EP2259785A4 - Fullerene therapies for inflammation - Google Patents

Fullerene therapies for inflammation

Info

Publication number
EP2259785A4
EP2259785A4 EP09718906A EP09718906A EP2259785A4 EP 2259785 A4 EP2259785 A4 EP 2259785A4 EP 09718906 A EP09718906 A EP 09718906A EP 09718906 A EP09718906 A EP 09718906A EP 2259785 A4 EP2259785 A4 EP 2259785A4
Authority
EP
European Patent Office
Prior art keywords
fullerene
therapies
inflammation
fullerene therapies
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP09718906A
Other languages
German (de)
French (fr)
Other versions
EP2259785A2 (en
EP2259785B1 (en
Inventor
Christopher Kepley
Robert P Lenk
Stephen R Wilson
Zhiguo Zhou
Darren K Macfarland
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Luna Innovations Inc
Original Assignee
Luna Innovations Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Luna Innovations Inc filed Critical Luna Innovations Inc
Publication of EP2259785A2 publication Critical patent/EP2259785A2/en
Publication of EP2259785A4 publication Critical patent/EP2259785A4/en
Application granted granted Critical
Publication of EP2259785B1 publication Critical patent/EP2259785B1/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/74—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C07C69/753—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring of polycyclic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2604/00—Fullerenes, e.g. C60 buckminsterfullerene or C70

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Hematology (AREA)
  • Neurology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Obesity (AREA)
  • Biomedical Technology (AREA)
  • Endocrinology (AREA)
  • Neurosurgery (AREA)
  • Emergency Medicine (AREA)
  • Transplantation (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
EP09718906.2A 2008-03-03 2009-03-03 Fullerene therapies for inflammation Active EP2259785B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3330908P 2008-03-03 2008-03-03
PCT/US2009/001333 WO2009114088A2 (en) 2008-03-03 2009-03-03 Fullerene therapies for inflammation

Publications (3)

Publication Number Publication Date
EP2259785A2 EP2259785A2 (en) 2010-12-15
EP2259785A4 true EP2259785A4 (en) 2012-12-19
EP2259785B1 EP2259785B1 (en) 2015-12-23

Family

ID=41065704

Family Applications (1)

Application Number Title Priority Date Filing Date
EP09718906.2A Active EP2259785B1 (en) 2008-03-03 2009-03-03 Fullerene therapies for inflammation

Country Status (6)

Country Link
US (1) US8680125B2 (en)
EP (1) EP2259785B1 (en)
JP (1) JP2011513400A (en)
AU (1) AU2009223841A1 (en)
CA (1) CA2717495C (en)
WO (1) WO2009114088A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014129513A1 (en) * 2013-02-19 2014-08-28 国立大学法人大阪大学 Agent for preventing or treating ulcerative colitis and novel fullerene derivative
CN114903916B (en) * 2022-04-28 2024-01-02 中国科学院化学研究所 Oral fullerene structure and preparation and application thereof in preventing and treating rheumatoid arthritis

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030027870A1 (en) * 2001-05-15 2003-02-06 Wilson Stephen R. Fullerene derivatives that modulate nitric oxide synthase and clamodulin activity
WO2005035441A2 (en) * 2003-10-10 2005-04-21 C Sixty Inc. Subtituted fullerene compositions and their use as antioxydants
WO2005037711A1 (en) * 2003-10-15 2005-04-28 C Sixty Inc. Amphiphilic [5:1]- and [3:3]- hexakisadducts of fullerenes
WO2006077597A2 (en) * 2005-01-21 2006-07-27 Ramot At Tel Aviv University Ltd. Novel neuroprotective compounds and uses thereof
EP1834637A1 (en) * 2004-12-07 2007-09-19 Vitamin C60 Bioresearch Corporation Preventive/therapeutic composition for free radical disease
EP1867337A1 (en) * 2005-03-23 2007-12-19 St. Marianna University School of Medicine Medicinal composition for treating/preventing motor organ disease
WO2008109032A2 (en) * 2007-03-02 2008-09-12 Luna Innovations Incorporated Amphiphilic or lipophilic polar functionalized fullerenes and their uses

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009114084A2 (en) 2008-03-03 2009-09-17 Luna Innovations Incorporated Method for treating wounds by administering fullerenes
EP2259786A4 (en) 2008-03-03 2011-03-09 Luna Innovations Inc Method for inhibiting the build-up of arterial plaque by administering fullerenes
US20110251158A1 (en) * 2008-03-03 2011-10-13 Luna Innovations Incorporated Fullerene therapies for inflammation and inhibition of build-up of arterial plaque
WO2009114089A2 (en) 2008-03-03 2009-09-17 Luna Innovations Incorporated Using fullerenes to enhance and stimulate hair growth
US20110009486A1 (en) 2008-03-03 2011-01-13 Luna Innovations Incorporated Method for treating pruritus by administering fullerenes

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030027870A1 (en) * 2001-05-15 2003-02-06 Wilson Stephen R. Fullerene derivatives that modulate nitric oxide synthase and clamodulin activity
WO2005035441A2 (en) * 2003-10-10 2005-04-21 C Sixty Inc. Subtituted fullerene compositions and their use as antioxydants
WO2005037711A1 (en) * 2003-10-15 2005-04-28 C Sixty Inc. Amphiphilic [5:1]- and [3:3]- hexakisadducts of fullerenes
EP1834637A1 (en) * 2004-12-07 2007-09-19 Vitamin C60 Bioresearch Corporation Preventive/therapeutic composition for free radical disease
WO2006077597A2 (en) * 2005-01-21 2006-07-27 Ramot At Tel Aviv University Ltd. Novel neuroprotective compounds and uses thereof
EP1867337A1 (en) * 2005-03-23 2007-12-19 St. Marianna University School of Medicine Medicinal composition for treating/preventing motor organ disease
WO2008109032A2 (en) * 2007-03-02 2008-09-12 Luna Innovations Incorporated Amphiphilic or lipophilic polar functionalized fullerenes and their uses

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO2009114088A2 *

Also Published As

Publication number Publication date
EP2259785A2 (en) 2010-12-15
AU2009223841A1 (en) 2009-09-17
JP2011513400A (en) 2011-04-28
US20110028522A1 (en) 2011-02-03
CA2717495C (en) 2017-05-23
WO2009114088A2 (en) 2009-09-17
WO2009114088A3 (en) 2009-12-03
US8680125B2 (en) 2014-03-25
EP2259785B1 (en) 2015-12-23
CA2717495A1 (en) 2009-09-17

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