EP2234630A4 - Method of stimulating the motility of the gastrointestinal system using ipamorelin - Google Patents

Method of stimulating the motility of the gastrointestinal system using ipamorelin

Info

Publication number
EP2234630A4
EP2234630A4 EP08864278A EP08864278A EP2234630A4 EP 2234630 A4 EP2234630 A4 EP 2234630A4 EP 08864278 A EP08864278 A EP 08864278A EP 08864278 A EP08864278 A EP 08864278A EP 2234630 A4 EP2234630 A4 EP 2234630A4
Authority
EP
European Patent Office
Prior art keywords
ipamorelin
motility
stimulating
gastrointestinal system
gastrointestinal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP08864278A
Other languages
German (de)
French (fr)
Other versions
EP2234630A1 (en
Inventor
William J Polvino
Richard Nelson
William R Mann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Helsinn Healthcare SA
Original Assignee
Helsinn Therapeutics US Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Helsinn Therapeutics US Inc filed Critical Helsinn Therapeutics US Inc
Publication of EP2234630A1 publication Critical patent/EP2234630A1/en
Publication of EP2234630A4 publication Critical patent/EP2234630A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/25—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nutrition Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP08864278A 2007-12-21 2008-11-26 Method of stimulating the motility of the gastrointestinal system using ipamorelin Withdrawn EP2234630A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US882807P 2007-12-21 2007-12-21
PCT/US2008/013156 WO2009082426A1 (en) 2007-12-21 2008-11-26 Method of stimulating the motility of the gastrointestinal system using ipamorelin

Publications (2)

Publication Number Publication Date
EP2234630A1 EP2234630A1 (en) 2010-10-06
EP2234630A4 true EP2234630A4 (en) 2012-08-08

Family

ID=40801504

Family Applications (1)

Application Number Title Priority Date Filing Date
EP08864278A Withdrawn EP2234630A4 (en) 2007-12-21 2008-11-26 Method of stimulating the motility of the gastrointestinal system using ipamorelin

Country Status (8)

Country Link
EP (1) EP2234630A4 (en)
JP (2) JP2011507842A (en)
KR (1) KR20100102157A (en)
CN (1) CN101951937A (en)
AU (1) AU2008341160A1 (en)
CA (1) CA2709913A1 (en)
TW (1) TW200940082A (en)
WO (1) WO2009082426A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG176717A1 (en) * 2009-06-12 2012-01-30 Helsinn Therapeutics Us Inc Ipamorelin diacetate injection and infusion solutions
WO2014156339A1 (en) * 2013-03-25 2014-10-02 ゼリア新薬工業株式会社 Postprandial gastrokinetic agent
WO2017180907A1 (en) * 2016-04-13 2017-10-19 Board Of Regents Of The University Of Nebraska Methods for administration and methods for treating cardiovascular diseases with resiniferatoxin

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1062229A1 (en) * 1998-03-09 2000-12-27 Zealand Pharmaceuticals A/S Pharmacologically active peptide conjugates having a reduced tendency towards enzymatic hydrolysis
EP1159964B1 (en) * 2000-05-31 2009-10-28 Pfizer Products Inc. Use of growth hormone secretagogues for stimulating gastrointestinal motility
RU2005102923A (en) * 2002-07-05 2005-10-10 Чугай Сеияку Кабушики Каиша (Jp) DIABETES MEDICINE
US7476653B2 (en) * 2003-06-18 2009-01-13 Tranzyme Pharma, Inc. Macrocyclic modulators of the ghrelin receptor
US7491695B2 (en) * 2003-06-18 2009-02-17 Tranzyme Pharma Inc. Methods of using macrocyclic modulators of the ghrelin receptor
AU2005272598B2 (en) * 2004-08-12 2011-11-17 Helsinn Therapeutics (U.S.), Inc. Method of stimulating the motility of the gastrointestinal system using growth hormone secretagogues
CN105381453B9 (en) * 2005-09-29 2019-01-11 益普生制药股份有限公司 Compositions and methods for stimulating gastrointestinal motility

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
KALINA VENKOVA ET AL: "Prokinetic Effects of a New Ghrelin Receptor Agonist TZP-101 in a Rat Model of Postoperative Ileus", DIGESTIVE DISEASES AND SCIENCES, KLUWER ACADEMIC PUBLISHERS-PLENUM PUBLISHERS, NE, vol. 52, no. 9, 10 April 2007 (2007-04-10), pages 2241 - 2248, XP019526062, ISSN: 1573-2568, DOI: 10.1007/S10620-007-9783-7 *
MURRAY1 C D R ET AL: "Ghrelin enhances gastric emptying in diabetic gastroparesis: a double blind, placebo controlled crossover study", GUT, BRITISH MEDICAL ASSOCIATION, LONDON, UK, vol. 54, 5 August 2005 (2005-08-05), pages 1693 - 1698, XP008126776, ISSN: 0017-5749, DOI: 10.1136/GUT.2005.069088 *
PEETERS ET AL: "Potential of ghrelin as a therapeutic approach for gastrointestinal motility disorders", CURRENT OPINION IN PHARMACOLOGY, ELSEVIER SCIENCE PUBLISHERS, NL, vol. 6, no. 6, 1 December 2006 (2006-12-01), pages 553 - 558, XP028058476, ISSN: 1471-4892, [retrieved on 20061201], DOI: 10.1016/J.COPH.2006.08.005 *
POITRAS P ET AL: "Gastrokinetic effect of ghrelin analog RC-1139 in the rat", PEPTIDES, ELSEVIER, AMSTERDAM, vol. 26, no. 9, 1 September 2005 (2005-09-01), pages 1598 - 1601, XP027856463, ISSN: 0196-9781, [retrieved on 20050901] *
See also references of WO2009082426A1 *

Also Published As

Publication number Publication date
TW200940082A (en) 2009-10-01
JP2013040206A (en) 2013-02-28
JP2011507842A (en) 2011-03-10
KR20100102157A (en) 2010-09-20
EP2234630A1 (en) 2010-10-06
CA2709913A1 (en) 2009-07-02
AU2008341160A1 (en) 2009-07-02
CN101951937A (en) 2011-01-19
WO2009082426A1 (en) 2009-07-02

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