EP2355666A1 - Natural antioxidative feed additive based on elements from berries - Google Patents
Natural antioxidative feed additive based on elements from berriesInfo
- Publication number
- EP2355666A1 EP2355666A1 EP09764174A EP09764174A EP2355666A1 EP 2355666 A1 EP2355666 A1 EP 2355666A1 EP 09764174 A EP09764174 A EP 09764174A EP 09764174 A EP09764174 A EP 09764174A EP 2355666 A1 EP2355666 A1 EP 2355666A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- additive
- feed
- antioxidative
- berries
- spp
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 235000021028 berry Nutrition 0.000 title claims abstract description 29
- 230000003078 antioxidant effect Effects 0.000 title claims abstract description 23
- 239000003674 animal food additive Substances 0.000 title claims description 9
- 241001465754 Metazoa Species 0.000 claims abstract description 42
- 239000000654 additive Substances 0.000 claims abstract description 33
- 230000000996 additive effect Effects 0.000 claims abstract description 31
- 235000001466 Ribes nigrum Nutrition 0.000 claims abstract description 14
- 244000078534 Vaccinium myrtillus Species 0.000 claims abstract description 14
- 235000008995 european elder Nutrition 0.000 claims abstract description 14
- 244000291414 Vaccinium oxycoccus Species 0.000 claims abstract description 13
- 241000208829 Sambucus Species 0.000 claims abstract description 12
- 240000001890 Ribes hudsonianum Species 0.000 claims abstract description 11
- 235000016954 Ribes hudsonianum Nutrition 0.000 claims abstract description 11
- 235000018735 Sambucus canadensis Nutrition 0.000 claims abstract description 11
- 235000007123 blue elder Nutrition 0.000 claims abstract description 11
- 235000007124 elderberry Nutrition 0.000 claims abstract description 11
- 239000000284 extract Substances 0.000 claims abstract description 9
- 235000017537 Vaccinium myrtillus Nutrition 0.000 claims abstract description 8
- 239000013543 active substance Substances 0.000 claims abstract description 8
- 239000000126 substance Substances 0.000 claims abstract description 8
- 235000002118 Vaccinium oxycoccus Nutrition 0.000 claims abstract description 7
- 241001444063 Aronia Species 0.000 claims abstract description 6
- 235000003095 Vaccinium corymbosum Nutrition 0.000 claims abstract description 5
- 235000021014 blueberries Nutrition 0.000 claims abstract description 5
- 238000009395 breeding Methods 0.000 claims abstract description 5
- 230000001488 breeding effect Effects 0.000 claims abstract description 5
- 239000006227 byproduct Substances 0.000 claims abstract description 5
- 235000017848 Rubus fruticosus Nutrition 0.000 claims abstract description 4
- 235000012545 Vaccinium macrocarpon Nutrition 0.000 claims abstract description 4
- 235000004634 cranberry Nutrition 0.000 claims abstract description 4
- 238000000605 extraction Methods 0.000 claims abstract description 4
- 235000007425 Aronia melanocarpa Nutrition 0.000 claims abstract description 3
- 240000005662 Aronia melanocarpa Species 0.000 claims abstract description 3
- 244000037295 Pyrus arbutifolia Species 0.000 claims abstract description 3
- 235000009838 Pyrus arbutifolia Nutrition 0.000 claims abstract description 3
- 241001312569 Ribes nigrum Species 0.000 claims abstract description 3
- 240000001717 Vaccinium macrocarpon Species 0.000 claims abstract description 3
- 235000019462 natural additive Nutrition 0.000 claims abstract description 3
- 244000169938 Empetrum nigrum Species 0.000 claims abstract 4
- 235000012778 Empetrum nigrum Nutrition 0.000 claims abstract 4
- 244000281247 Ribes rubrum Species 0.000 claims abstract 4
- 235000016911 Ribes sativum Nutrition 0.000 claims abstract 4
- 235000002355 Ribes spicatum Nutrition 0.000 claims abstract 4
- 235000016554 Rubus chamaemorus Nutrition 0.000 claims abstract 4
- 240000006831 Rubus chamaemorus Species 0.000 claims abstract 4
- 235000009122 Rubus idaeus Nutrition 0.000 claims abstract 4
- 244000235659 Rubus idaeus Species 0.000 claims abstract 4
- 235000017606 Vaccinium vitis idaea Nutrition 0.000 claims abstract 4
- 244000077923 Vaccinium vitis idaea Species 0.000 claims abstract 4
- 235000016357 Mirtillo rosso Nutrition 0.000 claims abstract 2
- 235000016897 Ribes triste Nutrition 0.000 claims abstract 2
- 241001092459 Rubus Species 0.000 claims abstract 2
- 244000172730 Rubus fruticosus Species 0.000 claims abstract 2
- 235000011034 Rubus glaucus Nutrition 0.000 claims abstract 2
- 244000275538 Rubus plicatus Species 0.000 claims abstract 2
- 244000151637 Sambucus canadensis Species 0.000 claims abstract 2
- 235000009001 Quillaja saponaria Nutrition 0.000 claims description 12
- 239000000203 mixture Substances 0.000 claims description 12
- 241001092473 Quillaja Species 0.000 claims description 7
- 238000000034 method Methods 0.000 claims description 7
- 240000006162 Chenopodium quinoa Species 0.000 claims description 4
- 244000269722 Thea sinensis Species 0.000 claims description 4
- 240000001548 Camellia japonica Species 0.000 claims description 2
- 235000015493 Chenopodium quinoa Nutrition 0.000 claims description 2
- 244000127993 Elaeis melanococca Species 0.000 claims description 2
- 235000018597 common camellia Nutrition 0.000 claims description 2
- 239000003995 emulsifying agent Substances 0.000 claims description 2
- 229930182490 saponin Natural products 0.000 claims description 2
- 150000007949 saponins Chemical class 0.000 claims description 2
- 235000017709 saponins Nutrition 0.000 claims description 2
- 240000003946 Saponaria officinalis Species 0.000 claims 2
- 235000001484 Trigonella foenum graecum Nutrition 0.000 claims 2
- 244000250129 Trigonella foenum graecum Species 0.000 claims 2
- 235000001019 trigonella foenum-graecum Nutrition 0.000 claims 2
- 239000001653 FEMA 3120 Substances 0.000 claims 1
- 241001532059 Yucca Species 0.000 claims 1
- 235000004552 Yucca aloifolia Nutrition 0.000 claims 1
