EP2376227A4 - Réseau numérique microfluidique programmable - Google Patents

Réseau numérique microfluidique programmable

Info

Publication number
EP2376227A4
EP2376227A4 EP09836688A EP09836688A EP2376227A4 EP 2376227 A4 EP2376227 A4 EP 2376227A4 EP 09836688 A EP09836688 A EP 09836688A EP 09836688 A EP09836688 A EP 09836688A EP 2376227 A4 EP2376227 A4 EP 2376227A4
Authority
EP
European Patent Office
Prior art keywords
digital array
programmable microfluidic
microfluidic digital
programmable
array
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP09836688A
Other languages
German (de)
English (en)
Other versions
EP2376227A1 (fr
Inventor
Brian Fowler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Standard Biotools Corp
Original Assignee
Fluidigm Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fluidigm Corp filed Critical Fluidigm Corp
Publication of EP2376227A1 publication Critical patent/EP2376227A1/fr
Publication of EP2376227A4 publication Critical patent/EP2376227A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
    • B01L3/502784—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • B01L7/525—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples with physical movement of samples between temperature zones
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00281—Individual reactor vessels
    • B01J2219/00286—Reactor vessels with top and bottom openings
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00306—Reactor vessels in a multiple arrangement
    • B01J2219/00313—Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks
    • B01J2219/00315—Microtiter plates
    • B01J2219/00317—Microwell devices, i.e. having large numbers of wells
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00389—Feeding through valves
    • B01J2219/00396—Membrane valves
    • B01J2219/00398—Membrane valves in multiple arrangements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00418—Means for dispensing and evacuation of reagents using pressure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
    • B01L2200/027—Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/089—Virtual walls for guiding liquids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
    • B01L2400/0427—Electrowetting

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Dispersion Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Hematology (AREA)
  • Micromachines (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Control Of Fluid Pressure (AREA)
EP09836688A 2008-12-08 2009-12-07 Réseau numérique microfluidique programmable Withdrawn EP2376227A4 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US12080408P 2008-12-08 2008-12-08
US15784509P 2009-03-05 2009-03-05
US16066209P 2009-03-16 2009-03-16
US16611309P 2009-04-02 2009-04-02
PCT/US2009/067037 WO2010077618A1 (fr) 2008-12-08 2009-12-07 Réseau numérique microfluidique programmable

Publications (2)

Publication Number Publication Date
EP2376227A1 EP2376227A1 (fr) 2011-10-19
EP2376227A4 true EP2376227A4 (fr) 2012-07-18

Family

ID=42310101

Family Applications (1)

Application Number Title Priority Date Filing Date
EP09836688A Withdrawn EP2376227A4 (fr) 2008-12-08 2009-12-07 Réseau numérique microfluidique programmable

Country Status (4)

Country Link
EP (1) EP2376227A4 (fr)
CN (3) CN104741159B (fr)
SG (4) SG172015A1 (fr)
WO (1) WO2010077618A1 (fr)

