EP2242524A1 - Passive flow regulator for infusion of medicaments - Google Patents

Passive flow regulator for infusion of medicaments

Info

Publication number
EP2242524A1
EP2242524A1 EP09709010A EP09709010A EP2242524A1 EP 2242524 A1 EP2242524 A1 EP 2242524A1 EP 09709010 A EP09709010 A EP 09709010A EP 09709010 A EP09709010 A EP 09709010A EP 2242524 A1 EP2242524 A1 EP 2242524A1
Authority
EP
European Patent Office
Prior art keywords
channel
membrane
spacer
regulator
substrate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP09709010A
Other languages
German (de)
French (fr)
Inventor
Eric Chappel
Stephan Gamper
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Debiotech SA
Original Assignee
Debiotech SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Debiotech SA filed Critical Debiotech SA
Publication of EP2242524A1 publication Critical patent/EP2242524A1/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
    • A61M5/16877—Adjusting flow; Devices for setting a flow rate
    • A61M5/16881—Regulating valves
    • G—PHYSICS
    • G05—CONTROLLING; REGULATING
    • G05D—SYSTEMS FOR CONTROLLING OR REGULATING NON-ELECTRIC VARIABLES
    • G05D7/00—Control of flow
    • G05D7/01—Control of flow without auxiliary power
    • G05D7/0106—Control of flow without auxiliary power the sensing element being a flexible member, e.g. bellows, diaphragm, capsule
    • G05D7/0113—Control of flow without auxiliary power the sensing element being a flexible member, e.g. bellows, diaphragm, capsule the sensing element acting as a valve
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/02—General characteristics of the apparatus characterised by a particular materials
    • A61M2205/0244—Micromachined materials, e.g. made from silicon wafers, microelectromechanical systems [MEMS] or comprising nanotechnology
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T29/00—Metal working
    • Y10T29/49—Method of mechanical manufacture
    • Y10T29/494—Fluidic or fluid actuated device making