- 235000012044 Yucca brevifolia Nutrition 0.000 claims 1
- 235000017049 Yucca glauca Nutrition 0.000 claims 1
- 235000004584 Yucca mohavensis Nutrition 0.000 claims 1
- 244000110633 Yucca schidigera Species 0.000 claims 1
- 235000006012 Yucca schidigera Nutrition 0.000 claims 1
- 150000007524 organic acids Chemical class 0.000 claims 1
- 235000005985 organic acids Nutrition 0.000 claims 1
- 235000013406 prebiotics Nutrition 0.000 claims 1
- 239000006041 probiotic Substances 0.000 claims 1
- 235000018291 probiotics Nutrition 0.000 claims 1
- 239000007952 growth promoter Substances 0.000 abstract description 5
- 239000013589 supplement Substances 0.000 abstract description 2
- 239000000047 product Substances 0.000 description 19
- 230000000694 effects Effects 0.000 description 13
- 239000003242 anti bacterial agent Substances 0.000 description 10
- 229940088710 antibiotic agent Drugs 0.000 description 10
- 241000282887 Suidae Species 0.000 description 9
- 239000000463 material Substances 0.000 description 9
- 238000004519 manufacturing process Methods 0.000 description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 7
- 235000013312 flour Nutrition 0.000 description 6
- 241000196324 Embryophyta Species 0.000 description 5
- 241001454523 Quillaja saponaria Species 0.000 description 5
- 239000004113 Sepiolite Substances 0.000 description 5
- 241000209140 Triticum Species 0.000 description 5
- 235000021307 Triticum Nutrition 0.000 description 5
- 239000003963 antioxidant agent Substances 0.000 description 5
- 235000006708 antioxidants Nutrition 0.000 description 5
- 235000013824 polyphenols Nutrition 0.000 description 5
- 229910052624 sepiolite Inorganic materials 0.000 description 5
- 235000019355 sepiolite Nutrition 0.000 description 5
- 235000021029 blackberry Nutrition 0.000 description 4
- 235000013305 food Nutrition 0.000 description 4
- 230000036541 health Effects 0.000 description 4
- 230000006872 improvement Effects 0.000 description 4
- 150000008442 polyphenolic compounds Chemical class 0.000 description 4
- 206010028980 Neoplasm Diseases 0.000 description 3
- 201000011510 cancer Diseases 0.000 description 3
- 239000000969 carrier Substances 0.000 description 3
- 230000000973 chemotherapeutic effect Effects 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 239000012141 concentrate Substances 0.000 description 3
- 235000021019 cranberries Nutrition 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 239000003651 drinking water Substances 0.000 description 3
- 235000020188 drinking water Nutrition 0.000 description 3
- 235000013399 edible fruits Nutrition 0.000 description 3
- 230000008821 health effect Effects 0.000 description 3
- 230000035882 stress Effects 0.000 description 3
- 235000013311 vegetables Nutrition 0.000 description 3
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 235000010208 anthocyanin Nutrition 0.000 description 2
- 239000004410 anthocyanin Substances 0.000 description 2
- 229930002877 anthocyanin Natural products 0.000 description 2
- 150000004636 anthocyanins Chemical class 0.000 description 2
- 230000000844 anti-bacterial effect Effects 0.000 description 2
- 230000000840 anti-viral effect Effects 0.000 description 2
- 239000006030 antibiotic growth promoter Substances 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 230000015556 catabolic process Effects 0.000 description 2
- 235000021050 feed intake Nutrition 0.000 description 2
- 235000011389 fruit/vegetable juice Nutrition 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 230000004968 inflammatory condition Effects 0.000 description 2
- 235000015110 jellies Nutrition 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 235000013372 meat Nutrition 0.000 description 2
- 235000013622 meat product Nutrition 0.000 description 2
- 244000005700 microbiome Species 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 230000036542 oxidative stress Effects 0.000 description 2
- 238000003825 pressing Methods 0.000 description 2
- 229910052711 selenium Inorganic materials 0.000 description 2
- 239000011669 selenium Substances 0.000 description 2
- 239000007921 spray Substances 0.000 description 2
- 229920001864 tannin Polymers 0.000 description 2
- 235000018553 tannin Nutrition 0.000 description 2
- 239000001648 tannin Substances 0.000 description 2
- 239000011709 vitamin E Substances 0.000 description 2
- PFTAWBLQPZVEMU-DZGCQCFKSA-N (+)-catechin Chemical compound C1([C@H]2OC3=CC(O)=CC(O)=C3C[C@@H]2O)=CC=C(O)C(O)=C1 PFTAWBLQPZVEMU-DZGCQCFKSA-N 0.000 description 1
- CHHHXKFHOYLYRE-UHFFFAOYSA-M 2,4-Hexadienoic acid, potassium salt (1:1), (2E,4E)- Chemical compound [K+].CC=CC=CC([O-])=O CHHHXKFHOYLYRE-UHFFFAOYSA-M 0.000 description 1
- 241000251468 Actinopterygii Species 0.000 description 1
- 206010003210 Arteriosclerosis Diseases 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- JMGZEFIQIZZSBH-UHFFFAOYSA-N Bioquercetin Natural products CC1OC(OCC(O)C2OC(OC3=C(Oc4cc(O)cc(O)c4C3=O)c5ccc(O)c(O)c5)C(O)C2O)C(O)C(O)C1O JMGZEFIQIZZSBH-UHFFFAOYSA-N 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- BCZXFFBUYPCTSJ-UHFFFAOYSA-L Calcium propionate Chemical compound [Ca+2].CCC([O-])=O.CCC([O-])=O BCZXFFBUYPCTSJ-UHFFFAOYSA-L 0.000 description 1
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 1
- 241000283086 Equidae Species 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 240000006927 Foeniculum vulgare Species 0.000 description 1
- 235000004204 Foeniculum vulgare Nutrition 0.000 description 1
- 244000068988 Glycine max Species 0.000 description 1
- 235000010469 Glycine max Nutrition 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 235000006679 Mentha X verticillata Nutrition 0.000 description 1
- 235000002899 Mentha suaveolens Nutrition 0.000 description 1
- 235000001636 Mentha x rotundifolia Nutrition 0.000 description 1
