EP2164622A4 - Surface modified aerosol particles, a method and apparatus for production thereof and powders and dispersions containing said particles - Google Patents

Surface modified aerosol particles, a method and apparatus for production thereof and powders and dispersions containing said particles

Info

Publication number
EP2164622A4
EP2164622A4 EP07730620.7A EP07730620A EP2164622A4 EP 2164622 A4 EP2164622 A4 EP 2164622A4 EP 07730620 A EP07730620 A EP 07730620A EP 2164622 A4 EP2164622 A4 EP 2164622A4
Authority
EP
European Patent Office
Prior art keywords
particles
powders
production
surface modified
dispersions containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP07730620.7A
Other languages
German (de)
French (fr)
Other versions
EP2164622A1 (en
EP2164622B1 (en
Inventor
Anna LÄHDE
Esko Kauppinen
David P Brown
Janne Raula
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teicos Pharma Oy
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of EP2164622A1 publication Critical patent/EP2164622A1/en
Publication of EP2164622A4 publication Critical patent/EP2164622A4/en
Application granted granted Critical
Publication of EP2164622B1 publication Critical patent/EP2164622B1/en
Not-in-force legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • B01J2/02—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops
    • B01J2/04—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops in a gaseous medium
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/5123—Organic compounds, e.g. fats, sugars
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5192—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/0095—Preparation of aerosols

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Pulmonology (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Nanotechnology (AREA)
  • Optics & Photonics (AREA)
  • Otolaryngology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Medicinal Preparation (AREA)
EP07730620.7A 2006-05-03 2007-05-31 Surface modified aerosol particles, a method for production thereof and powders and dispersions containing said particles Not-in-force EP2164622B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FI20060428A FI20060428L (en) 2006-05-03 2006-05-03 Surface-modified aerosol particles, method and device for their production and powders and dispersions containing said particles
PCT/FI2007/000151 WO2007125159A1 (en) 2006-05-03 2007-05-31 Surface modified aerosol particles, a method and apparatus for production thereof and powders and dispersions containing said particles

Publications (3)

Publication Number Publication Date
EP2164622A1 EP2164622A1 (en) 2010-03-24
EP2164622A4 true EP2164622A4 (en) 2013-10-23
EP2164622B1 EP2164622B1 (en) 2017-09-20

Family

ID=36539875

Family Applications (1)

Application Number Title Priority Date Filing Date
EP07730620.7A Not-in-force EP2164622B1 (en) 2006-05-03 2007-05-31 Surface modified aerosol particles, a method for production thereof and powders and dispersions containing said particles

Country Status (8)

Country Link
US (1) US8349295B2 (en)
EP (1) EP2164622B1 (en)
JP (1) JP2010528094A (en)
CN (1) CN101702885A (en)
BR (1) BRPI0721714A2 (en)
CA (1) CA2688288C (en)
FI (1) FI20060428L (en)
WO (1) WO2007125159A1 (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7906453B2 (en) * 2008-01-04 2011-03-15 Cabot Corporation Processes for controlling catalyst particle morphology
EP2296628B1 (en) * 2008-05-22 2014-05-14 3M Innovative Properties Company Process for manufacturing flowable powder drug compositions
CN104690295B (en) * 2013-12-05 2017-06-30 南通建陵纳米科技有限公司 The method for preparing monodisperse superfine particle
EP3157675A1 (en) * 2014-06-09 2017-04-26 Canatu Oy Catalyst particle and method for producing thereof
CN105664807B (en) * 2014-11-19 2019-10-29 中国辐射防护研究院 A kind of coagulation type monodisperse aerosol generating device
US9585835B1 (en) * 2015-09-16 2017-03-07 Sansa Corporation (Barbados) Inc. Inhalable nicotine formulations and methods of making and using the same
KR101827508B1 (en) * 2016-05-19 2018-02-12 한국생산기술연구원 Additive injection system for preventing high-temperature corrosion
WO2018002756A1 (en) * 2016-06-30 2018-01-04 Philip Morris Products S.A. Nicotine particles and compositions
US11458093B2 (en) 2016-06-30 2022-10-04 Philip Morris Products S.A. Nicotine particles
WO2018005930A1 (en) * 2016-07-01 2018-01-04 Pratim Biswas Synthesis of nanocomposites and their use in enhancing plant nutrition
US11285107B2 (en) * 2017-05-04 2022-03-29 Nanologica Ab Process for manufacturing porous silica particles loaded with at least one bioactive compound adapted for lung, nasal, sublingual, and/or pharyngeal delivery
EP3645092B1 (en) * 2017-06-30 2024-04-03 Avectas Limited Electrospray catheter
WO2022034029A1 (en) * 2020-08-11 2022-02-17 Merck Patent Gmbh Method for the collection of substances comprised in an environment for analytical purposes

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001031312A2 (en) * 1999-10-26 2001-05-03 Southern Illinois University Method for nanoparticle detection
US20010050055A1 (en) * 1997-12-12 2001-12-13 Takahiro Horiuchi Method and apparatus for modifying particles

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990002546A1 (en) * 1988-09-09 1990-03-22 The Ronald T. Dodge Company Pharmaceuticals microencapsulated by vapor deposited polymers and method
JP3506854B2 (en) * 1996-03-07 2004-03-15 シャープ株式会社 Particle surface modification method and apparatus therefor
US6051257A (en) * 1997-02-24 2000-04-18 Superior Micropowders, Llc Powder batch of pharmaceutically-active particles and methods for making same
JP3942732B2 (en) * 1998-06-01 2007-07-11 シャープ株式会社 Ink, color filter, color display device and manufacturing method thereof
US7521068B2 (en) * 1998-11-12 2009-04-21 Elan Pharma International Ltd. Dry powder aerosols of nanoparticulate drugs
FI20002215A0 (en) * 2000-10-06 2000-10-06 Orion Yhtymae Oyj Combination Particles
FR2825271B1 (en) * 2001-05-31 2003-08-08 Oreal COMPOSITION OF AEROSOL CONTAINING SILICATE PARTICLES AND POLYMERS

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20010050055A1 (en) * 1997-12-12 2001-12-13 Takahiro Horiuchi Method and apparatus for modifying particles
WO2001031312A2 (en) * 1999-10-26 2001-05-03 Southern Illinois University Method for nanoparticle detection

Also Published As

Publication number Publication date
US20100239507A1 (en) 2010-09-23
BRPI0721714A2 (en) 2016-10-11
FI20060428A0 (en) 2006-05-03
FI20060428L (en) 2007-11-04
EP2164622A1 (en) 2010-03-24
WO2007125159A1 (en) 2007-11-08
JP2010528094A (en) 2010-08-19
US8349295B2 (en) 2013-01-08
CN101702885A (en) 2010-05-05
EP2164622B1 (en) 2017-09-20
CA2688288C (en) 2016-08-30
CA2688288A1 (en) 2007-11-08

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