Definitions

  • the present invention is in the field of drug delivery in liquid form. It concerns more precisely the flux regulators used for this purpose.
  • FIGS. 1 and 2 The operating principle of a flow regulator of the state of the art (see FIGS. 1 and 2) is described in particular in the patent application WO 99/38552. It is a membrane 4 pierced at its center 6, which is deflected by the pressure of the reservoir and which comes into contact with a substrate 1 on which is etched a fluidic channel 5, the latter being p. ex. in the form of a spiral. The membrane 4 thus closes this channel 5 after contact, with the exception of the location where the central hole 6 is located. The liquid of the reservoir therefore flows through the central hole 6 and then along the channel 5.
  • the membrane 4 the distance between the membrane 4 and the substrate 1 and the channel 5 are dimensioned so that the fluid resistance of the channel 5 varies proportionally with the pressure in the tank.
  • the flux is therefore constant in a certain pressure range. It does not depend on the pressure. In case of overpressure, the channel 5 closes completely and the flow is interrupted.
  • the regulator described in WO 99/38552 is manufactured by etching, e.g. ex. chemical, or by ionic type dry fastener, the central hole 6 of the membrane 4, the membrane 4 itself, the spacer 3 between the membrane 4 and the substrate 1 and the channel 5 itself.
  • the membrane 4 and the spacer 3 are created simultaneously from the same element.
  • an error on the thickness of the membrane 4 also affects the thickness of the spacer 3 and vice versa.
  • the present invention relates to a new flow regulator structure and a new method which simplifies the assembly of the different parts of the regulator and which makes it possible to achieve better manufacturing tolerances by the same method used.
  • the flow regulator according to the invention successively comprises a substrate, a channel, a spacer and a membrane, the latter comprising a central hole communicating with the channel.
  • the regulator is characterized in that it is made from at least two distinct elements, the first element comprising the membrane and the second element comprising the spacer.
  • sheets of controlled thickness and low roughness are stacked, each sheet having a particular function.
  • These sheets are for example obtained by rolling, then by wire cutting or stamping, and then by mirror polishing.
  • the stack consists of a flat substrate with only one exit hole, a thin sheet with the through channel, a thin sheet with a disk pierced for the spacer, a thin sheet pierced in the center for the membrane.
  • This stack makes it possible to master before assembly all the thicknesses, such as for example the membrane, the spacer and the depth of the channel, which is thus perfectly defined by the thickness of the sheet chosen for this function.
  • the flow rate varies as the power of four on the side of this square in the approximation of the laminar regime for a Newtonian fluid and at constant temperature.
  • the tolerance on the depth is perfectly mastered and there remains only the tolerance on the width of the channel, that is to say that which was already rather well mastered previously.
  • the regulator according to the invention makes it possible to achieve flow accuracies which were not attainable by the standard machining methods of silicon or Pyrex.
  • the exit hole can also be offset on the edge of the membrane to have the inlet and the outlet of the fluid on the same side.
  • the regulator according to the invention can be completely clogged at a defined pressure in order to avoid overdoses. This threshold pressure is reached when the channel is completely covered by the membrane.
  • the regulator according to the invention may comprise means for measuring the deflection of the membrane, for example using strain gauges placed in the Wheatstone bridge configuration on the membrane. These gauges can be made by ion implantation or diffusion if the membrane is silicon. External gauges may also be placed on the membrane, for example by gluing, if said membrane is not made of a piezo-resistive material.
  • FIG. 1 already described above, illustrates a flow regulator of the state of the art in the rest position.
  • FIG. 1 illustrates the regulator of Figure 1 in active mode, when the membrane is deformed.
  • FIG. 3 presents an exploded and schematic view of a first embodiment of a flux regulator according to the invention.
  • FIG. 4 shows a second embodiment of a flux regulator according to the invention.
  • FIG. 5 illustrates the steps of a method for producing a substrate-channel assembly according to the invention.
  • FIG. 3a A first embodiment of the flux regulator according to the invention is illustrated in FIG. 3a. This is formed from four sheets 1 to 4, a first sheet intended to form the substrate, a second sheet 2 intended to contain the channel 5, a third sheet 3 having a large central opening 7 intended to form the spacer 4 and a fourth sheet acting as a membrane 4.
  • the membrane 4 may be made of polished silicon, a material that has excellent mechanical properties, but also metal or any other material that has a high elastic limit.
  • the piercing of the membrane 4 may be carried out by chemical etching or by very short-pulse laser drilling, such as for example the femtosecond laser, which avoids plastic deformation by heating the membrane 4.
  • the direction of the laser drilling is important because a bead may be present on the periphery of the hole 6.
