EP2270137A4 - Method for producing cells having characteristic of hematopoietic stem cells/progenitor cells - Google Patents

Method for producing cells having characteristic of hematopoietic stem cells/progenitor cells

Info

Publication number
EP2270137A4
EP2270137A4 EP09719288A EP09719288A EP2270137A4 EP 2270137 A4 EP2270137 A4 EP 2270137A4 EP 09719288 A EP09719288 A EP 09719288A EP 09719288 A EP09719288 A EP 09719288A EP 2270137 A4 EP2270137 A4 EP 2270137A4
Authority
EP
European Patent Office
Prior art keywords
cells
characteristic
hematopoietic stem
producing
progenitor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP09719288A
Other languages
German (de)
French (fr)
Other versions
EP2270137A1 (en
Inventor
Yoshimoto Katsura
Hiroshi Kawamoto
Tomokatsu Ikawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
RIKEN Institute of Physical and Chemical Research
Original Assignee
RIKEN Institute of Physical and Chemical Research
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by RIKEN Institute of Physical and Chemical Research filed Critical RIKEN Institute of Physical and Chemical Research
Publication of EP2270137A1 publication Critical patent/EP2270137A1/en
Publication of EP2270137A4 publication Critical patent/EP2270137A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0647—Haematopoietic stem cells; Uncommitted or multipotent progenitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/60—Transcription factors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/999—Small molecules not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/11—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from blood or immune system cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Hematology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Developmental Biology & Embryology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cell Biology (AREA)
  • Veterinary Medicine (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
EP09719288A 2008-03-11 2009-03-11 Method for producing cells having characteristic of hematopoietic stem cells/progenitor cells Withdrawn EP2270137A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2008061542 2008-03-11
PCT/JP2009/054698 WO2009113595A1 (en) 2008-03-11 2009-03-11 Method for producing cells having characteristic of hematopoietic stem cells/progenitor cells

Publications (2)

Publication Number Publication Date
EP2270137A1 EP2270137A1 (en) 2011-01-05
EP2270137A4 true EP2270137A4 (en) 2012-05-09

Family

ID=41065256

Family Applications (1)

Application Number Title Priority Date Filing Date
EP09719288A Withdrawn EP2270137A4 (en) 2008-03-11 2009-03-11 Method for producing cells having characteristic of hematopoietic stem cells/progenitor cells

Country Status (4)

Country Link
US (1) US20110158955A1 (en)
EP (1) EP2270137A4 (en)
JP (1) JP5660451B2 (en)
WO (1) WO2009113595A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110564692B (en) * 2018-07-31 2022-07-15 首都医科大学 Stem cells with enhanced immunoregulatory capacity, and preparation method, composition and application thereof
WO2023165503A1 (en) * 2022-03-02 2023-09-07 苏州血霁生物科技有限公司 Method for differentiating hematopoietic stem/progenitor cells into nk cells

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0860447B1 (en) * 1996-08-27 2007-07-18 Kyowa Hakko Kogyo Co., Ltd. Hematopoietic stem cell growth factor (scgf)
JPH10295369A (en) 1997-02-26 1998-11-10 Japan Tobacco Inc Production of hematopoietic stem cell
JP4453135B2 (en) 1999-12-09 2010-04-21 東ソー株式会社 Novel amplifying agent for hematopoietic cells
KR20050042046A (en) 2001-10-30 2005-05-04 다이이찌 세이야꾸 가부시기가이샤 Method of amplifying hematopoietic stem cells
US20040029271A1 (en) 2002-05-08 2004-02-12 Boehringer Ingelheim International Gmbh Pax5-deficient pro-B cells, methods of producing them and the use of such cells in human therapy
WO2004042040A1 (en) 2002-11-08 2004-05-21 Reprocell Inc. Expansion agents for stem cells
JP2004222502A (en) 2003-01-17 2004-08-12 Asahi Kasei Corp Method for amplifying hematopoietic stem cell
US7795024B2 (en) * 2003-05-02 2010-09-14 Insception Bioscience, Inc. Apparatus and methods for amplification of blood stem cell numbers
US20050130302A1 (en) 2003-09-29 2005-06-16 Reprocell Inc. Method and composition for regulating expansion of stem cells
JP2007037401A (en) 2003-11-21 2007-02-15 Foundation For Biomedical Research & Innovation Transcription factor-binding substance
JP4651282B2 (en) 2004-01-21 2011-03-16 田辺三菱製薬株式会社 Method for amplifying hematopoietic stem cells and hematopoietic progenitor cells
JP4706208B2 (en) 2004-08-27 2011-06-22 株式会社アイル Method for producing hematopoietic stem cells
JP2006067858A (en) 2004-08-31 2006-03-16 Dai Ichi Seiyaku Co Ltd Method for amplifying hematopoietic stem cell by cocultivation
JP2008061542A (en) 2006-09-06 2008-03-21 Riken Vitamin Co Ltd Soybean curd coagulated composition

