EP1973496A1 - Arterial endoprosthesis - Google Patents

Arterial endoprosthesis

Info

Publication number
EP1973496A1
EP1973496A1 EP07717737A EP07717737A EP1973496A1 EP 1973496 A1 EP1973496 A1 EP 1973496A1 EP 07717737 A EP07717737 A EP 07717737A EP 07717737 A EP07717737 A EP 07717737A EP 1973496 A1 EP1973496 A1 EP 1973496A1
Authority
EP
European Patent Office
Prior art keywords
blood
projections
stent
arterial
artery
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP07717737A
Other languages
German (de)
French (fr)
Inventor
Nicolas Durrleman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Association Rene Leriche
Original Assignee
Association Rene Leriche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Association Rene Leriche filed Critical Association Rene Leriche
Publication of EP1973496A1 publication Critical patent/EP1973496A1/en
Withdrawn legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
    • A61F2/06—Blood vessels
    • A61F2/07—Stent-grafts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
    • A61F2/06—Blood vessels
    • A61F2002/068—Modifying the blood flow model, e.g. by diffuser or deflector
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
    • A61F2/06—Blood vessels
    • A61F2/07—Stent-grafts
    • A61F2002/072—Encapsulated stents, e.g. wire or whole stent embedded in lining

Definitions

  • the present invention relates to an arterial stent, in particular aortic stent.
  • the aorta is an artery of the human body connected to the left ventricle of the heart and down the spine, giving rise to many blood vessels, which irrigate the entire body.
  • Aortic prostheses are commonly used in surgery. They are indeed able to reduce the risk of rupture of aneurysm, non-natural and localized dilation of the aorta, often because of an instantaneous death.
  • a tubular aortic endoprosthesis comprising a sealed duct located inside the aorta is known in particular. It is represented in FIG.
  • This duct 12 is adapted to the diameter of the aorta 4 with the aid of a spring 14, disposed inside the duct, so as to provide at the location of the aneurysm 6 a lane for circulation blood, this path being the usual diameter of the aorta.
  • this type of stent 2 is to prevent the blood from circulating in the dilated portion of the aneurysm 6.
  • a blood flow 18 can circulate outside the duct, because of the pressure exerted by the blood on the walls 16.
  • the object of the invention is in particular to remedy these drawbacks by providing an aortic stent capable of eliminating the risk of type 1 endoleaks, and thus of reducing the failure rate of the surgical procedure intended to place this prosthesis.
  • the subject of the invention is an arterial stent intended to be applied against the internal wall of an artery, characterized in that it comprises, on its external face, protrusions distributed so as to reduce the speed of a blood flow circulating between the artery and the stent.
  • the roughness of the surface is large, which ensures better adhesion of the prosthesis to the wall of the artery than in existing models, thus avoiding possible prosthetic migrations.
  • the stent according to the invention avoids type 3 endoleaks, which occur in the case of microdissure of the prosthesis duct.
  • the coagulated blood then prevents the fluid blood circulating inside the conduit from coming out by the micro Méchure.
  • the projections are of hemispherical shape.
  • the projections are staggered in the longitudinal direction of the stent.
  • the slowing of the flow is optimized.
  • the projections are made of microporous material. Such protrusions absorb part of the circulating blood in the dilated portion of the artery. The blood retained in the projections and thus rendered immobile coagulates rapidly. Now, the coagulation of the blood taking place step by step, the blood coagulated in the projections initiates the coagulation of the slowed blood circulating around them.
  • Coagulation is then faster because initiated in several places simultaneously.
  • the outer wall of the stent is covered with a film of a waterproof material, solubilizing slowly in contact with the blood, allowing the projections to keep a minimum volume during implantation.
  • the projections are then covered by the waterproof film and, during the first hours of residence of the prosthesis in the human body, the function of absorption of the projections is not activated.
  • the prosthesis Since the prosthesis is generally inserted into the human body by the femoral artery, then slid up the aneurysm up the aorta, its implementation is greatly facilitated by the fact that the projections are compacted and their volume is minimal. Thanks to the tight film, the blood does not penetrate immediately into the protrusions, which retain their minimal volume of compaction. A few hours after the placement of the stent, solubilization of the film in contact with the blood allows the microporous projections to act as described above.
  • the film is made of gelatin.
  • FIG. 1 is a view of an arterial stent according to the state of the prior art, commented before;
  • FIG. 2 is a side view of the stent according to a particular embodiment
  • FIG. 3A is a longitudinal section of the stent according to this embodiment, before its introduction into the human body;
  • FIG. 3B is a longitudinal section of the stent according to this embodiment, after its introduction to the place of the aneurysm.
  • the figures show the endoprosthesis 20 according to the invention.
  • the stent 2 Just like the stent 2 known to those skilled in the art and shown in Figure 1, it comprises a sealed conduit 12 ', polyester or PTFE (PolyTetraFluorEthylene), providing a way for the flow of blood to the place of the aneurysm 6, and a spring 14 ', generally made of a non-corrosive metal alloy, not harmful to the human body and allowing the conduit 12' to adapt to the diameter of the aorta.
  • PTFE PolyTetraFluorEthylene
  • the arterial stent 20 further comprises, on its outer face, hemispherical projections 22 arranged staggered in its longitudinal direction.
  • the projections 22 thus arranged create a "labyrinth effect": turbulences 24 occur accidentally in a blood stream 18, between the wall 16 of the aorta and the prosthesis 20. These turbulences 24 cause a decrease in the speed of blood in the endoleak.
  • the blood is also absorbed by these protrusions 22, which are made of microporous material, for example a woven polyester thread.
  • the absorbed blood is immobilized, which promotes its coagulation, or thrombosis.
  • the disturbed and slowed blood flowing in the vicinity of the projections 22 coagulates in turn easily because of its reduced speed and the presence of coagulated blood in its vicinity, since the coagulation is done step by step.
  • This coagulation of the blood thus makes it possible to permanently seal the orifice through which the flow of blood 18 was accidentally engaged in the dilated part of the aneurysm 6.
  • FIG. 3A shows the endoprosthesis 20 according to the invention before it is introduced into the human body.
  • the projections 22 are covered with a waterproof film 26 of gelatin.
  • the projections do not swell by absorption blood: they are compacted and the volume of the prosthesis 20 is minimal. This can be easily moved up the femoral artery and the aorta 4 to the aneurysm 6.
  • the film 26 of gelatin which is not harmful to the human body, dissolves in the blood, as seen in FIG. 3B, this material solubilizing slowly in contact with the blood.
  • the projections 22 are then in contact with the blood stream 18 and absorb it by "sponge effect". Therefore, their volume increases by absorption of the blood and they allow the coagulation of the latter and the obstruction of the orifice, as described above.
  • the projections 22 inflated after the introduction of the stent 20 also consolidate the positioning thereof by "crampon effect".
  • the stent 20 as described above thus has many advantages to reduce the risk of aneurysm rupture after surgery, eliminating certain types of endoleaks.