  • a circular recessed portion whose diameter is at least equal to the hole 6 of the membrane 4, which allows on the one hand increase the tolerances on the positioning of the membrane 4 with respect to the channel 5 and also to prevent this eventual bead from creating a spacing and thus a poor sealing of the channel 5 at the level of the hole 6.
  • the spacer 3, the channel 5 and the substrate 1 can be made for example of metal, such as for example steel, or more advantageously ceramic LTCC. These co-cured ceramics are in fact drilled, for example by laser, machined, aligned, serigraphed on the surface and then pressed in the green state, which allows three-dimensional stacks, and then the hot sintering makes it possible to assemble permanently and without leakage the different elements.
  • the final assembly method for example for rolled sheets of metal, can be a recess, a weld or a bonding. For large systems it is preferred to use a recess via two precision circular parts which enclose the different sheets, for example by clamping with screws. The upper part has to be recessed to create a cavity 9 above the membrane and pierced in the center for the arrival of the fluid.
  • the fluid outlet can be arranged in the lower part or in the upper part of the regulator.
  • exit holes 10 and 11 are respectively formed in the sheet 2 containing the channel 5 as well as in the substrate 1.
  • the membrane sheet 4 When the outlet is located on the same side as the inlet, the membrane sheet 4 also includes an outer hole of larger diameter than the central hole for the outlet.
  • the alignment is obtained either by additional centering holes, or by the substrate 1 itself. Indeed there is no tolerance on its thickness or its width. It is easy to imagine a kind of cavity in which the sheets would fit. Alignment pins can be used for large systems. Alignment is facilitated if the edges of the leaves are circular and the housing of the substrate in which these sheets fit.
  • the surface roughness of the membrane 4, the channel 5 and the substrate 1 must be much smaller than the characteristic dimensions of the component, that is to say the depth of the channel 5, the thickness of the spacer 3, the thickness of the membrane 4 and the diameter of the inlet hole 6.
  • the use of laminated sheets, machined and already mirror polished before the final assembly substantially reduces leaks during operation.
  • the channel 5 itself can be made by electroplating directly on the substrate 1, for example by lithographically making the negative channel 1 to achieve the deposition of the metal hook layer, which after growth will define the channel 5 embossed .
  • the negative part of the spacer 3 can also be made by electroplating. The surface roughness obtained by electroplating is entirely compatible with the proper functioning of the component. In order to preserve the layer assembly principle whose thickness is well controlled, it is possible to carry out the growth of the channel 5 negative on a sacrificial layer which will be dissolved before assembly on the substrate 1.
  • FIG. 4 represents an assembly of a passive flux regulator with the spacer 3, the channel 5 and the substrate 1 made in one piece, for example by plastic or ceramic injection, or by plastic embossing.
  • the cover 8 can also be made in this way.
  • the cover 8 includes a cavity 9 which allows a good distribution of the pressure above the membrane 4.
  • the membrane 4 is made of a material having a high elastic limit and advantageously the minimum of internal stresses.
  • the method according to the invention has many advantages compared to the machining methods of the state of the art. With the method according to the invention, the relative tolerances are wider, in particular for the micro machining of silicon or metal.
  • the method according to the invention consists mainly in the production of a single mold of required dimensions, for example by one or two electroplating operations. nickel on a positive or negative channel and spacer. Replication of the components by plastic injection or embossing from this mold achieves excellent relative tolerances and good surface roughness, with suitable process parameters such as pressure cooling and injection time. embossing. This method significantly reduces manufacturing costs and the number of process steps.
  • a coating may be necessary on all parts of the components to ensure their biocompatibility, for example a diamond layer, a layer of gold or titanium.
  • the various elements are then assembled by direct bonding plastic / silicon or plastic / metal, or by bonding, embedding.
  • a groove or a groove can be arranged in the plastic or ceramic substrate to be able to extend the glue.
  • the membrane 4 is then positioned on the substrate 1 for the polymerization with possibly a pressing pressure to maintain the assembly tolerances.
  • the difficulty is essentially reduced to a single critical alignment, namely that of the membrane 4 on the replicated part.
  • a self-centering technique via a groove or extra thickness on the replicated part can be used. Alignment holes may also be drilled in the membrane 4 and the replicated portion of the regulator.
  • FIG. 5 illustrates an exemplary embodiment of the master, including a deposition of SU8 after dry etching of the channel, followed by a photolith and possibly a metallization.
  • the invention is not limited to the embodiments illustrated and discussed in the present text.

