EP1955232A1 - Evaluation method and investigation system - Google Patents
Evaluation method and investigation systemInfo
- Publication number
- EP1955232A1 EP1955232A1 EP06818656A EP06818656A EP1955232A1 EP 1955232 A1 EP1955232 A1 EP 1955232A1 EP 06818656 A EP06818656 A EP 06818656A EP 06818656 A EP06818656 A EP 06818656A EP 1955232 A1 EP1955232 A1 EP 1955232A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- evaluation device
- concentration
- time
- analyte
- measurement data
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1495—Calibrating or testing of in-vivo probes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H10/00—ICT specially adapted for the handling or processing of patient-related medical or healthcare data
- G16H10/40—ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H20/00—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
- G16H20/10—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
- G16H20/17—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered via infusion or injection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2560/00—Constructional details of operational features of apparatus; Accessories for medical measuring apparatus
- A61B2560/02—Operational features
- A61B2560/0223—Operational features of calibration, e.g. protocols for calibrating sensors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/74—Details of notification to user or communication with user or patient ; user input means
- A61B5/742—Details of notification to user or communication with user or patient ; user input means using visual displays
- A61B5/743—Displaying an image simultaneously with additional graphical information, e.g. symbols, charts, function plots
Definitions
- the invention relates to a method for evaluating a series of measurement data that correlate with the concentration of a medically significant analyte in a human or animal body fluid.
- the invention further relates to a system for studying the metabolism of a human or animal with regard to a medically significant analyte.
- important bodily fluids include, for example, blood and interstitial fluid, as well as other fluids to which a tissue-implanted sensor may be exposed.
- glucose is glucose.
- glucose is an example of a medically significant analyte in a human or animal body fluid.
- the blood glucose concentration of a patient is of utmost medical importance. Studies have shown that extremely serious long-term consequences of diabetes mellitus (eg blindness due to retinopathy) can be avoided if blood sugar levels are carefully monitored and kept within narrow limits.
- Systems for examining and monitoring the glucose metabolism have a sensor module which allows a continuous or quasi-continuous measurement of the analyte concentration.
- suitable sensors can be implanted directly into subcutaneous fatty tissue or blood vessels. It is also possible to implant catheters via which an exchange between a dialysate and the surrounding body fluid is used to collect analytes.
- the dialysate can be transported via micro-fluidics to a sensor arranged outside the body.
- it is also possible to measure analyte concentrations by means of a non-invasive sensor, which is glued to the skin, for example.
- an analyte concentration can be determined from a raw or measured signal, for example a current, of a sensor
- the sensor used must be calibrated extensively.
- a prerequisite for a successful calibration is that raw signals output by the sensor with reference values of the analyte concentration which are determined on the basis of taken body fluid samples, sufficiently correlate.
- measurement sensitivities can change drastically over time, so that a renewed in vivo calibration may be required at regular intervals.
- the object of the invention is to show a way how disease-related features of the metabolism of a human or animal can be determined by evaluating a series of measurement data with reduced calibration effort, preferably free of calibration.
- This object is achieved by a method for evaluating a series of measurement data g, with the concentration of a medically significant analyte in a human or animal body fluid for times t- L to t n , over a period of at least 8 hours, preferably at least 24 hours are distributed, are selected from the period several time intervals, each extending over at least 1 hour, for the time intervals in each case by evaluating lying in the relevant time interval measurement data g a stability parameter is determined, the temporal dynamics , with which the concentration of the analyte changes in the time interval, characterized, and the stability parameters are evaluated to determine disease-specific features of the metabolism.
- the series preferably contains measurement data in a density of at least three data points per hour, more preferably at least six data points per hour, in particular at least ten data points per hour.
- the invention further relates to a system for studying the metabolism of a human or animal with regard to a medically significant analyte, comprising an evaluation device which is set up in such a way that it carries out the following steps during operation:
- a stability parameter is determined by evaluating measurement data lying in the relevant time interval, which characterizes the temporal dynamics with which the concentration of the analyte changes in the time intervals.