- CWEZAWNPTYBADX-UHFFFAOYSA-N Procyanidin Natural products OC1C(OC2C(O)C(Oc3c2c(O)cc(O)c3C4C(O)C(Oc5cc(O)cc(O)c45)c6ccc(O)c(O)c6)c7ccc(O)c(O)c7)c8c(O)cc(O)cc8OC1c9ccc(O)c(O)c9 CWEZAWNPTYBADX-UHFFFAOYSA-N 0.000 description 1
- 241000700159 Rattus Species 0.000 description 1
- 241000282849 Ruminantia Species 0.000 description 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
- IOYNQIMAUDJVEI-BMVIKAAMSA-N Tepraloxydim Chemical group C1C(=O)C(C(=N/OC\C=C\Cl)/CC)=C(O)CC1C1CCOCC1 IOYNQIMAUDJVEI-BMVIKAAMSA-N 0.000 description 1
- 229930003268 Vitamin C Natural products 0.000 description 1
- 229930003427 Vitamin E Natural products 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- JYIBXUUINYLWLR-UHFFFAOYSA-N aluminum;calcium;potassium;silicon;sodium;trihydrate Chemical compound O.O.O.[Na].[Al].[Si].[K].[Ca] JYIBXUUINYLWLR-UHFFFAOYSA-N 0.000 description 1
- 230000000845 anti-microbial effect Effects 0.000 description 1
- 208000011775 arteriosclerosis disease Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- 235000010331 calcium propionate Nutrition 0.000 description 1
- 239000004330 calcium propionate Substances 0.000 description 1
- 244000309466 calf Species 0.000 description 1
- ADRVNXBAWSRFAJ-UHFFFAOYSA-N catechin Natural products OC1Cc2cc(O)cc(O)c2OC1c3ccc(O)c(O)c3 ADRVNXBAWSRFAJ-UHFFFAOYSA-N 0.000 description 1
- 235000005487 catechin Nutrition 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 229950001002 cianidanol Drugs 0.000 description 1
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- 239000002734 clay mineral Substances 0.000 description 1
- 229910001603 clinoptilolite Inorganic materials 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 235000015872 dietary supplement Nutrition 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000000459 effect on growth Effects 0.000 description 1
- IVTMALDHFAHOGL-UHFFFAOYSA-N eriodictyol 7-O-rutinoside Natural products OC1C(O)C(O)C(C)OC1OCC1C(O)C(O)C(O)C(OC=2C=C3C(C(C(O)=C(O3)C=3C=C(O)C(O)=CC=3)=O)=C(O)C=2)O1 IVTMALDHFAHOGL-UHFFFAOYSA-N 0.000 description 1
- 238000009313 farming Methods 0.000 description 1
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- 229930003935 flavonoid Natural products 0.000 description 1
- 150000002215 flavonoids Chemical class 0.000 description 1
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- HVQAJTFOCKOKIN-UHFFFAOYSA-N flavonol Natural products O1C2=CC=CC=C2C(=O)C(O)=C1C1=CC=CC=C1 HVQAJTFOCKOKIN-UHFFFAOYSA-N 0.000 description 1
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- 235000011957 flavonols Nutrition 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 1
- 229940087559 grape seed Drugs 0.000 description 1
- 239000003673 groundwater Substances 0.000 description 1
- 235000008216 herbs Nutrition 0.000 description 1
- 239000010903 husk Substances 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 206010022000 influenza Diseases 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 239000008274 jelly Substances 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 244000000010 microbial pathogen Species 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
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- 235000016709 nutrition Nutrition 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 229940127557 pharmaceutical product Drugs 0.000 description 1
- 230000008092 positive effect Effects 0.000 description 1
- 235000010241 potassium sorbate Nutrition 0.000 description 1
- 239000004302 potassium sorbate Substances 0.000 description 1
- 229940069338 potassium sorbate Drugs 0.000 description 1
- 244000144977 poultry Species 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 229920002414 procyanidin Polymers 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- FDRQPMVGJOQVTL-UHFFFAOYSA-N quercetin rutinoside Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 FDRQPMVGJOQVTL-UHFFFAOYSA-N 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 235000005493 rutin Nutrition 0.000 description 1
- IKGXIBQEEMLURG-BKUODXTLSA-N rutin Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@@H]1OC[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 IKGXIBQEEMLURG-BKUODXTLSA-N 0.000 description 1
- ALABRVAAKCSLSC-UHFFFAOYSA-N rutin Natural products CC1OC(OCC2OC(O)C(O)C(O)C2O)C(O)C(O)C1OC3=C(Oc4cc(O)cc(O)c4C3=O)c5ccc(O)c(O)c5 ALABRVAAKCSLSC-UHFFFAOYSA-N 0.000 description 1
- 229960004555 rutoside Drugs 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 235000015170 shellfish Nutrition 0.000 description 1
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
- 235000010234 sodium benzoate Nutrition 0.000 description 1
- 239000004299 sodium benzoate Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 150000003505 terpenes Chemical class 0.000 description 1
- 235000007586 terpenes Nutrition 0.000 description 1
- MGSRCZKZVOBKFT-UHFFFAOYSA-N thymol Chemical class CC(C)C1=CC=C(C)C=C1O MGSRCZKZVOBKFT-UHFFFAOYSA-N 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
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- 210000001635 urinary tract Anatomy 0.000 description 1
- 208000019553 vascular disease Diseases 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
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- 239000002699 waste material Substances 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/10—Animal feeding-stuffs obtained by microbiological or biochemical processes
- A23K10/16—Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions
- A23K10/18—Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions of live microorganisms
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/30—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms
Definitions
- the present invention relates to a feed additive with antioxidative properties, and also to an antioxidative additive to feedstuffs based on natural or nature-identical substances and a feed mixture, which contains the additive, and to a method of breeding domestic animals.