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  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Automation & Control Theory (AREA)
  • Vascular Medicine (AREA)
  • Anesthesiology (AREA)
  • General Physics & Mathematics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Fluid Mechanics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Micromachines (AREA)

Abstract

Flow regulator for the infusion of medicaments, comprising, in succession, a substrate (1), a channel (5), a spacer (3) and a membrane (4), the latter having at least one hole (6) communicating with the channel (5), characterized in that the regulator is produced from at least two separate elements (1-4), the first element comprising the membrane (4) and the second element comprising the spacer (3).

Description

REGULATEUR DE FLUX PASSIF POUR INFUSION DE MEDICAMENTS PASSIVE FLUX REGULATOR FOR INFUSION OF DRUGS
Domaine de l'inventionField of the invention
La présente invention se situe dans le domaine de l'administration de médicaments sous forme liquide. Elle concerne plus précisément les régulateurs de flux utilisés à cet effet.The present invention is in the field of drug delivery in liquid form. It concerns more precisely the flux regulators used for this purpose.
Etat de la techniqueState of the art
Le principe de fonctionnement d'un régulateur de flux de l'état de la technique (voir figures 1 et 2) est décrit notamment dans la demande de brevet WO 99/38552. Il s'agit d'une membrane 4 percée en son centre 6, qui est défléchie par la pression du réservoir et qui entre en contact avec un substrat 1 sur lequel est gravé un canal fluidique 5, ce dernier se présentant p. ex. sous forme de colimaçon. La membrane 4 ferme donc ce canal 5 après contact, à l'exception de l'endroit où se trouve le trou central 6. Le liquide du réservoir s'écoule donc par le trou central 6 puis le long du canal 5. La membrane 4, la distance entre la membrane 4 et le substrat 1 ainsi que le canal 5 sont dimensionnées de telle sorte que la résistance fluidique du canal 5 varie proportionnellement avec la pression dans le réservoir. Le flux est donc constant dans une certaine gamme de pression. Il ne dépend donc pas de la pression. En cas de surpression, le canal 5 se ferme complètement et le flux est interrompu.The operating principle of a flow regulator of the state of the art (see FIGS. 1 and 2) is described in particular in the patent application WO 99/38552. It is a membrane 4 pierced at its center 6, which is deflected by the pressure of the reservoir and which comes into contact with a substrate 1 on which is etched a fluidic channel 5, the latter being p. ex. in the form of a spiral. The membrane 4 thus closes this channel 5 after contact, with the exception of the location where the central hole 6 is located. The liquid of the reservoir therefore flows through the central hole 6 and then along the channel 5. The membrane 4 the distance between the membrane 4 and the substrate 1 and the channel 5 are dimensioned so that the fluid resistance of the channel 5 varies proportionally with the pressure in the tank. The flux is therefore constant in a certain pressure range. It does not depend on the pressure. In case of overpressure, the channel 5 closes completely and the flow is interrupted.
Le régulateur décrit dans la demande WO 99/38552 est fabriqué par gravure, p. ex. chimique, ou par attache sèche de type ionique, du trou central 6 de la membrane 4, de la membrane 4 elle-même, de l'entretoise 3 entre la membrane 4 et le substrat 1 et du canal 5 lui-même. La membrane 4 et l'entretoise 3 sont donc créées simultanément à partir du même élément. Ainsi une erreur sur l'épaisseur de la membrane 4 se répercute également sur l'épaisseur de l'entretoise 3 et réciproquement. Exposé général de l'inventionThe regulator described in WO 99/38552 is manufactured by etching, e.g. ex. chemical, or by ionic type dry fastener, the central hole 6 of the membrane 4, the membrane 4 itself, the spacer 3 between the membrane 4 and the substrate 1 and the channel 5 itself. The membrane 4 and the spacer 3 are created simultaneously from the same element. Thus an error on the thickness of the membrane 4 also affects the thickness of the spacer 3 and vice versa. General presentation of the invention
La présente invention concerne une nouvelle structure de régulateur de flux ainsi qu'une nouvelle méthode qui simplifie l'assemblage des différentes parties du régulateur et qui permet d'atteindre de meilleures tolérances de fabrication de part même du procédé utilisé.The present invention relates to a new flow regulator structure and a new method which simplifies the assembly of the different parts of the regulator and which makes it possible to achieve better manufacturing tolerances by the same method used.
Le régulateur de flux selon l'invention comprend successivement un substrat, un canal, une entretoise et une membrane, cette dernière comportant un trou central communiquant avec le canal. Le régulateur se caractérise par le fait qu'il est réalisé à partir d'au moins deux éléments distincts, le premier élément comportant la membrane et le deuxième élément comportant l'entretoise.The flow regulator according to the invention successively comprises a substrate, a channel, a spacer and a membrane, the latter comprising a central hole communicating with the channel. The regulator is characterized in that it is made from at least two distinct elements, the first element comprising the membrane and the second element comprising the spacer.
Selon un mode de réalisation de l'invention, on empile des feuilles d'épaisseur contrôlée et de faible rugosité, chaque feuille ayant une fonction particulière. Ces feuilles sont par exemple obtenues par laminage, puis par découpe au fil ou étampage, puis par polissage miroir. Ainsi l'empilement se compose d'un substrat plat avec seulement un trou de sortie, d'une feuille mince avec le canal traversant, une feuille mince avec un disque percé pour l'entretoise, d'une feuille mince percée au centre pour la membrane. Cet empilement permet de bien maîtriser avant assemblage toutes les épaisseurs, comme par exemple la membrane, l'entretoise et la profondeur du canal qui est ainsi parfaitement défini par l'épaisseur de la feuille choisie pour cette fonction. Pour un canal de forme carrée, le débit varie comme la puissance quatre du côté de ce carré dans l'approximation du régime laminaire pour un fluide newtonien et à température constante. Par cette méthode la tolérance sur la profondeur est parfaitement