Classifications

• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
  • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
  • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
  • A61M5/142—Pressure infusion, e.g. using pumps
  • A61M5/14244—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
  • A61B5/00—Measuring for diagnostic purposes; Identification of persons
  • A61B5/15—Devices for taking samples of blood
  • A61B5/150007—Details
  • A61B5/150015—Source of blood
  • A61B5/150022—Source of blood for capillary blood or interstitial fluid
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
  • A61B5/00—Measuring for diagnostic purposes; Identification of persons
  • A61B5/15—Devices for taking samples of blood
  • A61B5/150007—Details
  • A61B5/150206—Construction or design features not otherwise provided for; manufacturing or production; packages; sterilisation of piercing element, piercing device or sampling device
  • A61B5/150229—Pumps for assisting the blood sampling
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
  • A61B5/00—Measuring for diagnostic purposes; Identification of persons
  • A61B5/15—Devices for taking samples of blood
  • A61B5/150007—Details
  • A61B5/150374—Details of piercing elements or protective means for preventing accidental injuries by such piercing elements
  • A61B5/150381—Design of piercing elements
  • A61B5/150389—Hollow piercing elements, e.g. canulas, needles, for piercing the skin
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
  • A61B5/00—Measuring for diagnostic purposes; Identification of persons
  • A61B5/15—Devices for taking samples of blood
  • A61B5/150007—Details
  • A61B5/150374—Details of piercing elements or protective means for preventing accidental injuries by such piercing elements
  • A61B5/150381—Design of piercing elements
  • A61B5/150503—Single-ended needles
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
  • A61B5/00—Measuring for diagnostic purposes; Identification of persons
  • A61B5/15—Devices for taking samples of blood
  • A61B5/150007—Details
  • A61B5/150801—Means for facilitating use, e.g. by people with impaired vision; means for indicating when used correctly or incorrectly; means for alarming
  • A61B5/150824—Means for facilitating use, e.g. by people with impaired vision; means for indicating when used correctly or incorrectly; means for alarming by visual feedback
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
  • A61B5/00—Measuring for diagnostic purposes; Identification of persons
  • A61B5/15—Devices for taking samples of blood
  • A61B5/150007—Details
  • A61B5/150847—Communication to or from blood sampling device
  • A61B5/15087—Communication to or from blood sampling device short range, e.g. between console and disposable
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
  • A61B5/00—Measuring for diagnostic purposes; Identification of persons
  • A61B5/15—Devices for taking samples of blood
  • A61B5/150969—Low-profile devices which resemble patches or plasters, e.g. also allowing collection of blood samples for testing
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
  • A61B5/00—Measuring for diagnostic purposes; Identification of persons
  • A61B5/15—Devices for taking samples of blood
  • A61B5/150977—Arrays of piercing elements for simultaneous piercing
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
  • A61B5/00—Measuring for diagnostic purposes; Identification of persons
  • A61B5/15—Devices for taking samples of blood
  • A61B5/151—Devices specially adapted for taking samples of capillary blood, e.g. by lancets, needles or blades
  • A61B5/15101—Details
  • A61B5/15103—Piercing procedure
  • A61B5/15107—Piercing being assisted by a triggering mechanism
  • A61B5/15109—Fully automatically triggered, i.e. the triggering does not require a deliberate action by the user, e.g. by contact with the patient's skin
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
  • A61B5/00—Measuring for diagnostic purposes; Identification of persons
  • A61B5/15—Devices for taking samples of blood
  • A61B5/151—Devices specially adapted for taking samples of capillary blood, e.g. by lancets, needles or blades
  • A61B5/15101—Details
  • A61B5/15115—Driving means for propelling the piercing element to pierce the skin, e.g. comprising mechanisms based on shape memory alloys, magnetism, solenoids, piezoelectric effect, biased elements, resilient elements, vacuum or compressed fluids
  • A61B5/15117—Driving means for propelling the piercing element to pierce the skin, e.g. comprising mechanisms based on shape memory alloys, magnetism, solenoids, piezoelectric effect, biased elements, resilient elements, vacuum or compressed fluids comprising biased elements, resilient elements or a spring, e.g. a helical spring, leaf spring, or elastic strap
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
  • A61B5/00—Measuring for diagnostic purposes; Identification of persons
  • A61B5/15—Devices for taking samples of blood
  • A61B5/151—Devices specially adapted for taking samples of capillary blood, e.g. by lancets, needles or blades
  • A61B5/15142—Devices intended for single use, i.e. disposable
  • A61B5/15144—Devices intended for single use, i.e. disposable comprising driving means, e.g. a spring, for retracting the piercing unit into the housing
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
  • A61M2205/00—General characteristics of the apparatus
  • A61M2205/35—Communication
  • A61M2205/3576—Communication with non implanted data transmission devices, e.g. using external transmitter or receiver
  • A61M2205/3592—Communication with non implanted data transmission devices, e.g. using external transmitter or receiver using telemetric means, e.g. radio or optical transmission
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
  • A61M2205/00—General characteristics of the apparatus
  • A61M2205/50—General characteristics of the apparatus with microprocessors or computers

