T3/en
Priority to EP17162265.7A priority patent/EP3216471B1/en
Publication of EP2384207A1 publication Critical patent/EP2384207A1/en
Application granted granted Critical
Publication of EP2384207B1 publication Critical patent/EP2384207B1/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/1452—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/14244—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
    • F04B17/00—Pumps characterised by combination with, or adaptation to, specific driving engines or motors
    • F04B17/03—Pumps characterised by combination with, or adaptation to, specific driving engines or motors driven by electric motors
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
    • F04B49/00—Control, e.g. of pump delivery, or pump pressure of, or safety measures for, machines, pumps, or pumping installations, not otherwise provided for, or of interest apart from, groups F04B1/00 - F04B47/00
    • F04B49/06—Control using electricity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A61M2205/3306—Optical measuring means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A61M2205/3365—Rotational speed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/50—General characteristics of the apparatus with microprocessors or computers
    • A61M2205/502—User interfaces, e.g. screens or keyboards
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/82—Internal energy supply devices
    • A61M2205/8206—Internal energy supply devices battery-operated
    • A61M2205/8212—Internal energy supply devices battery-operated with means or measures taken for minimising energy consumption
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/1452—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons
    • A61M5/14566—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons with a replaceable reservoir for receiving a piston rod of the pump

Definitions

  • Figure 4 is a side view of the motor 13 showing an optical encoder 19 in registration with the flags 15.
  • the control means (microcontroller/microprocessor - not shown) detects and counts these pulses.
  • the encoder signal causes an interrupt in the microcontroller/microprocessor.
  • An interrupt causes an interruption of the current software program flow, executes a special interrupt software routine and returns to the normal software flow after finish ing the interrupt routine. This technique is used to react immediately to external signals to make sure that every signal is recognized by the microprocessor.
  • a pair of flags 15 is located at 180° and will therefore generate 4 pulses per motor turn.
  • One encoder pulse is therefore equivalent to 5 motor pulses, assuming 20 motor pulses for a single turn of the motor shaft.

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Vascular Medicine (AREA)
  • Anesthesiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

This invention relates to an injection device for delivering a medicament to the human or animal body, in particular, but not exclusively, to a device having a replaceable medicament cartridge, including an auto-injector, wherein the injector device comprises: a housing; a piston rod for driving a bung of a medicament container; a drive mechanism including a motor for providing an output drive to the piston rod for delivering the medicament; and control means for controlling operation of the device.

