EP2263796A1 - Container with reference solution - Google Patents

Abstract

The container (1) has reference solution (2) contained in it for clinical chemistry, where the container has an outlet covered by a closure part (3). The reference solution is removed by puncture with a piercing element. A wick (4) soaked with reference solution is arranged in the container, which extends from the outlet inside an interior of the container, in which it is arranged with the large part of its length. Independent claims are also included for the following: (1) a system with a control unit; and (2) a method for receiving reference solution for the clinical chemistry.

Description

The invention relates to a container with reference solution for clinical chemistry contained therein, for example, glucose solution, lactate solution, cholesterol solution or hemoglobin solution.

Such reference solutions are needed for testing or calibrating gauges used, for example, by diabetics to determine their blood sugar levels. Manufacturers of measuring systems for the determination of analyte concentrations in body fluid samples therefore offer containers with reference solution in defined concentrations as part of such measuring systems.

Modern measuring instruments contain a lancing device for sample taking. For example, lancing elements can be used with a capillary channel, so that a body fluid sample can be automatically taken during a puncture.

To supply reference solutions to such measuring devices is associated with particular difficulties because of the small dimensions of typical lancing elements. Attempting to drop the reference solution onto a lancing device or applying it with a brush will generally lead to contamination of the measuring device with reference solution.

In the WO 2002/100265 A3 For this reason, a container is proposed which contains a sponge impregnated with reference solution and is closed with a membrane. To record reference solution, the meter is attached to the membrane and pierced with a lancing element. The inclusion of reference solution thus takes place in an analogous manner as a sample holder, namely with a puncturing movement of the lancing element.

A constant goal in the development of measuring systems is to simplify the handling and to save costs. The object of the invention is therefore to show a cost-effective way how it can be easier for users to supply meters with integrated lancing equipment without contamination with reference solution.

This object is achieved by a container having the features specified in claim 1 and by a container having the features specified in claim 11. The invention further relates to a system for measuring an analyte concentration in a human or animal body fluid sample, comprising such a container and a measuring device which contains a pricking device for taking samples. The invention also relates to a method for recording reference solution with a lancing element according to claim 15. Advantageous developments of the invention are the subject of dependent claims.

By arranging a wick in a container with reference solution contained therein, it is possible both to reduce the manufacturing outlay and to make handling much easier for users. Namely, with a wick, reference solution can be made available at the outlet regardless of the level of the container, so that reference solution can be absorbed by a piercing element of a puncturing instrument which pierces the wick. Advantageously, therefore, at the filling of the container with reference solution large tolerances are accepted, so that the container is partially filled with air. Namely, it does not hurt if the interior of the container is partially filled with air. Capillary forces of the wick always ensure that the full length of the wick is saturated with reference solution.

This is a significant advantage over that from the WO 2002/100265 A3 known container containing a soaked with reference solution sponge and is closed by a membrane. Namely, the known container must not contain any air, since a lancing element which hits an air bubble during the puncture may under certain circumstances take up no or insufficient reference solution. When filling liquids to avoid air bubbles or unfilled cavities in a container, however, causes a considerable technical effort. In addition, in the case of the known container there is the risk that the liquid is under pressure as a result of thermal expansion, so that reference solution escapes when the membrane comes through and contaminates the measuring device. With a container according to the invention, this danger can be avoided.

A further advantage of a container according to the invention is, in particular, the fact that a sample holder with particularly high reliability is possible. This is attributed to the fact that the fibers of a wick extend substantially in the direction of the stitch movement performed by a lancing element for receiving reference solution. The lancing element is therefore surrounded on its entire immersed in the wick length of the held between the fibers of the wick by capillary forces reference solution. The active length of the lancing element for the sampling is therefore maximum. This is an important advantage over known containers in which sponges or similar porous bodies are arranged. In fact, in the case of a sponge or a porous body, only that part of the lancing element can contribute to the sample intake, which extends into pores of the sponge, while a part of the lancing element enclosed on all sides by material of the sponge does not come into contact with reference solution.