- the stability parameters are evaluated in order to determine disease-specific features of the metabolism.
- the system further includes a sensor for determining measurement data that correlates to the concentration of a medically significant analyte in a human or animal body fluid.
- the selected time intervals adjoin one another, but it is also possible to choose overlapping time intervals or disjoint time intervals. It can already with the evaluation of individual time intervals be started before the Meß stylistserie is complete, so before the entire period has elapsed, from which the time intervals are selected.
- 1 shows an example of raw data of an implanted sensor in nanoamps above the blood glucose concentration in mg / dl; 2 shows an example of the course of measured values of an implanted glucose sensor over a period of 4 days;
- Fig. 3 determined by the method according to the invention stability parameters for different subjects
- Fig. 5 is a schematic representation of a system according to the invention.
- FIG. 1 raw data in nanoamperes measured with a sensor implanted in the subcutaneous fatty tissue of a subject is plotted against the blood glucose concentration in mg / dl.
- the glucose content was determined with a conventional capillary blood glucose meter.
- the raw data shown in Figure 1 could be used in conjunction with the simultaneously measured concentration values of the abscissa for calibration of the sensor. However, this is not necessary in the context of the invention. In the method described below, it suffices that there are measured values correlated with the blood glucose concentration.
- the raw data determined with an implanted sensor apart from noise and interfering signal components, show a proportionality to the analyte concentration.
- sensors have non-linear function curves, so that the raw data is transformed nonlinearly according to a function curve to produce measured values that are improved
- the following non-linear relationship may exist between the measuring current I of a sensor and the analyte concentration c:
- I I 0 + I g (I-exp (-c / c r ))
- I g is a limiting current which theoretically adds to the zero current I 0 at an infinite analyte concentration c;
- c r a reference concentration which characterizes the sensitivity of the sensor.
- the parameters I 0 , I g and c r can be determined ex-vivo in the production for a sensor type or a production batch with little effort.
- the parameters Cr and I g change , so that no absolute concentration values can be determined with a factory-determined function curve.
- this is not necessary for the method described below. It suffices that, by means of such a function curve, raw data can be used to determine measured values which are proportional to the analyte concentration apart from noise and interfering signal components, ie show a high correlation with the analyte concentration.
- these can be used directly as measured values for the method according to the invention or the measured values must first be calculated from raw data, for example by a statistical evaluation or a non-linear transformation according to the functional curve of the sensor used.
- correlation also means an anticorrelation, since a multiplication of the measured values by a factor of -1 in the essential relationships between the measured values and the underlying analyte concentrations is nothing changes.
- measured values are preferably evaluated whose correlation coefficient with the glucose concentration has an amount of at least 0.5, preferably at least 0.7, particularly preferably at least 0.9.
- the method can also be applied to measured data having poorer correlation coefficients, although the significance of the results obtained in such cases is correspondingly lower.
- FIG. 2 plots a series of quasi-continuous measurement data g in arbitrary units over time t for a period of 4 days. In this case, times are plotted on the abscissa to the measured data.
- the measured data shown in FIG. 2 are based on linearly transformed measured values as shown in FIG. 1, which were retrospectively smoothed with a median filter and an adaptive recursive filter.
- time intervals d, n were selected, which are shown in FIG. Embodiment correspond day and night times and thus reflect the expiration of the analyte concentration for waking hours and nocturnal rest periods.
- a stability parameter is determined by evaluating measurement data g in the relevant time interval, which characterizes the temporal dynamics with which the concentration of the analyte changes in the time interval. This stability parameter is evaluated to determine disease-specific features of the metabolism. In this way, an incipient diabetes illness can be detected or in the case of a diabetics insulin-dependent in the case of a determined disease-specific feature of the glucose metabolism a recommendation for the discontinuation of insulin administration can be assigned.