Definitions

• the invention relates to a miniaturized injection or sampling device for medical use comprising an elongated enclosure extending in a certain axial direction, at least one needle movable in the enclosure in said axial direction between a withdrawal position in the enclosure and a protruding position outside the enclosure, a mobile pump with the needle in the enclosure in said axial direction and adapted to circulate a medicinal substance to be injected or a substance to be taken between a reservoir and the needle, and displacement means adapted to move said needle in said axial direction.
• a portable injection device comprising in a chamber a reservoir for a medicinal substance connected to a needle, the reservoir and the needle being movable in the chamber, a pump for circulating the drug substance from the reservoir to the needle and means for moving the needle operable by an individual to perform self-injection.
• the means for moving the needle comprises springs initially compressed by a cover that the individual returns to release the springs.
• This injection device implies that, during the injection, the individual has easy access to the device and is in physical condition to perform this gesture - which can be excluded in case of emergency. Moreover, at the end of injection, the needle remains out of the enclosure, which can present a danger for the individual.
• the document FR2909001 also describes an injection or sampling device as described above, furthermore comprising a control unit which controls both the displacement of the needle and the triggering of the pump, but this device requires an action of the individual to make an injection.
• the object of the present invention is to provide a fully automatic injection device and safe for the individual.
• the subject of the invention is a miniaturized injection or sampling device for medical use comprising an elongate enclosure extending in a certain axial direction, at least one needle movable in the enclosure in said axial direction between a withdrawal position in the chamber and a protruding position outside the enclosure, a mobile pump with the needle in the enclosure in said axial direction and adapted to circulate a medicinal substance to be injected or a substance to be taken between a reservoir and the needle, and displacement means adapted to move said needle in said axial direction, characterized in that it further comprises in the enclosure a wireless signal receiver which in response to the reception of a signal of control actuates the moving means for moving the needle from the retracted position to the protruding position and in that a switch is further provided switch to actuate the pump in response to a certain displacement of the needle in the enclosure in said axial direction.
• the connection of the reservoir to the needle, and the movement of the needle to pierce the skin of the individual, then to retract into the enclosure of the device are made fully automatically by the displacement means actuated by an external control signal received by the wireless signal receiver.
• the means of displacement allow for the needle two positions: a projecting position only during injection (or sampling), and a withdrawal position before injection (or before sampling) and automatically after injection (or after sampling), so that the individual is not likely to hurt himself.
• the device according to the invention may have the following particularities:
• said moving means are arranged to move said needle in one direction or the other in said axial direction, and there is provided a timing means which actuates said moving means to move the needle from said projecting position to the position withdrawal after a certain period of operation of the pump;
• said moving means comprise return springs
• said return springs comprise a first spring provided with a first stiffness constant which expands to move said needle towards its projecting position at the same time as it compresses a second spring having a second stiffness constant less than said first stiffness constant, which second spring is expanded to move said needle from said projecting position to said retracted position;
• a first wireless signal transmitter disposed outside the enclosure and adapted to transmit said control signal for the wireless signal receiver
• the transmitter is disposed in an intradermal implant
• the transmitter comprises a chemical sensor
• said moving means further comprises a means for locking the position of the needle in said axial direction, the locking means being based on a shape memory material excited by an electric battery; said receiver is an RFID receiver;
• an alarm which is actuated by said receiver in response to receiving said control signal
• the alarm is transmitted by a second wireless signal transmitter disposed in the enclosure.