Landscapes

  • Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Prostheses (AREA)
  • Media Introduction/Drainage Providing Device (AREA)

Abstract

Arterial endoprosthesis (2), in particular for the aorta, having an outer face designed to bear against the inner wall of an artery, and comprising, on its outer face, projections (22) that are distributed in such a way as to reduce the speed of a flow of blood (18) circulating between the artery and the prosthesis (20).

Description

Endoprothèse artérielle. Arterial stent.
La présente invention concerne une endoprothèse artérielle, en particulier aortique.The present invention relates to an arterial stent, in particular aortic stent.
L'aorte est une artère du corps humain reliée au ventricule gauche du cœur et descendant le long de la colonne vertébrale, donnant naissance à de nombreux vaisseaux sanguins, qui irriguent tout le corps.The aorta is an artery of the human body connected to the left ventricle of the heart and down the spine, giving rise to many blood vessels, which irrigate the entire body.
Les prothèses aortiques sont couramment utilisées dans le cadre de la chirurgie. Elles sont en effet capables de diminuer le risque de rupture d'un anévrisme, dilatation non naturelle et localisée de l'aorte, souvent cause d'une mort instantanée.Aortic prostheses are commonly used in surgery. They are indeed able to reduce the risk of rupture of aneurysm, non-natural and localized dilation of the aorta, often because of an instantaneous death.
On connaît notamment, dans l'état de la technique, une endoprothèse aortique tubulaire comprenant un conduit étanche et située à l'intérieur de l'aorte. Elle est représentée sur la figure 1.In the state of the art, a tubular aortic endoprosthesis comprising a sealed duct located inside the aorta is known in particular. It is represented in FIG.
Ce conduit étanche 12 s'adapte au diamètre de l'aorte 4 avec l'aide d'un ressort 14, disposé à l'intérieur du conduit, de manière à ménager à l'endroit de l'anévrisme 6 une voie pour la circulation du sang, cette voie étant du diamètre habituel de l'aorte.This duct 12 is adapted to the diameter of the aorta 4 with the aid of a spring 14, disposed inside the duct, so as to provide at the location of the aneurysm 6 a lane for circulation blood, this path being the usual diameter of the aorta.
Le but de ce type d'endoprothèse 2 est d'empêcher le sang de circuler dans la partie dilatée de l'anévrisme 6. Toutefois, malgré la pression exercée par le ressort 14 sur le conduit 12 pour que celui-ci colle à la paroi 16 et rende la liaison paroi-prothèse 17 étanche, un flux sanguin 18 peut circuler en dehors du conduit, en raison de la pression exercée par le sang sur les parois 16.The purpose of this type of stent 2 is to prevent the blood from circulating in the dilated portion of the aneurysm 6. However, despite the pressure exerted by the spring 14 on the conduit 12 for it to stick to the wall 16 and makes the wall-prosthesis connection 17 tight, a blood flow 18 can circulate outside the duct, because of the pressure exerted by the blood on the walls 16.
Ce flux sanguin 18 circulant dans la partie dilatée de l'anévrisme en raison du défaut de l'accolement entre la prothèse 2 et la paroi 16 est un phénomène appelé « endofuites de type 1 ».This blood flow 18 flowing in the dilated portion of the aneurysm due to the lack of adhesion between the prosthesis 2 and the wall 16 is a phenomenon called "endoleaks type 1".
Ces fuites créent une pression sur la paroi 16 de l'anévrisme 6, ce qui ne permet pas d'éliminer complètement les risques d'une dilatation supplémentaire et, ainsi, d'une rupture.These leaks create pressure on the wall 16 of the aneurysm 6, which does not completely eliminate the risk of further expansion and, thus, a break.
L'invention a notamment pour but de remédier à ces inconvénients en fournissant une endoprothèse aortique capable d'éliminer les risques d'endofuites de type 1 , et, ainsi, de diminuer le taux d'échec de l'intervention chirurgicale destinée à mettre en place cette prothèse.The object of the invention is in particular to remedy these drawbacks by providing an aortic stent capable of eliminating the risk of type 1 endoleaks, and thus of reducing the failure rate of the surgical procedure intended to place this prosthesis.