maîtrisée et il ne subsiste que la tolérance sur la largeur du canal, c'est-à-dire celle qui était déjà plutôt bien maîtrisée précédemment. Le régulateur selon l'invention permet d'atteindre des précisions sur le débit qui n'étaient pas atteignables par les méthodes d'usinage standard de silicium ou de Pyrex.According to one embodiment of the invention, sheets of controlled thickness and low roughness are stacked, each sheet having a particular function. These sheets are for example obtained by rolling, then by wire cutting or stamping, and then by mirror polishing. Thus the stack consists of a flat substrate with only one exit hole, a thin sheet with the through channel, a thin sheet with a disk pierced for the spacer, a thin sheet pierced in the center for the membrane. This stack makes it possible to master before assembly all the thicknesses, such as for example the membrane, the spacer and the depth of the channel, which is thus perfectly defined by the thickness of the sheet chosen for this function. For a square-shaped channel, the flow rate varies as the power of four on the side of this square in the approximation of the laminar regime for a Newtonian fluid and at constant temperature. By this method the tolerance on the depth is perfectly mastered and there remains only the tolerance on the width of the channel, that is to say that which was already rather well mastered previously. The regulator according to the invention makes it possible to achieve flow accuracies which were not attainable by the standard machining methods of silicon or Pyrex.
Le trou de sortie peut également être déporté sur le bord de la membrane afin d'avoir l'entrée et la sortie du fluide du même côté. Le régulateur selon l'invention peut s'obstruer complètement à une pression définie afin d'éviter les surdosages. Cette pression seuil est atteinte lorsque le canal est entièrement recouvert par la membrane.The exit hole can also be offset on the edge of the membrane to have the inlet and the outlet of the fluid on the same side. The regulator according to the invention can be completely clogged at a defined pressure in order to avoid overdoses. This threshold pressure is reached when the channel is completely covered by the membrane.
La régulateur selon l'invention peut comprendre des moyens pour mesurer la déflection de la membrane, par exemple en utilisant des jauges de contraintes placées en configuration de pont de Wheatstone sur la membrane. Ces jauges peuvent être réalisées par implantation ionique ou par diffusion si la membrane est en silicium. Des jauges externes peuvent également être placées sur la membrane, par exemple par collage, si ladite membrane n'est pas réalisée dans un matériau piezo-résistif.The regulator according to the invention may comprise means for measuring the deflection of the membrane, for example using strain gauges placed in the Wheatstone bridge configuration on the membrane. These gauges can be made by ion implantation or diffusion if the membrane is silicon. External gauges may also be placed on the membrane, for example by gluing, if said membrane is not made of a piezo-resistive material.
Exposé détaillé de l'inventionDetailed exposition of the invention
L'invention est décrite plus en détail ci-après au moyen d'exemples illustrés par les figures suivantes :The invention is described in more detail below by means of examples illustrated by the following figures:
La figure 1 , déjà décrite précédemment, illustre un régulateur de flux de l'état de la technique en position de repos.FIG. 1, already described above, illustrates a flow regulator of the state of the art in the rest position.
La figure 2, également décrite précédemment, illustre le régulateur de la figure 1 en mode actif, lorsque la membrane est déformée.Figure 2, also described above, illustrates the regulator of Figure 1 in active mode, when the membrane is deformed.
La figure 3 présente une vue éclatée et schématique d'un premier mode de réalisation d'un régulateur de flux selon l'invention. La figure 4 présente un deuxième mode de réalisation d'un régulateur de flux selon l'invention. La figure 5 illustre les étapes d'un procédé de réalisation d'un ensemble substrat- canal selon l'invention.FIG. 3 presents an exploded and schematic view of a first embodiment of a flux regulator according to the invention. FIG. 4 shows a second embodiment of a flux regulator according to the invention. FIG. 5 illustrates the steps of a method for producing a substrate-channel assembly according to the invention.
Un premier mode de réalisation du régulateur de flux selon l'invention est illustré sur la figure 3a. Celui-ci est formé à partir de quatre feuilles 1 à 4, soit une première feuille destinée à former le substrat, une deuxième feuille 2 destinée à contenir le canal 5, une troisième feuille 3 comportant une grande ouverture centrale 7 destinée à former l'entretoise 3 et une quatrième feuille jouant le rôle de membrane 4. La membrane 4 peut être réalisée en silicium poli, soit un matériau qui possède d'excellentes propriétés mécaniques, mais aussi en métal ou tout autre matériau qui possède une haute limite élastique. Le perçage de la membrane 4 peut être réalisé par attaque chimique ou par perçage laser à très courte impulsion, comme par exemple le laser femtoseconde, ce qui évite les déformations plastiques par échauffement de la membrane 4. Le sens du perçage laser est important car un bourrelet peut être présent sur le pourtour du trou 6. Ainsi au centre du canal 5 on ménage de préférence une partie évidée circulaire dont le diamètre est au moins égal à au trou 6 de la membrane 4, ce qui permet d'une part d'augmenter les tolérances sur le positionnement de la membrane 4 par rapport au canal 5 et aussi d'éviter que cet éventuel bourrelet ne crée un espacement et donc une mauvaise étanchéité du canal 5 au niveau du trou 6.A first embodiment of the flux regulator according to the invention is illustrated in FIG. 3a. This is formed from four sheets 1 to 4, a first sheet intended to form the substrate, a second sheet 2 intended to contain the channel 5, a third sheet 3 having a large central opening 7 intended to form the spacer 4 and a fourth sheet acting as a membrane 4. The membrane 4 may be made of polished silicon, a material that has excellent mechanical properties, but also metal or any other material that has a high elastic limit. The piercing of the membrane 4 may be carried out by chemical etching or by very short-pulse laser drilling, such as for example the femtosecond laser, which avoids plastic deformation by heating the membrane 4. The direction of the laser drilling is important because a bead may be present on the periphery of the hole 6. Thus in the center of the channel 5 is preferably cleaned a circular recessed portion whose diameter is at least equal to the hole 6 of the membrane 4, which allows on the one hand increase the tolerances on the positioning of the membrane 4 with respect to the channel 5 and also to prevent this eventual bead from creating a spacing and thus a poor sealing of the channel 5 at the level of the hole 6.