• the device according to the invention may comprise a plurality of reservoirs respectively connected to a plurality of movable needles in the enclosure in a certain axial direction, and a plurality of pumps respectively adapted to circulate the substance between each reservoir and each needle and displacement means adapted to move simultaneously or selectively said needles in the axial direction in a protruding position outside the enclosure.
• the invention also extends to a garment comprising a housing intended to come into contact with a body part of an individual wearing the garment and a device according to the invention disposed in said garment housing in such a way that protruding position, the needle of the device enters the body of the individual.
• An injection device is particularly well suited for use for one or more emergency treatment injections (drug, vaccine or other) since the device equipped with radio-identification module can receive a signal controlling an injection from a sensor external to the device, is located within the body of the individual to detect a crisis, identified for example by a change in concentration of a substance (insulin for example), is arranged remotely to detect pollution for example.
• a crisis identified for example by a change in concentration of a substance (insulin for example)
• Figure 1 is a schematic longitudinal sectional view of an injection device according to the invention.
• Figure 2 is a schematic view of the injection device according to the invention.
• Figure 3 is a very schematic view showing the injection device according to the invention embedded in a garment worn by an individual.
• Figure 4 is a schematic longitudinal sectional view of the injection device according to the invention in a projecting position of the needles.
• Figure 5 is a schematic longitudinal sectional view of the injection device according to the invention in an intermediate position of the needles.
• Figure 6 is a schematic longitudinal sectional view of the injection device according to the invention in a locked needles withdrawal position in the device.
• Figure 7 is a schematic longitudinal sectional view of another embodiment of the injection device according to the invention having four tanks operable at the same time.
• FIG. 8 is a schematic cross-sectional view of the injection device of FIG. 7.
• Figure 9 is a schematic longitudinal sectional view of yet another embodiment of the injection device according to the invention having four separately operable reservoirs.
• FIG. 10 is a schematic cross-sectional view of the injection device of FIG. 9.
• FIG. 1 shows an embodiment of the injection device
• the chamber 2 is formed of a base with a wall bottom 5 intended to be placed on the skin of an individual (see Figure 3) and a lid 6 which fits snugly on the base.
• the reservoir 3 may be chosen from vials of various volumes, here tubular, glass or rigid plastic material and advantageously from commercial vials.
• the lower support 4 here cylindrical, carries one or more needles 7 aligned in the axial direction A and a pump 8 for circulating the drug substance from the reservoir 3 to the needles 7.
• the pump 8, the needles 7 and the reservoir 3 on the support 4 are thus integral in translation in the chamber 2 in the axial direction A.
• the needles 7 are in the position of withdrawal in the enclosure 2, so invisible and safe for the individual.
• FIG. 1 shows that the needles 7 are in the position of withdrawal in the enclosure 2, so invisible and safe for the individual.
• the injection device 1 comprises disposed in the enclosure 2 displacement means 9 composed of two substantially identical upper helical return springs 1 1 intended to move the reservoir 3 and the needles 7 in the direction axial A in a first downward direction, so as to reach a protruding position of the needles 7 in which they are out of the chamber 2 through one or more openings 12 respectively of the bottom wall 5 of the enclosure 2, and two substantially identical lower helical return springs 13 for moving the reservoir 3 and the needles 7 in the axial direction A in a second direction upwards, so as to reach a position of withdrawal of the needles 7 in which those -ci are retracted into the enclosure 2.
• the stiffness constant K1 of the upper springs 1 1 is greater than the stiffness constant K2 of the lower springs 13.
• the injection device 1 also comprises, as represented in FIG. 1, two wireless signal-emitter receivers 14, 15 disposed in the enclosure 2, preferably on an intermediate support 16 secured in movement with the reservoir 3 respectively and upper support 17 movable in the enclosure 2.
• the transmitter-receivers 14,15 are able to actuate the displacement means 9, and in particular the respective electrical modules or batteries 18,19 respective displacement means 9, in response to a control signal from a 43.44 wireless signal transmitter external to the device (see Figure 3 below).
• the control signal transmitted by the wireless signal transmitter 43, 44 may be encrypted according to the application of the device 1.