The wick may be loose in the container. However, it is preferred that the wick is attached to the container. For example, the wick may be materially bonded to a container wall.

An advantageous development of the invention provides that the container has a container wall which surrounds the outlet and carries the closure part, wherein the container wall forms a stop for application to a puncturing device for a sampling. In this way, it is possible to prevent reference solution from being forced out of the container when a puncture device is being used for sampling by pressure being exerted thereon. This is an important advantage because the pressed out reference solution could pollute the lancing device and falsify future measurements. In order to form a stop, relatively rigid-walled container walls can be used, as is common, for example, with plastic bottles. Wall thicknesses of 1 mm and more are particularly suitable.

However, a stop can also be formed with substantially thinner walls, for example by arranging in the container a ring which surrounds the wick. During a sampling, the container wall which surrounds the outlet rests on the ring and is supported by it, so that the container wall can form a load-bearing stop, regardless of its strength.

Preferably, the container withstands a contact force of at least 3 N when applying a puncturing device for a sampling, without reference solution being forced out of the outlet. In general, a user applies a force of 3 Newton to 9 Newton when applying a puncture device to a container with reference solution. A container should also be able to withstand such a force, without thereby reference solution is pressed out when the container is open.

Preferably, the fibers forming the wick are evenly distributed over its cross section. This measure has the advantage that a sampling can be carried out with the same reliability, regardless of where it is inserted at the end face of the wick.

The wick of a container according to the invention may be similar to the wick of a candle made of interwoven fibers. However, such an integration is not required. As a wick, in particular, a fiber bundle can be used. For example, the fiber bundle, like the bristles of a brush, can protrude from the outlet into the interior of the container. The fiber bundle can be fixed in a channel, wherein the wick rests on a channel wall over a predominant part of its length, preferably substantially over its full length. The channel may for example be formed by a tube which projects into the interior of the container. It is also possible that the channel wall is the inner wall of the container.

The closure part of a container according to the invention may be formed, for example, as a membrane. It is also possible to make the container resealable and to use as a closure part, for example, a screw cap. Preferably, however, the closure part is fastened to the container via a predetermined breaking point. In this way, the closure part can form a seal, the integrity of which ensures that the reference solution actually has the expected concentration and has not been adversely affected by harmful environmental influences. For example, the closure part may be integrally formed together with a container wall enclosing the outlet, preferably as an injection-molded part. It is particularly advantageous to attach the closure part to the container such that it can be rotated, for example by providing it with two wings. But it is also possible to form the closure part so that it is broken off by a kinking movement of the container.

In the case of a closure part formed integrally with the container, the closure part is preferably smaller than the rest of the container. But it is also possible that the closure part is formed larger than the container and also has an interior, in which reference solution is located. In the language of the present application, the container is defined by the fact that the wick is attached to it. When the closure part is removed from the container, it is thus clear, according to the usage used in the context of the present invention, which part is to be regarded as a container and which part as a closure part. Preferably, the container forms a stop on which a puncturing device rests when removing reference solution. For example, the outlet may be formed at a neck of the container, in particular by the container being shaped similar to a bottle. The part of the container which adjoins the neck from the outlet can advantageously form the stop.

Since only a very small amount of reference solution is required for testing or calibrating a measuring device, a container according to the invention may, for example, also be designed as a tube which is closed at one end by a bottom and at the other end has the outlet from which the wick extends into the interior of the container. In such a container, a neck, on which the outlet is arranged, may be formed as a predetermined breaking point between the container and a closure part. But it is also possible to form the outlet as a recess in a container wall, in which a puncturing device for removing reference solution is used. Such a recess may in particular be formed to fit the shape of a puncturing device, so that the outlet and puncturing device, such as the lock and the key, match one another.