Description

Description
MEDICAL INJECTION DEVICE WITH ELECTRIC MOTOR DRIVE CONTROL
This invention relates to injection devices for delivering medicine to the human or animal body and in particular, but not exclusively, to devices having a replaceable medicament cartridge, including auto-injectors. Such devices are commonly used by those with diabetes for the administration of insulin.
Medicament delivery devices are routinely used by persons without formal medical training, i.e. patients where self-management of their condition is increasingly common. These circumstances set a number of requirements for medicament delivery devices of this kind. The injector should be robust in construction, yet easy to use in terms of its operation by a user and the manipulation of the parts. In the case of those with diabetes, many users will be of impaired vision and may also be physically infirm. Devices that are too large of cumbersome may therefore prove difficult to use, particularly someone with reduced dexterity.
Patent Specification US 6,340,357 describes a drug delivery system in which the dose setting is read into an electronic circuit and the dose setting movement of the dose setting elements relative to each other is performed by an electromechanical device, e.g. a motor controlled by the electronic circuit in accordance with the read in dose setting. The electronic control enables the apparatus to intervene by resetting a dose if a miss- handling of the device by the user is detected during dose setting, such as opening of the cartridge holder.
Patent Specification WO 2007/094833 describes a metering system for automatically adjusting for differential thermal expansion/contraction for the efficient, accurate and reproducible metered delivery of fluids. The system allows the metering system drive to re-zero itself to produce an accurate volumetric delivery of fluid from the dispensing container. It is also known to detect a stall of the motor that drives the dose delivery and to warn the user if a dose fails to be delivered. However, there remains a problem in the resetting of the device following detection of a motor stall event.
It is an aim of the present invention to provide a medication delivery device that alleviates this problem.
According to the present invention, there is provided an injection device for delivering a medicament to a patient, wherein the injector device comprises: a housing; a piston rod for driving a bung of a medicament container; a drive mechanism including a motor for providing an output drive to the piston rod for delivering the medicament; and control means for controlling operation of the device; characterised in that: the control means comprises: a drive signal generator for generating an input drive signal for the motor; an encoder for generating an encoder output signal indicative of the output drive of the motor; and means for varying the operational control of the device in dependence on a comparison between the input drive signal and the encoder output.
The input drive signal may be stepper pulses for driving the motor. The encoder output signal may be a pulsed signal having a timing characteristic that corresponds to the output drive of the motor. A plurality of reference points may be included in the device, each reference point being indicative of a different operational aspect of the device, including any one or more of: backstop position; dose delivered; door position; drive position; and reset threshold. The reference points preferably relate to the input drive signal such that respective reference points correspond to respective counts of the stepper pulses with reference to a device datum. A comparison between counts of the pulsed encoder output with counts of the stepper pulses may be indicative of motor slip. In the event that motor slip or stall is detected the control means is operative for determining the quantum of slip relative to one of the reference points whereupon said varying means adjusts the operational control of the device according to a predetermined criteria. The variation in operation control may be such as to urge the device to a target operational state. For example, when the quantum exceeds a predetermined threshold value, the motor may be deliberately stalled against a predetermined reference point representative of the target state. For example, the motor drive may be varied so the state of the device is changed to a dose reset position or a 'cartridge door open state' for enabling replacement of the cartridge. Alternatively, the motor may be controlled such as to rewind the piston rod to a backstop which defines a device datum or device reset position.
Embodiments of the present invention are advantageous in that the injector automatically initiates a reset action when necessary and without needing user interaction. This leads to an improvement in battery life and an avoidance or reduction in motor stall noise.
The invention will now be further described by way of example with reference to the accompanying drawings, in which like reference numerals designate like elements:
Figure 1 is a front view of an auto-injector that may include an embodiment of the present invention;
Figure 2 is a front view of the auto-injector of Figure 1 with a medicament cartridge door shown in an open position for receiving a medicament cartridge;
Figure 3 is a perspective view of a motor for use in embodiments of the present invention; Figure 4 is a side view of the motor of Figure 3 with an encoder;
Figure 5a is a timing chart of motor drive and encoder output;
Figure 5b is a timing chart of motor drive and encoder output showing motor slip;
Figure 6 is a flow chart illustrating a decision sequence that may be performed by the control means; and Figure 7 is a functional block diagram of the control means.