A cet effet, l'invention a pour objet une endoprothèse artérielle destinée à s'appliquer contre la paroi interne d'une artère, caractérisée en ce qu'elle comporte, sur sa face externe, des saillies réparties de manière à diminuer la vitesse d'un flux sanguin circulant entre l'artère et l'endoprothèse.For this purpose, the subject of the invention is an arterial stent intended to be applied against the internal wall of an artery, characterized in that it comprises, on its external face, protrusions distributed so as to reduce the speed of a blood flow circulating between the artery and the stent.
Ces saillies créent à leur voisinage des turbulences qui perturbent le flux et le ralentissent. La thrombose, ou coagulation du sang, est alors favorisée. Le sang ainsi coagulé peut alors contribuer à boucher l'orifice permettant le passage du sang à l'extérieur du conduit, ce qui évite les endofuites.These projections create in their vicinity turbulences which disturb the flow and slow it down. Thrombosis, or blood clotting, is then favored. The blood as well coagulated can then help to plug the opening allowing the passage of blood outside the conduit, which avoids endoleaks.
De plus, du fait de la présence des saillies, la rugosité de la surface est grande, ce qui assure une meilleure adhérence de la prothèse à la paroi de l'artère que dans les modèles existants, évitant ainsi les éventuelles migrations prothétiques.In addition, because of the presence of the projections, the roughness of the surface is large, which ensures better adhesion of the prosthesis to the wall of the artery than in existing models, thus avoiding possible prosthetic migrations.
En outre, l'endoprothèse selon l'invention permet d'éviter les endofuites de type 3, qui se produisent dans le cas d'une microdéchirure du conduit de la prothèse. Le sang coagulé évite alors au sang fluide circulant à l'intérieur du conduit d'en sortir par la microdéchirure.In addition, the stent according to the invention avoids type 3 endoleaks, which occur in the case of microdissure of the prosthesis duct. The coagulated blood then prevents the fluid blood circulating inside the conduit from coming out by the microdéchure.
Dans un mode de réalisation particulier, les saillies sont de forme hémisphérique.In a particular embodiment, the projections are of hemispherical shape.
Dans un mode de réalisation particulier, les saillies sont disposées en quinconce selon la direction longitudinale de l'endoprothèse. Ainsi, le ralentissement du flux est optimisé.In a particular embodiment, the projections are staggered in the longitudinal direction of the stent. Thus, the slowing of the flow is optimized.
Avantageusement, les saillies sont réalisées en matériau microporeux. De telles saillies absorbent une partie du sang circulant dans la partie dilatée de l'artère. Le sang retenu dans les saillies et ainsi rendu immobile coagule rapidement. Or, la coagulation du sang s'effectuant de proche en proche, le sang coagulé dans les saillies initie la coagulation du sang ralenti circulant autour d'elles.Advantageously, the projections are made of microporous material. Such protrusions absorb part of the circulating blood in the dilated portion of the artery. The blood retained in the projections and thus rendered immobile coagulates rapidly. Now, the coagulation of the blood taking place step by step, the blood coagulated in the projections initiates the coagulation of the slowed blood circulating around them.
La coagulation est alors plus rapide car initiée à plusieurs endroits simultanément.Coagulation is then faster because initiated in several places simultaneously.
Avantageusement, la paroi externe de l'endoprothèse est recouverte d'une pellicule d'un matériau étanche, se solubilisant lentement au contact du sang, permettant aux saillies de garder un volume minimal lors de l'implantation.Advantageously, the outer wall of the stent is covered with a film of a waterproof material, solubilizing slowly in contact with the blood, allowing the projections to keep a minimum volume during implantation.
Les saillies sont alors recouvertes par la pellicule étanche et, durant les premières heures de séjour de la prothèse dans le corps humain, la fonction d'absorption des saillies n'est pas activée.The projections are then covered by the waterproof film and, during the first hours of residence of the prosthesis in the human body, the function of absorption of the projections is not activated.
