EP2299820A4 - Ophthalmische formulierung einer rho-kinasehemmerverbindung - Google Patents
Ophthalmische formulierung einer rho-kinasehemmerverbindungInfo
- Publication number
- EP2299820A4 EP2299820A4 EP09767519A EP09767519A EP2299820A4 EP 2299820 A4 EP2299820 A4 EP 2299820A4 EP 09767519 A EP09767519 A EP 09767519A EP 09767519 A EP09767519 A EP 09767519A EP 2299820 A4 EP2299820 A4 EP 2299820A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- kinase inhibitor
- inhibitor compound
- rho kinase
- ophthalmic formulation
- ophthalmic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
- A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Ophthalmology & Optometry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US7351908P | 2008-06-18 | 2008-06-18 | |
PCT/US2009/047108 WO2009155209A1 (en) | 2008-06-18 | 2009-06-11 | Ophthalmic formulation of rho kinase inhibitor compound |
Publications (2)
Publication Number | Publication Date |
---|---|
EP2299820A1 EP2299820A1 (de) | 2011-03-30 |
EP2299820A4 true EP2299820A4 (de) | 2012-11-14 |
Family
ID=41434400
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP09767519A Withdrawn EP2299820A4 (de) | 2008-06-18 | 2009-06-11 | Ophthalmische formulierung einer rho-kinasehemmerverbindung |
Country Status (3)
Country | Link |
---|---|
EP (1) | EP2299820A4 (de) |
JP (1) | JP2011524912A (de) |
WO (1) | WO2009155209A1 (de) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103249305A (zh) * | 2010-07-27 | 2013-08-14 | 印斯拜尔药品股份有限公司 | 使用前药形式的激酶抑制剂化合物治疗眼科疾病的方法 |
EP3183346A4 (de) | 2014-08-22 | 2018-10-24 | Auckland Uniservices Limited | Kanalmodulator |
US20210292766A1 (en) | 2018-08-29 | 2021-09-23 | University Of Massachusetts | Inhibition of Protein Kinases to Treat Friedreich Ataxia |
WO2020072456A1 (en) * | 2018-10-02 | 2020-04-09 | Case Western Reserve University | Compounds for treating myelin related disorders |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1256574A1 (de) * | 2000-02-01 | 2002-11-13 | Kirin Beer Kabushiki Kaisha | Stickstoff-enthaltende verbindungen mit kinasehemmender wirkung sowie diese enthaltende medikamente |
US20070149548A1 (en) * | 2005-12-22 | 2007-06-28 | Alcon Manufacturing, Ltd. | (indazol-5-yl)-pyrazines and (1,3-dihydro-indol-2-one)-pyrazines for treating rho kinase-mediated diseases and conditions |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2502583A1 (en) * | 2002-09-12 | 2004-03-25 | Kirin Beer Kabushiki Kaisha | Isoquinoline derivatives having kinase inhibitory activity and medicament containing the same |
US7563906B2 (en) * | 2003-10-15 | 2009-07-21 | Ube Industries, Ltd. | Indazole derivatives |
US20050272851A1 (en) * | 2004-06-04 | 2005-12-08 | Xerox Corporation | Wax emulsion for emulsion aggregation toner |
-
2009
- 2009-06-11 JP JP2011514714A patent/JP2011524912A/ja not_active Withdrawn
- 2009-06-11 EP EP09767519A patent/EP2299820A4/de not_active Withdrawn
- 2009-06-11 WO PCT/US2009/047108 patent/WO2009155209A1/en active Application Filing
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1256574A1 (de) * | 2000-02-01 | 2002-11-13 | Kirin Beer Kabushiki Kaisha | Stickstoff-enthaltende verbindungen mit kinasehemmender wirkung sowie diese enthaltende medikamente |
US20070149548A1 (en) * | 2005-12-22 | 2007-06-28 | Alcon Manufacturing, Ltd. | (indazol-5-yl)-pyrazines and (1,3-dihydro-indol-2-one)-pyrazines for treating rho kinase-mediated diseases and conditions |
Non-Patent Citations (1)
Title |
---|
See also references of WO2009155209A1 * |
Also Published As
Publication number | Publication date |
---|---|
WO2009155209A1 (en) | 2009-12-23 |
EP2299820A1 (de) | 2011-03-30 |
JP2011524912A (ja) | 2011-09-08 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 20101215 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK TR |
|
AX | Request for extension of the european patent |
Extension state: AL BA RS |
|
DAX | Request for extension of the european patent (deleted) | ||
A4 | Supplementary search report drawn up and despatched |
Effective date: 20121011 |
|
RIC1 | Information provided on ipc code assigned before grant |
Ipc: A61K 9/08 20060101AFI20121005BHEP Ipc: A61K 31/4545 20060101ALI20121005BHEP Ipc: A61K 31/454 20060101ALI20121005BHEP Ipc: A61K 31/4725 20060101ALI20121005BHEP Ipc: A61K 31/416 20060101ALI20121005BHEP |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20130511 |