EP2376905A4 - Simultaneous measurment of the in vivo metabolism of isoforms of a biomolecule - Google Patents
Simultaneous measurment of the in vivo metabolism of isoforms of a biomoleculeInfo
- Publication number
- EP2376905A4 EP2376905A4 EP09826718A EP09826718A EP2376905A4 EP 2376905 A4 EP2376905 A4 EP 2376905A4 EP 09826718 A EP09826718 A EP 09826718A EP 09826718 A EP09826718 A EP 09826718A EP 2376905 A4 EP2376905 A4 EP 2376905A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- measurment
- biomolecule
- isoforms
- simultaneous
- vivo metabolism
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5082—Supracellular entities, e.g. tissue, organisms
- G01N33/5088—Supracellular entities, e.g. tissue, organisms of vertebrates
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Cell Biology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Toxicology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11394008P | 2008-11-12 | 2008-11-12 | |
US11513808P | 2008-11-17 | 2008-11-17 | |
PCT/US2009/064146 WO2010056815A1 (en) | 2008-11-12 | 2009-11-12 | Simultaneous measurment of the in vivo metabolism of isoforms of a biomolecule |
Publications (2)
Publication Number | Publication Date |
---|---|
EP2376905A1 EP2376905A1 (en) | 2011-10-19 |
EP2376905A4 true EP2376905A4 (en) | 2012-10-03 |
Family
ID=42170316
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP09826718A Withdrawn EP2376905A4 (en) | 2008-11-12 | 2009-11-12 | Simultaneous measurment of the in vivo metabolism of isoforms of a biomolecule |
Country Status (7)
Country | Link |
---|---|
US (1) | US20110294138A1 (en) |
EP (1) | EP2376905A4 (en) |
JP (1) | JP2012508886A (en) |
CN (1) | CN102246033A (en) |
AU (1) | AU2009314110C1 (en) |
CA (1) | CA2743282A1 (en) |
WO (1) | WO2010056815A1 (en) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2009062152A1 (en) * | 2007-11-09 | 2009-05-14 | Washington University In St. Louis | Methods for measuring the metabolism of cns derived biomolecules in vivo |
WO2013081735A1 (en) * | 2011-10-17 | 2013-06-06 | The Washington University | Metabolism of sod1 in csf |
JP2016506491A (en) * | 2012-11-20 | 2016-03-03 | ワシントン・ユニバーシティWashington University | Diagnosis method of amyloid pathology using analysis of amyloid β-enrichment dynamics |
CN103675133A (en) * | 2013-12-05 | 2014-03-26 | 陈东 | Method for detecting amino acids and organic acids in cells through gas chromatography-mass spectrometry |
WO2016054247A1 (en) * | 2014-09-30 | 2016-04-07 | Washington University | Tau kinetic measurements |
JP6870468B2 (en) * | 2017-05-15 | 2021-05-12 | 株式会社島津製作所 | Peptide analysis method |
WO2019028080A1 (en) | 2017-07-31 | 2019-02-07 | Quest Diagnostics Investments Llc | Apolipoprotein e isotype detection by mass spectrometry |
US20200371115A1 (en) * | 2017-08-15 | 2020-11-26 | Georgetown University | Apoe modifications and uses thereof |
CN107765015A (en) * | 2017-09-08 | 2018-03-06 | 中国计量科学研究院 | It is a kind of quantitatively to detect A β in brain tissue40The method of albumen |
US11085935B2 (en) | 2018-05-03 | 2021-08-10 | Washington University | Methods of treating based on site-specific tau phosphorylation |
WO2024133743A1 (en) * | 2022-12-21 | 2024-06-27 | EM Scientific Limited | Method for diagnosing and/or classifying the severity of a neurodegenerative disease |
CN117471007B (en) * | 2023-10-31 | 2024-08-09 | 广东省中医院(广州中医药大学第二附属医院、广州中医药大学第二临床医学院、广东省中医药科学院) | Plasma beta-amyloid detection method |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2006107814A2 (en) * | 2005-04-06 | 2006-10-12 | Washington University In St. Louis | Methods for measuring the metabolism of neurally derived biomolecules in vivo |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP4508645B2 (en) * | 2002-01-04 | 2010-07-21 | ザ ロックフェラー ユニバーシティー | Compositions and methods for the prevention and treatment of amyloid-beta peptide related diseases |
EP1483399B1 (en) * | 2002-02-12 | 2008-10-29 | The Regents of the University of California | Measurement of biosynthesis and breakdown rates of biological molecules that are inaccessible or not easily accessible to direct sampling, non-invasively, by label incorporation into metabolic derivatives and catabolitic products |
US20070231909A1 (en) * | 2005-10-13 | 2007-10-04 | Applera Corporation | Methods for the development of a biomolecule assay |