- Antibiotic growth promoters were therefore phased out in the EU by the end of 2005.
- the need for alternatives is increasing, since the ban on growth promoters has now led to an increasing use of antibiotics to treat various problems in domestic animal production.
- cranberries contain procyanidins, which are believed to exert an antibacterial effect by linking to bacteria and toxins, so they are thus beneficial against infections of the urinary tract and others (Duthie, 2007: Berry Fruits. MoI. Nutr. Food Res. 51 , 643).
- Elderberry has certain antiviral effect; it stimulates the immune system, and it has been suggested that it is effective against influenza (Wu et al. 2005: Aglycones and sugar moieties alter anthocyanin absorption and metabolism after berry consumption in weanling pigs. The Journal of Nutrition 135, 2417-2424).
- German patent application (DE 102007001349) describes an additive for animals based on the residues from pressing various berries and from vines.
- these residues from pressing must be treated using a special enzyme- based method.
- Such methods are very costly.
- the present invention relates to a natural additive with antioxidative properties to be used as a supplement in feed for animals and/or to their drinking water, containing natural and/or nature-identical active substances, which contain antioxidative elements and which is obtained from one or several of the following berries: blackcurrants ⁇ Ribes nigrum), elderberries ⁇ Sambucus spp.), blueberries (Vaccinium myrtillus), cranberries (Vaccinium oxycoccus; V. microcarpum; V.
- the invention also relates to a feed mix for domestic animals containing the additive together with a conventional feedstuff, and a procedure used in breeding domestic animals, by means of which the animals are fed with the feedstuff mix, also in the form of wet fodder or as top dressing, and when it is given to them in their drinking water.
- the additive can be based on one or several waste products, which at present have no other significant practical use, and thus the active component is very cheap and cost effective, while the production of the product is simplified.
- the components of the additive according to the invention are obtainable based on a by-product from the production of foods, especially jellies or juices and the like, obtained from the berries mentioned above or obtained from the actual berries or the leaves.
- pomace a by-product is produced, known as pomace.
- This pomace consists of the skins of berries, seeds, and sometimes fruit pulp.
- the antioxidant content of the pomace is high, and it is similarly high in the leaves of blackberry and cranberry bushes and elderberry trees.
- the component can be exploited either as whole elements or as extracts of the whole elements or of the by-products. Extraction can be carried out with the aid of water, alcohol or a combination of these.
- the resulting fluid product can be reduced until its water content is not more than 8- 15%, normally to a maximum water content of 10% water; or it can be conserved, for instance by adding 3 to 10% by weight of NaCI or some other salt; and it can then be stored for drying later.
- a type of acid that is acceptable in feed such as citric acid, tartaric acid or lactic acid or a mixture of these, the addition of which will at the same time positively influence the effectiveness of the product.
- a preservative such as sodium benzoate, potassium sorbate or calcium propionate.
- the pomace products, extracts and dried and powdered plant parts can be further concentrated to the extent necessary by the removal of some of the water in the product. This can be done by filtration, extraction, centrifugation and other conventional methods.
- the components in the additive according to the invention contain a number of active substances which are of interest.
- the most essential include substances, primarily polyphenols, with antioxidative properties and tannins.
- the additive according to the invention has the following advantageous effects among others:
- the additive according to the invention can with great advantage be used for both monogastric animals and for ruminants, including cattle, pigs, poultry, calves, horses, fish, shellfish and social animals or pets, hereafter referred to as domestic animals.
- Suitable carriers in order to obtain the properties mentioned in the commercial feed additive are primarily mineral carriers in the form of clay minerals and zeoliths - especially sepiolite and clinoptilolite - and secondarily vegetable carriers such as wheat flour, wheat bran, ground soya husk, etc. Calcium carbonate may also be usable as a carrier, not so much because of its technical properties, but because of its low price. The same applies to grape seed flour, a known carrier that is frequently used in animal feed.
- Vegetable matter and the pomace can to a greater or lesser extent be pre-ground before they are mixed with the carrier in question.
- the additive according to the invention has proved to have a significant effect on domestic animals' intake of feed, their daily growth and exploitation of feed.
- the reasons for the effects referred to are not fully clarified, since there may be more than those discovered up to the present.
- the reasons already confirmed include the following.
- the additive according to the invention can be added to any other desired feed product for any domestic animal as previously mentioned.
- the additive should preferably be added so that the quantity of additive intended for 1000kg feed contains 1 - 500Og of the antioxidative component, 100-500Og, 500-5000 g, 1000- 5000 g of the antioxidative component, calculated as dry matter.
