EP2121085A1

EP2121085A1 - Device for administering a product

Info

Publication number: EP2121085A1
Application number: EP08719246A
Authority: EP
Inventors: Gianpaolo Belloli
Original assignee: Individual
Current assignee: Individual
Priority date: 2007-03-12
Filing date: 2008-03-07
Publication date: 2009-11-25
Also published as: WO2008110890A1; ITBO20070166A1

Abstract

A device (10) for administering a liquid product to a user, in particular for administering a pharmaceutical product, comprising a container (12) that presents a product (11) containing space (14), which leads to a product outlet opening and which is provided with means for driving the product out of the container (12) and means for associating it with means for injecting the product. The device comprises means (18) for closing the product outlet opening (16), said closing means (18) being connected to the container (12) through breakable connection means (20).

Description

Device for administering a product

Technical Field

This invention relates to a device for administering a liquid product to a user, in particular for administering a pharmaceutical product or the like.

Background Art

Syringes for administering pharmaceutical products are known. These syringes comprise a glass barrel for containing the pharmaceutical product and a needle fixedly inserted into the glass body and used to inject a predetermined dose of the product into the patient. For syringes of this kind, the glass barrel is sterilized together with the predetermined product dose, with the disadvantage of a high cost, however, due to the use of glass and to the need to handle a containing barrel into which the needle has been pre-inserted. An additional cost factor for syringes of this kind is the need to use suitable means, such as, for example a separate cap made of a suitable material, to close the end of the needle through which the liquid is injected.

Moreover, these customary prefilled syringes present an additional problem when it comes to disposing of them. Indeed, since the barrel of the syringe is made of glass and the pre-inserted needle is made of metal, the syringe barrel cannot be readily disposed of in bins used for collecting waste glass. Indeed, plastic syringes with empty containing bodies are also known.

When a syringe of this type has to be used, a needle is inserted into the end hub of the containing barrel and is used to draw product into the containing barrel and to inject the product into the patient.

These plastic syringes are not designed to receive a product and thus to be sterilized at a high temperature in an autoclave together with the product.

Disclosure of the Invention

This invention provides a device for administering a liquid product to a user, in particular a pharmaceutical product, comprising a barrel that presents a product containing space, which leads to a product outlet opening, and means for associating the containing space with means for injecting the product, the device being characterized in that it comprises means for closing the product outlet opening, said closing means being connected to the barrel through breakable connection means. In this way, a plastic barrel closure is obtained which can be easily used to make prefilled injection devices that can be easily sterilized at a high temperature in an autoclave. A low-cost, easy-to-use injection device is thus obtained.

The invention also provides an advantageous method for making a device for administering a liquid product to a user, in particular for making a device for administering a pharmaceutical product or the like, an advantageous method for administering a liquid product to a user, in particular for administering a pharmaceutical product or the like, and an advantageous kit for administering a liquid product to a user, in particular for administering a pharmaceutical product or the like.

Brief Description of the Drawings

These and other characteristics of the invention are clearly described in the appended claims and the advantages of the invention are apparent from the detailed description which follows, with reference to the accompanying drawings which illustrate preferred non-limiting embodiments of it provided purely by way of example, and in which:

- Figure IA is a schematic perspective view of a preferred embodiment of the device for administering a liquid product according to the invention;

- Figure IB is a schematic longitudinal section view of the first preferred embodiment of the device for administering a product;

- Figures 2A to 2E are schematic perspective views illustrating the different steps of making the first preferred embodiment of the device for administering a liquid product according to the invention;

- Figures 3A to 3F are schematic perspective views illustrating the different steps in the procedure for using the first preferred embodiment of the administering device;

- Figure 4 is a schematic perspective view of a first preferred embodiment of an administering kit comprising a first preferred embodiment of the administering device; - Figure 5 is a schematic perspective view of a second preferred embodiment of an administering kit comprising a second preferred embodiment of the administering device;

- Figure 6 is a schematic perspective view of a third preferred embodiment of an administering kit comprising a third preferred embodiment of the administering device according to the invention;

- Figure 7 is a schematic perspective view of a fourth preferred embodiment of an administering kit comprising the third preferred embodiment of the administering device according to the invention.

Description of the Preferred Embodiments of the Invention

Figures IA and IB illustrate a first preferred embodiment of a device, in particular in the form of a component or part of a syringe, for administering a liquid product to a user, in particular for administering a pharmaceutical product.