The outlet is formed in a container according to the invention as a container opening covered by the closure part, in which the wick is arranged. The wick can block this opening, so that even with a possible overpressure in the interior of the container, there is little risk of reference solution spraying out of the container when the closure part is removed. In order to reduce this slight danger, a pressure equalization channel closed off by the closure part may be provided in addition to the wick. For example, in addition to the opening blocked by the wick, there may be another opening through which gas can escape from the interior of the container as soon as the closure part is removed.

The wick can protrude slightly with the closure part something out of the container and thus out of the outlet. Preferably, the wick protrudes with the closure part removed at most on a length out of the container which is smaller than the width of the wick. In an approximately cylindrically shaped wick, its width is the diameter. Generally speaking, the width of the wick is its greatest extent perpendicular to its longitudinal direction. The wick is on the vast Part of its length between the outlet and a container bottom, in particular between the predetermined breaking point, via which the closure part is attached to the container, and arranged the container bottom. Particularly preferably, the wick is arranged completely in the container.

A further advantageous embodiment of the invention provides that the wick is arranged in a channel. Preferably, the wick rests on a channel wall over a predominant part of its length. It is further preferred that the wick protrudes from the channel at most for a length which is smaller than its width. Through the channel, the fibers forming the wick can advantageously be held together, so that liquid can be held and transported by capillary forces between the fibers. It is preferred that the channel tapers to the removal point. The density of the wick increases from the interior of the container to the sampling point.

Another aspect of the present invention relates to a container with reference solution for clinical chemistry contained therein, wherein the container has an interior divided by a membrane into two chambers. One of the two chambers contains the reference solution, while the other chamber is filled with air, wherein at least one container opening causes a pressure equalization between the air-filled chamber and the container environment. In this way, it can be achieved that the pressure in the chamber containing the reference solution deviates at most negligibly from the atmospheric air pressure of the container environment. Therefore, when puncturing the reference solution-containing chamber, there is no fear that a larger amount of reference solution will leak out and contaminate a meter.

The outlet of such a container can be closed with a membrane as a closure part, which is pierced to remove reference solutions with a lancing element. At the outlet, preferably a body soaked in reference solution, in particular a wick, is arranged. Such a wick, as explained above, preferably extends from the outlet into the interior of the container, more precisely into the chamber containing the reference solution.

Another aspect of the present invention relates to a container having a reference solution for clinical chemistry contained therein, wherein the container contains a body soaked with reference solution and has a stopper for abutment with a puncture device for sampling. The stop can absorb a pressure exerted by the application of a puncturing device without the pressure inside the container being increased to such an extent that reference solution is forced out of the container. By a stop thus the risk of contamination of the puncturing device is reduced.

In a rigid-walled container, the stop can easily be formed by the container walls. In the case of a thin-walled container, for example a foil bag, an annular disc which surrounds the body soaked in reference solution can be arranged in the container. Such an annular disc can support a container wall covering it, so that the wall section covering the annular disc can be used as a stop. A container with a stop can also be designed as a blister, that is to say as a container with a bottom plate on which a film is fastened, so that a container interior is formed between the film and the bottom plate. The stop can be formed by a surrounding the container interior region of the bottom plate. Pressure on the bottom plate in an area surrounding the container interior does not increase the pressure inside the container.

A container filled with reference solution forms a measuring system together with a measuring device containing a lancing device for sample collection. The container may contain, for example, 100 .mu.l to 200 .mu.l reference solution

Figur 1

eine schematische Darstellung eines Längsschnitts eines erfindungs- gemäßen Behälters;

Figur 2

einen Querschnitt zu Figur 1;

Figur 3

eine schematische Darstellung eines weiteren Ausführungsbeispiels in einem Querschnitt;

Figur 4

das in Figur 1 gezeigte Ausführungsbeispiel bei der Entnahme von Re- ferenzlösung;

Figur 5

eine schematische Darstellung eines weiteren Ausführungsbeispiels in einem Längsschnitt;

Figur 6

das in Figur 5 gezeigte Ausführungsbeispiel bei der Entnahme von Re- ferenzlösung;

