EP2249646A4 - Pharmacophores duals, antagonistes des récepteurs muscariniques et inhibiteurs de l'activité pde4 - Google Patents

Pharmacophores duals, antagonistes des récepteurs muscariniques et inhibiteurs de l'activité pde4

Info

Publication number
EP2249646A4
EP2249646A4 EP09707940.4A EP09707940A EP2249646A4 EP 2249646 A4 EP2249646 A4 EP 2249646A4 EP 09707940 A EP09707940 A EP 09707940A EP 2249646 A4 EP2249646 A4 EP 2249646A4
Authority
EP
European Patent Office
Prior art keywords
pde4
antagonistics
muscarinic
pharmacophores
dual
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP09707940.4A
Other languages
German (de)
English (en)
Other versions
EP2249646A1 (fr
Inventor
James Francis Callahan
Tindy Li
Zehong Wan
Hongxing Yan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of EP2249646A1 publication Critical patent/EP2249646A1/fr
Publication of EP2249646A4 publication Critical patent/EP2249646A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Transplantation (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP09707940.4A 2008-02-06 2009-02-05 Pharmacophores duals, antagonistes des récepteurs muscariniques et inhibiteurs de l'activité pde4 Withdrawn EP2249646A4 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2657408P 2008-02-06 2008-02-06
PCT/US2009/033132 WO2009100169A1 (fr) 2008-02-06 2009-02-05 Pharmacophores duals, antagonistes des récepteurs muscariniques et inhibiteurs de l'activité pde4

Publications (2)

Publication Number Publication Date
EP2249646A1 EP2249646A1 (fr) 2010-11-17
EP2249646A4 true EP2249646A4 (fr) 2013-09-25

Family

ID=40952448

Family Applications (1)

Application Number Title Priority Date Filing Date
EP09707940.4A Withdrawn EP2249646A4 (fr) 2008-02-06 2009-02-05 Pharmacophores duals, antagonistes des récepteurs muscariniques et inhibiteurs de l'activité pde4

Country Status (2)

Country Link
EP (1) EP2249646A4 (fr)
WO (1) WO2009100169A1 (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR081377A1 (es) 2010-05-10 2012-08-29 Gilead Sciences Inc Compuestos de pirazolopiridina bifuncionales
NZ603136A (en) 2010-05-10 2014-11-28 Gilead Sciences Inc Bifunctional quinoline derivatives
US8415483B2 (en) 2010-12-22 2013-04-09 Astrazeneca Ab Compounds and their use as BACE inhibitors
US9650336B2 (en) 2011-10-10 2017-05-16 Astrazeneca Ab Mono-fluoro beta-secretase inhibitors
US9000183B2 (en) 2012-06-20 2015-04-07 Astrazeneca Ab Cyclohexane-1,2′-indene-1′,2″-imidazol compounds and their use as BACE inhibitors
US9000182B2 (en) 2012-06-20 2015-04-07 Astrazeneca Ab 2H-imidazol-4-amine compounds and their use as BACE inhibitors
US9000185B2 (en) 2012-06-20 2015-04-07 Astrazeneca Ab Cycloalkyl ether compounds and their use as BACE inhibitors
US9000184B2 (en) 2012-06-20 2015-04-07 Astrazeneca Ab Cyclohexane-1,2′-naphthalene-1′,2″-imidazol compounds and their use as BACE inhibitors
US10548882B2 (en) 2012-06-21 2020-02-04 Astrazeneca Ab Camsylate salt
WO2017089347A1 (fr) 2015-11-25 2017-06-01 Inserm (Institut National De La Sante Et De La Recherche Medicale) Procédés et compositions pharmaceutiques pour le traitement de mélanomes résistant aux inhibiteurs de braf

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005090352A1 (fr) * 2004-03-16 2005-09-29 Glaxo Group Limited Compose de pyrazolo[3,4-b]pyridine, et son utilisation en tant qu'inhibiteur de pdea4

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6670364B2 (en) * 2001-01-31 2003-12-30 Telik, Inc. Antagonists of MCP-1 function and methods of use thereof
GB0230045D0 (en) * 2002-12-23 2003-01-29 Glaxo Group Ltd Compounds
EP1940836A1 (fr) * 2005-09-29 2008-07-09 Glaxo Group Limited Compose de pyrazolo[3,4-b]pyridine et utilisation en tant qu'inhibiteur de pde4
GB0614570D0 (en) * 2006-07-21 2006-08-30 Glaxo Group Ltd Compounds

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005090352A1 (fr) * 2004-03-16 2005-09-29 Glaxo Group Limited Compose de pyrazolo[3,4-b]pyridine, et son utilisation en tant qu'inhibiteur de pdea4

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO2009100169A1 *

Also Published As

Publication number Publication date
EP2249646A1 (fr) 2010-11-17
WO2009100169A1 (fr) 2009-08-13

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20100903

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK TR

AX Request for extension of the european patent

Extension state: AL BA RS

DAX Request for extension of the european patent (deleted)
RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: GLAXO GROUP LIMITED

A4 Supplementary search report drawn up and despatched

Effective date: 20130826

RIC1 Information provided on ipc code assigned before grant

Ipc: C07D 471/04 20060101AFI20130820BHEP

Ipc: A01N 43/42 20060101ALI20130820BHEP

Ipc: A61P 37/06 20060101ALI20130820BHEP

Ipc: A61K 31/437 20060101ALI20130820BHEP

Ipc: A61P 11/08 20060101ALI20130820BHEP

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20140325