- measured data g are first calculated from measured values, as shown in FIG. 1, a linear transformation f being carried out as a calculation step.
- further calculation steps are preferably carried out in which the measured values are processed and smoothed with suitable filter algorithms and statistical methods before or after performing the linear transformation f. If the measuring sensitivity of the sensor used is sufficiently constant in time, the same transformation can be used for several intervals. Frequently, however, the measuring sensitivity and / or the background signal changes in the case of implanted sensors, so that preferably a transformation f is determined individually for different intervals.
- the linear transformation f is selected in each case for the individual time intervals such that the mean value of the measured data g of the relevant time interval corresponds to a predetermined value.
- this predetermined value is 0, but in principle can also be chosen any other constant.
- the linear transformation f can also be selected such that interval limits are specified and the smallest measurement data point of the lower interval limit, for example the value 0, and the largest measurement data point of the upper interval limit, for example the value 1, is assigned.
- the linear transformations f are not yet uniquely determined by specifying an average value of the measured data or interval limits.
- the linear transformations f are further selected such that the standard deviation of the measured data g of the relevant time interval corresponds to a predetermined value, for example 1.
- the first time derivative g 1 of the measured data g is formed in a calculation step. Since measured data usually as discrete measuring points, ie at best, quasi-continuously present, the first time derivative g 1 is formed numerically, for example with a polynomial filter. In a further calculation step, the standard deviation of the values of the time derivative g 1 of the relevant interval is calculated.
- the standard deviation thus determined characterizes the temporal dynamics with which the concentration of the analyte changes in the considered time interval and can therefore be used directly as a stability parameter.
- a stability parameter a function of the standard deviation, for example the square of the standard deviation.
- the glucose metabolism of a healthy subject is characterized by the fact that the body's own regulatory mechanisms rapidly counteract a rise in the glucose concentration caused by food intake, so that the standard deviation of the values of the time derivative g 1 is relatively large. A rapid increase is followed by a rapid decrease, so that both high positive and high negative values of the first time derivative g 'occur in a time interval.
- diabetes mellitus causes the standard deviation of the values of the time derivative g 1 to be significantly smaller than in a healthy subject.
- Insulinaben prepared in the prior art, considerable problems.
- selected insulin dosages are based to a considerable extent on the experience of the treating physician or the patient himself.
- a physician prepares a dosage plan which, on the one hand, determines the quantity and frequency of insulin administrations to cover an insulin requirement and, further
- Instructions include how to dose additional insulin doses in response to increased glucose concentration readings and meals.
- Insulin supplements to cover the insulin requirement are referred to as the basal rate and additional insulin-related meals as a bolus in this context.
- the general dosage regimen, according to which a diabetic determines the dosage of insulin doses to be administered, is called an attitude.
- diabetes management includes a number of other key points to reduce the likelihood of metabolic imbalances (E. Standl et al: Fundamentals of Diabetes Management, in Diabetology in Clinic and practice, publisher H. Mehnert et al. , Thieme Verlag, Stuttgart, 2003, page 132 ff).
- the most important component of diabetes management is self-monitoring of the metabolism, primarily the glucose level, but in some cases also of cumulative parameters such as ketone body concentrations, HbAlc, or glycated serum proteins.
- Diabetes management typically also includes non-pharmacological therapeutic measures (eg nutritional plan, physical activity) and, in particular, type 2 diabetic patients, medicines such as oral antidiabetics.
- non-pharmacological therapeutic measures eg nutritional plan, physical activity
- type 2 diabetic patients medicines such as oral antidiabetics.
- An important component of diabetes management is also the monitoring of the overall risk profile, especially with regard to diabetes-related late damage, whereby additional studies of kidney function, lipid profile and blood pressure can be consulted.
- a central component of a diabetes management system is the long-term use of a documentation system, in which the aforementioned data on metabolic self-control and attitude, but also on nutrition and other relevant
- the described method can make an important contribution to a diabetes management system, since by analyzing the stability parameters, important data about disease-specific features of the metabolism can be determined.
