EP2051726A4 - METHOD FOR TREATING PAIN AND SYSTEMATICALLY SEEKING ANALGESIC COMPOUNDS - Google Patents

METHOD FOR TREATING PAIN AND SYSTEMATICALLY SEEKING ANALGESIC COMPOUNDS

Info

Publication number
EP2051726A4
EP2051726A4 EP07796903A EP07796903A EP2051726A4 EP 2051726 A4 EP2051726 A4 EP 2051726A4 EP 07796903 A EP07796903 A EP 07796903A EP 07796903 A EP07796903 A EP 07796903A EP 2051726 A4 EP2051726 A4 EP 2051726A4
Authority
EP
European Patent Office
Prior art keywords
systematically
seeking
treating pain
analgesic compounds
analgesic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP07796903A
Other languages
German (de)
French (fr)
Other versions
EP2051726B1 (en
EP2051726A2 (en
Inventor
J Michael Mcintosh
Baldomero M Olivera
Michael A Ellison
Michelle Vincler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Utah Research Foundation Inc
Original Assignee
University of Utah Research Foundation Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Utah Research Foundation Inc filed Critical University of Utah Research Foundation Inc
Publication of EP2051726A2 publication Critical patent/EP2051726A2/en
Publication of EP2051726A4 publication Critical patent/EP2051726A4/en
Application granted granted Critical
Publication of EP2051726B1 publication Critical patent/EP2051726B1/en
Not-in-force legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1767—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
    • G01N33/9406—Neurotransmitters
    • G01N33/944—Acetylcholine
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Food Science & Technology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Transplantation (AREA)
EP07796903.8A 2006-07-18 2007-07-17 Methods for treating pain and screening analgesic compounds Not-in-force EP2051726B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US83146806P 2006-07-18 2006-07-18
PCT/US2007/016163 WO2008011006A2 (en) 2006-07-18 2007-07-17 Methods for treating pain and screening analgesic compounds

Publications (3)

Publication Number Publication Date
EP2051726A2 EP2051726A2 (en) 2009-04-29
EP2051726A4 true EP2051726A4 (en) 2012-06-20
EP2051726B1 EP2051726B1 (en) 2018-04-18

Family

ID=38957314

Family Applications (1)

Application Number Title Priority Date Filing Date
EP07796903.8A Not-in-force EP2051726B1 (en) 2006-07-18 2007-07-17 Methods for treating pain and screening analgesic compounds

Country Status (6)

Country Link
US (1) US9717775B2 (en)
EP (1) EP2051726B1 (en)
JP (2) JP5558817B2 (en)
AU (1) AU2007275764B2 (en)
CA (1) CA2657532C (en)
WO (1) WO2008011006A2 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008011006A2 (en) 2006-07-18 2008-01-24 University Of Utah Research Foundation Methods for treating pain and screening analgesic compounds
US9284358B2 (en) * 2006-07-18 2016-03-15 University Of Utah Research Foundation Conotoxin peptides
WO2014194284A1 (en) 2013-05-31 2014-12-04 Mcintosh J Michael Conotoxin peptides, pharmaceutical compositions and uses thereof
KR102170077B1 (en) * 2018-05-21 2020-10-27 인하대학교 산학협력단 Specific monoclonal antibody against autocatalytic loop portion of PRSS14/ST14 and use thereof
EP4393504A2 (en) * 2018-12-26 2024-07-03 Skinmed Co., Ltd. Acetylcholine receptor inhibitory peptides and uses thereof
US11612661B2 (en) 2019-01-04 2023-03-28 Kineta Chronic Pain, Llc Conotoxin peptide analogs and uses for the treatment of pain and inflammatory conditions
AU2019418319B2 (en) * 2019-01-04 2025-08-21 Pacira Pharmaceuticals, Inc. Conotoxin peptide analogs and uses for the treatment of pain and inflammatory conditions
WO2020234179A1 (en) * 2019-05-17 2020-11-26 Janssen Pharmaceutica Nv Expression systems for the alpha 9/alpha 10 nicotinic acetylcholine receptor and methods of use thereof
CN113493502B (en) * 2020-04-01 2023-09-12 广西大学 α-conotoxin peptide TxIE, pharmaceutical compositions and uses thereof
WO2023008913A1 (en) * 2021-07-27 2023-02-02 주식회사 스킨메드 Optimized shortened peptide that binds to acetylcholine receptor, and use thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000044769A1 (en) * 1999-01-29 2000-08-03 University Of Utah Research Foundation Conotoxin peptides
EP1090991A1 (en) * 1999-09-29 2001-04-11 Sanofi-Synthelabo Novel nicotinic acetylcholine receptor subunit, its isolation and use
WO2002064740A2 (en) * 2001-02-09 2002-08-22 Cognetix, Inc. Cone snail peptides