• wireless signal receiver-transmitter also called RFID module (Radio-Frequency Identification, identification by radio-frequency)
• RFID module Radio-Frequency Identification, identification by radio-frequency
• an electronic module which generally comprises an antenna associated with an electronic chip which enables it to receive and respond to radio frequency signals transmitted from a radio transceiver.
• the injection device 1 further comprises in the enclosure 2, preferably on the lower support 4, another wireless signal receiver-transmitter 20 adapted to receive a signal from the pump 8 and to transmit a signal of end of injection to the radio identification module 15, as will be detailed later.
• the device 1 may also comprise a delay means 21 connected to the pump 8 which defines a predetermined injection duration as a function of the volume of drug to be injected.
• the displacement means 9 comprise on the intermediate support 16 two lower pads 22 diametrically symmetrical and pointing upwards in the direction A, on the upper support 17 two lower hollow tubes 23 diametrically symmetrical pointing downwards in the direction A and intended to respectively receive the lower pads 22 and two upper pads 24 diametrically symmetrical and pointing upwards in the direction A, finally on the lid 6 of the enclosure 2 two upper hollow tubes 25 diametrically symmetrical pointing downwards in the direction A and intended to receive respectively the upper pads 24.
• the two lower springs 13 are attached to an end portion thereof on the bottom wall 5 of the enclosure 2 and to the other end portion thereof on the lower support. 4.
• the two upper springs 1 1 are attached to an end portion thereof on the intermediate support 16 so as to encircle the lower pads 22 and the other end portion thereof on the upper support 17 prior to use of the device 1, the upper support 17 is mounted on the intermediate support 16 so that the lower pads 22 are fully engaged in the lower hollow tubes 23 and the lower hollow tubes 23 are fully engaged in the upper springs 1 1 and the cover 6 is mounted on the upper support 17 so that the upper pads 24 are barely engaged in the upper hollow tubes 25.
• the springs sup 1 1 are then compressed and the lower springs 13 relaxed, the lower springs 13 opposing the axial displacement of the lower support 4 towards the bottom wall 5 and thus keeping the needles 7 set back inside the enclosure 2.
• This provides a compact injection device 1 of reduced volume once mounted, and also easily removable.
• the lower pads 22 and upper 24 are respectively equipped with a first element of locking means 10 for moving means 9 in the form of a 26,27 pin with shape memory
• the lower hollow tubes 23 and upper 25 are respectively equipped with a second element of locking means 10 displacement means 9 in the form of first and second respective housing 28,29,30,31 respectively arranged at the lower and upper ends of the hollow tubes 23, 25, preferably diametrically opposed.
• Shape-memory pins are pins capable of successively presenting an elongate or retracted shape in response to a control signal transmitted by the emitter-receivers 14, 15 via the respective electrical modules 18, 19 arranged in the enclosure 2 , preferably respectively on the intermediate support 16 and the upper support 17.
• the locking means 10 may also be in the form of electromagnets or movable hooks operable by the electrical modules 18,19.
• the pin 26 does not protrude laterally from the pad 22 (respectively 24) so as to allow axial displacement of the pad 22 (respectively 24) in the corresponding hollow tube 23 (respectively 25) .
• the pin 26 protrudes laterally out of the stud 22 (respectively 24) and engages in the housings 28 or 29 (respectively 30 or 31) so as to lock the stud 22 (respectively 24) with the corresponding hollow tube 23 (respectively 25): the stud will be locked in a position of the stud completely engaged in the corresponding hollow tube when the pin 26 (respectively 27) elongated is inserted into the housing 28 (respectively 30), or in a protruding position of the stud out of the corresponding hollow tube when the elongated pin 26 (respectively 27) is inserted into the housing 29 (respectively 31).
• One or more percussion cones 32 disposed on the pump 8 point towards one or more complementary lids 33 disposed on the reservoir 3 so as to pass through the respective lids 33 to create a passage between the reservoir 3 and the needles 7 via the pump 8 when the reservoir 3 is moved in the chamber 2 in the axial direction A to the lower support 4 over a distance noted y in Figure 1.
• An elastic member 310 is disposed between the pump 8 and the reservoir 3 so as initially to maintain the reservoir 3 at a distance from the pump 8 such that the covers 33 are not traversed by the cones 32.
• the percussion cones 32 are surrounded by a seal (not shown) sealing the connection between the cones 32 and the covers 33.
