EP2270137A4 - Method for producing cells having characteristic of hematopoietic stem cells/progenitor cells - Google Patents
Method for producing cells having characteristic of hematopoietic stem cells/progenitor cellsInfo
- Publication number
- EP2270137A4 EP2270137A4 EP09719288A EP09719288A EP2270137A4 EP 2270137 A4 EP2270137 A4 EP 2270137A4 EP 09719288 A EP09719288 A EP 09719288A EP 09719288 A EP09719288 A EP 09719288A EP 2270137 A4 EP2270137 A4 EP 2270137A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- cells
- characteristic
- hematopoietic stem
- producing
- progenitor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0647—Haematopoietic stem cells; Uncommitted or multipotent progenitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/60—Transcription factors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/999—Small molecules not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/11—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from blood or immune system cells
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Hematology (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Developmental Biology & Embryology (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Cell Biology (AREA)
- Veterinary Medicine (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2008061542 | 2008-03-11 | ||
PCT/JP2009/054698 WO2009113595A1 (en) | 2008-03-11 | 2009-03-11 | Method for producing cells having characteristic of hematopoietic stem cells/progenitor cells |
Publications (2)
Publication Number | Publication Date |
---|---|
EP2270137A1 EP2270137A1 (en) | 2011-01-05 |
EP2270137A4 true EP2270137A4 (en) | 2012-05-09 |
Family
ID=41065256
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP09719288A Withdrawn EP2270137A4 (en) | 2008-03-11 | 2009-03-11 | Method for producing cells having characteristic of hematopoietic stem cells/progenitor cells |
Country Status (4)
Country | Link |
---|---|
US (1) | US20110158955A1 (en) |
EP (1) | EP2270137A4 (en) |
JP (1) | JP5660451B2 (en) |
WO (1) | WO2009113595A1 (en) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110564692B (en) * | 2018-07-31 | 2022-07-15 | 首都医科大学 | Stem cells with enhanced immunoregulatory capacity, and preparation method, composition and application thereof |
WO2023165503A1 (en) * | 2022-03-02 | 2023-09-07 | 苏州血霁生物科技有限公司 | Method for differentiating hematopoietic stem/progenitor cells into nk cells |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0860447B1 (en) * | 1996-08-27 | 2007-07-18 | Kyowa Hakko Kogyo Co., Ltd. | Hematopoietic stem cell growth factor (scgf) |
JPH10295369A (en) | 1997-02-26 | 1998-11-10 | Japan Tobacco Inc | Production of hematopoietic stem cell |
JP4453135B2 (en) | 1999-12-09 | 2010-04-21 | 東ソー株式会社 | Novel amplifying agent for hematopoietic cells |
KR20050042046A (en) | 2001-10-30 | 2005-05-04 | 다이이찌 세이야꾸 가부시기가이샤 | Method of amplifying hematopoietic stem cells |
US20040029271A1 (en) | 2002-05-08 | 2004-02-12 | Boehringer Ingelheim International Gmbh | Pax5-deficient pro-B cells, methods of producing them and the use of such cells in human therapy |
WO2004042040A1 (en) | 2002-11-08 | 2004-05-21 | Reprocell Inc. | Expansion agents for stem cells |
JP2004222502A (en) | 2003-01-17 | 2004-08-12 | Asahi Kasei Corp | Method for amplifying hematopoietic stem cell |
US7795024B2 (en) * | 2003-05-02 | 2010-09-14 | Insception Bioscience, Inc. | Apparatus and methods for amplification of blood stem cell numbers |
US20050130302A1 (en) | 2003-09-29 | 2005-06-16 | Reprocell Inc. | Method and composition for regulating expansion of stem cells |
JP2007037401A (en) | 2003-11-21 | 2007-02-15 | Foundation For Biomedical Research & Innovation | Transcription factor-binding substance |
JP4651282B2 (en) | 2004-01-21 | 2011-03-16 | 田辺三菱製薬株式会社 | Method for amplifying hematopoietic stem cells and hematopoietic progenitor cells |
JP4706208B2 (en) | 2004-08-27 | 2011-06-22 | 株式会社アイル | Method for producing hematopoietic stem cells |