Figur 7

eine schematische Darstellung eines weiteren Ausführungsbeispiels in einem Längsschnitt;

Figur 8

eine schematische Darstellung eines weiteren Ausführungsbeispiels in einem Längsschnitt;

Figur 9

eine schematische Darstellung eines weiteren Ausführungsbeispiels in einem Längsschnitt;

Figur 10

das in Figur 9 gezeigte Ausführungsbeispiel bei der Entnahme von Re- ferenzlösung;

Figur 11

eine schematische Darstellung eines weiteren Ausführungsbeispiels;

Figur 12

eine Schnittansicht zu Figur 11;

Figur 13

eine Abwandlung des in Figur 11 gezeigten Ausführungsbeispiels;

Figur 14

eine weitere Abwandlung des in Figur 11 gezeigten Ausführungsbei- spiels;

Further details and advantages of the invention will be explained with reference to embodiments with reference to the accompanying drawings. The same and corresponding components are provided with matching reference numerals. Show it:

FIG. 1

a schematic representation of a longitudinal section of a container according to the invention;

FIG. 2

a cross section to FIG. 1 ;

FIG. 3

a schematic representation of another embodiment in a cross section;

FIG. 4

this in FIG. 1 embodiment shown in the removal of reference solution;

FIG. 5

a schematic representation of another embodiment in a longitudinal section;

FIG. 6

this in FIG. 5 embodiment shown in the removal of reference solution;

FIG. 7

a schematic representation of another embodiment in a longitudinal section;

FIG. 8

a schematic representation of another embodiment in a longitudinal section;

FIG. 9

a schematic representation of another embodiment in a longitudinal section;

FIG. 10

this in FIG. 9 embodiment shown in the removal of reference solution;

FIG. 11

a schematic representation of another embodiment;

FIG. 12

a sectional view too FIG. 11 ;

FIG. 13

a modification of the in FIG. 11 shown embodiment;

FIG. 14

another variation of the in FIG. 11 shown Ausführungsbei- game;

FIG. 1 shows a longitudinal section of a container 1 containing reference solution 2 in a clinical chemistry, for example, glucose solution. The container is closed by a closure part 3. The closure part 3 covers an outlet from which a wick 4 extends into the interior of the container 1. To remove reference solution 2, the closure part 3 is removed from the container 1 and pierced with a lancing element in the thereby exposed outlet and thus in the wick 4. In this case, a puncturing device is applied to a stop which is formed by a surrounding the wick 4 and thus also the outlet container wall. The container walls are sufficiently stable to be able to withstand a force of at least 3 N, which is typically exerted by the pressing of a puncturing device to the stop, without reference solution 2 is pressed out of the container 1.

The wick 4 is formed by a fiber bundle which is arranged completely in the container 1. One end of the fiber bundle 4 is arranged in the outlet, that is to say the container opening formed by removal of the closure part 3, and fastened there to the container 1. The other end of the wick 4 is arranged in the interior of the container 1 contained in the reference solution 2 and immersed in the reference solution 2 when the container 1 is oriented so that its outlet points upwards. The fibers of the wick 4 extend in the longitudinal direction thereof.

The wick 4 is attached to, more precisely inside, the container 1 by the wick 4 is arranged in a channel and rests on most of its length on the channel wall. The wick 4 is attached to the channel wall, preferably by being welded to the channel wall. The channel is formed in the illustrated embodiment as an extending into the interior of the container 1 tube. The channel containing the wick 4 narrows towards the removal point, for example, in that the interior space of the channel is conical.

The closure part 3 is connected to the container 1 via a predetermined breaking point. The predetermined breaking point can be designed, for example, as a circumferential constriction. In the illustrated embodiment, the closure part 3 is for turning off or kinked and therefore has two wings that facilitate the application of torque to a user.