Etant donné que la prothèse est généralement insérée dans le corps humain par l'artère fémorale, puis glissée jusqu'à l'anévrisme en remontant l'aorte, sa mise en place de celle-ci est en effet grandement facilitée par le fait que les saillies sont compactées et que leur volume est minimal. Grâce à la pellicule étanche, le sang ne pénètre pas immédiatement dans les saillies, lesquelles conservent leur volume minimal de compaction. Quelques heures après la mise en place de l'endoprothèse, la solubilisation de la pellicule au contact du sang permet aux saillies microporeuses d'agir de la façon décrite ci-dessus.Since the prosthesis is generally inserted into the human body by the femoral artery, then slid up the aneurysm up the aorta, its implementation is greatly facilitated by the fact that the projections are compacted and their volume is minimal. Thanks to the tight film, the blood does not penetrate immediately into the protrusions, which retain their minimal volume of compaction. A few hours after the placement of the stent, solubilization of the film in contact with the blood allows the microporous projections to act as described above.
Optionnellement, la pellicule est réalisée en gélatine. L'invention sera mieux comprise à la lecture de la description qui va suivre, donnée uniquement à titre d'exemple et faite en se référant aux dessins annexés dans lesquels :Optionally, the film is made of gelatin. The invention will be better understood on reading the description which follows, given solely by way of example and with reference to the appended drawings in which:
- la figure 1 est une vue d'une endoprothèse artérielle suivant l'état de l'art antérieur, commentée auparavant ;- Figure 1 is a view of an arterial stent according to the state of the prior art, commented before;
- la figure 2 est une vue de côté de l'endoprothèse selon un mode de réalisation particulier ;- Figure 2 is a side view of the stent according to a particular embodiment;
- la figure 3A est une coupe longitudinale de l'endoprothèse selon ce même mode de réalisation, avant son introduction dans le corps humain ;- Figure 3A is a longitudinal section of the stent according to this embodiment, before its introduction into the human body;
- la figure 3B est une coupe longitudinale de l'endoprothèse selon ce même mode de réalisation, après sa mise en place à l'endroit de l'anévrisme.- Figure 3B is a longitudinal section of the stent according to this embodiment, after its introduction to the place of the aneurysm.
On a représenté sur les figures l'endoprothèse 20 selon l'invention. Tout comme l'endoprothèse 2 connue de l'homme du métier et représentée sur la figure 1 , celle-ci comporte un conduit étanche 12', en polyester ou PTFE (PolyTetraFluorEthylène), ménageant une voie pour la circulation du sang à l'endroit de l'anévrisme 6, et un ressort 14', réalisé généralement en un alliage métallique non corrosif, non nocif pour le corps humain et permettant au conduit 12' de s'adapter au diamètre de l'aorte.The figures show the endoprosthesis 20 according to the invention. Just like the stent 2 known to those skilled in the art and shown in Figure 1, it comprises a sealed conduit 12 ', polyester or PTFE (PolyTetraFluorEthylene), providing a way for the flow of blood to the place of the aneurysm 6, and a spring 14 ', generally made of a non-corrosive metal alloy, not harmful to the human body and allowing the conduit 12' to adapt to the diameter of the aorta.
L'endoprothèse artérielle 20 comporte en outre, sur sa face externe, des saillies 22 hémisphériques disposées en quinconce selon sa direction longitudinale.The arterial stent 20 further comprises, on its outer face, hemispherical projections 22 arranged staggered in its longitudinal direction.
Les saillies 22 ainsi disposées créent un "effet labyrinthe" : des turbulences 24 se produisent de manière accidentelle dans un flux sanguin 18, entre la paroi 16 de l'aorte et la prothèse 20. Ces turbulences 24 entraînent une diminution de la vitesse du sang dans l'endofuite.The projections 22 thus arranged create a "labyrinth effect": turbulences 24 occur accidentally in a blood stream 18, between the wall 16 of the aorta and the prosthesis 20. These turbulences 24 cause a decrease in the speed of blood in the endoleak.