- the described method it is also possible to determine recommendations for adjusting the dosage of insulin doses or, in general, for diabetes management, for example for non-drug therapeutic measures, even without knowledge of absolute glucose concentration values by evaluating the stability parameters. For example, if there is a sharp increase in glucose concentration within a time interval after a meal, which is only slowly or incompletely broken down, the stan- Dard deviation of the values of the time derivative g 1 of the measured data g would be smaller than would be the case with a rapid and complete return of the glucose concentrations to the physiological equilibrium concentration. In such a case, it would be appropriate to increase the bolus of insulin doses.
- the recommendation can be given to reduce the intake of bread units in a meal or to counteract the increase in glucose concentration after a meal by physical activity.
- the stability parameters of time intervals in which no meals are taken it can be checked whether the set basal rate meets the needs of the patient.
- the method described is therefore preferably realized as a computer program product which can be loaded directly into the memory of a digital computer and comprises software sections with which the steps of the described method are executed when the product is running on a computer.
- a stability vector is determined from the stability parameters of different time intervals, the components of which in each case characterize the time dynamics with which the concentration of the analyte changes in the relevant time interval for a time interval.
- the Components of the stability vector the stability parameters determined for the respective intervals.
- FIG. 3 shows examples of such a stability vector for various subjects.
- the stability vector shown in FIG. 3 has two components, namely a stability parameter Sd for watch periods of the test persons (6:00 am to 10:00 pm) and a stability parameter Sn for nocturnal rest periods (10:00 pm to 6:00 pm).
- the corresponding time intervals d, n are indicated in FIG.
- the abscissa indicates the value of the stability parameter Sd for waking times
- the ordinate indicates the value of the stability parameter Sn for nocturnal rest periods in arbitrary units.
- Stability vectors of healthy subjects are shown in Figure 3 by circles (•), stability vectors of diabetics by crosses (X).
- An alternative stability parameter for such an application can be obtained by means of a frequency analysis of the first or the second time derivative g 1 or g 1 'of the measured data g.
- the time derivatives are practically stationary, ie they have no significant positive or negative trend over this window.
- a good control stability in the metabolism then shows up in an accumulation of fluctuations in the time course of g 'or g 1 '.
- a Fourier transformation of the time derivative g 'or g'', especially the calculation of a power spectrum, allows the analysis of these fluctuations.
- the ratio of the spectral intensity of high frequencies to the spectral intensity of low frequencies in the power spectrum of the time derivative g 1 of the measured data can be, for example, g.
- the ratio of the spectral intensity of high frequencies in relation to the spectral intensity of low frequencies of the power spectrum of the second time derivative g 1 'of the measured data g can also be used as a stability parameter.
- the control stability of the glucose concentration can also be improved in the subsequent phases.
- the pumping rate of such an insulin pump can be checked and optionally adjusted, for example, by comparing determined stability parameters with predetermined parameter ranges and, in the case of a deviation upward or downward, the pumping rate for the relevant time of day is increased or decreased.
- time intervals which are limited by identical times are always comparable.
- the beginning of an interval can also be determined by a relevant daily event, in particular the intake of a meal. This procedure is especially recommended for people with a rather erratic daily routine.
- the night phases n of the measurement data g shown in FIG. 2 were each subdivided into five consecutive intervals A, B, C, D, E of 1.6 hours each, and those for the individual intervals of the different nights - Stability parameters averaged for each interval.
- a stability vector has been formed which has five components SA, SB, SC, SD, SE, each of the five components being an average of four stability parameters appropriate for the relevant interval in the four nights of Figure 2 were determined.
- the deviation ⁇ SA, ⁇ SB, ⁇ SC, ⁇ SD, ⁇ SE of components SA, SB, SC, SD and SE of the stability vector thus determined is of an ideal value (2.5 in the arbitrary units of Figure 3) Pentagram indicated. From the center of the pentagram runs through its corners in each case an axis which indicates the value of the deviation .DELTA.S of the stability parameter S from the ideal value in the relevant time interval.
