EP2307015A4 - A pharmaceutical composition for preventing or treating osteoporosis comprising benzamidine derivatives or their salts, and alendronic acid or its salt - Google Patents

A pharmaceutical composition for preventing or treating osteoporosis comprising benzamidine derivatives or their salts, and alendronic acid or its salt

Info

Publication number
EP2307015A4
EP2307015A4 EP09803174A EP09803174A EP2307015A4 EP 2307015 A4 EP2307015 A4 EP 2307015A4 EP 09803174 A EP09803174 A EP 09803174A EP 09803174 A EP09803174 A EP 09803174A EP 2307015 A4 EP2307015 A4 EP 2307015A4
Authority
EP
European Patent Office
Prior art keywords
salts
salt
preventing
pharmaceutical composition
treating osteoporosis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP09803174A
Other languages
German (de)
French (fr)
Other versions
EP2307015A2 (en
Inventor
Jin Soo Lee
Yun Ha Hwang
Jei Man Ryu
Jae Hoon Park
Duk Kyun Chung
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dong Wha Pharm Co Ltd
Original Assignee
Dong Wha Pharm Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dong Wha Pharm Co Ltd filed Critical Dong Wha Pharm Co Ltd
Publication of EP2307015A2 publication Critical patent/EP2307015A2/en
Publication of EP2307015A4 publication Critical patent/EP2307015A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
    • A61K31/663—Compounds having two or more phosphorus acid groups or esters thereof, e.g. clodronic acid, pamidronic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
EP09803174A 2008-08-01 2009-07-31 A pharmaceutical composition for preventing or treating osteoporosis comprising benzamidine derivatives or their salts, and alendronic acid or its salt Withdrawn EP2307015A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR20080075792 2008-08-01
PCT/KR2009/004277 WO2010013969A2 (en) 2008-08-01 2009-07-31 A pharmaceutical composition for preventing or treating osteoporosis comprising benzamidine derivatives or their salts, and alendronic acid or its salt

Publications (2)

Publication Number Publication Date
EP2307015A2 EP2307015A2 (en) 2011-04-13
EP2307015A4 true EP2307015A4 (en) 2012-05-16

Family

ID=41610865

Family Applications (1)

Application Number Title Priority Date Filing Date
EP09803174A Withdrawn EP2307015A4 (en) 2008-08-01 2009-07-31 A pharmaceutical composition for preventing or treating osteoporosis comprising benzamidine derivatives or their salts, and alendronic acid or its salt

Country Status (6)

Country Link
EP (1) EP2307015A4 (en)
JP (1) JP2011529875A (en)
KR (1) KR20100014173A (en)
CN (1) CN102149380B (en)
CA (1) CA2732863A1 (en)
WO (1) WO2010013969A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20100014090A (en) * 2008-08-01 2010-02-10 동화약품주식회사 A pharmaceutical composition for preventing or treating osteoporosis comprising benzamidine derivative or its salt, and bisphosphonate

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003007947A1 (en) * 2001-07-19 2003-01-30 Dong Wha Pharm. Ind. Co., Ltd. Use of 4-[(4-thiazolyl)phenoxl] alkoxy-benzamidine derivatives for treatment of osteoporosis
WO2006004369A1 (en) * 2004-07-05 2006-01-12 Dong Wha Pharmaceutical. Ind. Co., Ltd. Pharmaceutical composition for the treatment of bone fracture
WO2010013975A2 (en) * 2008-08-01 2010-02-04 Dong Wha Pharmaceutical Co., Ltd. A pharmaceutical composition for preventing or treating osteoporosis comprising benzamidine derivative or its salt, and bisphosphonate