As illustrated, the device 10 comprises a cylindrical containing barrel 12 made of a suitable plastic material and having an outside surface and an inside surface 12' forming a space or chamber 14 for containing the liquid product 11 to be administered.

As illustrated, the containing space 14 leads to an outlet opening 16 through which the product 11 is transferred from the syringe to respective means, or needle, for injecting the product into the user's body and to be associated with the barrel 12 at the time of use. The needle is not illustrated in Figures IA and IB.

The device according to the invention comprises means for driving the product out of the barrel 12 and means for associating it, or connecting it, with respective injection means, in particular with a respective needle, as described in more detail below.

The product 11 outlet opening 16 is advantageously closed by suitable closing means 18 that are integrally connected to the barrel 12 through breakable connecting means, labelled 20 in the drawings.

In this way, a suitable closure or seal for the plastic container 12 is obtained which can be easily used to make prefilled injection devices that can be easily sterilized at a high temperature in an autoclave.

A low-cost, advantageously easy-to-use injection device is thus obtained. The closing means or cap 18 are advantageously made of a plastic material as a single part with the barrel 12. The breakable connecting means 20 are also advantageously made as a single part with the barrel 12.

Thus, in a single moulding or like operation, it is possible to make both the barrel 12 and the closing means 18, which can easily be separated from the barrel 12, at the time the administering device is used, by breaking the connecting means 20.

The means for associating the needle with the product injection means comprise the outside surface 17 of a product outlet nozzle 15, and extending from the barrel 12, in particular from the end wall 12" of the barrel.

In practice, and as it is known, the head of the infusion needle is pressed over the outside surface of the nozzle 15.

As illustrated, the product outlet opening 16 opens at the free end of the nozzle 15.

As illustrated, the product nozzle 15 extends from the barrel and is conical in shape, tapering towards the free end product outlet opening 16. Advantageously, the means 18 for closing the barrel opening 16 are embodied by a full, enlarged portion of material which is associated with the nozzle 15 at the free product outlet end 16' of the nozzle 15.

Advantageously, the closing means 18 are embodied by a full, enlarged portion that extends radially or peripherally beyond the peripheral or outside edge of the nozzle 15, at the point where it connects to the enlarged portion 18.

In this way, there is no risk of the user breaking the nozzle 15 in the attempt to separate the enlarged portion 18 from the nozzle. Damage to the nozzle would make it difficult or impossible to fit the injection means or needle.

Advantageously, as illustrated, the closing portion 18 has a substantially cylindrical part 18a, from which extends a conical portion 18b which is smaller in diameter than the cylindrical portion 18a and which tapers or converges towards the portion connected to the nozzle 15.

As illustrated, the enlarged portion 18a extends radially beyond the peripheral profile of the nozzle 15, forming an area that easily attaches or connects to advantageous snap means for facilitating breakage, as described in more detail below.

As illustrated, the closing portion 18 is longitudinally aligned with the barrel and with the nozzle 15 extending therefrom.

Advantageously, the breakable connecting means 20 are embodied by at least one pre-weakened area located between the barrel 12 and the means 18 that close the product outlet opening 16.

Advantageously, the breakable connecting means 20 comprise a pre- weakened area provided at the means for association with the product injection means, and, more specifically, at the end of the nozzle 15 through which the product passes.

In particular, the breakable connecting means are embodied by a circumferentially thinner portion whose diameter is smaller than the outside diameter of the nozzle 15, and of the closing element 18b at the connection between the closing portion 18 and the nozzle 15. In practice, the pre-weakened area 20 is obtained by reducing the thickness or diameter of the portion that extends circumferentially around the full circular profile of the nozzle 15.

In practice, as illustrated, the breakable connecting portion 20 is defined by the reduced thickness of the closing element or seal 18b and has a transversal strip 20' for delimiting and sealing the opening 16 at the end of the nozzle.

Thus, the nozzle 15 is sealed in such a way as to avoid damage to the nozzle when the closure 18 is removed so that the user can easily fit the injection needle head.

For facilitating disengagement of the closing portion 18 from the barrel 12, advantageous means are provided for holding or gripping the closing means 18, said gripping means comprising a first and a second radial tab 181 and 182 that are transversally or radially aligned with each other and extend from the outside surface of the enlarged cylindrical portion 18a of the closure 18.