L'entretoise 3, le canal 5 et le substrat 1 peuvent être réalisés par exemple en métal, comme par exemple l'acier, ou plus avantageusement en céramique co- cuite LTCC. Ces céramiques co-cuites sont en effet percées, par exemple par laser, usinées, alignées, sérigraphiées en surface puis pressées à l'état cru, ce qui permet des empilements tridimensionnels, et ensuite le frittage à chaud permet d'assembler de manière définitive et sans fuite les différents éléments. La méthode d'assemblage final, par exemple pour des feuilles laminées en métal, peut être un encastrement, une soudure ou encore un collage. Pour les systèmes de grandes dimensions on utilise de préférence un encastrement via deux pièces circulaires de précision qui enserrent les différentes feuilles, par exemple par serrage à l'aide de vis. La partie supérieure doit être évidée pour créer une cavité 9 au dessus de la membrane et percée au centre pour l'arrivée du fluide.The spacer 3, the channel 5 and the substrate 1 can be made for example of metal, such as for example steel, or more advantageously ceramic LTCC. These co-cured ceramics are in fact drilled, for example by laser, machined, aligned, serigraphed on the surface and then pressed in the green state, which allows three-dimensional stacks, and then the hot sintering makes it possible to assemble permanently and without leakage the different elements. The final assembly method, for example for rolled sheets of metal, can be a recess, a weld or a bonding. For large systems it is preferred to use a recess via two precision circular parts which enclose the different sheets, for example by clamping with screws. The upper part has to be recessed to create a cavity 9 above the membrane and pierced in the center for the arrival of the fluid.
La sortie du fluide peut être aménagée dans la partie inférieure ou dans la partie supérieure du régulateur.The fluid outlet can be arranged in the lower part or in the upper part of the regulator.
Lorsque la sortie du fluide se situe côté opposé à l'entrée 6 (voir figure 3), des trous de sortie 10 et 11 sont aménagés respectivement dans la feuille 2 contenant le canal 5 ainsi que dans le substrat 1.When the outlet of the fluid is situated opposite the inlet 6 (see FIG. 3), exit holes 10 and 11 are respectively formed in the sheet 2 containing the channel 5 as well as in the substrate 1.
Lorsque la sortie est situé du même côté que l'entrée, la feuille membrane 4 comprend également un trou extérieur de diamètre plus important que le trou central pour la sortie.When the outlet is located on the same side as the inlet, the membrane sheet 4 also includes an outer hole of larger diameter than the central hole for the outlet.
L'alignement est obtenu soit par des trous supplémentaires de centrage, soit par le substrat 1 lui-même. En effet il n'y a pas de tolérance sur son épaisseur ni sur sa largeur. Il est facile d'imaginer une sorte de cavité dans laquelle viendrait s'encastrer les feuillets. Des goupilles d'alignement peuvent être utilisées pour des systèmes de grandes dimensions. L'alignement est facilité si les pourtours des feuilles sont circulaires ainsi que le logement du substrat dans lequel viennent s'encastrer ces feuilles.The alignment is obtained either by additional centering holes, or by the substrate 1 itself. Indeed there is no tolerance on its thickness or its width. It is easy to imagine a kind of cavity in which the sheets would fit. Alignment pins can be used for large systems. Alignment is facilitated if the edges of the leaves are circular and the housing of the substrate in which these sheets fit.
La rugosité de surface de la membrane 4, du canal 5 et du substrat 1 doit être très inférieure aux dimensions caractéristiques du composant, c'est-à-dire de la profondeur du canal 5, de l'épaisseur de l'entretoise 3, de l'épaisseur de la membrane 4 et du diamètre du trou d'entrée 6. L'utilisation de feuilles laminées, usinées et déjà polies miroir avant l'assemblage final permet de réduire sensiblement les fuites lors du fonctionnement.The surface roughness of the membrane 4, the channel 5 and the substrate 1 must be much smaller than the characteristic dimensions of the component, that is to say the depth of the channel 5, the thickness of the spacer 3, the thickness of the membrane 4 and the diameter of the inlet hole 6. The use of laminated sheets, machined and already mirror polished before the final assembly substantially reduces leaks during operation.
Le canal 5 proprement dit peut être réalisé par galvanoplastie directement sur le substrat 1 , par exemple en réalisant par lithographie le négatif du canal 1 afin de réaliser le dépôt de la couche d'accroché métallique, qui après croissance va définir le canal 5 en relief. La partie négative de l'entretoise 3 peut également être réalisées par galvanoplastie. La rugosité de surface obtenue par galvanoplastie est tout à fait compatible avec le bon fonctionnement du composant. Afin de conserver le principe d'assemblage de couche dont l'épaisseur est bien maîtrisée, on peut réaliser la croissance du négatif du canal 5 sur une couche sacrificielle qui sera dissoute avant assemblage sur le substrat 1.The channel 5 itself can be made by electroplating directly on the substrate 1, for example by lithographically making the negative channel 1 to achieve the deposition of the metal hook layer, which after growth will define the channel 5 embossed . The negative part of the spacer 3 can also be made by electroplating. The surface roughness obtained by electroplating is entirely compatible with the proper functioning of the component. In order to preserve the layer assembly principle whose thickness is well controlled, it is possible to carry out the growth of the channel 5 negative on a sacrificial layer which will be dissolved before assembly on the substrate 1.