- Those skilled in the art will immediately be able to adapt the quantity of additive to the specific type of feed that is appropriate for any given type of domestic animal.
- Blackcurrant pomace 35 g
- Elderberry pomace 50 g
- Blackcurrant extract (water extract, spray dried): 7.5 g Elderberry extract (water extract, spray dried): 20.8 g
- the tests comprised a control group and a test group with approx. thirty animals in each group for the tests of Quiponin Blackcurrant, Quiponin Elderberry, Quiponin B (2) and Quiponin Concentrate and 40 pigs per group for the test of Quiponin B (1). All the pigs were fed ad libitum with the same feed. 2000 ppm of the given test product were added to the feed of the test groups. The pigs were weighed at the start, after 10 days and after 21 days. Feed intake was measured on the same days, so that exploitation of the feed could be calculated.
- Table 1 Results, first test period (10 days), index shown as test/control (T/C)
- test feed showed the greatest effect on daily growth in the first test period. Particularly conspicuous is the improvement of 43% in the test group that was given Quiponin Blackcurrant, and the extreme improvement of 167% in the pigs that were fed Quiponin B - although it should be noted, however, that there was very little growth generally in the latter test. Similarly, there was greater daily growth in the second test period in all the test groups fed with one of the four variants. The improvement in this period ranged from 3-20%.
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Abstract
Natural additive with antioxidative properties for use as an additive to feed for animals, and containing natural and/or nature-identical active substances that originate from one or several of the following antioxidative elements: Blackcurrant (Ribes nigrum), elderberry (Sambucus spp.), blueberry (Vaccinium myrtillus), cranberry (Vaccinium oxycoccus; V. microcarpum; V. macrocarpum), chokeberry (Aronia spp., especially Aronia arbutifolia; Aronia melanocarpa), blackberry (Rubus spp., especially R. plicatus and R. fruticosus), cloudberry (Rubus Chamaemorus), cowberry (Vaccinium vitis idaea), crowberry (Empetrum nigrum), raspberry (Rubus idaeus), redcurrant (Ribes rubrum). The additive is characterized in that the antioxidative components may be derived from whole berries or leaves or an extract of the same, or from a by-product based on berries or leaves, which can originates as a residue after the removal of one or several of the content substances or by the extraction of these. The additive is effective as a supplement to feed as a replacement for traditional growth promoters when breeding domestic animals.
Description
Natural antioxidative feed additive based on elements from berries
Technical field
The present invention relates to a feed additive with antioxidative properties, and also to an antioxidative additive to feedstuffs based on natural or nature-identical substances and a feed mixture, which contains the additive, and to a method of breeding domestic animals.
Technical background Since antibiotic and chemotherapeutic growth promoters have been phased out in domestic animal production in the EU, an acute need to find alternatives has arisen.
In recent years increasing attention has been directed to the fact that the widespread use of antibiotics and chemotherapeutical substances has resulted in problems. Larger and larger numbers of pathogenic microorganisms have developed resistance to the antibiotics concerned, which thus became less effective. Additionally, there is a risk of residues of antibiotics in meat products, so that antibiotics are also consumed by humans, and consequently, microorganisms that cause disease in humans may also become resistant. Similarly, there is a risk that microorganisms that are resistant to antibiotics may be eaten with meat products. Finally, there is a risk that antibiotics may be returned to the groundwater and watercourses.
It is now considered that the continued use of various antibiotics as growth promoters will among other things increase the risk that an epidemic may arise among animals and/or humans, which cannot be controlled with antibiotics. A considerable number of people have already developed allergies to specific antibiotics. In addition, one of the chemotherapeutical growth promoters used up to now has been shown to cause cancer.
Antibiotic growth promoters were therefore phased out in the EU by the end of
2005. The need for alternatives is increasing, since the ban on growth promoters has now led to an increasing use of antibiotics to treat various problems in domestic animal production.
Because of the factors described above, and in order to safeguard the economy and sustainability of breeding domestic animals, alternative methods are now being sought to ensure that domestic animals can be reared free from disease, without the use of antibiotics.
These measures can with advantage be based on natural or nature-identical active substances. Their effects on the animals' growth and exploitation of feed should also be equal to the classical growth promoters or better, to ensure that these new additives are accepted by the farmer on the one hand and by the animal feed industry on the other.
It is well known that many plants contain various functional and/or antibacterial substances, including saponins, flavonoids, tannins, hydroxycymenes and terpenes, and the use of such active substances from plant material in pharmaceutical products is also well known. A number of the positive properties of these active substances are due to their antioxidative properties. Antioxidants protect cells against breakdown and against harmful substances, reduce the risks of infection and have a special effect in periods of high production and stress.
The use of these natural substances as daily dietary supplements for animals has also been proposed. In many cases the claimed effects of such active plant components are not sufficiently documented, however, and many of these components are only present in small quantities in the plants concerned, while they are often too costly and/or difficult to obtain to be used daily for preventive purposes in animal feed.
It is well known that berries, and especially blackcurrants, blueberries and cranberries, have a high content of polyphenols with antioxidative capacity
(Kahkonen et al., 2001 : Berry phenolics and their antioxidant activity. J. Agric. Food Chem 49, 4076-4082). Among other things, these berries contain anthocyanins, flavonol, rutin and catechin. Studies have shown the potential of berry fruits in preventing diseases like cancer and arteriosclerosis, and the mechanisms are assumed to be based on the way in which polyphenols counteract oxidative stress and inflammatory conditions (Neto, 2007: Cranberry and blueberry: Evidence for protective effects against cancer and vascular diseases. MoI. Nutr. Food Res. 51 , 652-664). Besides these, cranberries contain procyanidins, which are believed to exert an antibacterial effect by linking to bacteria and toxins, so they are thus beneficial against infections of the urinary tract and others (Duthie, 2007: Berry Fruits. MoI. Nutr. Food Res. 51 , 643). Elderberry has certain antiviral effect; it stimulates the immune system, and it has been suggested that it is effective against influenza (Wu et al. 2005: Aglycones and sugar moieties alter anthocyanin absorption and metabolism after berry consumption in weanling pigs. The Journal of Nutrition 135, 2417-2424).