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4352883A (en) 1979-03-28 1982-10-05 Damon Corporation Encapsulation of biological material
US4353888A (en) 1980-12-23 1982-10-12 Sefton Michael V Encapsulation of live animal cells
US4883666A (en) 1987-04-29 1989-11-28 Massachusetts Institute Of Technology Controlled drug delivery system for treatment of neural disorders
US5283187A (en) 1987-11-17 1994-02-01 Brown University Research Foundation Cell culture-containing tubular capsule produced by co-extrusion
US5158881A (en) 1987-11-17 1992-10-27 Brown University Research Foundation Method and system for encapsulating cells in a tubular extrudate in separate cell compartments
DE3829766A1 (en) 1988-09-01 1990-03-22 Akzo Gmbh METHOD FOR PRODUCING MEMBRANES
DE3829752A1 (en) 1988-09-01 1990-03-22 Akzo Gmbh INTEGRAL ASYMMETRICAL POLYAETHERSULPHONE MEMBRANE, METHOD FOR THE PRODUCTION AND USE FOR ULTRAFILTRATION AND MICROFILTRATION
US5082670A (en) 1988-12-15 1992-01-21 The Regents Of The University Of California Method of grafting genetically modified cells to treat defects, disease or damage or the central nervous system
US5084350A (en) 1990-02-16 1992-01-28 The Royal Institution For The Advance Of Learning (Mcgill University) Method for encapsulating biologically active material including cells
US5618531A (en) 1990-10-19 1997-04-08 New York University Method for increasing the viability of cells which are administered to the brain or spinal cord
DK0585368T3 (en) 1991-04-25 1998-03-16 Univ Brown Res Found Implantable biocompatible immuno-insulating vehicle for delivery of selected therapeutic products
US5854217A (en) 1992-09-28 1998-12-29 Bearsden Bio, Inc. Allosteric modulators of the NMDA receptor and their use in the treatment of CNS disorders and enhancement of CNS function
DE69423522T2 (en) 1993-04-27 2000-09-21 Cytotherapeutics, Inc. ACRYLNITRILE POLYMER MEMBRANE
EP0708670A4 (en) 1993-06-23 1998-07-01 Cytotherapeutics Inc Method and apparatus for sealing implantable, membrane encapsulation devices
CA2169292C (en) 1993-08-12 2010-11-23 E. Edward Baetge Improved compositions and methods for the delivery of biologically active molecules using genetically altered cells contained in biocompatible immunoisolatory capsules
US5550050A (en) 1994-04-15 1996-08-27 Cytotherapeutics, Inc. Method for implanting encapsulated cells in a host
US5776747A (en) 1994-07-20 1998-07-07 Cytotherapeutics, Inc. Method for controlling the distribution of cells within a bioartificial organ using polycthylene oxide-poly (dimethylsiloxane) copolymer
US5834029A (en) 1994-07-20 1998-11-10 Cytotherapeutics, Inc. Nerve guidance channel containing bioartificial three-dimensional hydrogel extracellular matrix derivatized with cell adhesive peptide fragment
US5837234A (en) 1995-06-07 1998-11-17 Cytotherapeutics, Inc. Bioartificial organ containing cells encapsulated in a permselective polyether suflfone membrane
IN181898B (en) 1995-06-07 1998-10-24 Cytotherapeutics Inc
AU7204996A (en) 1995-10-02 1997-04-28 Cytotherapeutics, Inc. Method for treating amyotrophic lateral sclerosis
EP0893950A4 (en) * 1996-03-26 2002-02-27 Univ California SELECTIVE ACTIVATION OF TARGET CELLS BY EXPRESSION OF A RECEPTOR SUPERIORALLY ACTIVATED BY A SYNTHETIC LIGAND AND COUPLED TO A PROTEIN G
US5844077A (en) 1997-04-28 1998-12-01 Cytotherapeutics, Inc. Use of conantokins for producing analgesia or for neuroprotection
US6265541B1 (en) * 1997-12-31 2001-07-24 University Of Utah Research Foundation Uses of α-conotoxin peptides
WO2000044776A1 (en) 1999-01-29 2000-08-03 University Of Utah Research Foundation Alpha-conotoxin peptides
JP2003509045A (en) 1999-09-15 2003-03-11 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ Nicotinic acetylcholine receptor: alpha 10 subunit
AUPR409401A0 (en) 2001-03-29 2001-04-26 University Of Melbourne, The Analgesic compound
JP2009502976A (en) * 2005-08-02 2009-01-29 メタボリック・ファーマシューティカルズ・リミテッド Peptide conjugates for oral delivery of hydrophilic peptide analgesics
AU2006236006B2 (en) 2006-04-13 2012-09-06 The University Of Queensland Cyclised a-conotoxin peptides
US9284358B2 (en) 2006-07-18 2016-03-15 University Of Utah Research Foundation Conotoxin peptides
WO2008011006A2 (en) 2006-07-18 2008-01-24 University Of Utah Research Foundation Methods for treating pain and screening analgesic compounds