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6221654B1 (en) 1996-09-25 2001-04-24 California Institute Of Technology Method and apparatus for analysis and sorting of polynucleotides based on size
US8052792B2 (en) 2001-04-06 2011-11-08 California Institute Of Technology Microfluidic protein crystallography techniques
US7306672B2 (en) 2001-04-06 2007-12-11 California Institute Of Technology Microfluidic free interface diffusion techniques
US7144616B1 (en) 1999-06-28 2006-12-05 California Institute Of Technology Microfabricated elastomeric valve and pump systems
US7459022B2 (en) 2001-04-06 2008-12-02 California Institute Of Technology Microfluidic protein crystallography
US8709153B2 (en) 1999-06-28 2014-04-29 California Institute Of Technology Microfludic protein crystallography techniques
DE60031540T2 (de) 1999-06-28 2007-05-16 California Institute Of Technology, Pasadena Mikromechanische pump- und ventilsysteme
US7867763B2 (en) 2004-01-25 2011-01-11 Fluidigm Corporation Integrated chip carriers with thermocycler interfaces and methods of using the same
US20050118073A1 (en) 2003-11-26 2005-06-02 Fluidigm Corporation Devices and methods for holding microfluidic devices
US7351376B1 (en) 2000-06-05 2008-04-01 California Institute Of Technology Integrated active flux microfluidic devices and methods
EP1334347A1 (fr) 2000-09-15 2003-08-13 California Institute Of Technology Dispositifs a debit transversal microfabriques et procedes associes
US7378280B2 (en) 2000-11-16 2008-05-27 California Institute Of Technology Apparatus and methods for conducting assays and high throughput screening
US7691333B2 (en) 2001-11-30 2010-04-06 Fluidigm Corporation Microfluidic device and methods of using same
AU2003224817B2 (en) 2002-04-01 2008-11-06 Fluidigm Corporation Microfluidic particle-analysis systems
EP2213615A3 (fr) 2002-09-25 2012-02-29 California Institute of Technology Intégration microfluidique à large échelle
US8220494B2 (en) 2002-09-25 2012-07-17 California Institute Of Technology Microfluidic large scale integration
WO2004040001A2 (fr) 2002-10-02 2004-05-13 California Institute Of Technology Analyse microfluidique d'acides nucleiques
US7604965B2 (en) 2003-04-03 2009-10-20 Fluidigm Corporation Thermal reaction device and method for using the same
US8828663B2 (en) 2005-03-18 2014-09-09 Fluidigm Corporation Thermal reaction device and method for using the same
WO2004103563A2 (fr) 2003-05-20 2004-12-02 Fluidigm Corporation Procede et systeme pour dispositif microfluidique et son imagerie
US7407799B2 (en) 2004-01-16 2008-08-05 California Institute Of Technology Microfluidic chemostat
CN103884698B (zh) 2004-06-07 2017-04-12 先锋生物科技股份有限公司 用于微流体器件的光学透镜系统和方法
EP1838431A4 (fr) 2004-12-03 2012-08-22 California Inst Of Techn Dispositifs microfluidiques a circuits de reactions chimiques
WO2006060748A2 (fr) 2004-12-03 2006-06-08 California Institute Of Technology Soupapes a tamis microfluidiques
EP1882189A2 (fr) 2005-04-20 2008-01-30 Fluidigm Corporation Moteur d'analyse et base de donnees permettant de manipuler des parametres destines a des systemes fluidiques sur une puce
EP1938101A2 (fr) 2005-09-13 2008-07-02 Fluidigm Corporation Dispositifs et procedes de dosage microfluidique
US7815868B1 (en) 2006-02-28 2010-10-19 Fluidigm Corporation Microfluidic reaction apparatus for high throughput screening
US8055034B2 (en) 2006-09-13 2011-11-08 Fluidigm Corporation Methods and systems for image processing of microfluidic devices
US8473216B2 (en) 2006-11-30 2013-06-25 Fluidigm Corporation Method and program for performing baseline correction of amplification curves in a PCR experiment
WO2008089493A2 (fr) 2007-01-19 2008-07-24 Fluidigm Corporation Dispositifs microfluidiques d'efficacité élevée et de précision élevée et procédés
CN102056838B (zh) 2008-04-11 2013-07-03 弗卢丁公司 微流体装置和方法
CN104043490A (zh) 2008-07-25 2014-09-17 弗卢丁公司 用于制造集成流体芯片的方法和系统
US8617488B2 (en) 2008-08-07 2013-12-31 Fluidigm Corporation Microfluidic mixing and reaction systems for high efficiency screening
US8058630B2 (en) 2009-01-16 2011-11-15 Fluidigm Corporation Microfluidic devices and methods
US8551787B2 (en) 2009-07-23 2013-10-08 Fluidigm Corporation Microfluidic devices and methods for binary mixing
SG169918A1 (en) 2009-10-02 2011-04-29 Fluidigm Corp Microfluidic devices with removable cover and methods of fabrication and application
US10022696B2 (en) 2009-11-23 2018-07-17 Cyvek, Inc. Microfluidic assay systems employing micro-particles and methods of manufacture
EP2504701B1 (fr) 2009-11-23 2017-09-13 Cyvek, Inc. Procédé et appareil destiné à réaliser des dosages
US9700889B2 (en) 2009-11-23 2017-07-11 Cyvek, Inc. Methods and systems for manufacture of microarray assay systems, conducting microfluidic assays, and monitoring and scanning to obtain microfluidic assay results
US9759718B2 (en) 2009-11-23 2017-09-12 Cyvek, Inc. PDMS membrane-confined nucleic acid and antibody/antigen-functionalized microlength tube capture elements, and systems employing them, and methods of their use
US9500645B2 (en) 2009-11-23 2016-11-22 Cyvek, Inc. Micro-tube particles for microfluidic assays and methods of manufacture
US10065403B2 (en) 2009-11-23 2018-09-04 Cyvek, Inc. Microfluidic assay assemblies and methods of manufacture
US9855735B2 (en) 2009-11-23 2018-01-02 Cyvek, Inc. Portable microfluidic assay devices and methods of manufacture and use
US9353406B2 (en) 2010-10-22 2016-05-31 Fluidigm Corporation Universal probe assay methods
CN106552682B (zh) 2011-03-22 2020-06-19 西维克公司 微流体装置以及制造方法和用途
US9168531B2 (en) 2011-03-24 2015-10-27 Fluidigm Corporation Method for thermal cycling of microfluidic samples
US9644231B2 (en) 2011-05-09 2017-05-09 Fluidigm Corporation Nucleic acid detection using probes
WO2012154876A1 (fr) 2011-05-09 2012-11-15 Fluidigm Corporation Détection d'acide nucléique à l'aide d'une sonde
DE102012100824A1 (de) 2012-02-01 2013-09-05 Albert-Ludwigs-Universität Freiburg Gemultiplexte Digital PCR
KR102070469B1 (ko) 2012-03-08 2020-01-28 싸이벡, 아이엔씨 미세유체 분석 어셈블리 및 제조방법
CN104155462B (zh) * 2014-08-19 2015-11-18 国家纳米科学中心 一种微流控免疫检测分析芯片及其分析仪器
US10228367B2 (en) 2015-12-01 2019-03-12 ProteinSimple Segmented multi-use automated assay cartridge
CN113664820B (zh) * 2021-08-11 2022-08-16 华中科技大学 一种用于软体机器人逻辑控制的微流控芯片及软体机器人