Even though there is scientific evidence of the health-promoting effects of many different types of berry fruits, the extent to which berries are used in daily feed is very limited. As a component in animal feed for animals yielding marketable produce or for pets, berries are completely absent and unknown, and similarly, there have been no scientific or popular studies centered on the health-promoting effects of berries on the health and production of animals bred for marketing. A few published studies describe the effects of berries on the health of rats or the absorption of polyphenols in pigs, but the purposes of these studies have been to obtain knowledge with a view to use for humans, while the animals were simply used as models. No attention has been paid to the use of berries for animals yielding marketable produce, possibly owing to the high prices of berries, as a result of which the use of berries would not make sense economically in farming, where feeding costs must be kept to a minimum.
Various patents describe products and methods concerned with the health- promoting effects of berries on people. Very few patents refer to products
containing berries for animals. The use of blackberry leaves and whole blackberries as a component in a feed mixture is described in a Polish patent (PL 173665). Here blackberries are included in a mixture of herbs and vegetables such as mint and fennel. This invention does not relate to a combination of several different berries with antioxidative properties. It is precisely the combination of different berries in this unique composition that produces the surprising effect on growth and exploitation of feed.
A German patent application (DE 102007001349) describes an additive for animals based on the residues from pressing various berries and from vines. However, these residues from pressing must be treated using a special enzyme- based method. Such methods are very costly. Thus there is a need for a cost- effective additive with antioxidative properties, which can be used for animals.
Surprisingly, it has now been shown that small quantities of a mixture of different parts of berries will have the effect of promoting growth and health when used as a cost-effective additive to feed and drinking water for domestic animals.
Brief description of the invention The present invention relates to a natural additive with antioxidative properties to be used as a supplement in feed for animals and/or to their drinking water, containing natural and/or nature-identical active substances, which contain antioxidative elements and which is obtained from one or several of the following berries: blackcurrants {Ribes nigrum), elderberries {Sambucus spp.), blueberries (Vaccinium myrtillus), cranberries (Vaccinium oxycoccus; V. microcarpum; V. macrocarpum), chokeberries (Aronia spp., especially Aronia arbutifolia; Aronia melanocarpa) and natural emulgators, especially Quillaja (quillaja saponaria), Quinoa (Chenopodium quinoa), tea {Camellia spp., such as C. oleifera and C. sinensis), as well as conventional supplementary substances and/or additives.
The invention also relates to a feed mix for domestic animals containing the additive together with a conventional feedstuff, and a procedure used in breeding
domestic animals, by means of which the animals are fed with the feedstuff mix, also in the form of wet fodder or as top dressing, and when it is given to them in their drinking water.
Moreover, the additive can be based on one or several waste products, which at present have no other significant practical use, and thus the active component is very cheap and cost effective, while the production of the product is simplified.
The extent of the usefulness of the invention will be shown in the following detailed description. It should be understood, however, that the detailed description and the specific examples, in which the preferred embodiments of the invention are indicated, are given only for illustration, since various alterations and modifications within the scope of the invention will be apparent to a person skilled in the art based on the detailed description.
Detailed description of the invention
The components of the additive according to the invention are obtainable based on a by-product from the production of foods, especially jellies or juices and the like, obtained from the berries mentioned above or obtained from the actual berries or the leaves.
During the production of jelly or juice a by-product is produced, known as pomace. This pomace consists of the skins of berries, seeds, and sometimes fruit pulp. The antioxidant content of the pomace is high, and it is similarly high in the leaves of blackberry and cranberry bushes and elderberry trees.
The component can be exploited either as whole elements or as extracts of the whole elements or of the by-products. Extraction can be carried out with the aid of water, alcohol or a combination of these.
When the pomace products are exploited and the extracts are produced, the resulting fluid product can be reduced until its water content is not more than 8-
15%, normally to a maximum water content of 10% water; or it can be conserved, for instance by adding 3 to 10% by weight of NaCI or some other salt; and it can then be stored for drying later. To ensure the keeping qualities further, it is advantageous to add 0 to 5% of a type of acid that is acceptable in feed, such as citric acid, tartaric acid or lactic acid or a mixture of these, the addition of which will at the same time positively influence the effectiveness of the product. Similarly, it may be advantageous to add a preservative, such as sodium benzoate, potassium sorbate or calcium propionate.
The pomace products, extracts and dried and powdered plant parts can be further concentrated to the extent necessary by the removal of some of the water in the product. This can be done by filtration, extraction, centrifugation and other conventional methods.
The components in the additive according to the invention contain a number of active substances which are of interest. The most essential include substances, primarily polyphenols, with antioxidative properties and tannins. The additive according to the invention has the following advantageous effects among others:
1) An antioxidative effect in the animal
* protects against cell breakdown
* reduces the consumption of other antioxidants such as vitamin E and selenium
3) It improves the animal's productivity and health because * it has antimicrobial and antiviral properties
* it hinders inflammatory conditions
* It improves the balance between antioxidants and radicals in stress situations, thus has the effect of reducing oxidative stress
4) Effects on product quality
* reduction of liquid loss in meat (drip loss)
* improvement of the meat color
* keeps fresh longer
The additive according to the invention can with great advantage be used for both monogastric animals and for ruminants, including cattle, pigs, poultry, calves, horses, fish, shellfish and social animals or pets, hereafter referred to as domestic animals.