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5451700A (en) * 1991-06-11 1995-09-19 Ciba-Geigy Corporation Amidino compounds, their manufacture and methods of treatment
CN1144806A (en) * 1996-07-25 1997-03-12 南京药物研究所 Amino-diphosphinic acids bone absorption inhibitor and preparation method of its sodium salt
KR100513302B1 (en) * 1997-02-04 2005-11-11 동화약품공업주식회사 3-amino-1,2-benzoisoxazole derivatives, process for preparation, and use thereof
US5998390A (en) * 1998-09-28 1999-12-07 The Research Foundation Of State University Of New York Combination of bisphosphonate and tetracycline
KR100317935B1 (en) * 1999-10-20 2001-12-22 유승필 Pharmaceutical compositions and preparations for treatment of metabolic bone disease
JP2003292453A (en) * 2002-04-02 2003-10-15 Asahi Kasei Corp Medicinal agent composition for treating bone disease
US20060173009A1 (en) * 2003-01-07 2006-08-03 Hiroyuki Kanoh Agent inducing increase in bone mass
MXPA05013637A (en) * 2003-08-13 2006-02-24 Chiron Corp Gsk-3 inhibitors and uses thereof.
EP1742631A4 (en) * 2004-04-28 2009-11-11 Merck & Co Inc Fluorinated 4-azasteroids as androgen receptor modulators
JP2009017222A (en) * 2007-07-04 2009-01-22 Panasonic Corp Color adjustment apparatus, color adjustment method, and integrated circuit of color adjustment apparatus

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003007947A1 (en) * 2001-07-19 2003-01-30 Dong Wha Pharm. Ind. Co., Ltd. Use of 4-[(4-thiazolyl)phenoxl] alkoxy-benzamidine derivatives for treatment of osteoporosis
WO2006004369A1 (en) * 2004-07-05 2006-01-12 Dong Wha Pharmaceutical. Ind. Co., Ltd. Pharmaceutical composition for the treatment of bone fracture
WO2010013975A2 (en) * 2008-08-01 2010-02-04 Dong Wha Pharmaceutical Co., Ltd. A pharmaceutical composition for preventing or treating osteoporosis comprising benzamidine derivative or its salt, and bisphosphonate

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
BLACK D M ET AL: "THE EFFECTS OF PARATHYROID HORMONE AND ALENDRONATE ALONE OR IN COMBINATION IN POSTMENOPAUSAL OSTEOPOROSIS", NEW ENGLAND JOURNAL OF MEDICINE, vol. 349, no. 13, 25 September 2003 (2003-09-25), MASSACHUSETTS MEDICAL SOCIETY, BOSTON, MA, US, pages 1207 - 1215, XP009045315, ISSN: 1533-4406, DOI: 10.1056/NEJMOA031975 *
GREENSPAN SUSAN L ET AL: "Combination therapy with hormone replacement and alendronate for prevention of bone loss in elderly women: A randomized controlled trial.", JAMA (JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION), vol. 289, no. 19, 21 May 2003 (2003-05-21), pages 2525 - 2533+CORR, XP002672632, ISSN: 0098-7484 *

Also Published As

Publication number Publication date
CN102149380A (en) 2011-08-10
WO2010013969A3 (en) 2010-05-27
KR20100014173A (en) 2010-02-10
CN102149380B (en) 2012-12-05
WO2010013969A2 (en) 2010-02-04
JP2011529875A (en) 2011-12-15
EP2307015A2 (en) 2011-04-13
CA2732863A1 (en) 2010-02-04

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Legal Events

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PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR

AX Request for extension of the european patent

Extension state: AL BA RS

DAX Request for extension of the european patent (deleted)
RIC1 Information provided on ipc code assigned before grant

Ipc: A61P 19/10 20060101ALI20120405BHEP

Ipc: A61K 31/663 20060101ALI20120405BHEP

Ipc: A61K 31/426 20060101AFI20120405BHEP

A4 Supplementary search report drawn up and despatched

Effective date: 20120416

17Q First examination report despatched

Effective date: 20130123

STAA Information on the status of an ep patent application or granted ep patent

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18D Application deemed to be withdrawn

Effective date: 20130403