Le sang est également absorbé par ces saillies 22, qui sont réalisées en matériau microporeux, par exemple en un fil polyester tissé. Le sang absorbé est immobilisé, ce qui favorise sa coagulation, ou thrombose. Le sang perturbé et ralenti circulant au voisinage des saillies 22 coagule alors à son tour facilement en raison de sa vitesse réduite et de la présence de sang coagulé à son voisinage, puisque la coagulation se fait de proche en proche.The blood is also absorbed by these protrusions 22, which are made of microporous material, for example a woven polyester thread. The absorbed blood is immobilized, which promotes its coagulation, or thrombosis. The disturbed and slowed blood flowing in the vicinity of the projections 22 coagulates in turn easily because of its reduced speed and the presence of coagulated blood in its vicinity, since the coagulation is done step by step.
Cette coagulation du sang permet donc de boucher durablement l'orifice par lequel le flux de sang 18 s'était engagé accidentellement dans la partie dilatée de l'anévrisme 6.This coagulation of the blood thus makes it possible to permanently seal the orifice through which the flow of blood 18 was accidentally engaged in the dilated part of the aneurysm 6.
On a représenté, sur la figure 3A, l'endoprothèse 20 selon l'invention, avant qu'elle ne soit introduite dans le corps humain. Dans ce cas, les saillies 22 sont recouvertes d'une pellicule étanche 26 de gélatine.FIG. 3A shows the endoprosthesis 20 according to the invention before it is introduced into the human body. In this case, the projections 22 are covered with a waterproof film 26 of gelatin.
Ainsi, lorsque la prothèse est introduite dans le corps humain par l'artère fémorale, (artère de la jambe), plus étroite que l'aorte, les saillies ne se gonflent pas par absorption de sang : elles sont donc compactées et le volume de la prothèse 20 est minimal. Celle-ci peut donc être déplacée facilement, en remontant l'artère fémorale et l'aorte 4, jusqu'à l'anévrisme 6.Thus, when the prosthesis is introduced into the human body by the femoral artery, (artery of the leg), narrower than the aorta, the projections do not swell by absorption blood: they are compacted and the volume of the prosthesis 20 is minimal. This can be easily moved up the femoral artery and the aorta 4 to the aneurysm 6.
Une fois la prothèse mise en place, la pellicule 26 de gélatine, non nocive pour le corps humain, se dissout dans le sang, comme on le voit sur la figure 3B, ce matériau se solubilisant lentement au contact du sang.Once the prosthesis is put in place, the film 26 of gelatin, which is not harmful to the human body, dissolves in the blood, as seen in FIG. 3B, this material solubilizing slowly in contact with the blood.
Les saillies 22 sont alors au contact du sang du flux 18 et l'absorbent par "effet éponge". Par conséquent, leur volume augmente par absorption du sang et elles permettent la coagulation de ce dernier et l'obstruction de l'orifice, de la manière décrite plus haut.The projections 22 are then in contact with the blood stream 18 and absorb it by "sponge effect". Therefore, their volume increases by absorption of the blood and they allow the coagulation of the latter and the obstruction of the orifice, as described above.
Les saillies 22 ainsi gonflées après la mise en place de l'endoprothèse 20 permettent également de consolider le positionnement de celle-ci par "effet crampon". Les saillies 22 gonflées, en augmentant la rugosité de la surface externe du conduit 12', assurent en effet une meilleure adhérence de l'endoprothèse 20 à la paroi et rend difficile tout déplacement de celle-ci.The projections 22 inflated after the introduction of the stent 20 also consolidate the positioning thereof by "crampon effect". The swollen projections 22, by increasing the roughness of the outer surface of the conduit 12 ', indeed provide better adhesion of the stent 20 to the wall and makes it difficult to move it.
L'endoprothèse 20 telle que décrite précédemment présente donc de nombreux avantages permettant de réduire les risques de rupture d'anévrisme après une opération chirurgicale, en éliminant plus particulièrement certains types d'endofuites.The stent 20 as described above thus has many advantages to reduce the risk of aneurysm rupture after surgery, eliminating certain types of endoleaks.
Il est cependant bien entendu que l'invention ne se limite pas au mode de réalisation précédemment décrit. However, it is understood that the invention is not limited to the embodiment described above.