Formulation of Commercial Products with the Additive According to the Invention Depending on the concentration in the raw product, and the variation of the concentration of the active substances relevant to the additive according to the invention, it may be necessary to mix the raw product with a suitable carrier, so that a final product appears which on the one hand is reasonably standardized, and on the other hand is not too concentrated to allow it to be mixed directly into the feed either on the premises of ready-feed manufacturers or by those who mix feed at home.
Suitable carriers in order to obtain the properties mentioned in the commercial feed additive are primarily mineral carriers in the form of clay minerals and zeoliths - especially sepiolite and clinoptilolite - and secondarily vegetable carriers such as wheat flour, wheat bran, ground soya husk, etc. Calcium carbonate may also be usable as a carrier, not so much because of its technical properties, but because of its low price. The same applies to grape seed flour, a known carrier that is frequently used in animal feed.
Vegetable matter and the pomace can to a greater or lesser extent be pre-ground before they are mixed with the carrier in question.
The additive according to the invention has proved to have a significant effect on domestic animals' intake of feed, their daily growth and exploitation of feed. The reasons for the effects referred to are not fully clarified, since there may be more than those discovered up to the present. The reasons already confirmed include
the following.
The Additive according to the invention
* reduces the consumption of other antioxidants such as vitamin E1 vitamin C and selenium in animals yielding marketable products and in pet animals
* reduces the negative effects of stress factors
The additive according to the invention can be added to any other desired feed product for any domestic animal as previously mentioned. The additive should preferably be added so that the quantity of additive intended for 1000kg feed contains 1 - 500Og of the antioxidative component, 100-500Og, 500-5000 g, 1000- 5000 g of the antioxidative component, calculated as dry matter. Those skilled in the art will immediately be able to adapt the quantity of additive to the specific type of feed that is appropriate for any given type of domestic animal.
Examples
A number of tests have been carried out to verify the additive.
To produce 1 kg of feed additive - formulated as a premix - the following materials must be mixed in the dry state, referred to in the following as "Quiponin B":
Blackcurrant pomace: 35 g
Elderberry pomace 15 g Ground and dried material from the bark of the soap bark tree (Quillaja): 50 g
Sepiolite: 450 g
Wheat flour: 450 g
To produce 1kg of feed additive - formulated as a premix - the following materials must be mixed in the dry state, referred to in the following as "Quiponin blackcurrant":
Blackcurrant pomace: 50 g
Ground and dried material from the bark of the soap bark tree (Quillaja): 50 g Sepiolite: 450 g
Wheat flour: 450 g
To produce 1kg of feed additive - formulated as a premix - the following materials must be mixed in the dry state, referred to in the following as "Quiponin elderberry":
Elderberry pomace: 50 g
Ground and dried material from the bark of the soap bark tree (Quillaja): 50 g
Sepiolite: 450 g
Wheat flour: 450 g
To produce 1 kg of feed additive - formulated as a premix - the following materials must be mixed in the dry state, referred to in the following as "Quiponin B Concentrate":
Blackcurrant extract (water extract, spray dried): 7.5 g Elderberry extract (water extract, spray dried): 20.8 g
Ground and dried material from the bark of the soap bark tree (Quillaja): 50 g
Sepiolite: 460 g
Wheat flour: 461.7 g
Introduction
Five tests were carried out with newly weaned piglets at two different test locations. The tests comprised a control group and a test group with approx. thirty animals in each group for the tests of Quiponin Blackcurrant, Quiponin Elderberry, Quiponin B (2) and Quiponin Concentrate and 40 pigs per group for the test of Quiponin B (1). All the pigs were fed ad libitum with the same feed. 2000 ppm of the given test product were added to the feed of the test groups. The pigs were weighed at the start, after
10 days and after 21 days. Feed intake was measured on the same days, so that exploitation of the feed could be calculated.
ImlaEΞlE!
While the tests with Quiponin
Gόritrόϊ;HHy::-' :fc;Test: Blackcurrant, Quiponin Elderberry, Quiponin B (2) and Quiponin Concentrate were carried out at the Danish farm S, the test of Quiponin B (1) was carried out at the Czech Institute of Animal Production.
Results
The following tables show the results of a number of tests in which Quiponin products were tested on young pigs, and the effect on daily growth, feed intake (Fl) and feed conversion rate (FCR).
Table 1: Results, first test period (10 days), index shown as test/control (T/C)
able 2: Results, second test period ), index shown as test/control (T/C)
All variants of the test feed showed the greatest effect on daily growth in the first test period. Particularly conspicuous is the improvement of 43% in the test group that was given Quiponin Blackcurrant, and the extreme improvement of 167% in the pigs that were fed Quiponin B - although it should be noted, however, that there was very little growth generally in the latter test. Similarly, there was greater daily growth in the second test period in all the test groups fed with one of the four variants. The improvement in this period ranged from 3-20%.
The pigs' intake of feed was increased in four of the test groups compared with the control. The test products improved the exploitation of the feed by 3-11% in the total period.
Since the product has now been described, it will become apparent that it can be varied in many ways. Such variations shall not be regarded as deviations from the scope of the invention, and it will be apparent to those skilled in the art that all such modifications should also be considered to be comprised in the scope of the claims that follow.
Claims
1. Natural additive with antioxidative properties for use as an additive to feed for animals, and containing natural and/or nature-identical active substances that originate from one or several of the following antioxidative elements: Blackcurrant (Ribes nigrum), elderberry (Sambucus spp.), blueberry (Vaccinium myrtillus), cranberry (Vaccinium oxycoccus; V. microcarpum; V. macrocarpum), chokeberry (Aronia spp., especially Aronia arbutifolia; Aronia melanocarpa), blackberry (Rubus spp., especially R. plicatus and R. fruticosus), cloudberry (Rubus Chamaemorus), cowberry (Vaccinium vitis idaea), crowberry (Empetrum nigrum), raspberry (Rubus idaeus), redcurrant (Ribes rubrum).