In FIG. 2 is a cross-sectional view too FIG. 1 shown along the section line AA. FIG. 2 thus also shows a plan view of the outlet of the container 1 with removed closure part 3. As can be seen therein, the wick 4 fills a in FIG. 1 from the closure part 3 covered container opening. The fibers forming the wick 4 are evenly distributed over the cross section thereof.

In addition to the wick 4 are one or more pressure equalization channels 5, which are also closed by the closure part 3. When the closure part 3 is removed from the container 1, gas can escape from the interior of the container 1 through the pressure compensation channel 5 or air can penetrate into the interior of the container 1, so that any over or underpressure present is reduced. The wick 4 and its fibers extend in the direction of the pressure equalization channel. 5

As FIG. 1 shows the wick 4 and the reference solution 2 contained interior of the container 1 is partially filled with air. The wick 4 extends from the outlet so far into the interior of the container 1 that the wick 4 is immersed in the reference solution 2 when the outlet is directed upwards. The wick 4 is therefore soaked with reference solution 2 over its entire length, so that reference solution 2 can be removed even with a very short lancing element, with which wick 4 arranged in the outlet is inserted. In order to increase the capillary action of the wick 4, the reference solution 2 may be mixed with a surfactant so that its surface tension is reduced.

The container 1 may have a bottom of foil 6. In this way, a main part of the container 1 together with the closure part 3 made of plastic as an injection molded part, ie in one piece, prepared, and then the wick 4 used and reference solution 2 are filled. Thereafter, a film 6 glued to the main part of the container and this can be closed.

The bottom 6 can be, for example, a plastic-coated metal foil, for example a plastic-coated aluminum foil. Advantageously, the film 6 can be glued to the main part of the container 1 and printed with a batch information, such as the expiration date.

Instead of a film 6, a main part of the container 1, for example, closed by the fact that the lower edges after filling of reference solution as in a tube connected to each other, for example, glued or welded.

In FIG. 3 is a further embodiment of a container 1 with reference solution 2 contained therein in a cross section according to FIG. 2 shown. The only difference from the preceding embodiment is in another form of pressure equalization channels 5 extending adjacent the wick 4.

FIG. 4 schematically shows the removal of reference solution by means of a piercing element 15 from the in FIG. 1 For removal, a puncturing device with its housing 14 is attached to the container 1, so that 4 reference solution 2 can be absorbed by a stitch in the wick. In FIG. 4 When the reference solution 2 is withdrawn, the container 1 is oriented with its outlet oriented downwards, so that the stitch movement carried out by the puncturing element 15 is directed upward. However, the container 1 can be oriented as desired for a sampling.

FIG. 5 shows a further embodiment of a container 1 with reference solution contained therein 2. In this embodiment, similar to the embodiments shown above, a closure member 3 is connected via a predetermined breaking point with a container. However, in this embodiment, the closure part 3 is larger than the container 1 containing the wick 4. In this exemplary embodiment, therefore, the closure part 3 also has an interior space contained in reference solution 2 and a bottom sealed with film 6. This embodiment shows that for purposes of the present invention, the container 1 is defined by its property that the wick 4 is attached to it. FIG. 6 schematically shows how a lancing element 15 is inserted into the wick 4 for sampling.

As with the embodiments shown above, the outlet is located at a neck of the container. This measure has the advantage that the container forms a stop for the device housing 14 attached to the container 1 during a sampling.

FIG. 7 shows a further embodiment of a container 1 with contained therein reference solution 2 for clinical chemistry, for example, glucose solution, lactate solution, cholesterol solution or hemoglobin solution. The container 1 is composed of two nested wall elements 1a, 1b and has a divided by a membrane 11 into two chambers interior. One of the two chambers contains reference solution 2, to which one surfactant may be admixed while the other chamber is filled with air. Container openings with pressure compensation channels 5 leading through the wall element 1b effect a pressure equalization between the air-filled chamber and the container environment.