Non-Patent Citations (10)

* Cited by examiner, † Cited by third party
Title
CORNELIS MURRE: "Helix-loop-helix proteins and lymphocyte development", NATURE IMMUNOLOGY, NATURE PUBLISHING GROUP, GB, vol. 6, no. 11, 27 October 2005 (2005-10-27), pages 1079 - 1086, XP009157702, ISSN: 1529-2908, DOI: 10.1038/NI1260 *
IKAWA TOMOKATSU ET AL: "Long-term cultured E2A-deficient hematopoietic progenitor cells are pluripotent", IMMUNITY, CELL PRESS, US, vol. 20, no. 3, 1 March 2004 (2004-03-01), pages 349 - 360, XP009157675, ISSN: 1074-7613 *
JALECO A C ET AL: "Genetic modification of human B-cell development: B-cell development is inhibited by the dominant negative helix loop helix factor Id3", BLOOD, AMERICAN SOCIETY OF HEMATOLOGY, US, vol. 94, no. 8, 15 October 1999 (1999-10-15), pages 2637 - 2646, XP009133172, ISSN: 0006-4971 *
KÖRBLING M ET AL: "Peripheral blood stem cell versus bone marrow allotransplantation: Does the source of hematopoietic stem cells matter?", BLOOD, AMERICAN SOCIETY OF HEMATOLOGY, US, vol. 98, no. 10, 15 November 2001 (2001-11-15), pages 2900 - 2908, XP002983922, ISSN: 0006-4971, DOI: 10.1182/BLOOD.V98.10.2900 *
MELANDER CHRISTIAN ET AL: "Regulation of gene expression with pyrrole-imidazole polyamides", JOURNAL OF BIOTECHNOLOGY, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 112, no. 1-2, 26 August 2004 (2004-08-26), pages 195 - 220, XP007907307, ISSN: 0168-1656, DOI: 10.1016/J.JBIOTEC.2004.03.018 *
MELANIE W. QUONG ET AL: "E protein function in lymphocyte development", ANNUAL REVIEW OF IMMUNOLOGY, vol. 20, no. 1, 1 April 2002 (2002-04-01), pages 301 - 322, XP055023186, ISSN: 0732-0582, DOI: 10.1146/annurev.immunol.20.092501.162048 *
MING JI ET AL: "Id2 intrinsically regulates lymphoid and erythroid development via interaction with different target proteins", BLOOD, vol. 112, no. 4, 15 August 2008 (2008-08-15), pages 1068 - 1077, XP055198853, DOI: 10.1182/blood-2008-01-133504 *
MURRE CORNELIS: "Regulation and function of the E2A proteins in B cell development", ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY, SPRINGER, US, vol. 596, 1 January 2007 (2007-01-01), pages 1 - 7, XP009157701, ISSN: 0065-2598, ISBN: 978-0-387-69078-0 *
See also references of WO2009113595A1 *
STEPHEN L NUTT ET AL: "Commitment to the B-lymphoid lineage depends on the transcription factor", NATURE: INTERNATIONAL WEEKLY JOURNAL OF SCIENCE, NATURE PUBLISHING GROUP, UNITED KINGDOM, vol. 01, no. 6753, 7 October 1999 (1999-10-07), pages 556 - 562, XP009157706, ISSN: 0028-0836, DOI: 10.1038/44076 *

Also Published As

Publication number Publication date
JP5660451B2 (en) 2015-01-28
WO2009113595A1 (en) 2009-09-17
JPWO2009113595A1 (en) 2011-07-21
EP2270137A1 (en) 2011-01-05
US20110158955A1 (en) 2011-06-30

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