2. Additive according to claim ^ c h a r a c t e r i z e d in that the antioxidative components derive from whole berries or leaves or an extract of the same, or from a by-product based on berries or leaves, which can be obtained as a residue after the removal of one or several of the content substances or by the extraction of these.
3. Additive according to any of the foregoing claims, ch a racte rized in that it comprises a natural emulsifier containing saponins from Quillaja (Quillaja saponaήa), Quinoa (chenopodium quinoa), tea (camellia spp., such as C. oleifera and C. sinensis), fenugreek (Trigonella foenum graecum), soapwort (Saponaria officinalis), or yucca (such as Yucca schidigera)
4. Additive according to any of the foregoing claims, ch a racte rized in that it comprises the combination with another feed additive, especially probiotics, prebiotics and organic acids.
5. Additive according to any of the foregoing claims, ch a racte rized in that a quantity of additive calculated for 1000kg feed contains 1 - 500Og of the antioxidative component, measured as dry matter.
6. Additive according to any of the foregoing claims, ch a ra cte rized in that it includes a carrier that is acceptable in feed.
7. Feed mixture for domestic animals including components of the additive according to any of claims 1 -5 together with a conventional feed.
8. A procedure for breeding domestic animals, c h a ra cte r iz e d in that the animals are fed with a feed mixture according to claim 6.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200801540 | 2008-11-10 | ||
| PCT/DK2009/050285 WO2010051814A1 (en) | 2008-11-10 | 2009-10-29 | Natural antioxidative feed additive based on elements from berries |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EP2355666A1 true EP2355666A1 (en) | 2011-08-17 |
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ID=41693494
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP09764174A Withdrawn EP2355666A1 (en) | 2008-11-10 | 2009-10-29 | Natural antioxidative feed additive based on elements from berries |
Country Status (2)
| Country | Link |
|---|---|
| EP (1) | EP2355666A1 (en) |
| WO (1) | WO2010051814A1 (en) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102458433B (en) * | 2009-05-29 | 2017-02-15 | 吉布控股(纳尔逊)有限公司 | a supplement containing black currants or boysenberries |
| WO2012102626A1 (en) * | 2011-01-28 | 2012-08-02 | Gibb Holdings (Nelson) Limited | A supplement |
| AU2013258018B2 (en) * | 2012-05-11 | 2016-05-05 | Oterra A/S | A composition comprising chlorophyllin as a green pigment |
| CN102845594B (en) * | 2012-08-06 | 2013-08-14 | 王茜 | Low-cholesterol animal health product |
| ES2721278T3 (en) | 2013-07-14 | 2019-07-30 | Olle Svenssons Partiaffaer Ab | Alloid compositions of the Ribes species to treat conditions associated with mitochondrial function or inhibition of pDE4, PDE5 and IKK-BETA |
| JP2016013122A (en) * | 2014-06-10 | 2016-01-28 | 小浜海産物株式会社 | Feed for aquatic organism and culture method |
| RU2596281C1 (en) * | 2015-09-22 | 2016-09-10 | Олег Иванович Квасенков | Bread kvass production method |
| KR101936620B1 (en) | 2018-09-18 | 2019-01-09 | 주식회사이-글벳 | Manufacturing Method of Feed Additives Comprising Aronia melanocarpa |
| US11033492B2 (en) * | 2019-05-14 | 2021-06-15 | Mary Hartman | Equine dietary supplement |
| CA3163474A1 (en) | 2019-12-02 | 2021-06-10 | Botanitec Spa | Composition enriched in polyphenols and flavonoids for use as biostimulant and antimicrobial for agriculture applications |
| CN113115860A (en) * | 2021-04-01 | 2021-07-16 | 广西壮族自治区农业科学院 | Application and use method of aronia melanocarpa fruit residues |
| CN113785908A (en) * | 2021-07-30 | 2021-12-14 | 南京雷德蒙德农业科技有限公司 | Composition with anti-stress effect and preparation method thereof |
| CN115104672B (en) * | 2022-03-28 | 2024-10-29 | 诺维特星盟饲料科技(辽宁)有限公司 | Aronia melanocarpa pellet feed and preparation method and application thereof |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4197294A (en) * | 1976-04-14 | 1980-04-08 | Samuel Klein | Feed for poultry |
| GB9926919D0 (en) * | 1999-11-15 | 2000-01-12 | Park Tonks Limited | Animal feed |
| GB0202258D0 (en) * | 2002-01-31 | 2002-03-20 | Dodson & Horrell Ltd | Annimal feed supplement |
| GB0405540D0 (en) * | 2004-03-11 | 2004-04-21 | Glaxo Group Ltd | Novel use |
| US20070071849A1 (en) * | 2005-09-29 | 2007-03-29 | Mcneff Larry C | Methods and Compositions for Increasing Feeding or Production Characteristics in Animals |
| AU2007273955B2 (en) * | 2006-06-08 | 2012-09-06 | Mars, Incorporated | Composition for improving eye health |
| FR2906109B1 (en) * | 2006-09-22 | 2009-09-04 | Physcience Soc Par Actions Sim | SUPPLEMENTS FOR THE PREVENTION AND CONTROL OF URINARY INFECTIONS |
-
2009
- 2009-10-29 WO PCT/DK2009/050285 patent/WO2010051814A1/en not_active Ceased
- 2009-10-29 EP EP09764174A patent/EP2355666A1/en not_active Withdrawn
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