EP2028938A4 - 3,4-disubstituted coumarin and quinolone compounds - Google Patents

3,4-disubstituted coumarin and quinolone compounds

Info

Publication number
EP2028938A4
EP2028938A4 EP06759899A EP06759899A EP2028938A4 EP 2028938 A4 EP2028938 A4 EP 2028938A4 EP 06759899 A EP06759899 A EP 06759899A EP 06759899 A EP06759899 A EP 06759899A EP 2028938 A4 EP2028938 A4 EP 2028938A4
Authority
EP
European Patent Office
Prior art keywords
quinolone compounds
coumarin
disubstituted
disubstituted coumarin
quinolone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP06759899A
Other languages
German (de)
French (fr)
Other versions
EP2028938A1 (en
Inventor
Bin Xu
Qiang Zhu
Hyun-Joon Cho
Reza Fathi
Zhen Yang
Anthony Sandrasagra
Yixin Liu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
XTL Biopharmaceuticals Ltd
Original Assignee
XTL Biopharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by XTL Biopharmaceuticals Ltd filed Critical XTL Biopharmaceuticals Ltd
Publication of EP2028938A1 publication Critical patent/EP2028938A1/en
Publication of EP2028938A4 publication Critical patent/EP2028938A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/42—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4
    • C07D311/56—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4 without hydrogen atoms in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/68—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with nitrogen atoms directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
EP06759899A 2006-05-15 2006-05-15 3,4-disubstituted coumarin and quinolone compounds Withdrawn EP2028938A4 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2006/018857 WO2007133211A1 (en) 2006-05-15 2006-05-15 3,4-disubstituted coumarin and quinolone compounds

Publications (2)

Publication Number Publication Date
EP2028938A1 EP2028938A1 (en) 2009-03-04
EP2028938A4 true EP2028938A4 (en) 2010-07-07

Family

ID=38694184

Family Applications (1)

Application Number Title Priority Date Filing Date
EP06759899A Withdrawn EP2028938A4 (en) 2006-05-15 2006-05-15 3,4-disubstituted coumarin and quinolone compounds

Country Status (5)

Country Link
EP (1) EP2028938A4 (en)
JP (1) JP2009537518A (en)
AU (1) AU2006343604A1 (en)
CA (1) CA2694955A1 (en)
WO (1) WO2007133211A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9353122B2 (en) 2013-02-15 2016-05-31 Kala Pharmaceuticals, Inc. Therapeutic compounds and uses thereof

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090312406A1 (en) * 2008-06-12 2009-12-17 Hsing-Pang Hsieh Coumarin compounds and their use for treating viral infection
US9688688B2 (en) 2013-02-20 2017-06-27 Kala Pharmaceuticals, Inc. Crystalline forms of 4-((4-((4-fluoro-2-methyl-1H-indol-5-yl)oxy)-6-methoxyquinazolin-7-yl)oxy)-1-(2-oxa-7-azaspiro[3.5]nonan-7-yl)butan-1-one and uses thereof
CA2900680C (en) 2013-02-20 2021-08-10 Kala Pharmaceuticals, Inc. Quinoline and quinazoline compounds and uses thereof for treating and/or preventing diseases
US9890173B2 (en) 2013-11-01 2018-02-13 Kala Pharmaceuticals, Inc. Crystalline forms of therapeutic compounds and uses thereof
MX355330B (en) 2013-11-01 2018-04-16 Kala Pharmaceuticals Inc CRYSTALLINE FORMS OF THERAPEUTIC COMPOUNDS and USES THEREOF.
US10392399B2 (en) 2016-09-08 2019-08-27 Kala Pharmaceuticals, Inc. Crystalline forms of therapeutic compounds and uses thereof
US10336767B2 (en) 2016-09-08 2019-07-02 Kala Pharmaceuticals, Inc. Crystalline forms of therapeutic compounds and uses thereof
WO2018048747A1 (en) 2016-09-08 2018-03-15 Kala Pharmaceuticals, Inc. Crystalline forms of therapeutic compounds and uses thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005068450A1 (en) * 2004-01-06 2005-07-28 Vivoquest, Inc. 4-thio coumarins