The reference solution 2 containing chamber may be partially or completely filled, so in addition to reference solution also contain air, which in FIG. 7 is indicated by an air bubble 16. This chamber has an outlet which is closed by a closure part, namely a membrane 12. At the outlet, a body impregnated with reference solution 2, for example a sponge 13, is arranged.

To remove reference solution 2, a puncturing device 14 can be attached to the outlet closed by the membrane 12 and the membrane 12 can be pierced with a lancing element 15, which has a sample receiving device, for example a capillary channel. But it is also possible to remove the membrane 12 from the outlet before a sting. For example, the membrane 12 can be cited as a sealing film. In particular, the membrane may be a metal foil, which is preferably coated with plastic.

The outlet of the container 1 is adapted to the shape of the puncturing device 14 to facilitate users to correctly attach the puncturing device 14 to the membrane 12 for removal of reference solution 2.

The membrane 12 may have a hydrophobic surface. In this way it can be prevented that after a perforation of the membrane 12 reference solution 2 exits from the container 1 by itself and causes contamination.

The two container parts 1a, 1b are preferably rigid-walled. Such wall elements 1a, 1b can be produced inexpensively, for example, as injection-molded parts made of plastic. The wall element 1 a forms together with the membrane 11 a container containing the reference solution. The container part 1b has the function of protecting the membrane 11 from damage. The two wall elements 1a, 1b are preferably locked together. In this way, the production cost can be advantageously reduced.

In order to achieve the desired pressure equalization between the air-filled chamber and the environment of the container 1, a single opening with a pressure equalization channel 5 is sufficient per se. However, as in the illustrated exemplary embodiment, a plurality of openings with pressure compensation channels 5 are preferred. If a user in handling the container 1 covers some of the openings 5 with pressure equalization channels 5, this is harmless, since even a single uncovered opening with a pressure equalization channel 5 allows sufficient pressure equalization.

FIG. 8 shows a further embodiment, which differs from the in FIG. 7 illustrated embodiment essentially only differs in that the porous body 13 has been replaced by a wick 4. To avoid repetition is in this context to the description in the FIGS. 1 to 4 referenced embodiments.

In FIG. 9 a further embodiment is shown, which differs from that in the FIGS. 7 and 8th illustrated embodiments essentially differs in that a container wall a pointing to the diaphragm 11 mandrel 16th shows. The wall elements 1a, 1b are movable relative to each other in this embodiment. By the two wall elements 1a, 1b are compressed, the wall element 1 b is moved with the mandrel 17 to the membrane 11, so that the mandrel 17 pierces the membrane 11. This is in FIG. 10 shown.

When the two wall elements 1a, 1b are pushed into each other by pressure, the mandrel 16 attached to one of the two wall elements 1a, 1b pierces the membrane 11. It is preferred that the two wall elements 1a, 1b engage one another during compression in an end position so that a used container 1, ie a container 1 with pierced membrane 11, is easily recognizable. For clarification, one of the two wall elements 1a, 1b may have a marking, for example a colored ring, which is concealed when the two wall elements 1a, 1b are pushed into one another.

In the FIGS. 11 and 12 is a further embodiment of a container 1 is shown with reference solution contained therein. In contrast to the embodiments described above, the illustrated container 1 has a relatively thin container wall, which consists for example of plastic film. So that the container wall can still form a stop for application to a puncturing device for sampling, an annular disc 7 is arranged in the container, which surrounds a container 4 soaked in reference solution, for example a wick or a sponge. For a sampling can be pressed with a puncturing device against a supported by the annular disc 7 section of the container wall, without thereby appreciably increases the fluid pressure inside the container.

The in the FIGS. 11 and 12 shown container may be, for example, a foil bag or a blister. A blister is a package consisting of a bottom plate carrying a foil so that a container interior is formed between the foil and the bottom plate.

In order to protect a thin-walled top of the illustrated container from damage, the top may be covered with a peel-off adhesive label 3, for example made of paper or foil. To remove the adhesive label from the film withdrawn and then the container covered with the reference solution body covered container wall pierced with a lancing element. The adhesive label in this case forms the removable closure part 3 of the container 1.

