EP2238146A4 - Hämagglutinin-polypeptide und -reagenzien sowie verfahren in zusammenhang damit - Google Patents

Hämagglutinin-polypeptide und -reagenzien sowie verfahren in zusammenhang damit

Info

Publication number
EP2238146A4
EP2238146A4 EP09701014A EP09701014A EP2238146A4 EP 2238146 A4 EP2238146 A4 EP 2238146A4 EP 09701014 A EP09701014 A EP 09701014A EP 09701014 A EP09701014 A EP 09701014A EP 2238146 A4 EP2238146 A4 EP 2238146A4
Authority
EP
European Patent Office
Prior art keywords
reagents
methods relating
hemagglutinin polypeptides
hemagglutinin
polypeptides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP09701014A
Other languages
English (en)
French (fr)
Other versions
EP2238146A2 (de
Inventor
Ram Sasisekharan
Karthik Viswanathan
Aarthi Chandrasekaran
Rahul Raman
Aravind Srinivasan
S Raguram
Viswanathan Sasisekharan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Massachusetts Institute of Technology
Original Assignee
Massachusetts Institute of Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US11/969,040 external-priority patent/US20090081193A1/en
Application filed by Massachusetts Institute of Technology filed Critical Massachusetts Institute of Technology
Publication of EP2238146A2 publication Critical patent/EP2238146A2/de
Publication of EP2238146A4 publication Critical patent/EP2238146A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/12—Libraries containing saccharides or polysaccharides, or derivatives thereof
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56983—Viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
    • G01N2333/08—RNA viruses
    • G01N2333/11—Orthomyxoviridae, e.g. influenza virus
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2400/00—Assays, e.g. immunoassays or enzyme assays, involving carbohydrates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Food Science & Technology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pulmonology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Communicable Diseases (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Oncology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
EP09701014A 2008-01-03 2009-01-02 Hämagglutinin-polypeptide und -reagenzien sowie verfahren in zusammenhang damit Withdrawn EP2238146A4 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US1878308P 2008-01-03 2008-01-03
US11/969,040 US20090081193A1 (en) 2006-08-14 2008-01-03 Hemagglutinin polypeptides, and reagents and methods relating thereto
US30112608A 2008-11-17 2008-11-17
PCT/US2009/030058 WO2009089121A2 (en) 2008-01-03 2009-01-02 Hemagglutinin polypeptides, and reagents and methods relating thereto

Publications (2)

Publication Number Publication Date
EP2238146A2 EP2238146A2 (de) 2010-10-13
EP2238146A4 true EP2238146A4 (de) 2012-03-21

Family

ID=40853716

Family Applications (1)

Application Number Title Priority Date Filing Date
EP09701014A Withdrawn EP2238146A4 (de) 2008-01-03 2009-01-02 Hämagglutinin-polypeptide und -reagenzien sowie verfahren in zusammenhang damit

Country Status (3)

Country Link
EP (1) EP2238146A4 (de)
CA (1) CA2711334A1 (de)
WO (1) WO2009089121A2 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0817682A2 (pt) 2007-10-16 2015-04-07 Peptimmune Inc Métodos para projetar e preparar vacinas compreendendo composições de polímero de sequência direcionada via a expansão direta de epítopos
EP2640405A4 (de) 2010-09-21 2015-04-15 Massachusetts Inst Technology An den menschen angepasste ha-polypeptide, impfstoffe daraus und influenza-behandlung damit
US10226527B2 (en) * 2010-10-04 2019-03-12 Massachusetts Institute Of Technology Hemagglutinin polypeptides, and reagents and methods relating thereto
EP3492101A3 (de) 2012-05-10 2019-10-23 Massachusetts Institute Of Technology Mittel zur influenzaneutralisierung

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008073161A2 (en) * 2006-08-14 2008-06-19 Massachusetts Institute Of Technology Hemagglutinin polypeptides, and reagents and methods relating thereto

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008073161A2 (en) * 2006-08-14 2008-06-19 Massachusetts Institute Of Technology Hemagglutinin polypeptides, and reagents and methods relating thereto

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
AARTHI CHANDRASEKARAN ET AL: "Glycan topology determines human adaptation of avian H5N1 virus hemagglutinin", NATURE BIOTECHNOLOGY, NATURE PUBLISHING GROUP, NEW YORK, NY, US, vol. 26, no. 1, 6 January 2008 (2008-01-06), pages 107 - 113, XP008132307, ISSN: 1087-0156, [retrieved on 20080106], DOI: 10.1038/NBT1375 *
KUMARI KSHAMA ET AL: "Receptor binding specificity of recent human H3N2 influenza viruses", VIROLOGY JOURNAL, BIOMED CENTRAL, LONDON, GB, vol. 4, no. 1, 9 May 2007 (2007-05-09), pages 42, XP021025487, ISSN: 1743-422X, DOI: 10.1186/1743-422X-4-42 *
STEVENS JAMES ET AL: "Structure and receptor specificity of the hemagglutinin from an H5N1 influenza virus", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE, WASHINGTON, DC; US, vol. 312, no. 5772, 1 April 2006 (2006-04-01), pages 404 - 410, XP002533276, ISSN: 0036-8075, [retrieved on 20060316], DOI: 10.1126/SCIENCE.1124513 *
VISWANATHAN KARTHIK ET AL: "Glycans as receptors for influenza pathogenesis", GLYCOCONJUGATE JOURNAL, KLUWER ACADEMIC PUBLISHERS, BO, vol. 27, no. 6, 1 August 2010 (2010-08-01), pages 561 - 570, XP002604175, ISSN: 1573-4986, [retrieved on 20100824], DOI: 10.1007/S10719-010-9303-4 *

Also Published As

Publication number Publication date
WO2009089121A2 (en) 2009-07-16
WO2009089121A3 (en) 2009-10-08
CA2711334A1 (en) 2009-07-16
EP2238146A2 (de) 2010-10-13

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RIN1 Information on inventor provided before grant (corrected)

Inventor name: SASISEKHARAN, VISWANATHAN

Inventor name: RAGURAM, S.

Inventor name: SRINIVASAN, ARAVIND

Inventor name: RAMAN, RAHUL

Inventor name: CHANDRASEKARAN, AARTHI

Inventor name: VISWANATHAN, KARTHIK

Inventor name: SASISEKHARAN, RAM

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Ipc: C07H 21/04 20060101ALI20120216BHEP

Ipc: A61K 38/16 20060101ALI20120216BHEP

Ipc: C40B 40/12 20060101ALI20120216BHEP

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