The grip tabs 181, 182 have a respective flattened body 181a, 182a, with a suitably shaped profile, having a portion 181b, 182b extending transversally of the enlarged portion 18a and respective portions 181c, 182c which extend longitudinally towards the barrel 12 and which taper radially towards the centre, that is to say, converge towards the end surface 12" of the barrel.

As illustrated, the radial tabs 181, 182 extend radially beyond the peripheral edge of the cylindrical barrel 12.

In the embodiment illustrated, the grip tabs 181, 182 have respective radial ends 181', 182', of reduced diameter or thickness, which connect them to the barrel 12, in particular to the outside surface of the nozzle 15 near the end 12" of the barrel, and which define respective breakable means for connection to the barrel. As illustrated, on the side opposite the product outlet, the barrel 12 has an inlet opening 22.

More specifically, said opening is advantageously used to fill the product 11 into the barrel and to insert product drive means, such as the plunger 24 for example, into the barrel.

The device according to the invention also advantageously comprises, at the same end as the inlet opening 22, means for closing the barrel 12 and for holding the product within.

As shown in the drawings, the means for closing the barrel at the inlet opening end 22, comprise a stopper 24 that is pressed in in such a way that its outside circumferential surface rubs against the inside surface 12' of the barrel 12.

The stopper 24 constitutes means for holding the liquid product 11 within the barrel and also serves as means for driving the liquid out of the syringe.

For this purpose, the stopper 24 comprises means 28 for engaging means used for driving the liquid out, said engagement means being embodied by a central recess formed in the middle of the stopper 24, into which a suitable pin forming part of a plunger rod, not illustrated in Figures IA and IB, can be inserted. As illustrated, the recess 28 for engaging the plunger rod is located on the side of the stopper 24 facing the outside of the barrel. As illustrated, at its inlet opening end 22, the barrel 12 has a widened edge

121 with which a membrane or film 26 for sealing the barrel is associated.

As illustrated, the film 26 has a substantially quadrangular, or rectangular, shape, while the engagement edge 121 has a curvilinear profile.

As illustrated, the corner portions 26a of the sealing film 26 extend transversally beyond the corresponding portion 121' of the widened engagement edge and serve as means for facilitating the removal of the sealing film 26 from the respective end of the barrel 12.

As illustrated, the widened edge 121 has, in particular, a first and a second transversal lip 121a, 121b extending radially to a greater extent on two opposite sides of the barrel 12.

In practice, this provides a large surface for connection to the sealing film 26 which makes it possible, if necessary, to hold the product 11 within the barrel 12 instead of using the stopper 24 for this purpose, as shown clearly in Figure 5.

As illustrated, the retaining portion 121 has a substantially elliptic profile and extends transversally, or radially, beyond the peripheral edge of the barrel 12, with the lips 121a, 121b substantially aligned with the grip tabs 181, 182 of the closing means 18 at the product outlet end.

In practice, the invention provides a device for administering a liquid 11, which contains said liquid in a prefilled and sterilized condition, and which is provided with suitable means for closing the outlet end 16 and the inlet end 22, and where the means for closing the barrel at the outlet end are advantageously in the form of breakable means.

Figures 2 A to 2E illustrate a method for making a device for administering a liquid product to a user, in particular a pharmaceutical product. As shown in Figure 2A, the method comprises the step of preparing a barrel 12 of the type described above, that is to say, having means for closing or sealing a liquid outlet opening which are connected to the barrel by breakable means that can be snapped off at the liquid outlet opening 16 and comprising means 17 for association with respective injection means, the liquid outlet opening 16 being located at the end of said association means.

Advantageously, the barrel 12 has a chamber, or space, 14 for containing the product and an opening 22 which communicates with the containing chamber or space 14 and through which the product 11 is filled, as shown in Figure 2B.

Advantageously, means 24, 26 for closing the product containing space 14 are placed, as illustrated in Figures 2C, 2D and 2E and the barrel 12 with the product 11 in it is sterilized at a high temperature in a suitable autoclave.

Advantageously, sterilization is performed after the means 24, 26 for closing the product containing space 14 have been placed.

In practice, as illustrated in Figure 2A, an empty barrel having the characteristics described above, labelled 12, is filled with liquid 11 by suitable means 30 through the inlet opening 22, as illustrated in Figure 2B.

