EP2150858A4 - Novel hydrazone-based and oxime-based fluorescent and chromophoric/pro-fluorescent and pro-chromophoric reagents and linkers - Google Patents

Novel hydrazone-based and oxime-based fluorescent and chromophoric/pro-fluorescent and pro-chromophoric reagents and linkers

Info

Publication number
EP2150858A4
EP2150858A4 EP07794844A EP07794844A EP2150858A4 EP 2150858 A4 EP2150858 A4 EP 2150858A4 EP 07794844 A EP07794844 A EP 07794844A EP 07794844 A EP07794844 A EP 07794844A EP 2150858 A4 EP2150858 A4 EP 2150858A4
Authority
EP
European Patent Office
Prior art keywords
chromophoric
pro
fluorescent
linkers
oxime
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP07794844A
Other languages
German (de)
French (fr)
Other versions
EP2150858A1 (en
Inventor
David A Schwartz
Leopoldo Mendoza
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SOLULINK Inc
Original Assignee
SOLULINK Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SOLULINK Inc filed Critical SOLULINK Inc
Publication of EP2150858A1 publication Critical patent/EP2150858A1/en
Publication of EP2150858A4 publication Critical patent/EP2150858A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B26/00—Hydrazone dyes; Triazene dyes
    • C09B26/02—Hydrazone dyes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54353—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals with ligand attached to the carrier via a chemical coupling agent
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
EP07794844A 2007-05-14 2007-05-14 Novel hydrazone-based and oxime-based fluorescent and chromophoric/pro-fluorescent and pro-chromophoric reagents and linkers Withdrawn EP2150858A4 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2007/011529 WO2008140452A1 (en) 2007-05-14 2007-05-14 Novel hydrazone-based and oxime-based fluorescent and chromophoric/pro-fluorescent and pro-chromophoric reagents and linkers

Publications (2)

Publication Number Publication Date
EP2150858A1 EP2150858A1 (en) 2010-02-10
EP2150858A4 true EP2150858A4 (en) 2013-01-02

Family

ID=40002491

Family Applications (1)

Application Number Title Priority Date Filing Date
EP07794844A Withdrawn EP2150858A4 (en) 2007-05-14 2007-05-14 Novel hydrazone-based and oxime-based fluorescent and chromophoric/pro-fluorescent and pro-chromophoric reagents and linkers

Country Status (3)

Country Link
EP (1) EP2150858A4 (en)
AU (1) AU2007353457A1 (en)
WO (1) WO2008140452A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9222936B2 (en) 2007-04-18 2015-12-29 Solulink, Inc. Methods and/or use of oligonucleotide conjugates for suppressing background due to cross-hybridization
CA2687178C (en) * 2007-05-23 2014-02-04 Ventana Medical Systems, Inc. Polymeric carriers for immunohistochemistry and in situ hybridization
US8309306B2 (en) 2008-11-12 2012-11-13 Nodality, Inc. Detection composition
US20120258881A1 (en) * 2010-11-22 2012-10-11 The University Of Chicago Methods and/or Use of Oligonucleotide Conjugates for Assays and Microscopy/Imaging Detections

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5210203A (en) * 1985-06-25 1993-05-11 Siska Diagnostics, Inc. Sulfonamide-derivative compounds for tagging nucleic acid probes
US5629421A (en) * 1993-12-15 1997-05-13 Hodagaya Chemical Co., Ltd. Hydrazone compounds
US20020081591A1 (en) * 1999-07-29 2002-06-27 Lukhtanov Eugeny Alexander Attachment of oligonucleotides to solid supports through schiff base type linkages for capture and detection of nucleic acids
US20030013857A1 (en) * 2000-03-22 2003-01-16 Solulink Incorporated Hydrazine-based and carbonyl-based bifunctional crosslinking reagents
US20040039182A1 (en) * 2000-04-03 2004-02-26 Terence Chamberlain Mono-and bis-hydrazone pigments

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5156840A (en) * 1982-03-09 1992-10-20 Cytogen Corporation Amine-containing porphyrin derivatives
US5719061A (en) * 1994-10-20 1998-02-17 The United States Of America As Represented By The Secretary Of The Navy Fluorescent detection of hydrazine, monomethylhydrazine, and 1,1-dimethylhydrazine by derivatization with aromatic dicarboxaldehydes
US20050069794A1 (en) * 2003-09-25 2005-03-31 Nusrallah Jubran Organophotoreceptor with charge transport material having fluorenone hydrazone groups

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5210203A (en) * 1985-06-25 1993-05-11 Siska Diagnostics, Inc. Sulfonamide-derivative compounds for tagging nucleic acid probes
US5629421A (en) * 1993-12-15 1997-05-13 Hodagaya Chemical Co., Ltd. Hydrazone compounds
US20020081591A1 (en) * 1999-07-29 2002-06-27 Lukhtanov Eugeny Alexander Attachment of oligonucleotides to solid supports through schiff base type linkages for capture and detection of nucleic acids
US20030013857A1 (en) * 2000-03-22 2003-01-16 Solulink Incorporated Hydrazine-based and carbonyl-based bifunctional crosslinking reagents
US20040039182A1 (en) * 2000-04-03 2004-02-26 Terence Chamberlain Mono-and bis-hydrazone pigments

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
KATZ L ET AL: "HYDRAZINE DERIVATIVES. I. BENZALTHIO- AND BISBENZALDITHIO-SALICYLHYDRAZIDES", JOURNAL OF ORGANIC CHEMISTRY, ACS, US, vol. 18, no. 10, 1 January 1953 (1953-01-01), pages 1380 - 1402, XP002223788, ISSN: 0022-3263, DOI: 10.1021/JO50016A019 *
SCOTT W L ET AL: "Synthesis of reagents for the one step incorporation of hydrazide functionality onto the lysine residues of proteins, and their use as linkers for carbonyl containing molecules", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON, ELSEVIER SCIENCE, GB, vol. 6, no. 13, 9 July 1996 (1996-07-09), pages 1491 - 1496, XP004175739, ISSN: 0960-894X, DOI: 10.1016/S0960-894X(96)00265-X *
See also references of WO2008140452A1 *

Also Published As

Publication number Publication date
AU2007353457A1 (en) 2008-11-20
EP2150858A1 (en) 2010-02-10
WO2008140452A1 (en) 2008-11-20

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