• a switch 35 adapted to switch when it comes into contact with a stop 36 disposed on the bottom wall 5 and whose function is to actuate the pump 8 in response to a certain axial displacement needles 7 in the chamber 2 along the direction A over a distance marked x in FIG.
• the pump 8 can be an electric motor pump powered by a battery 34 through the switch 35.
• the pump 8 can be made from micro-mechanical or electromechanical microfluidic systems called MEMS or MOEMS powered by the battery 34 which can be a battery, a bio battery, an internal fuel or an inert gas.
• the injection time of the drug substance can be conditioned by the autonomy of the supply.
• the pump 8 of the injection device 1 may for example be a peristaltic pump, rotary or centrifugal, or a diaphragm pump or vane, or more generally any suitable technology for pumping and injection.
• a visual or audible alarm 38 provided in the chamber 2 can be actuated by one of the wireless signal receivers 14, 15 in response to the receiving the control signal to indicate to the individual the beginning of an injection.
• the alarm may be transmitted by a wireless transmitter 38 disposed in the chamber 2 adapted to communicate information on the injection to another wireless signal receiver (not shown) disposed outside the enclosure 2, and for example alerting help.
• the stroke x of the lower support 4 in the chamber 2 is designed so that the needles 7 penetrate to a pre-determined depth in the dermis or muscle tissue of the individual adapted to the medical treatment, depending on the type of injection hypodermic, intradermal, intramuscular or intravenous.
• the needles 7 penetrate the dermis to a distance of 0.2 millimeters (mm) to 0.8 mm.
• the needles 7 penetrate the muscle tissue to a distance of 2 mm to 3 mm.
• the needles 7 have a diameter of about 0.05 mm to 0.2 mm for a length of about 0.5 mm to 3 mm, depending on the medical applications. They are made of materials suitable for medical use, such as medical stainless steel, polymers or ceramics for example. The needles may be made so as to hold on the surface disinfectants or anesthetic or healing, for example by having a surface having micro-scratches, vents or a certain porosity.
• the size of the injection device 1 varies between 2 to 5 cm in diameter and between 2 to 5 cm in height depending on the product to be injected.
• the size of the pump 8 varies between 2 to 5 cm in width and length and between 0.5 to 2 cm in height depending on the product to be injected.
• the injection device 1 according to the invention (and in particular the needles 7) is sterile and packaged so as to remain sterile until use of the device
• the bottom wall 5 of the enclosure 2 intended to be in contact with the skin of the individual is covered by a protective film 37 through which the needles 7 during an injection.
• FIG. 2 it is possible to see a transparent window 39 on the cover 6 of the enclosure 2 which possibly allows the individual to check the level of filling of the tank 3.
• a transparent window 39 on the cover 6 of the enclosure 2 which possibly allows the individual to check the level of filling of the tank 3.
• the tank 3 and a part of the enclosure 2 are made of a transparent material.
• FIG. 3 shows a garment 40 comprising a housing 41, possibly made of transparent material, intended to come into contact with a body part of an individual wearing garment 40, here for example the top of arm 42, the injection device 1 according to the invention being disposed in said housing 41 so that in the projecting position of the needles 7, the needles 7 penetrate into the body of the individual to the predetermined depth.
• the injection device 1 comprises for this purpose a fixing means 46, such as for example elastics, which plate the bottom wall 5 of the device 1 on the arm 42 of the individual.
• the wireless signal transmitter 43, 44 external to the device and adapted to transmit the control signal intended for the wireless signal receivers 14, 15 may be disposed either in an intradermal implant 43 integrated in the body of the individual, either in an external device 44 such as a computer for example.
• the wireless signal transmitter 43, 44 may comprise a chemical sensor capable of detecting, for example, a change in environmental pollution or a change in the concentration of an individual body substance such as insulin or an abnormal change in physiological data of the individual, so as to emit the control signal of an injection.
• Figure 1 there is shown schematically the device 1 before use, that is to say that the needles 7 are recessed in the chamber 2, the upper springs January 1 being compressed and the lower springs 13 being expanded.
• the locking of the displacement means is then carried out as follows: the pins 26, here in elongate position in the respective housings 28, lock the pads 22 completely engaged in the corresponding hollow tubes 23 and the pins 27, here in the extended position in the respective housings 31, lock the studs 24 in the released position out of the corresponding hollow tubes 25.