In figure 1 , an auto-injector 1 comprises a case 2 having a display 3 for displaying functional information relating to the operation of the auto-injector, including the set dose, number of doses remaining in the medicament cartridge. User interface buttons 4, 5 and 6 are provided to allow the user to operate the injector including priming, setting a dose, opening a medicament cartridge holder and door 7, and activating the dispensing of the set dose. A threaded needle attachment 8 is provided to which a needle can be attached for dose delivery and subsequently removed and discarded. A cover (not shown) may be provided to fit over the lower portion of the case 2 to assist in protect the device from the ingress of particles and fluid. Figure 2 shows the auto-injector 1 with the cartridge holder and door 7 in an open position for receiving a replacement medicament cartridge 9.
Figure 3 shows a motor 13 within a drive mechanism (see figure 7). The motor is provided with a pair of flags 15 disposed at 180 degrees with reference to one another. An output gear 17 engages with a gear train (not shown) of the drive mechanism for driving the piston rod of the auto-injector 1. The motor 13 may be a stepping motor driven by a pulsed drive signal or stepper pulses illustrated schematically in Figures 5a and 5b below. The pulsed drive signal is generated by an electronic control circuit within the control means. The control means will be described in more detail with reference to figures 5a to 7.
Figure 4 is a side view of the motor 13 showing an optical encoder 19 in registration with the flags 15. As the drive shaft of the motor 13 rotates the flags 15, every edge of a flag causes a change in the output of the optical encoder 19, so that the encoder outputs a series of output pulses representative of the angular velocity of the drive shaft. The control means (microcontroller/microprocessor - not shown) detects and counts these pulses. The encoder signal causes an interrupt in the microcontroller/microprocessor. An interrupt causes an interruption of the current software program flow, executes a special interrupt software routine and returns to the normal software flow after finish ing the interrupt routine. This technique is used to react immediately to external signals to make sure that every signal is recognized by the microprocessor. In the embodiment shown in figure 4, a pair of flags 15 is located at 180° and will therefore generate 4 pulses per motor turn. One encoder pulse is therefore equivalent to 5 motor pulses, assuming 20 motor pulses for a single turn of the motor shaft.
Figure 5a illustrates the relative timing between the motor drive or stepper pulses and the encoder output pulses during normal drive mechanism movement of the device. In this example, there are 5 motor stepper pulses to one encoder output pulse, the control means being programmed to expect 5 motor stepper pulses to one encoder output pulse. Consequently, when 20 motor stepper pulses are counted at the same time that the control means counts 4 encoder output pulses, the control comparison determines that the device is driving normally. That is, there is no motor slippage or no motor stall. Figure 5a illustrates a situation where a count comparison between the encoder pulse output is such as to indicate 15 motor stepper pulses whereas the actual count by the control means corresponds to 19 or 20 pulses. In this case the control means determines from the comparison that the motor movement has encountered slippage. At this point, a subroutine is run by software programmed into the control means to make a determination as to the state of the auto-injector in relation to predetermined reference points and a device datum position. The position of the piston rod when in a fully retracted position may represent a backstop position or datum position (i.e. "zero") from which other device reference points may be referenced. The datum position also corresponds to an absolute motor position so that incremental movements relative to that correspond to other operational states of the device. These other device reference points are between zero and a maximum motor travel position through 26858 motor stepper pulses. For example, from the datum position, a medicament cartridge 9 door latch open position may be represented by, for example, a motor position that corresponds to "datum position + 4 pulses". A priming dose may be determined to have been effected by movement of the motor 13 through 84 pulses from the backstop datum position.
Figure 6 shows an example of an administration routine that may be run with the control means software during the administration of medicament. At 60, the user inputs via input buttons 4-6 a desire to start the administration of a dose of medicament. The motor stepper and encoder pulse counts are examined at step 62 to determine if they differ from one another by more than a predetermined amount. If YES, the control means rewinds the drive mechanism until the motor stalls at the backstop, at which point the device may be datumed or reset. The control means software may then calculate the deficit in the medicament administered and perform means to administer this dose. If NO, the administration continues until the dose is completely expelled.
Figure 7 is a functional block diagram of the control means 70, to which is connected a user input 72 corresponding to the user interface buttons 4-6 of Figure 1 , and the drive mechanism 74. The control means 70 includes dial buttons 76 through which the user can dial the required dose and an LC display 78 for displaying the set dose. The control means software sets a dose value corresponding to that set by the user at 80 and converts this into an appropriate pulse value for the stepper motor 13 at 82. At 84, the software determines the current position of the motor 13 by looking at the current pulse count of the stepper pulses generated by the motor and determines a motor target position 86 in terms of stepper pulses that corresponds to the reference point representative of the piston rod position that will deliver the dose set at 76/80. The control means software, motor control 88, generates the required stepper pulses to drive the motor 13 of the drive mechanism 74 and compares encoder and motor pulses.

