EP2260019A4 - Modulation of enzymatic structure, activity, and/or expression level - Google Patents

Modulation of enzymatic structure, activity, and/or expression level

Info

Publication number
EP2260019A4
EP2260019A4 EP08726395A EP08726395A EP2260019A4 EP 2260019 A4 EP2260019 A4 EP 2260019A4 EP 08726395 A EP08726395 A EP 08726395A EP 08726395 A EP08726395 A EP 08726395A EP 2260019 A4 EP2260019 A4 EP 2260019A4
Authority
EP
European Patent Office
Prior art keywords
modulation
activity
expression level
enzymatic structure
enzymatic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP08726395A
Other languages
German (de)
French (fr)
Other versions
EP2260019A1 (en
Inventor
Rajinder Bhasin
Paul Bingham
Lakmal W Boteju
Zuzana Zachar
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of EP2260019A1 publication Critical patent/EP2260019A1/en
Publication of EP2260019A4 publication Critical patent/EP2260019A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/52—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/385—Heterocyclic compounds having sulfur as a ring hetero atom having two or more sulfur atoms in the same ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00—Thiocarboxylic acids
    • C07C327/20—Esters of monothiocarboxylic acids
    • C07C327/32—Esters of monothiocarboxylic acids having sulfur atoms of esterified thiocarboxyl groups bound to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
EP08726395A 2008-03-04 2008-03-04 Modulation of enzymatic structure, activity, and/or expression level Withdrawn EP2260019A4 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2008/002853 WO2009110859A1 (en) 2008-03-04 2008-03-04 Modulation of enzymatic structure, activity, and/or expression level

Publications (2)

Publication Number Publication Date
EP2260019A1 EP2260019A1 (en) 2010-12-15
EP2260019A4 true EP2260019A4 (en) 2011-08-03

Family

ID=41056265

Family Applications (1)

Application Number Title Priority Date Filing Date
EP08726395A Withdrawn EP2260019A4 (en) 2008-03-04 2008-03-04 Modulation of enzymatic structure, activity, and/or expression level

Country Status (10)

Country Link
EP (1) EP2260019A4 (en)
JP (1) JP2011513395A (en)
KR (1) KR20110004846A (en)
CN (1) CN102089276A (en)
AU (1) AU2008352076A1 (en)
BR (1) BRPI0821176A2 (en)
CA (1) CA2717511A1 (en)
IL (1) IL207943A0 (en)
MX (1) MX2010009673A (en)
WO (1) WO2009110859A1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8263653B2 (en) 2007-04-18 2012-09-11 Cornerstone Pharmaceuticals, Inc. Pharmaceutical formulations containing lipoic acid derivatives
CN102056605A (en) * 2008-04-04 2011-05-11 罗伯特·绍尔 Pharmaceutical composition
AU2014398232B2 (en) 2014-06-19 2019-11-28 Rafael Pharmaceuticals, Inc. Pharmaceutical compounds
WO2015195071A1 (en) 2014-06-19 2015-12-23 Robert Shorr Pharmaceutical compounds
JP2022514084A (en) * 2018-12-20 2022-02-09 ラファエル ファーマシューティカルズ， インコーポレイテッド Oral therapy with 6,8-bis-benzylthio-octanoic acid

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5679697A (en) * 1993-11-26 1997-10-21 Garnett; Merrill Palladium complexes and methods for using same in the treatment of tumors
US5693664A (en) * 1993-12-21 1997-12-02 Asta Medica Aktiengesellschaft Use of R-(+)-α-lipoic acid, R-(-)dihydrolipoic acid and metabolites in the form of the free acid or salts or esters or amides for the preparation of drugs for the treatment of diabetes mellitus as well as of its sequelae
WO2000024734A1 (en) * 1998-10-26 2000-05-04 The Research Foundation Of State University Of New York Lipoic acid derivatives and their use in treatment of disease
WO2000048594A1 (en) * 1999-02-16 2000-08-24 The Center For The Improvement Of Human Functioning International, Inc. Use of lipoic acid combination with ascorbic acid in the treatment of cancer
WO2000061143A1 (en) * 1999-04-09 2000-10-19 Antibioticos S.P.A. The use of alpha lipoic acid in the antimetastatic treatment
WO2006119355A2 (en) * 2005-05-03 2006-11-09 Albert Einstein College Of Medicine Of Yeshiva University Mammalian hypothalamic nutrient modulation of glucose metabolism
WO2008131117A1 (en) * 2007-04-18 2008-10-30 Cornerstone Pharmaceuticals, Inc. Lipoic acid derivatives
WO2008131114A2 (en) * 2007-04-18 2008-10-30 Cornerstone Pharmaceuticals, Inc. Pharmaceutical formulations containing lipoic acid derivatives