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070166199A1 (en) * 2006-01-19 2007-07-19 Kionix Corporation Microfluidic systems and control methods
WO2007109375A2 (fr) * 2006-03-22 2007-09-27 The Regents Of The University Of California Vannes à verrouillage multiplexées pour dispositifs microfluidiques et processeurs

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8550119B2 (en) * 1999-06-28 2013-10-08 California Institute Of Technology Microfabricated elastomeric valve and pump systems
EP2213615A3 (fr) * 2002-09-25 2012-02-29 California Institute of Technology Intégration microfluidique à large échelle
US6923216B2 (en) * 2003-04-15 2005-08-02 Entegris, Inc. Microfluidic device with ultraphobic surfaces
EP1796824A4 (fr) * 2004-05-02 2016-10-19 Fluidigm Corp Dispositif de réaction thermique et méthode d'utilisation de semblable
EP1938101A2 (fr) * 2005-09-13 2008-07-02 Fluidigm Corporation Dispositifs et procedes de dosage microfluidique
CN102056838B (zh) 2008-04-11 2013-07-03 弗卢丁公司 微流体装置和方法

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070166199A1 (en) * 2006-01-19 2007-07-19 Kionix Corporation Microfluidic systems and control methods
WO2007109375A2 (fr) * 2006-03-22 2007-09-27 The Regents Of The University Of California Vannes à verrouillage multiplexées pour dispositifs microfluidiques et processeurs

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO2010077618A1 *

Also Published As

Publication number Publication date
SG172015A1 (en) 2011-07-28
SG10201404682WA (en) 2014-10-30
CN102281950B (zh) 2015-05-06
CN105964316A (zh) 2016-09-28
CN104741159A (zh) 2015-07-01
CN102281950A (zh) 2011-12-14
WO2010077618A1 (fr) 2010-07-08
CN104741159B (zh) 2017-01-18
SG10201404683TA (en) 2014-10-30
EP2376227A1 (fr) 2011-10-19
SG10201404685PA (en) 2014-10-30

Similar Documents

Publication Publication Date Title
SG10201404683TA (en) Programmable microfluidic digital array
GB2447684B (en) Biogasoline
IL239553B (en) Digital DNA sequencing
GB0813490D0 (en) Solid state material
EP2008282A4 (fr) Cellule programmable
GB0813093D0 (en) Polymeric materials
ZA200907985B (en) Electrowetting based digital microfluidics
IL185609A0 (en) Multi function senssor
EP2352801A4 (fr) Matériaux électroactifs
DK2135129T3 (en) Midler til hurtigfastgørelse til brillestang
GB0819055D0 (en) Polymeric materials
EP2352802A4 (fr) Matériaux électroactifs
GB2469991B (en) Polymeric materials
EP2352803A4 (fr) Matières électroactives
GB0818967D0 (en) Polymeric materials
GB0902610D0 (en) Materials
GB0724258D0 (en) Novel combinations
EP2507280A4 (fr) Materiaux polymeres
GB0715132D0 (en) Tissue-adhesive materials
DE112010003339A5 (de) Programmierbarer Stempel
GB0713587D0 (en) Insulaitng materials
EP2107940A4 (fr) Élément de garniture façonné
HU0700706D0 (en) Digital sepulture
PL383687A1 (pl) Element nośny
GB0814373D0 (en) Tissue-adhesive materials

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20110614

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR

DAX Request for extension of the european patent (deleted)
A4 Supplementary search report drawn up and despatched

Effective date: 20120618

RIC1 Information provided on ipc code assigned before grant

Ipc: B01L 3/00 20060101AFI20120612BHEP

17Q First examination report despatched

Effective date: 20130716

GRAP Despatch of communication of intention to grant a patent

Free format text: ORIGINAL CODE: EPIDOSNIGR1

INTG Intention to grant announced

Effective date: 20170220

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20170704