SG186689A1 (en) * | 2007-12-28 | 2013-01-30 | Univ Tennessee Res Foundation | Treatment and prophylaxis of amyloidosis |
-
2009
- 2009-11-12 JP JP2011536454A patent/JP2012508886A/en active Pending
- 2009-11-12 CN CN2009801503537A patent/CN102246033A/en active Pending
- 2009-11-12 EP EP09826718A patent/EP2376905A4/en not_active Withdrawn
- 2009-11-12 WO PCT/US2009/064146 patent/WO2010056815A1/en active Application Filing
- 2009-11-12 AU AU2009314110A patent/AU2009314110C1/en not_active Ceased
- 2009-11-12 CA CA2743282A patent/CA2743282A1/en not_active Abandoned
- 2009-11-12 US US13/129,036 patent/US20110294138A1/en not_active Abandoned
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2006107814A2 (en) * | 2005-04-06 | 2006-10-12 | Washington University In St. Louis | Methods for measuring the metabolism of neurally derived biomolecules in vivo |
Non-Patent Citations (10)
Title |
---|
BATEMAN ET AL: "Stable Isotope Labeling Tandem Mass Spectrometry (SILT) to Quantify Protein Production and Clearance Rates", JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, ELSEVIER SCIENCE INC, US, vol. 18, no. 6, 17 May 2007 (2007-05-17), pages 997 - 1006, XP022082116, ISSN: 1044-0305, DOI: 10.1016/J.JASMS.2007.02.009 * |
HENRIQUES ANA GABRIELA ET AL: "Isoform specific amyloid-beta protein precursor metabolism", JOURNAL OF ALZHEIMER'S DISEASE, vol. 11, no. 1, March 2007 (2007-03-01), pages 85 - 95, XP008155207, ISSN: 1387-2877 * |
HIROAKI FUKUMOTO ET AL: "APOE [epsilon]3/[epsilon]4 heterozygotes have an elevated proportion of apolipoprotein E4 in cerebrospinal fluid relative to plasma, independent of Alzheimer's disease diagnosis", EXPERIMENTAL NEUROLOGY, vol. 183, no. 1, 1 September 2003 (2003-09-01), pages 249 - 253, XP055036080, ISSN: 0014-4886, DOI: 10.1016/S0014-4886(03)00088-8 * |
PATTERSON ET AL: "Incorporation of a stable isotopically labeled amino acid into multiple human apolipoproteins.", THE JOURNAL OF LIPID RESEARCH, vol. 32, no. 7, 1 July 1991 (1991-07-01), pages 1063 - 1072, XP055036092, ISSN: 0022-2275 * |
RICHARD E. GREGG ET AL: "Apolipoprotein E metabolism in normolipoproteinemic human subjects", JOURNAL OF LIPID RESEARCH, vol. 25, 1 January 1984 (1984-01-01), pages 1167 - 1176, XP055036070 * |
SATYABRATA KAR ET AL: "Interactions between beta-amyloid and central cholinergic neurons: implications for Alzheimer's disease", J PSYCHIATRY NEUROSCI, vol. 29, no. 6, 1 January 2004 (2004-01-01), pages 427 - 441, XP055036069 * |
SAVAGE MARY J ET AL: "Turnover of amyloid beta-protein in mouse brain and acute reduction of its level by phorbol ester", JOURNAL OF NEUROSCIENCE, NEW YORK, NY, US, vol. 18, no. 5, 1 March 1998 (1998-03-01), pages 1743 - 1752, XP002960500, ISSN: 0270-6474 * |
See also references of WO2010056815A1 * |
SUZANNE E. WAHRLE ET AL: "Differential metabolism of ApoE isoforms in plasma and CSF", EXPERIMENTAL NEUROLOGY, vol. 183, no. 1, 1 September 2003 (2003-09-01), pages 4 - 6, XP055036071, ISSN: 0014-4886, DOI: 10.1016/S0014-4886(03)00185-7 * |
TAMAOKA ET AL: "Amyloid-beta-protein isoforms in brain of subjects with PS1-linked, beta APP-linked and sporadic Alzheimer disease.", MOLECULAR BRAIN RESEARCH, vol. 56, no. 1-2, 1 May 1998 (1998-05-01), pages 178 - 185, XP055036072, ISSN: 0169-328X * |
Also Published As
Publication number | Publication date |
---|---|
AU2009314110B2 (en) | 2014-08-21 |
AU2009314110C1 (en) | 2015-04-09 |
JP2012508886A (en) | 2012-04-12 |
CN102246033A (en) | 2011-11-16 |
CA2743282A1 (en) | 2010-05-20 |
AU2009314110A1 (en) | 2010-05-20 |
EP2376905A1 (en) | 2011-10-19 |
WO2010056815A1 (en) | 2010-05-20 |
US20110294138A1 (en) | 2011-12-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 20110610 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR |
|
DAX | Request for extension of the european patent (deleted) | ||
RIN1 | Information on inventor provided before grant (corrected) |
Inventor name: DOBROWOLSKA, JUSTYNA Inventor name: WILDSMITH, KRISTIN R. Inventor name: BATEMAN, RANDALL J. Inventor name: MUNSELL, LING Inventor name: MAWUENYEGA, KWASI G. |
|
A4 | Supplementary search report drawn up and despatched |
Effective date: 20120903 |
|
RIC1 | Information provided on ipc code assigned before grant |
Ipc: G01N 33/58 20060101ALI20120828BHEP Ipc: G01N 33/68 20060101AFI20120828BHEP |
|
17Q | First examination report despatched |
Effective date: 20131001 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20150310 |