- this method can also be applied to a whole day or another period of time and / or a different subdivision can be made.
- an N-corner diagram results, wherein each corner of the diagram is assigned a component of an N-component stability vector.
- the deviation ⁇ S of the stability parameter S from the ideal value is zero by definition.
- the results of two diabetics are shown by dashed lines 2, 3. If one compares the course of lines 2, 3 of the insulin-dependent diabetic with the line 1 of the healthy subject, it is noticeable that the line 2 shows relatively small deviations from the ideal course of the healthy subject, which suggests that in the subject in question only minor disease-specific features of the metabolism are present.
- the line 3, which indicates the deviation ⁇ S of the stability parameter for the other diabetic shows a clear Deviation from the ideal course. This indicates that the patient's setting should be adjusted for the insulin dose.
- the quality of the glycemic self-control and thus also the quality of the adjustment of insulin dosages can be determined by an evaluation of the areas between the lines 2, 3 of a subject to be examined and the reference line.
- FIG. 5 shows the essential components of a system with which the metabolism of a human or animal can be investigated in accordance with the method described above.
- a measuring unit measures t n measured values with a sensor 10 at successive times.
- the measured values are transmitted wirelessly, in the illustrated case, to a receiver 12, from which the measured values are forwarded to an evaluation device 13, which contains a microprocessor 14 and a data memory 15.
- the output of results is done by means of an output unit 17, which may include a display or other common output means.
- the data processing of the evaluation device 13 is digital and there are provided corresponding converters for converting analog signals into digital signals.
- the system further includes an input unit 16, via which data or commands can be transmitted to the evaluation device 13. For example, by determining a blood glucose value at the beginning of a night phase on a sample of body fluid taken using a commercially available test strip and an associated test device and making it available to the evaluation device 13, the evaluation device can determine the course of the Glucose concentration during the night phase are estimated, in particular to indicate whether a dangerous underrun or exceeding the normoglylamisehen range happens.
- the stability parameters determined by the method described above are stored to be available for long-term evaluation in the context of diabetes management.
- the output unit 17 are the
- the system can evaluate the success of therapeutic recommendations, for example by performing a stability analysis of sensor data taken after a recommended therapeutic action in a given period of time.
Abstract
Description
Claims
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP06818656A EP1955232A1 (en) | 2005-12-03 | 2006-11-18 | Evaluation method and investigation system |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP05026421.7A EP1793321B1 (en) | 2005-12-03 | 2005-12-03 | Evaluation method and analysis system of an analyte in the bodily fluid of a human or animal |
EP06818656A EP1955232A1 (en) | 2005-12-03 | 2006-11-18 | Evaluation method and investigation system |
PCT/EP2006/011089 WO2007062755A1 (en) | 2005-12-03 | 2006-11-18 | Evaluation method and investigation system |
Publications (1)
Publication Number | Publication Date |
---|---|
EP1955232A1 true EP1955232A1 (en) | 2008-08-13 |
Family
ID=35965935
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP05026421.7A Active EP1793321B1 (en) | 2005-12-03 | 2005-12-03 | Evaluation method and analysis system of an analyte in the bodily fluid of a human or animal |
