EP1940398A1 - Use of pramipexol for treating moderate to severe restless legs syndrome (rls) - Google Patents
Use of pramipexol for treating moderate to severe restless legs syndrome (rls)Info
- Publication number
- EP1940398A1 EP1940398A1 EP06807270A EP06807270A EP1940398A1 EP 1940398 A1 EP1940398 A1 EP 1940398A1 EP 06807270 A EP06807270 A EP 06807270A EP 06807270 A EP06807270 A EP 06807270A EP 1940398 A1 EP1940398 A1 EP 1940398A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- rls
- severe
- moderate
- use according
- active ingredient
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/428—Thiazoles condensed with carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
Definitions
- the invention relates to the use of 2-amino-6-n-propylamino-4,5,6,7-tetrahydrobenzo-thiazole, its (+) - or (-) - enantiomer or its pharmacologically acceptable salts for the treatment of moderate to severe Restless Legs Syndrome (RLS).
- RLS Restless Legs Syndrome
- Pramipexole - the 2-amino-6-n-propylamino-4,5,6,7-tetrahydrobenzo-thiazole dihydrochloride - is a dopamine D2 / D3 agonist whose synthesis is described in European Patent 186,087.
- Pramipexole is primarily for the treatment of idiopathic Parkinson's, known as monotherapy or in combination with levodopa. From German patent application DE 38 43 227 it is known that pramipexole lowers the prolactin serum level, furthermore it is known from German patent application DE 39 33 738 to use pramipexole to lower high TSH levels.
- Restless Legs Syndrome (synonyms: RLS, Anxietas tibiarum, Restless Legs Syndrome, Wittmaack-Ekbom Syndrome) is a neurological disorder characterized by an uncontrolled urge to move the legs. Usually, unpleasant and sometimes painful sensations in the legs, such as tingling, pulling, tearing, itching, burning, cramps, etc. are accompanying symptoms of the disease. RLS is estimated to affect up to ten percent of those aged 30 to 79 years old. The symptoms worsen towards evening and at night, so that those affected often additionally suffer from sleep disorders. The consequences are fatigue and irritability during the day with the corresponding consequences for daily work and the shaping of social life.
- L-DOPA levodopa
- the term improvements in the symptoms of RLS is understood to mean that pramipexole increases the score on the RLSRS scale after 3 weeks of treatment by at least 10 points, preferably by at least 12 points, more preferably by at least 14, and even more preferably by can reduce at least 15 points and this value continues beyond that.
- pramipexole in single doses in the form of tablets containing 0.1 to 1.5 mg, preferably 0.1 to 1 mg, more preferably 0.125 mg, to 0.75 mg of active ingredient taken once a day, extremely efficient and well tolerated. With continuous administration of pramipexole Remains the symptom improvement in RLS patients for at least 6 months or more (sustained effect).
- Preferred daily dosages are between 0.08 and 1 mg.
- the following daily dosages and all intermediate values are: 0.088 mg, 0.18 mg, 0.125 mg, 0.25 mg; 0.35 mg, 0.5 mg; 0.7 mg, 0.75 mg.
- Pramipexole is preferably added as free base, 2-amino-6-n-propylamino-4, 5,6,7-tetrahydrobenzothiazoline or in the form of a pharmacologically acceptable salt. Particular preference is given to salts with hydrochloric acid, in particular the dihydrochloride.
- the severity of RLS symptoms increased significantly more significantly over the study period in the placebo group than in the pramipexole group.
- the adjusted mean deviation (SE) from the baseline according to the international RLS scale was +14.86 for the placebo group and +2.03 for the pramipexole group.
- SE mean deviation
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Psychology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Abstract
The invention relates to the use of 2-amino-6-n-propylamino- 4,5,6,7-tetrahydrobenzo-thiazol, the (+)- or (-)-enantiomers thereof or the pharmacologically compatible salts thereof for treating moderate to severe restless legs syndrome (RLS).
Description
Verwendung von Pramipexol zur Behandlung des moderaten bis schweren Use of pramipexole for the treatment of moderate to severe
Restless Legs Syndroms (RLS)Restless Legs Syndrome (RLS)
Die Erfindung betrifft die Verwendung von 2-Amino-6-n-propylamino- 4,5,6,7- tetrahydrobenzo-thiazol, seinem (+)- oder (-)-Enantiomer oder dessen pharmakologisch verträgliche Salze zur Behandlung des moderaten bis schweren Restless Legs Syndroms (RLS).The invention relates to the use of 2-amino-6-n-propylamino-4,5,6,7-tetrahydrobenzo-thiazole, its (+) - or (-) - enantiomer or its pharmacologically acceptable salts for the treatment of moderate to severe Restless Legs Syndrome (RLS).