Claims

REVENDICATIONS
1. Endoprothèse artérielle ayant une face externe destinée à s'appliquer contre la paroi interne d'une artère, caractérisée en ce qu'elle comporte, sur sa face externe, des saillies (22) réparties de manière à diminuer la vitesse d'un flux sanguin (18) circulant entre l'artère et l'endoprothèse (20).1. arterial stent having an outer face intended to be applied against the inner wall of an artery, characterized in that it comprises, on its outer face, projections (22) distributed so as to reduce the speed of a blood flow (18) flowing between the artery and the stent (20).
2. Endoprothèse artérielle selon la revendication 1, dans laquelle les saillies (22) sont de forme hémisphérique.The arterial stent of claim 1, wherein the projections (22) are hemispherical in shape.
3. Endoprothèse artérielle selon la revendication 1 ou 2, dans laquelle les saillies (22) sont disposées en quinconce selon la direction longitudinale de l'endoprothèse (20).The arterial stent of claim 1 or 2, wherein the projections (22) are staggered in the longitudinal direction of the stent (20).
4. Endoprothèse artérielle selon l'une quelconque des revendications 1 à 3, dans laquelle les saillies (22) sont réalisées en matériau microporeux.The arterial stent of any one of claims 1 to 3, wherein the projections (22) are made of microporous material.
5. Endoprothèse artérielle selon l'une quelconque des revendications 1 à 4, dont la paroi externe est recouverte d'une pellicule (26) d'un matériau étanche, se solubilisant lentement au contact du sang, permettant aux saillies de garder un volume minimal lors de l'implantation.Arterial stent according to any one of claims 1 to 4, the outer wall of which is covered with a film (26) of a sealing material, solubilizing slowly in contact with the blood, allowing the projections to keep a minimum volume. during implantation.
6. Endoprothèse artérielle selon l'une quelconque des revendications 1 à 5, dans laquelle la pellicule (26) est en gélatine.The arterial stent of any one of claims 1 to 5, wherein the film (26) is gelatin.
7. Endoprothèse aortique constituée par une endoprothèse artérielle selon l'une quelconque des revendication 1 à 6. Aortic stent consisting of an arterial stent according to any one of claims 1 to 6.
EP07717737A 2006-01-11 2007-01-11 Arterial endoprosthesis Withdrawn EP1973496A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0600235A FR2895901B1 (en) 2006-01-11 2006-01-11 ARTERIAL ENDOPROTHESIS
PCT/FR2007/050639 WO2007080352A1 (en) 2006-01-11 2007-01-11 Arterial endoprosthesis

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EP1973496A1 true EP1973496A1 (en) 2008-10-01

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EP (1) EP1973496A1 (en)
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CA3133857A1 (en) 2019-03-20 2020-09-24 inQB8 Medical Technologies, LLC Aortic dissection implant

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WO2007080352A1 (en) 2007-07-19
FR2895901B1 (en) 2008-04-18
US20090326635A1 (en) 2009-12-31
FR2895901A1 (en) 2007-07-13

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