In the next step, illustrated in Figure 2C, a stopper 24 is inserted into the opening 22 to serve both as means for closing the barrel 12 and as a plunger for driving the liquid out, and lastly, as illustrated in Figures 2D and 2E, a film or membrane 26 is applied to the transversal tabs 121a, 121b at the top of the barrel

12.

The stopper 24 is pressed in until its underside 24' touches the surface of the liquid 11, thereby eliminating to the greatest possible extent all the air that is in contact with the liquid. Figures 3A to 3F illustrate an advantageous method for administering a liquid product to a user, in particular for administering a pharmaceutical product or the like.

In this method, first of all, as shown in Figures 3A and 3B, means 18 for closing the product outlet opening 16 of a prefilled, hermetically sealed barrel 12 are disengaged from the barrel by breaking the connecting means 20, 181', 182' located between the closing means 18 and the barrel 12 itself, and next, as shown in Figures 3C and 3D, product injection means 40 are fitted to the barrel 12 at the product outlet opening 16.

As illustrated, the injection means or needle 40, comprise a head 41 that is applied to the outside surface 17 of the product outlet nozzle 15 extending from the barrel 12 and having at the end of it a product outlet opening 16 from which the closing element 18 was previously separated.

Next, as illustrated in Figure 3E, the sealing film or membrane 26 is removed from the top 121 of the barrel 12 and, as illustrated in Figure 3F, a plunger rod 44 having a pin 46 that fits into the hole 28 made in the stopper 24 is inserted.

At this point, the needle can be inserted into the body of the patient and the top 48 of the plunger rod pressed to force the liquid product 11 out of the barrel 12 through the needle 40, thereby administering the product to the patient as required. Figures 4 to 7 illustrate different kits for administering a liquid product to a user, in particular for administering a pharmaceutical product.

As shown in Figure 4, a first embodiment 50 of the kit comprises a container 52 consisting of a base, made preferably of rigid or semi-rigid plastic, and a top sealing film 54 that cooperates with the widened edge 53 of the container 52.

The kit comprises an administering device embodied by a prefilled barrel 12, as described above, in closed or sealed condition, a plunger rod 44, packed in a respective bag 44', and a needle holder cap 43, packed in a respective bag 43', containing a needle which is not shown in Figure 4. Figure 5, shows a second preferred embodiment 150 of the administering kit, comprising a container 52, 54 identical to the one of the first embodiment and therefore not described again.

In addition to a needle holder cap 43 containing a needle and packed in a respective bag 43', the second kit embodiment comprises an administering device 110 having a barrel 112 prefilled with product, a plunger rod 144, packed in a respective bag 44' and prefitted with a plunger 24 for driving the liquid 11.

In the second embodiment, the administering device 110 is the same as the device 10 described above, differing only in that the stopper/plunger 24 is not pre- inserted into the barrel 112. The means for closing the opening 22 are therefore constituted by the film 26 alone.

Figure 6 illustrates a third preferred embodiment 250 of the kit for administering a liquid product, in particular for administering a pharmaceutical product. The third embodiment comprises an administering device 222 having a barrel prefilled with the liquid to be administered, where the liquid is held within the barrel 12 solely by the stopper/plunger 24 with the plunger rod 44 already fitted to it being preinserted into the plunger/stopper 24 inside the barrel 12 and extending longitudinally outside the barrel.

The third embodiment also comprises a needle holder cap 43, containing a needle and packed in a respective bag 43'. This third kit is a package comprising a container 152 consisting of a base, made preferably of rigid or semi-rigid plastic and provided with a top sealing film 154 applied to the widened edge 153 of the container base. The container 152, 154 is smaller in size than the containers of the first and second kit embodiments 50, 150 described above. A fourth preferred kit 350 for administering a liquid product to a user, in particular for administering a pharmaceutical product or the like, comprises an administering device 222 having the same characteristics as the third preferred embodiment and is not described again.

The device 222 of the fourth preferred kit embodiment is housed in a container 352 which is even smaller since it does not include an injection needle and which also consists of a container base 352, made preferably of rigid or semirigid plastic and provided with a top sealing film 354 applied to the widened edge 353 of the container base.

Thus provided is a plurality of advantageous kits for easily administering a liquid product, in particular a pharmaceutical product or the like to a user.

The body of the device is made preferably of a plastic material, especially a rigid plastic material, that is resistant to high temperatures.