La figure 4 représente un assemblage d'un régulateur de flux passif avec l'entretoise 3, le canal 5 et le substrat 1 réalisés en une seule pièce, par exemple par injection de matière plastique ou de céramique, ou encore par embossage de plastique. Le capot 8 peut également être réalisé de cette manière. Le capot 8 inclut une cavité 9 qui permet une bonne répartition de la pression au dessus de la membrane 4.FIG. 4 represents an assembly of a passive flux regulator with the spacer 3, the channel 5 and the substrate 1 made in one piece, for example by plastic or ceramic injection, or by plastic embossing. The cover 8 can also be made in this way. The cover 8 includes a cavity 9 which allows a good distribution of the pressure above the membrane 4.
La membrane 4 est en matériau possédant une haute limite élastique et avantageusement le minimum de contraintes internes.The membrane 4 is made of a material having a high elastic limit and advantageously the minimum of internal stresses.
Cette méthode présente de nombreux avantages par rapport aux méthodes d'usinage de l'état de la technique. Avec la méthode selon l'invention, les tolérances relatives sont plus larges, en particulier pour le micro usinage du silicium ou du métal. Lorsque le substrat, le canal et l'entretoise sont formés à partir d'un seul élément, la méthode selon l'invention consiste principalement en la réalisation d'un moule unique de dimensions requises, par exemple par une ou deux opérations de galvanoplastie de nickel sur un positif ou un négatif du canal et de l'entretoise. La réplication des composants par injection plastique ou par embossage à partir de ce moule permet d'atteindre des tolérances relatives excellentes ainsi qu'une bonne rugosité de surface, moyennant des paramètres de procédé adaptés comme le refroidissement sous pression et le temps d'injection ou d'embossage. Cette méthode permet de réduire considérablement les coûts de fabrication et le nombre d'étape de procédé. Un revêtement peut être nécessaire sur toutes les parties des composants pour assurer leur biocompatibilité, par exemple une couche diamantée, une couche d'or ou encore de titane. Les différents éléments sont ensuite assemblés par bonding direct plastique / silicium ou plastique / métal, ou encore par collage, encastrement. Une saignée ou une rainure peut être aménagée dans le substrat plastique ou céramique pour pouvoir étendre la colle. La membrane 4 est ensuite positionnée sur le substrat 1 pour la polymérisation avec éventuellement une pression d'appui afin de maintenir les tolérances d'assemblage.This method has many advantages compared to the machining methods of the state of the art. With the method according to the invention, the relative tolerances are wider, in particular for the micro machining of silicon or metal. When the substrate, the channel and the spacer are formed from a single element, the method according to the invention consists mainly in the production of a single mold of required dimensions, for example by one or two electroplating operations. nickel on a positive or negative channel and spacer. Replication of the components by plastic injection or embossing from this mold achieves excellent relative tolerances and good surface roughness, with suitable process parameters such as pressure cooling and injection time. embossing. This method significantly reduces manufacturing costs and the number of process steps. A coating may be necessary on all parts of the components to ensure their biocompatibility, for example a diamond layer, a layer of gold or titanium. The various elements are then assembled by direct bonding plastic / silicon or plastic / metal, or by bonding, embedding. A groove or a groove can be arranged in the plastic or ceramic substrate to be able to extend the glue. The membrane 4 is then positioned on the substrate 1 for the polymerization with possibly a pressing pressure to maintain the assembly tolerances.
Dans la configuration microréplication, la difficulté se réduit essentiellement à un seul alignement critique, à savoir celui de la membrane 4 sur la pièce répliquée. Une technique d'autocentrage via une rainure ou une surépaisseur sur la pièce répliquée peut être utilisée. Des trous d'alignement peuvent également être percés dans la membrane 4 et la partie répliquée du régulateur.In the microreplication configuration, the difficulty is essentially reduced to a single critical alignment, namely that of the membrane 4 on the replicated part. A self-centering technique via a groove or extra thickness on the replicated part can be used. Alignment holes may also be drilled in the membrane 4 and the replicated portion of the regulator.
Pour les méthodes de fabrication impliquant une microréplication, il faut une attention toute particulière pour la réalisation du modèle de la pièce d'origine (master) qui servira ensuite à générer les moules d'injection ou les têtes d'embossage. Les tolérances requises pour cet élément imposent la réalisation du master par les techniques de micro-usinage.For manufacturing methods involving microreplication, special attention must be paid to the design of the original part (master) which will then be used to generate the injection molds or embossing heads. The tolerances required for this element require the realization of the master by micromachining techniques.
1. Gravure humide, par exemple KOH, d'une plaque de silicium pour réaliser l'entretoise puis gravure sèche pour la spirale, avec un léger angle pour faciliter le démoulage. 2. Gravure sèche ou humide de Pyrex pour la spirale et réalisation de l'entretoise par dépôt de résine, par exemple du SU8 par spinning, suivi d'une photolithographie et enfin éventuellement une métallisation (voir process flow ci-après).1. Wet etching, for example KOH, of a silicon wafer to make the spacer then dry etching for the spiral, with a slight angle to facilitate demolding. 2. Dry or wet etching of Pyrex for the spiral and realization of the spacer by deposition of resin, for example SU8 by spinning, followed by photolithography and eventually optionally a metallization (see process flow below).
La figure 5 illustre un exemple de réalisation du master, incluant un dépôt de SU8 après gravure sèche du canal, suivi d'une photolitho et éventuellement d'une métallisation. Bien évidemment, l'invention ne se limite pas aux modes de réalisation illustrés et discuté dans le présent texte. FIG. 5 illustrates an exemplary embodiment of the master, including a deposition of SU8 after dry etching of the channel, followed by a photolith and possibly a metallization. Of course, the invention is not limited to the embodiments illustrated and discussed in the present text.