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0772176B2 (en) * 1991-04-03 1995-08-02 コリア リサーチ インスティチュート オブ ケミカル テクノロジイ 2-quinolinone derivative
IL123701A (en) * 1995-10-13 2002-03-10 Agrevo Uk Ltd Heterocyclic fungicides and some new compounds
FR2749585B1 (en) * 1996-06-11 1998-08-14 Hoechst Marion Roussel Inc NOVEL AROMATIC DERIVATIVES SUBSTITUTED BY RIBOSIS, PROCESS FOR THEIR PREPARATION AND THEIR APPLICATION AS MEDICAMENTS

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005068450A1 (en) * 2004-01-06 2005-07-28 Vivoquest, Inc. 4-thio coumarins

Non-Patent Citations (19)

* Cited by examiner, † Cited by third party
Title
ANSCHÜTZ R: "Ueber die Benzotetronsäuregruppe", JUSTUS LIEBIGS ANALEN DER CHEMIE, vol. 367, 1 January 1909 (1909-01-01), pages 219 - 270, XP002576917 *
BANDYOPADHYAY C ET AL: "Synthesis of coumarin derivatives from 4-oxo-4H-1-benzopyran-3-caroboxaldehyde via 3-(arylaminomethylene)chromane-2,4-dione", TETRAHEDRON, vol. 56, 1 January 2000 (2000-01-01), pages 3583 - 3587, XP002576926 *
BUKALEV VM ET AL: "Synthesis of 4,7-diamino-3-formylcoumarins and azomethines derived from them", CHEMISTRY OF HETEROCYCLIC COMPOUNDS, vol. 29, no. 3, 1 January 1993 (1993-01-01), pages 282 - 291, XP002576923 *
CHECCHI S ET AL: "RICERCHE SPORA LA 4-IDROSSICUMARINA E DERIVATI. - NOTA IX. CLORURAZIONE DELLA 4-IDROSSICUMARINA E REAZIONI FRA 4-CLOROCUMARINA E COMPOSTI SODICI DI ESTERI E CHETONI AVENTI UN METILENE ATTIVO", GAZZETTA CHIMICA ITALIANA, SOCIETA CHIMICA, ITALIANA, ROME; IT, vol. 99, 1 January 1969 (1969-01-01), pages 501 - 513, XP009042561, ISSN: 0016-5603 *
HEBER D: "2.5-Dioxo-2H,5H-(1)-benzopyrano(4,3-b)pyridine durch cyclisierung 3-substituierter 4-aminocumarine", ARCHIV DER PHARMAZIE, vol. 320, no. 7, 1 July 1987 (1987-07-01), pages 577 - 581, XP002576922 *
IVANOV IC ET AL: "Two method for the preparation of 3-dialkylaminomethyl derivatives (Mannich bases) of 4-aminocoumarin: a new type of intramolecular hydride transfer", SYNTHESIS, vol. 6, 1 January 1995 (1995-01-01), pages 633 - 634, XP002576919 *
KARANDASHOVA LA ET AL: "Basicity of 3-formyl-4,7-diaminocoumarins and their azomethine derivatives", CHEMISTRY OF HETEROCYCLIC COMPOUNDS, vol. 29, no. 3, 1 January 1993 (1993-01-01), pages 292 - 294, XP002576925 *
KIRPICHENOK MA ET AL: "Reactions of 4-chloro-7-dialkylamino- and 3-alkyl-4-chloro-7-dialkylaminocoumarins with primary and secondary alkylamines", CHEMISTRY OF HETEROCYCLIC COMPOUNDS, vol. 26, no. 26, 1 January 1990 (1990-01-01), pages 698 - 701, XP002576932 *
KIRPICHENOK MA ET AL: "Synthesis and spectral and luminescent properties of 3-formyl-7-dialkylaminocoumarins", CHEMISTRY OF HETEROCYCLIC COMPOUNDS, vol. 27, no. 11, 1 January 1991 (1991-01-01), pages 1193 - 1199, XP002576921 *
KUROKI Y: "thermal ene reaction of 4-(2-alkenylamino)-3-formyl-2(2H)-chromenones", TETRAHEDRON, vol. 50, no. 4, 1 January 1994 (1994-01-01), pages 1063 - 1072, XP002576927 *