The invention described above is susceptible of industrial application and may be modified and adapted in several ways without thereby departing from the scope of the inventive concept. Moreover, all the details of the invention may be substituted by technically equivalent elements.

Claims

1. A device (10) for administering a liquid product to a user, in particular for administering a pharmaceutical product or the like, comprising a barrel (12) that presents a space (14) for containing the product (11) and which leads to a product outlet opening (16), and means for associating the containing space with means for injecting the product, the device being characterized in that it comprises means (18) for closing the product outlet opening (16), said closing means (18) being connected to the barrel (12) through breakable connecting means (20).

2. The device according to claim 1 or according to the preamble to claim 1, characterized in that it comprises means (18) for closing the product outlet opening (16), said closing means (18) being made as a single part with the barrel (12).

3. The device according to any of the foregoing claims, characterized in that the breakable connecting means (20) are made as a single part with the barrel (12).

4. The device according to any of the foregoing claims or according to the preamble to claim 1, characterized in that the means for association with the product injection means comprise the outside surface (17) of a product outlet nozzle (15) extending from the barrel (12) and provided with the product outlet opening (16).

5. The device according to claim 4, characterized in that the product outlet nozzle (15) extends from the barrel (12) and is conical in shape.

6. The device according to any of the foregoing claims, characterized in that the closing means are embodied by a full portion (18).

7. The device according to any of the foregoing claims, characterized in that the closing means are embodied by a portion (18) that is larger than the nozzle

(15).

8. The device according to claim 6 or 7, characterized in that the closing portion (18) has a part (18b) that tapers towards the barrel (12).

9. The device according to any of the foregoing claims, characterized in that the breakable connecting means (20) are located at the means (17) for association with the product injection means.

10. The device according to any of the foregoing claims, characterized in that the breakable connecting means (20) are located at the end of the means (17) for association with the product injection means.

11. The device according to any of the foregoing claims, characterized in that the breakable connecting means (20) are located at the end of the nozzle (15).

12. The device according to any of the foregoing claims, characterized in that the breakable connecting means (20) are embodied by a pre-weakened portion between the barrel (12) and the closing means (18).

13. The device according to any of the foregoing claims, characterized in that the breakable connecting means (20) are embodied by a circumferentially thinner portion.

14. The device according to any of the foregoing claims, characterized in that it comprises means for gripping the closing means (18).

15. The device according to claim 14, characterized in that the means for gripping the closing means (18) comprise a radial tab (181).

16. The device according to claim 15, characterized in that the means for gripping the closing means (18) comprise a second radial tab (182) transversally aligned with the first tab (181).

17. The device according to any of the foregoing claims from 14 to 16, characterized in that the means for gripping the closing means (18) are associated with the barrel (12) by breakable connecting means (181', 182').

18. The device according to any of the foregoing claims or according to the preamble to claim 1, characterized in that the barrel (12) has an inlet opening (22).

19. The device according to claim 18, characterized in that it comprises means (24, 26) for closing the barrel (12) at the same end as the inlet opening (22).

20. The device according to claim 19, characterized in that the means for closing the barrel at the inlet opening end (22), comprise a stopper (24) that is pressed in in such a way that its outside surface rubs against the inside surface (12') of the barrel (12).

21. The device according to any of the foregoing claims or according to the preamble to claim 1, characterized in that it comprises a stopper (24) that defines means for driving the product.

22. The device according to claim 20 or 21, characterized in that the stopper (24) comprises means (28) designed to be engaged by a plunger rod.

23. The device according to any of the foregoing claims from 19 to 22, characterized in that the means for closing the barrel at the product inlet end (22) comprise a strip of film (26).

24. The device according to any of the foregoing claims or according to the preamble to claim 1, characterized in that at the product inlet opening end (22) the barrel (12) has a widened edge (121).

25. The device according to claim 24, characterized in that the widened edge (121) comprises at least one extension lip (121a) extending from the barrel (12).

26. The device according to claim 25, characterized in that the widened edge (121) comprises a second extension lip (121b) extending from the barrel (12) on the side opposite that on which the first extension lip (121a) extends.

27. The device according to any of the foregoing claims from 24 to 26, characterized in that the extension lips (121a, 121b) are on the longitudinal extensions of the respective grip tabs (181, 182) of the means (18) for closing the outlet opening (16).

28. The device according to any of the foregoing claims from 24 to 27, characterized in that the barrel sealing film (26) has a portion (26a) that extends beyond the widened edge (121), defining means for gripping the sealing film.