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000044769A1 (en) * 1999-01-29 2000-08-03 University Of Utah Research Foundation Conotoxin peptides
EP1090991A1 (en) * 1999-09-29 2001-04-11 Sanofi-Synthelabo Novel nicotinic acetylcholine receptor subunit, its isolation and use
WO2002064740A2 (en) * 2001-02-09 2002-08-22 Cognetix, Inc. Cone snail peptides

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
"OPL152 ACV1, a novel alpha-conotoxin, promotes functional recovery in injured neurons and reduces oxidative stress levels", JOURNAL OF NEUROLOGICAL SCIENCES, ELSEVIER SCIENTIFIC PUBLISHING CO, AMSTERDAM, NL, vol. 238, 1 January 2005 (2005-01-01), pages S84 - S85, XP027711165, ISSN: 0022-510X, [retrieved on 20050101] *
J. M. MCINTOSH: "A Novel -Conotoxin, PeIA, Cloned from Conus pergrandis, Discriminates between Rat 9 10 and 7 Nicotinic Cholinergic Receptors", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 280, no. 34, 1 January 2005 (2005-01-01), pages 30107 - 30112, XP055026958, ISSN: 0021-9258, DOI: 10.1074/jbc.M504102200 *
MICHAEL ELLISON ET AL: "[alpha]-RgIA: A Novel Conotoxin That Specifically and Potently Blocks the [alpha]9[alpha]10 nAChR + , +", BIOCHEMISTRY, vol. 45, no. 5, 1 February 2006 (2006-02-01), pages 1511 - 1517, XP055026858, ISSN: 0006-2960, DOI: 10.1021/bi0520129 *
See also references of WO2008011006A2 *

Also Published As

Publication number Publication date
CA2657532A1 (en) 2008-01-24
JP2014210784A (en) 2014-11-13
US9717775B2 (en) 2017-08-01
EP2051726B1 (en) 2018-04-18
EP2051726A2 (en) 2009-04-29
AU2007275764A1 (en) 2008-01-24
WO2008011006A3 (en) 2008-06-19
JP2009545526A (en) 2009-12-24
JP5953338B2 (en) 2016-07-20
WO2008011006A2 (en) 2008-01-24
JP5558817B2 (en) 2014-07-23
US20090203616A1 (en) 2009-08-13
AU2007275764B2 (en) 2013-11-14
CA2657532C (en) 2019-06-18

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