PRYANISHNIKOVA NT ET AL: "Synthesis and study of the pharmacological properties of 3,4-diaminocoumarins and 3-substituted 4-aminothiocoumarins", PHARMACEUTICAL CHEMISTRY JOURNAL, vol. 12, no. 12, 1 January 1978 (1978-01-01), pages 1590 - 1593, XP002576928 *
SAVEL'EV VL ET AL: "Synthesis and pharmacological activity of 4H-(1)-benzopyrano(3,4-d)imidazol-4-ones", PHARMACEUTICAL CHEMISTRY JOURNAL, vol. 17, no. 6, 1 January 1983 (1983-01-01), pages 423 - 425, XP002576924 *
SAVEL'EV VL ET AL: "Synthesis and study of the properties of 4-substituted 3-aminomethylcoumarins", CHEMISTRY OF HETEROCYCLIC COMPOUNDS, vol. 18, no. 7, 1 January 1982 (1982-01-01), pages 676 - 679, XP002576920 *
SAVEL'EV: "N-(3-nitro(amino)coumarin-4-yl)antrhranilic acid amides. Synthesis of 6, 7, 8, 13-tetrahydro(1)benzopyrano(4,3-b)(1,4)benzodiazepine-6,8-dione", CHEMISTRY OF HETEROCYCLIC COMPOUNDS, vol. 25, no. 9, 1 January 1989 (1989-01-01), pages 1011 - 1014, XP002576930 *
See also references of WO2007133211A1 *
STADLBAUER W ET AL: "Isochinoline(4,3-c)chinolone aus phenylmalonylheterocyclen", MONATSHEFTE FÜR CHEMIE, vol. 113, 1 January 1982 (1982-01-01), pages 751 - 760, XP002576929 *
STADLBAUER W ET AL: "SYNTHESE VON INDOLEN UND ISOCHINOLONEN AUS PHENYLMALONYLHETEROCYCLEN/ /SYNTHESIS OF INDOLES AND ISOQUINOLONES FROM PHENYLMALONATE HETEROCYCLES", MONATSHEFTE FUR CHEMIE, SPRINGER VERLAG WIEN, AT LNKD- DOI:10.1007/BF00810008, vol. 115, no. 4, 1 January 1984 (1984-01-01), pages 467 - 475, XP009049675, ISSN: 0026-9247 *
STEINFÜHRER T ET AL: "heterocyclisch (c)-anellierte Cumarine aus 4-Azido-3-cumarinecarbaldehyden", LIEBIGS ANNALEN DER CHEMIE, vol. 1, 1 January 1992 (1992-01-01), pages 23 - 28, XP002576931 *
TABAKOVIC K ET AL: "A novel transformation of 4-aylaminocoumarins to 6H-1-benzopyrano[4,3-b]quinolin-6-ones", SYNTHESIS, vol. 3, 1 January 1987 (1987-01-01), pages 308 - 310, XP002576918 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9353122B2 (en) 2013-02-15 2016-05-31 Kala Pharmaceuticals, Inc. Therapeutic compounds and uses thereof

Also Published As

Publication number Publication date
CA2694955A1 (en) 2007-11-22
AU2006343604A1 (en) 2007-11-22
WO2007133211A1 (en) 2007-11-22
EP2028938A1 (en) 2009-03-04
JP2009537518A (en) 2009-10-29

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Legal Events

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RIN1 Information on inventor provided before grant (corrected)

Inventor name: LIU, YIXIN

Inventor name: SANDRASAGRA, ANTHONY

Inventor name: YANG, ZHEN

Inventor name: FATHI, REZA

Inventor name: CHO, HYUN-JOON

Inventor name: ZHU, QIANG

Inventor name: XU, BIN

RIC1 Information provided on ipc code assigned before grant

Ipc: C07D 311/56 20060101ALI20100525BHEP

Ipc: C07D 215/22 20060101ALI20100525BHEP

Ipc: A61K 31/44 20060101ALI20100525BHEP

Ipc: A01N 43/42 20060101AFI20080123BHEP

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