JP2006067858A (en) | 2004-08-31 | 2006-03-16 | Dai Ichi Seiyaku Co Ltd | Method for amplifying hematopoietic stem cell by cocultivation |
JP2008061542A (en) | 2006-09-06 | 2008-03-21 | Riken Vitamin Co Ltd | Soybean curd coagulated composition |
-
2009
- 2009-03-11 JP JP2010502861A patent/JP5660451B2/en not_active Expired - Fee Related
- 2009-03-11 WO PCT/JP2009/054698 patent/WO2009113595A1/en active Application Filing
- 2009-03-11 EP EP09719288A patent/EP2270137A4/en not_active Withdrawn
- 2009-03-11 US US12/922,037 patent/US20110158955A1/en not_active Abandoned
Non-Patent Citations (10)
Title |
---|
CORNELIS MURRE: "Helix-loop-helix proteins and lymphocyte development", NATURE IMMUNOLOGY, NATURE PUBLISHING GROUP, GB, vol. 6, no. 11, 27 October 2005 (2005-10-27), pages 1079 - 1086, XP009157702, ISSN: 1529-2908, DOI: 10.1038/NI1260 * |
IKAWA TOMOKATSU ET AL: "Long-term cultured E2A-deficient hematopoietic progenitor cells are pluripotent", IMMUNITY, CELL PRESS, US, vol. 20, no. 3, 1 March 2004 (2004-03-01), pages 349 - 360, XP009157675, ISSN: 1074-7613 * |
JALECO A C ET AL: "Genetic modification of human B-cell development: B-cell development is inhibited by the dominant negative helix loop helix factor Id3", BLOOD, AMERICAN SOCIETY OF HEMATOLOGY, US, vol. 94, no. 8, 15 October 1999 (1999-10-15), pages 2637 - 2646, XP009133172, ISSN: 0006-4971 * |
KÖRBLING M ET AL: "Peripheral blood stem cell versus bone marrow allotransplantation: Does the source of hematopoietic stem cells matter?", BLOOD, AMERICAN SOCIETY OF HEMATOLOGY, US, vol. 98, no. 10, 15 November 2001 (2001-11-15), pages 2900 - 2908, XP002983922, ISSN: 0006-4971, DOI: 10.1182/BLOOD.V98.10.2900 * |
MELANDER CHRISTIAN ET AL: "Regulation of gene expression with pyrrole-imidazole polyamides", JOURNAL OF BIOTECHNOLOGY, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 112, no. 1-2, 26 August 2004 (2004-08-26), pages 195 - 220, XP007907307, ISSN: 0168-1656, DOI: 10.1016/J.JBIOTEC.2004.03.018 * |
MELANIE W. QUONG ET AL: "E protein function in lymphocyte development", ANNUAL REVIEW OF IMMUNOLOGY, vol. 20, no. 1, 1 April 2002 (2002-04-01), pages 301 - 322, XP055023186, ISSN: 0732-0582, DOI: 10.1146/annurev.immunol.20.092501.162048 * |
MING JI ET AL: "Id2 intrinsically regulates lymphoid and erythroid development via interaction with different target proteins", BLOOD, vol. 112, no. 4, 15 August 2008 (2008-08-15), pages 1068 - 1077, XP055198853, DOI: 10.1182/blood-2008-01-133504 * |
MURRE CORNELIS: "Regulation and function of the E2A proteins in B cell development", ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY, SPRINGER, US, vol. 596, 1 January 2007 (2007-01-01), pages 1 - 7, XP009157701, ISSN: 0065-2598, ISBN: 978-0-387-69078-0 * |
See also references of WO2009113595A1 * |
STEPHEN L NUTT ET AL: "Commitment to the B-lymphoid lineage depends on the transcription factor", NATURE: INTERNATIONAL WEEKLY JOURNAL OF SCIENCE, NATURE PUBLISHING GROUP, UNITED KINGDOM, vol. 01, no. 6753, 7 October 1999 (1999-10-07), pages 556 - 562, XP009157706, ISSN: 0028-0836, DOI: 10.1038/44076 * |
Also Published As
Publication number | Publication date |
---|---|
JP5660451B2 (en) | 2015-01-28 |
WO2009113595A1 (en) | 2009-09-17 |
JPWO2009113595A1 (en) | 2011-07-21 |
EP2270137A1 (en) | 2011-01-05 |
US20110158955A1 (en) | 2011-06-30 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 20101011 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK TR |
|
AX | Request for extension of the european patent |
Extension state: AL BA RS |
|
DAX | Request for extension of the european patent (deleted) | ||
A4 | Supplementary search report drawn up and despatched |
Effective date: 20120410 |
|
RIC1 | Information provided on ipc code assigned before grant |
Ipc: C12N 15/09 20060101ALI20120402BHEP Ipc: A61P 37/04 20060101ALI20120402BHEP Ipc: A61K 35/12 20060101ALI20120402BHEP Ipc: C12N 5/10 20060101AFI20120402BHEP |
|
17Q | First examination report despatched |
Effective date: 20150709 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20151120 |