Claims

Claims
1. An injection device for delivering a medicament to a patient, wherein the injector device comprises: a housing; a piston rod for driving a bung of a medicament container; a drive mechanism including a motor for providing an output drive to the piston rod for delivering the medicament; and control means for controlling operation of the device; characterised in that: the control means comprises: a drive signal generator for generating an input drive signal for the motor; an encoder for generating an encoder output signal indicative of the output drive of the motor; and means for varying the operational control of the device in dependence on a comparison between the input drive signal and the encoder output.
2. An injection device according to claim 1 , wherein the input drive signal comprises stepper pulses for driving the motor.
3. An injection device according to claim 1 or claim 2, wherein the encoder output signal is a pulsed signal having a timing characteristic that corresponds to the output drive of the motor.
4. An injection device according to claim 1 , claim 2 or claim 3, wherein a plurality of reference points are included in the device, each reference point being indicative of a different operational aspect of the device.
5. An injection device according to claim 4, wherein the reference points include any one or more of: backstop position; dose delivered; door position; drive position; and reset threshold.
6. An injection device according to claims 2 to 4, or claims 2 to 4 and 5, wherein the reference points relate to the input drive signal such that respective reference points correspond to respective counts of the stepper pulses with reference to a device datum.
7. An injection device according to claim 3, wherein a comparison between counts of the pulsed encoder output with counts of the stepper pulses is indicative of motor stall or motor slip.
8. An injection device according to claim 7, wherein in the event that motor slip or stall is detected the control means is operative for determining the quantum of slip relative to one of the reference points whereupon said varying means adjusts the operational control of the device according to a predetermined criteria.
9. An injection device according to claim 7, wherein the motor is deliberately stalled against a predetermined reference point when the quantum of slip exceeds a predetermined threshold value.
10. An auto-injection device according to any one of the preceding claims.
EP09796390.4A 2008-12-29 2009-12-23 Medical injection device with electric motor drive control Active EP2384207B1 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP09796390.4A EP2384207B1 (en) 2008-12-29 2009-12-23 Medical injection device with electric motor drive control
DK17162265.7T DK3216471T3 (en) 2008-12-29 2009-12-23 MEDICAL INJECTION DEVICE WITH ELECTRIC MOTOR DRIVE
EP17162265.7A EP3216471B1 (en) 2008-12-29 2009-12-23 Medical injection device with electric motor drive control

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP08022476 2008-12-29
EP09796390.4A EP2384207B1 (en) 2008-12-29 2009-12-23 Medical injection device with electric motor drive control
PCT/EP2009/067827 WO2010076275A1 (en) 2008-12-29 2009-12-23 Medical injection device with electric motor drive control

Related Child Applications (1)

Application Number Title Priority Date Filing Date
EP17162265.7A Division EP3216471B1 (en) 2008-12-29 2009-12-23 Medical injection device with electric motor drive control

Publications (2)

Publication Number Publication Date
EP2384207A1 true EP2384207A1 (en) 2011-11-09
EP2384207B1 EP2384207B1 (en) 2017-03-29

Family

ID=40626800

Family Applications (2)

Application Number Title Priority Date Filing Date
EP17162265.7A Active EP3216471B1 (en) 2008-12-29 2009-12-23 Medical injection device with electric motor drive control
EP09796390.4A Active EP2384207B1 (en) 2008-12-29 2009-12-23 Medical injection device with electric motor drive control

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EP17162265.7A Active EP3216471B1 (en) 2008-12-29 2009-12-23 Medical injection device with electric motor drive control

Country Status (6)

Country Link
US (2) US9297370B2 (en)
EP (2) EP3216471B1 (en)
JP (1) JP5717649B2 (en)
CA (1) CA2748381A1 (en)
DK (2) DK2384207T3 (en)
WO (1) WO2010076275A1 (en)

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US11571516B2 (en) 2016-06-06 2023-02-07 E3D Agricultural Cooperative Association Multiple use computerized injector

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WO2010076275A1 (en) 2010-07-08
DK3216471T3 (en) 2019-03-25
EP3216471A1 (en) 2017-09-13
EP3216471B1 (en) 2018-12-12
EP2384207B1 (en) 2017-03-29
JP2012513786A (en) 2012-06-21
US20120116311A1 (en) 2012-05-10
JP5717649B2 (en) 2015-05-13
US10314968B2 (en) 2019-06-11
CA2748381A1 (en) 2010-07-08
US20190201613A9 (en) 2019-07-04
DK2384207T3 (en) 2017-07-10
US9297370B2 (en) 2016-03-29
US20160271323A1 (en) 2016-09-22

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