On such a label 3 for the protection of the outlet can be dispensed with a suitable packaging of the container 1 also. The outlet of the container is then covered by the container wall end of the enclosed by the annular disc 7 channel in which the reference solution impregnated body 4 is arranged. The portion of the container wall covering the reference solution-impregnated body 4 may in such a case be regarded as a closure part.

To remove the reference solution from a container, as in the FIGS. 11 and 12 is shown to be as simple as possible for a user, the container may have means for fixing on the fingertip, for example, an adhesive surface or a loop 8, as shown schematically in FIG FIG. 13 is shown. Since body fluid samples are usually taken with pricking equipment from the fingertip of a straight finger 9, with such an attachment, the user's usual movements can also be applied to the removal of reference solution.

In order to allow a user to remove reference solution with usual movements, the container can also be provided with a longer handle, as shown schematically in FIG FIG. 14 is shown. Also in this way, the puncturing device for removing reference solution can be pressed against a voltage applied to the fingertip container.

reference numerals

1

container

1a

wall element

1b

wall element

2

reference solution

3

closing part

4

wick

5

Pressure compensation channel

6

foil

7

washer

8th

loop

9

finger

11

membrane

12

membrane

13

sponge

14

Lancing device housing

15

piercing member

16

bubble

17

mandrel

Claims (15)

Container with reference solution for clinical chemistry contained therein, the container (1) having an outlet covered by a closure part (3), on which reference solution (2) can be taken by puncturing with a lancing element (15),
characterized in that
in the container (1) a reference solution (2) soaked wick (4) is arranged, which extends from the outlet into an interior of the container (1), in which it is arranged with the largest part of its length. A container according to claim 1, characterized in that the container (1) has a container wall which surrounds the wick (4) and carries the closure part (3), wherein the container wall forms a stop for application to a puncturing device for sampling. Container according to one of the preceding claims, characterized in that the container withstands a contact pressure of at least 3 N when applying a puncturing device for a sampling, without reference solution is forced out of the outlet. Container according to one of the preceding claims, characterized in that the closure part (3) is fastened to the container (1) via a predetermined breaking point. Container according to one of the preceding claims, characterized in that in addition to the wick (4) a pressure compensation channel (5) extends, which is closed by the closure part (3). Container according to one of the preceding claims, characterized in that the wick (4) is formed as a fiber bundle. Container according to one of the preceding claims, characterized in that, with the closure part (3) removed , the wick (4) projects out of the container (1) at a maximum length which is smaller than its width. Container according to one of the preceding claims, characterized in that the wick (4) is immersed in the reference solution (2) when the outlet is directed upwards. Container according to one of the preceding claims, characterized in that one end of the wick (4) is arranged at the outlet. Container with reference solution for clinical chemistry, characterized in that the container (1) has a divided into two chambers by a membrane (11) interior, wherein one of the two chambers containing the reference solution (2) and the other chamber with air is filled, wherein at least one container opening causes a pressure equalization between the air-filled chamber and the container environment. Container according to claim 10, characterized in that in the reference solution (2) containing chamber with a reference solution (2) soaked body, preferably a wick (4), is arranged. Container according to claim 10 or 11, characterized in that the container (1) is composed of two nested wall elements (1a, 1b). Container according to claim 12, characterized in that the two wall elements (1a, 1b) are movable relative to each other, wherein a container wall carries a mandrel (17) pointing at the membrane (11). A system for measuring an analyte concentration of a human or animal body fluid sample, comprising a container according to any one of the preceding claims and a meter containing a pricking device for sampling. Method for receiving reference solution (2) for clinical chemistry with a puncturing element (15), wherein the reference solution (2) is mounted in a container (1), characterized in that the lancing element (15) is placed in a solution containing reference solution (2 ) soaked wick (4) is placed in the container (2).

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