• the receiver 14 of the device 1 When the receiver 14 of the device 1 receives a control signal from a subcutaneous 43 or external transmitter 44, it actuates the moving means 9 via the electric battery 18, which unlock the upper springs 1 1 which are then free to relax.
• the expansion of the upper springs 1 1 first causes the displacement of the reservoir 3 towards the support 4 in the axial direction A down the distance y, which drives the percussion cones 32 in the covers 33 and creates a passage between the tank 3 and the needles 7.
• the stiffness constant K1 of the upper springs 1 1 being greater than the stiffness constant K2 of the lower springs 13, the lower springs 13 are compressed under the pressure of the expansion of the upper springs 1 1.
• the expansion of the upper springs 1 1 then causes the displacement in the axial direction A down the distance x of the assembly formed by the reservoir 3 and the support 4 with the needles 7 and the pump 8, then the output of the needles 7 out of the chamber 2 through the openings 12 and the film 37 and finally the penetration of the needles 7 into the individual at the predetermined depth.
• the switch 35 in contact with the stop 36 actuates the pump 8 to inject the drug product.
• the delay means 21 then begins to count down the duration of the injection, that is to say the duration of the power supply of the pump 8 by the battery 34.
• the alarm 38 is simultaneously triggered by the receiver- transmitter 14.
• the injection is performed automatically, simply and safely upon receipt of the control signal, without any action of the individual carrying the injection device 1.
• FIG. 4 diagrammatically shows the device 1 during the injection, that is to say that the needles 7 are out of the enclosure 2, the upper springs 1 1 being relaxed and the lower springs 13 being tablets.
• the locking of the displacement means 9 is then carried out as follows: the pins 26, here in elongate position in the respective housings 29, lock the studs 22 in the disengaged position out of the corresponding hollow tubes 23 and the pins 27, here in the extended position in the respective housings 31, lock the studs 24 in the released position out of the corresponding hollow tubes 25.
• the timing means 21 controls the stopping of the pump 8 which sends an end of injection signal to the receiver 20.
• the receiver-transmitter 20 then transmits a signal to the receiver 15 which actuates the moving means 9 via the battery 19 to unlock the lower springs 13 which are then free to relax.
• the expansion of the lower springs 13 causes the needles 7 to be withdrawn into the chamber 2 in the axial direction A upwards over the distance x.
• FIG. 5 diagrammatically shows the device 1 immediately after the injection, that is to say that the needles 7 are being withdrawn in the enclosure 2, the upper springs 1 1 still being relaxed and the lower springs 13 beginning to relax.
• the displacement means 9 are locked at the pins 26 which are here engaged in the extended position in the respective housings 29 and free at the pins 27 which, here in retracted position, allow the pads 24 to engage in the hollow tubes 25 under the pressure of the trigger of the lower springs 13.
• the moving means 9 When the lower springs 13 are completely relaxed, the moving means 9 are actuated by the receiver 15 which transmits a signal to the battery 19, to lock the lower springs 13, so as to lock the needles 7 in the retracted position in the enclosure 2.
• FIG. 6 diagrammatically shows the device 1 locked in the safety position after the injection when the needles 7 are fully retracted into the chamber 2, the upper springs 1 1 and the lower springs 13 being completely relaxed.
• the displacement means 9 are now locked at the level of the pins 26 which, here engaged in elongate position in the respective housings 29, block the pads 22 in the disengaged position out of the corresponding hollow tubes 23, and at the pins 27 which , engaged in the extended position in the respective housings 30, block the pads 24 in the fully engaged position in the corresponding hollow tubes 25.
• the injection device 1 is blocked, the pump 8 can not be reused and the needles can not leave the enclosure.
• the device 1 according to the invention could also be made with a different number of springs 1 1, 13, pads 22,24 and corresponding hollow tubes 23,25 without departing from the scope of the invention.
• the materials used to make the different components of the injection device may advantageously be made of recyclable materials.
• FIGS. 7 and 8 show diagrammatically another embodiment of the injection device 101 according to the invention having a plurality of substantially identical reservoirs 103A, 103B, 103C, 103D, each containing a different medicinal substance and operable simultaneously.
• the device 101 allows a simultaneous injection of several substances, for example immiscible or not compatible with each other. It is obvious that the injection device 101 could be designed with a different number of tanks without departing from the scope of the present invention.