EP06818656A Withdrawn EP1955232A1 (en) | 2005-12-03 | 2006-11-18 | Evaluation method and investigation system |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP05026421.7A Active EP1793321B1 (en) | 2005-12-03 | 2005-12-03 | Evaluation method and analysis system of an analyte in the bodily fluid of a human or animal |
Country Status (6)
Country | Link |
---|---|
US (1) | US8734347B2 (en) |
EP (2) | EP1793321B1 (en) |
JP (1) | JP5031762B2 (en) |
DK (1) | DK1793321T3 (en) |
ES (1) | ES2609385T3 (en) |
WO (1) | WO2007062755A1 (en) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7545272B2 (en) | 2005-02-08 | 2009-06-09 | Therasense, Inc. | RF tag on test strips, test strip vials and boxes |
EP2071339A3 (en) * | 2007-12-12 | 2015-05-20 | Sysmex Corporation | System for providing animal test information and method of providing animal test information |
US8657746B2 (en) * | 2010-10-28 | 2014-02-25 | Medtronic Minimed, Inc. | Glucose sensor signal purity analysis |
EP3434184B1 (en) * | 2014-04-10 | 2021-10-27 | DexCom, Inc. | Glycemic urgency assessment and alerts interface |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4221848C2 (en) | 1992-07-03 | 2001-04-12 | Eckhard Salzsieder | Method and arrangement for automatic in situ calibration of intracorporeal glucose measuring devices |
US7624028B1 (en) * | 1992-11-17 | 2009-11-24 | Health Hero Network, Inc. | Remote health monitoring and maintenance system |
EP0910023A2 (en) | 1997-10-17 | 1999-04-21 | Siemens Aktiengesellschaft | Method and device for the neuronal modelling of a dynamic system with non-linear stochastic behavior |
JP3692751B2 (en) * | 1997-12-24 | 2005-09-07 | 松下電器産業株式会社 | Blood glucose meter with diabetes judgment function |
JPH11318872A (en) * | 1998-05-18 | 1999-11-24 | Matsushita Electric Ind Co Ltd | Blood sugar meter with diabetes judging function |
US6925393B1 (en) | 1999-11-18 | 2005-08-02 | Roche Diagnostics Gmbh | System for the extrapolation of glucose concentration |
JP2001212114A (en) * | 2000-02-02 | 2001-08-07 | Matsushita Electric Ind Co Ltd | Blood sugar meter |
US7890295B2 (en) | 2000-02-23 | 2011-02-15 | Medtronic Minimed, Inc. | Real time self-adjusting calibration algorithm |
EP1309271B1 (en) | 2000-08-18 | 2008-04-16 | Animas Technologies LLC | Device for prediction of hypoglycemic events |
US6841389B2 (en) * | 2001-02-05 | 2005-01-11 | Glucosens, Inc. | Method of determining concentration of glucose in blood |
US7399277B2 (en) * | 2001-12-27 | 2008-07-15 | Medtronic Minimed, Inc. | System for monitoring physiological characteristics |
WO2005057175A2 (en) * | 2003-12-09 | 2005-06-23 | Dexcom, Inc. | Signal processing for continuous analyte sensor |
-
2005
- 2005-12-03 ES ES05026421.7T patent/ES2609385T3/en active Active
- 2005-12-03 EP EP05026421.7A patent/EP1793321B1/en active Active
- 2005-12-03 DK DK05026421.7T patent/DK1793321T3/en active
-
2006
- 2006-11-18 WO PCT/EP2006/011089 patent/WO2007062755A1/en active Application Filing
- 2006-11-18 EP EP06818656A patent/EP1955232A1/en not_active Withdrawn
- 2006-11-18 JP JP2008542634A patent/JP5031762B2/en not_active Expired - Fee Related
-
2008
- 2008-05-30 US US12/130,091 patent/US8734347B2/en active Active
Non-Patent Citations (1)
Title |
---|
See references of WO2007062755A1 * |
Also Published As
Publication number | Publication date |
---|---|
JP5031762B2 (en) | 2012-09-26 |
DK1793321T3 (en) | 2017-01-16 |
US8734347B2 (en) | 2014-05-27 |
EP1793321A1 (en) | 2007-06-06 |
JP2009519048A (en) | 2009-05-14 |
US20080262333A1 (en) | 2008-10-23 |
WO2007062755A1 (en) | 2007-06-07 |
EP1793321B1 (en) | 2016-11-16 |
ES2609385T3 (en) | 2017-04-20 |
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