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1172110A3 (en) * 2000-07-07 2003-09-17 Basf Aktiengesellschaft Use of lipoic acid as a bioavailaty enhancer of mineral salts
US20020071234A1 (en) * 2000-10-25 2002-06-13 George Alexanian Battery powered programmable remote switch controller

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5679697A (en) * 1993-11-26 1997-10-21 Garnett; Merrill Palladium complexes and methods for using same in the treatment of tumors
US5693664A (en) * 1993-12-21 1997-12-02 Asta Medica Aktiengesellschaft Use of R-(+)-α-lipoic acid, R-(-)dihydrolipoic acid and metabolites in the form of the free acid or salts or esters or amides for the preparation of drugs for the treatment of diabetes mellitus as well as of its sequelae
WO2000024734A1 (en) * 1998-10-26 2000-05-04 The Research Foundation Of State University Of New York Lipoic acid derivatives and their use in treatment of disease
WO2000048594A1 (en) * 1999-02-16 2000-08-24 The Center For The Improvement Of Human Functioning International, Inc. Use of lipoic acid combination with ascorbic acid in the treatment of cancer
WO2000061143A1 (en) * 1999-04-09 2000-10-19 Antibioticos S.P.A. The use of alpha lipoic acid in the antimetastatic treatment
WO2006119355A2 (en) * 2005-05-03 2006-11-09 Albert Einstein College Of Medicine Of Yeshiva University Mammalian hypothalamic nutrient modulation of glucose metabolism
WO2008131117A1 (en) * 2007-04-18 2008-10-30 Cornerstone Pharmaceuticals, Inc. Lipoic acid derivatives
WO2008131114A2 (en) * 2007-04-18 2008-10-30 Cornerstone Pharmaceuticals, Inc. Pharmaceutical formulations containing lipoic acid derivatives

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
KOROTCHKINA LIOUBOV G ET AL: "R-lipoic acid inhibits mammalian pyruvate dehydrogenase kinase", FREE RADICAL RESEARCH, vol. 38, no. 10, October 2004 (2004-10-01), pages 1083 - 1092, XP008138351, ISSN: 1071-5762 *
See also references of WO2009110859A1 *

Also Published As

Publication number Publication date
IL207943A0 (en) 2010-12-30
WO2009110859A1 (en) 2009-09-11
BRPI0821176A2 (en) 2015-10-06
MX2010009673A (en) 2011-03-15
CN102089276A (en) 2011-06-08
CA2717511A1 (en) 2009-09-11
KR20110004846A (en) 2011-01-14
JP2011513395A (en) 2011-04-28
EP2260019A1 (en) 2010-12-15
AU2008352076A1 (en) 2009-09-11

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Legal Events

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PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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Effective date: 20100903

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Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT RO SE SI SK TR

AX Request for extension of the european patent

Extension state: AL BA MK RS

DAX Request for extension of the european patent (deleted)
A4 Supplementary search report drawn up and despatched

Effective date: 20110704

RIC1 Information provided on ipc code assigned before grant

Ipc: A61K 31/385 20060101ALI20110628BHEP

Ipc: A61K 31/19 20060101ALI20110628BHEP

Ipc: C07C 271/02 20060101AFI20110628BHEP

RIN1 Information on inventor provided before grant (corrected)

Inventor name: ZACHAR, ZUZANA

Inventor name: BOTEJU, LAKMAL, W.

Inventor name: BINGHAM, PAUL

Inventor name: BHASIN, RAJINDER

17Q First examination report despatched

Effective date: 20121113

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20130524