• the reservoirs 103A, 103B are disposed on the support 4 and are separated by a wall 107 and each in correspondence with one or more needles 107A, 107B respectively.
• a respective pump 108A, 108B is intended to circulate the drug substance from each reservoir 103A, 103B to the corresponding needles 107A, 107B.
• One or more percussion cones 132A, 132B are disposed on each pump 108A, 108B and point towards respective complementary lids 133A, 133B disposed on each tank 103A, 103B.
• the needles 107A, 107B are in the retracted position in the chamber 2, therefore invisible and safe for the individual.
• the displacement device 9 causes the output of all the needles 107A, 107B of the enclosure 2 and a simultaneous injection of the substances contained in all the reservoirs 103A, 103B occurs as described above in correspondence with the injection device 1.
• FIGS. 9 and 10 show diagrammatically another embodiment of the injection device 201 according to the invention having a plurality of substantially identical reservoirs 203, 303, 403, 503, each containing a different drug substance, operable from individual and selective manner, the tanks being movable in translation along an axis 245.
• the injection device 201 and allows to inject each substance selectively at a chosen time. It is obvious that the injection device 201 could also be designed with a different number of tanks without departing from the scope of the present invention.
• the reservoir 203 is disposed on a support 204 in correspondence with one or more needles 207.
• a pump 208 intended to circulate the drug substance from the reservoir 203 to the needles 207 is housed on the support 204.
• One or more percussion cones 232 disposed on the pump 208 point towards one or more complementary lids 233 disposed on the reservoir 203.
• the needles 207 are in the retracted position in the chamber 2, so invisible and safe for the individual carrying the injection device 201.
• displacement means 209 disposed in the enclosure 2 and associated with the reservoir 203 comprise one or more substantially identical upper coil springs 21 1 intended to move the reservoir 203 and the needles 207 in the axial direction A. in a first direction downwards, so as to reach a projecting position of the needles 207, and one or more lower helical springs 213 fixed between the support 204 and the bottom wall 5 of the enclosure 2, substantially identical intended to move the reservoir 203 and the needles 207 in the axial direction A in a second direction upwards, so as to reach a needle retraction position 207.
• the stiffness constant of the upper springs 21 1 is greater than the stiffness constant of the lower springs 213.
• the injection device 201 furthermore comprises, associated with each reservoir 203, two wireless signal-emitter receivers 214, 215 disposed respectively in the enclosure 2 on an intermediate support 216 and an upper support 217.
• the transmitter-receivers 214, 225 play here a role similar to the transceivers 14,15 of the device 1 described above, and in particular they actuate electric batteries 218,219 displacement means 209 in response to a control signal from a wireless signal transmitter 43,44 external to the device (shown in Figure 3).
• the injection device 201 further comprises, in the chamber 2, preferably on the lower support 204, a timing means 221 which defines a predetermined injection duration as a function of the volume of drug to injecting into the reservoir 203, and a wireless signal receiver-transmitter 220 adapted to receive a signal from the timing means 221 and to transmit an end of injection signal to the radio identification modules 214,215.
• the displacement means 209 comprise a set of pads 222,224 and corresponding hollow tubes 223,225 respectively disposed on the intermediate support 216, the upper support 217 and the cover 6 of the enclosure 2 , the upper springs 21 1 being fixed between the supports 216 and 217 so as to encircle the lower pads 222 and the lower hollow tubes 223.
• a control signal is sent by a transmitter 43, 44 selectively to one of the transmitter receivers 214, 314, 414 (not shown), 514 (not shown) respectively corresponding to one of the tanks 203, 303, 403, 503, for example the receiver 214 associated with the reservoir 203.
• the associated displacement device 209 then causes the exit of the needles 207 from the chamber 2 and an injection of the substance contained in the reservoir 203 occurs as described above in correspondence with the injection device 1. It is obviously also possible with the injection device 201 simultaneous selective injection of two or more substances contained in two or more tanks by sending a control signal to two or more receivers-transmitters corresponding.
• the miniaturized device according to the invention can also serve as a blood sampling device for example for subsequent analyzes.