Claims

Revendications claims
1. Régulateur de flux pour l'infusion de médicaments comprenant successivement un substrat (1 ), un canal (5), une entretoise (3) et une membrane (4), cette dernière comportant au moins un trou (6) communiquant avec le canal (5), caractérisé par le fait que le régulateur est réalisé à partir d'au moins deux éléments distincts (1 -4), le premier élément comportant la membrane (4) et le deuxième élément comportant l'entretoise (3).1. Flow regulator for the infusion of drugs successively comprising a substrate (1), a channel (5), a spacer (3) and a membrane (4), the latter comprising at least one hole (6) communicating with the channel (5), characterized in that the regulator is made from at least two distinct elements (1 -4), the first element comprising the membrane (4) and the second element comprising the spacer (3).
2. Régulateur de flux selon la revendication précédente dans lequel le premier élément est une feuille.2. Flow controller according to the preceding claim wherein the first element is a sheet.
3. Régulateur de flux selon l'une des revendications précédentes dans lequel le deuxième élément comporte également le canal (5).3. Flow controller according to one of the preceding claims wherein the second element also comprises the channel (5).
4. Régulateur de flux selon la revendication précédente dans lequel le deuxième élément comporte également le substrat (1 ).4. Flow controller according to the preceding claim wherein the second element also comprises the substrate (1).
5. Régulateur de flux selon la revendication 1 ou 2 comprenant un troisième élément qui comporte le substrat (1 ) et le canal (5).Flow controller according to claim 1 or 2, comprising a third element which comprises the substrate (1) and the channel (5).
6. Régulateur de flux selon la revendication 1 ou 2 comprenant quatre éléments (1 -4), le premier (4) comportant la membrane, le deuxième (3) comportant l'entretoise, le troisième (2) comportant le canal et le quatrième6. Flow controller according to claim 1 or 2 comprising four elements (1 -4), the first (4) comprising the membrane, the second (3) having the spacer, the third (2) having the channel and the fourth
(1 ) comportant le substrat.(1) comprising the substrate.
7. Régulateur de flux selon la revendication précédente dans lequel les quatre éléments (1 -4) sont des feuilles.7. Flow controller according to the preceding claim wherein the four elements (1 -4) are sheets.
8. Régulateur de flux selon la revendication précédente dans lequel au moins une des feuilles (1 -4) est obtenue par laminage. Flow regulator according to the preceding claim wherein at least one of the sheets (1 -4) is obtained by rolling.
9. Régulateur de flux selon la revendication 7 ou 8 dans lequel au moins une des feuilles (1 -4) (4) est réalisée en silicium poli.Flow regulator according to claim 7 or 8 wherein at least one of the sheets (1-4) (4) is made of polished silicon.
10. Régulateur de flux selon l'une des revendications précédentes comprenant des moyens pour mesurer la déflection de la membrane (4).Flow regulator according to one of the preceding claims, comprising means for measuring the deflection of the membrane (4).
1 1. Régulateur selon l'une des revendications précédentes constitué d'au moins une feuille dont le pourtour est circulaire.1. Regulator according to one of the preceding claims consisting of at least one sheet whose circumference is circular.
12. Régulateur selon l'une des revendications précédentes dont le pourtour interne de l'entretoise (3) est circulaire.12. Regulator according to one of the preceding claims, the inner periphery of the spacer (3) is circular.
13. Régulateur selon l'une des revendications précédentes dimensionné de manière à ce que le chemin fluidique soit obstrué lorsqu'une pression seuil du fluide à l'intérieur du régulateur est atteinte.13. Regulator according to one of the preceding claims sized so that the fluid path is obstructed when a threshold pressure of the fluid inside the regulator is reached.
14. Méthode de fabrication d'un régulateur de flux selon l'une des revendication précédentes comprenant l'empilement de quatre feuilles (1 - 4), la première étant destinée à former un substrat (1 ), la deuxième un canal (5), la troisième une entretoise (3) et la quatrième une membrane (4).14. Method of manufacturing a flux regulator according to one of the preceding claims comprising the stack of four sheets (1 - 4), the first being intended to form a substrate (1), the second a channel (5). , the third a spacer (3) and the fourth a membrane (4).
15. Méthode selon la revendication précédente comprenant une étape d'alignement des feuilles (1 -4).15. Method according to the preceding claim comprising a step of aligning the sheets (1 -4).
16. Méthode de fabrication selon l'une des revendications 1 à 12 caractérisée par le fait que l'entretoise (3) et/ou le canal (5) sont créés par galvanoplastie ou tout autre méthode de dépôt. 16. Method of manufacture according to one of claims 1 to 12 characterized in that the spacer (3) and / or the channel (5) are created by electroplating or any other method of deposition.
EP09709010A 2008-02-09 2009-02-06 Passive flow regulator for infusion of medicaments Withdrawn EP2242524A1 (en)

Applications Claiming Priority (2)

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IB2008050473 2008-02-09
PCT/EP2009/051414 WO2009098314A1 (en) 2008-02-09 2009-02-06 Passive flow regulator for infusion of medicaments

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Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2359886A1 (en) * 2010-02-12 2011-08-24 Debiotech S.A. Micromechanic passive flow regulator
DE102011051140A1 (en) * 2011-02-25 2012-08-30 Embedded Microsystems Bremen GmbH (EMB) Applikationszentrum für Mikrosystemtechnik flow resistance
CN106975117A (en) 2011-09-21 2017-07-25 拜耳医药保健有限责任公司 Continuous multiple fluid pump device, driving and actuating system and method
EP2754935A1 (en) * 2013-01-10 2014-07-16 Debiotech S.A. Adjustable passive flow regulator
CN107427411B (en) 2015-01-09 2021-04-02 拜耳医药保健有限公司 Multi-fluid delivery system with multi-use disposable set and features thereof
JP6638222B2 (en) * 2015-06-23 2020-01-29 株式会社ジェイテクト Flow control device
JP6900360B2 (en) 2015-07-08 2021-07-07 デビオテック ソシエテ アノニム Systems and methods for cleaning filters

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3463182A (en) * 1967-04-10 1969-08-26 Singer General Precision Constant pressure fluid regulator
NL7002383A (en) * 1970-02-19 1971-08-23
US4581624A (en) * 1984-03-01 1986-04-08 Allied Corporation Microminiature semiconductor valve
US5163920A (en) * 1991-01-30 1992-11-17 Infusaid Inc. Flow regulator damper element
DE69435124D1 (en) * 1993-10-04 2008-09-25 Res Internat Inc Micromachined filters
US6203523B1 (en) * 1998-02-02 2001-03-20 Medtronic Inc Implantable drug infusion device having a flow regulator
EP1334279A1 (en) * 2000-11-06 2003-08-13 Nanostream, Inc. Uni-directional flow microfluidic components
US6786708B2 (en) * 2002-07-18 2004-09-07 The Regents Of The University Of Michigan Laminated devices and methods of making same
WO2005036182A1 (en) * 2003-10-15 2005-04-21 Matsushita Electric Industrial Co., Ltd. Method of passing fluid in capillary chip

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO2009098314A1 *

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