29. The device according to any of the foregoing claims, characterized in that the connecting means (20) are embodied by a portion whose diameter or thickness is smaller than the outside diameter of the nozzle (15).

30. The device according to any of the foregoing claims, characterized in that the connecting means (20) are embodied by a portion whose thickness is smaller than the thickness of the closing portion (18).

31. The device according to any of the foregoing claims from 6 to 30, characterized in that the closing portion (18) has a cylindrical part (18a) that extends radially beyond the nozzle.

32. The device according to any of the foregoing claims, characterized in that the barrel is filled with the liquid product (11) to be administered.

33. The device according to any of the foregoing claims, characterized in that the barrel (12) has a general cylindrical shape.

34. The device according to any of the foregoing claims, characterized in that the barrel (12) is made of plastic.

35. A method for making a device for administering a liquid product to a user, in particular for making a device for administering a pharmaceutical product or the like, characterized in that use is made of a barrel (12) that comprises a space (14) for containing the product (11) and which leads to a product outlet opening (16), and means for associating the containing space with means for injecting the product, and where means (18) are provided for closing the product outlet opening (16), said closing means (18) being connected to the barrel (12) through breakable connecting means (20).

36. The method according to claim 35 or according to the preamble to claim 35, characterized in that use is made of a barrel (12) made of plastic, defining a space

(14) for containing the product (11), and an opening (22) in communication with the containing space (14); in that a predetermined quantity of the product (11) is filled into the containing space (14); in that means for closing the inlet opening (22) are inserted into the product containing space (14); and in that the barrel (12) is sterilized together with the product (11) it contains.

37. The method according to claims 35 or 36, characterized in that sterilization is done by heating.

38. The method according to any of the foregoing claims from 35 to 37, characterized in that sterilization is done after closing the barrel.

39. The method according to any of the foregoing claims from 35 to 38, characterized in that use is made of means for closing the barrel at the inlet opening end (22) and which comprise a stopper (24) that is pressed in in such a way that its outside surface rubs against the inside surface (12') of the barrel (12).

40. The method according to any of the foregoing claims from 35 to 39, characterized in that the means (24) for closing the barrel are moved into contact with the product (11) contained in the barrel.

41. The method according to any of the foregoing claims from 35 to 40, characterized in that the means for closing the barrel comprise a strip of film (26) for sealing the barrel.

42. The method according to any of the foregoing claims from 35 to 41, characterized in that the barrel sealing film (26) is applied to the end of a widened edge (121) of the barrel.

43. The method according to any of the foregoing claims from 35 to 42 or according to the preamble to claim 35, characterized in that use is made of a device according to any of the foregoing claims from 1 to 34.

44. A method for administering a liquid product to a user, in particular for administering a pharmaceutical product or the like, characterized in that, starting from a prefilled barrel (12), means (18) for closing the product outlet opening (16) are disengaged from the barrel (12) by breaking the connecting means (20) located between the closing means (18) and the barrel (12) itself and in that product injection means (40) are then fitted to the barrel (12) at the product outlet opening (16).

45. The method according to claim 44, characterized in that the injection means are associated with the outside surface (17) of a product outlet nozzle (15) extending from the barrel (12) and provided with the product outlet opening (16).

46. The method according to claim 44 or 45, characterized in that comprises a step of disengaging means (26) for closing an inlet opening (22) of the barrel.

47. The method according to any of the foregoing claims from 44 to 46, characterized in that it comprises a step of engaging means (44) for driving the product out of the barrel (12).

48. The method according to any of the foregoing claims from 44 to 47, characterized in that it comprises a step of engaging a rod (44) forming part of the product drive means with a stopper (24) that has been inserted into the barrel (12).

49. A kit (50, 150, 250, 350) for administering a liquid product to a user, in particular for administering a pharmaceutical product or the like, characterized in that it comprises a container (52, 54) and a device (10, 150, 250, 350) for administering a liquid product (11) according to any of the foregoing claims from 1 to 34.

50. The kit according to claim 49, characterized in that it comprises an injection needle.

51. The kit according to claim 49 or 50, characterized in that it comprises a plunger rod (44) for driving out the product.

52. The kit according to any of the foregoing claims from 49 to 51, characterized in that it comprises a drive rod (44) fitted with a plunger (24) for driving out the product.