Landscapes

• Health & Medical Sciences (AREA)
• Life Sciences & Earth Sciences (AREA)
• Engineering & Computer Science (AREA)
• Animal Behavior & Ethology (AREA)
• Hematology (AREA)
• Veterinary Medicine (AREA)
• Public Health (AREA)
• Biomedical Technology (AREA)
• Heart & Thoracic Surgery (AREA)
• General Health & Medical Sciences (AREA)
• Pathology (AREA)
• Surgery (AREA)
• Molecular Biology (AREA)
• Medical Informatics (AREA)
• Biophysics (AREA)
• Physics & Mathematics (AREA)
• Manufacturing & Machinery (AREA)
• Vascular Medicine (AREA)
• Anesthesiology (AREA)
• Infusion, Injection, And Reservoir Apparatuses (AREA)
• Medicinal Preparation (AREA)

Applications Claiming Priority (2)

Publications (1)

Family

ID=39876515

Family Applications (1)

Country Status (3)

Cited By (2)

Families Citing this family (4)

Family Cites Families (5)

• 2008
  • 2008-08-04 FR FR0855393A patent/FR2934500B1/fr not_active Expired - Fee Related
• 2009
  • 2009-07-24 EP EP09740388A patent/EP2376141A2/de not_active Withdrawn
  • 2009-07-24 WO PCT/FR2009/051503 patent/WO2010015770A2/fr not_active Ceased

Non-Patent Citations (1)

Also Published As

Similar Documents

Legal Events