EP2250167A4 - Arylmethylidene heterocycles as novel analgesics - Google Patents
Arylmethylidene heterocycles as novel analgesicsInfo
- Publication number
- EP2250167A4 EP2250167A4 EP09707147A EP09707147A EP2250167A4 EP 2250167 A4 EP2250167 A4 EP 2250167A4 EP 09707147 A EP09707147 A EP 09707147A EP 09707147 A EP09707147 A EP 09707147A EP 2250167 A4 EP2250167 A4 EP 2250167A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- arylmethylidene
- heterocycles
- novel analgesics
- analgesics
- novel
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 229940035676 analgesics Drugs 0.000 title 1
- 239000000730 antalgic agent Substances 0.000 title 1
- 125000000623 heterocyclic group Chemical group 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/46—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/48—Nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/54—Nitrogen and either oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Neurology (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2732908P | 2008-02-08 | 2008-02-08 | |
| US13525308P | 2008-07-17 | 2008-07-17 | |
| PCT/CA2009/000158 WO2009097695A1 (en) | 2008-02-08 | 2009-02-09 | Arylmethylidene heterocycles as novel analgesics |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EP2250167A1 EP2250167A1 (en) | 2010-11-17 |
| EP2250167A4 true EP2250167A4 (en) | 2012-05-16 |
Family
ID=40951764
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP09707147A Withdrawn EP2250167A4 (en) | 2008-02-08 | 2009-02-09 | Arylmethylidene heterocycles as novel analgesics |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20090275538A1 (en) |
| EP (1) | EP2250167A4 (en) |
| JP (1) | JP2011511014A (en) |
| AR (1) | AR070603A1 (en) |
| AU (1) | AU2009212072A1 (en) |
| CA (1) | CA2714966A1 (en) |
| CL (1) | CL2009000294A1 (en) |
| TW (1) | TW200934774A (en) |
| WO (1) | WO2009097695A1 (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5914357B2 (en) | 2010-01-15 | 2016-05-11 | インセルム（インスティチュート ナショナル デ ラ サンテ エ デ ラ リシェルシェ メディカル） | Compounds for the treatment of autism |
| EP2732815A1 (en) | 2012-11-16 | 2014-05-21 | Neurochlore | Modulators of intracellular chloride concentration for treating fragile X syndrome |
| WO2016025778A1 (en) | 2014-08-15 | 2016-02-18 | The Johns Hopkins University | Compositions and methods for treating refractory seizures |
| CN111187217A (en) * | 2020-02-11 | 2020-05-22 | 威海厚普生物科技有限公司 | Preparation method of high-purity 1-methyl-2-thiohydantoin |
| US20240197728A1 (en) | 2021-04-14 | 2024-06-20 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for treating refractory epilepsy |
| CN113813262B (en) * | 2021-10-26 | 2023-04-11 | 徐州医科大学 | Application of CLP257 in preparation of anxiety prevention and treatment medicines |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR037714A1 (en) * | 2001-12-06 | 2004-12-01 | Maxia Pharmaceuticals Inc | DERIVATIVES OF TIAZOLIDINONA AND OXAZOLIDINONA 2-SUBSTITUTED FOR THE INHIBITION OF PHOSPHATES AND THE TREATMENT OF CANCER |
| US20050019825A9 (en) * | 2002-03-15 | 2005-01-27 | Qing Dong | Common ligand mimics: pseudothiohydantoins |
| US7344850B2 (en) * | 2003-12-30 | 2008-03-18 | Princeton University | Identification of active-site inhibitors of glycosyltransferases using a generalizable high-throughput screen |
| WO2005082363A1 (en) * | 2004-02-20 | 2005-09-09 | Board Of Regents, The University Of Texas System | Thiazolone compounds for treatment of cancer |
| DE102005024012A1 (en) * | 2005-05-20 | 2006-11-23 | Grünenthal GmbH | Use of 2,5-disubstituted thiazole-4-one derivatives in pharmaceuticals |
| US7438916B2 (en) * | 2005-10-14 | 2008-10-21 | Virginia Tech Intellectual Properties, Inc. | Therapeutic target for protozoal diseases |
| KR100814109B1 (en) * | 2006-01-09 | 2008-03-14 | 한국생명공학연구원 | Rhodanine derivatives, a process for the preparation thereof and pharmaceutical composition containing the same |
-
2009
- 2009-02-08 CL CL2009000294A patent/CL2009000294A1/en unknown
- 2009-02-09 EP EP09707147A patent/EP2250167A4/en not_active Withdrawn
- 2009-02-09 TW TW098104117A patent/TW200934774A/en unknown
- 2009-02-09 AU AU2009212072A patent/AU2009212072A1/en not_active Abandoned
- 2009-02-09 US US12/368,058 patent/US20090275538A1/en not_active Abandoned
- 2009-02-09 WO PCT/CA2009/000158 patent/WO2009097695A1/en active Application Filing
- 2009-02-09 JP JP2010545338A patent/JP2011511014A/en active Pending
- 2009-02-09 CA CA2714966A patent/CA2714966A1/en not_active Abandoned
- 2009-02-10 AR ARP090100454A patent/AR070603A1/en unknown
Non-Patent Citations (1)
| Title |
|---|
| No further relevant documents disclosed * |
Also Published As
| Publication number | Publication date |
|---|---|
| EP2250167A1 (en) | 2010-11-17 |
| CL2009000294A1 (en) | 2009-10-23 |
| WO2009097695A1 (en) | 2009-08-13 |
| CA2714966A1 (en) | 2009-08-13 |
| JP2011511014A (en) | 2011-04-07 |
| AU2009212072A1 (en) | 2009-08-13 |
| TW200934774A (en) | 2009-08-16 |
| AR070603A1 (en) | 2010-04-21 |
| US20090275538A1 (en) | 2009-11-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
| 17P | Request for examination filed |
Effective date: 20100908 |
|
| AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK TR |
|
| AX | Request for extension of the european patent |
Extension state: AL BA RS |
|
| DAX | Request for extension of the european patent (deleted) | ||
| A4 | Supplementary search report drawn up and despatched |
Effective date: 20120417 |
|
| RIC1 | Information provided on ipc code assigned before grant |
Ipc: C07F 9/6558 20060101ALI20120411BHEP Ipc: C07D 487/04 20060101ALI20120411BHEP Ipc: C07D 417/12 20060101ALI20120411BHEP Ipc: C07D 417/04 20060101ALI20120411BHEP Ipc: C07D 403/04 20060101ALI20120411BHEP Ipc: C07D 277/32 20060101ALI20120411BHEP Ipc: A61P 29/00 20060101ALI20120411BHEP Ipc: A61P 25/04 20060101ALI20120411BHEP Ipc: A61K 31/55 20060101ALI20120411BHEP Ipc: A61K 31/5377 20060101ALI20120411BHEP Ipc: A61K 31/501 20060101ALI20120411BHEP Ipc: A61K 31/496 20060101ALI20120411BHEP Ipc: A61K 31/454 20060101ALI20120411BHEP Ipc: A61K 31/425 20060101ALI20120411BHEP Ipc: A61K 31/421 20060101ALI20120411BHEP Ipc: C07D 417/14 20060101AFI20120411BHEP |
|
| STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
| 18D | Application deemed to be withdrawn |
Effective date: 20120901 |