Pramipexol - das 2-Amino-6-n-propylamino-4,5,6,7-tetrahydrobenzo-thiazoldihydrochlorid - ist ein Dopamine - D2/D3 Agonist dessen Synthese in dem europäischen Patent 186 087 beschrieben ist. Pramipexol ist in erster Linie zur Behandlung des idiopathischen Parkinsons, als Monotherapie oder in Kombination mit Levodopa, bekannt. Aus der deutschen Patentanmeldung DE 38 43 227 ist bekannt, dass Pramipexol den Prolactinserumspiegel senkt, weiterhin ist aus der deutschen Patentanmeldung DE 39 33 738 bekannt, Pramipexol zur Senkung hoher TSH- Spiegel einzusetzen. Eine transdermale Applikation ist in dem US- Patent 51,112,842 beschrieben, und die WO Patentanmeldung PCT/EP93/03389 beschreibt die Verwendung von Pramipexol als Antidepressivum. Mit der WO9831362 wird vorgeschlagen, Pramipexol zur Behandlung des Restless Leg Syndroms zu verwenden.Pramipexole - the 2-amino-6-n-propylamino-4,5,6,7-tetrahydrobenzo-thiazole dihydrochloride - is a dopamine D2 / D3 agonist whose synthesis is described in European Patent 186,087. Pramipexole is primarily for the treatment of idiopathic Parkinson's, known as monotherapy or in combination with levodopa. From German patent application DE 38 43 227 it is known that pramipexole lowers the prolactin serum level, furthermore it is known from German patent application DE 39 33 738 to use pramipexole to lower high TSH levels. Transdermal application is described in US Patent 51,112,842 and WO Patent Application PCT / EP93 / 03389 describes the use of pramipexole as an antidepressant. With WO9831362 it is proposed to use pramipexole for the treatment of restless leg syndrome.
Restless Legs Syndrom (synonyme Bezeichnungen: RLS, Anxietas tibiarum, Syndrom der unruhigen Beine, Wittmaack-Ekbom-Syndrom) ist eine neurologische Erkrankung, welche durch einen unkontrollierten Drang, die Beine zu bewegen gekennzeichnet ist. Üblicherweise sind unangenehme und zum Teil schmerzende Wahrnehmungen in den Beinen, wie Kribbeln, Ziehen, Reißen, Jucken, Brennen, Krämpfe usw. Begleitsymptome der Erkrankung. Von RLS sind schätzungsweise bis zu zehn Prozent der 30 bis 79 Jährigen betroffen. Die Symptome verschlechtern sich gegen Abend und in der Nacht, so dass die Betroffenen häufig zusätzlich unter Schlafstörungen leiden. Die Folgen sind Müdigkeit und Gereiztheit am Tag mit den entsprechenden Konsequenzen für die tägliche Arbeit und die Gestaltung des sozialen Lebens.Restless Legs Syndrome (synonyms: RLS, Anxietas tibiarum, Restless Legs Syndrome, Wittmaack-Ekbom Syndrome) is a neurological disorder characterized by an uncontrolled urge to move the legs. Usually, unpleasant and sometimes painful sensations in the legs, such as tingling, pulling, tearing, itching, burning, cramps, etc. are accompanying symptoms of the disease. RLS is estimated to affect up to ten percent of those aged 30 to 79 years old. The symptoms worsen towards evening and at night, so that those affected often additionally suffer from sleep disorders. The consequences are fatigue and irritability during the day with the corresponding consequences for daily work and the shaping of social life.
Obwohl RLS in der Bevölkerung weit verbreitet auftritt, bleibt die Krankheit dennoch meist unerkannt, bzw. undiagnostiziert. Die Erkrankung beeinflusst die Lebensqualität von Millionen Menschen weltweit. Die Betroffenen nehmen den Einfiuss auf ihr Alltagsleben
zumeist als schwerwiegender wahr als den Einfluss chronischer Erkrankungen wie Bluthochdruck, Diabetes oder Herzerkrankungen.Although RLS is widespread in the population, the disease still remains mostly undetected or undiagnosed. The disease affects the quality of life of millions of people worldwide. The victims take the influence on their everyday lives mostly as more serious than the influence of chronic diseases such as hypertension, diabetes or heart disease.
Wenn die Schlaf- bzw. Lebensqualität des Patienten zunehmend durch RLS eingeschränkt ist oder die Patienten an Tagesmüdigkeit leiden, ist die Indikation zur Therapie gegeben. Eine Therapiebedürftigkeit tritt in der Regel im Alter von 40-50 Jahren ein.If the quality of sleep or quality of life of the patient is increasingly limited by RLS or the patients suffer from daytime fatigue, the indication for therapy is given. A need for treatment usually occurs at the age of 40-50 years.
In Therapiestudien zeigten Monotherapien mit Dopaminagonisten, Opiaten, Benzodiazepinen, Carbamazepin, Clonidin oder Levodopa (L-DOPA) in Kombination mit einem Dopadecarboxylasehemmer unterschiedliche Erfolge. Über Anwendungen von L-DOPA bei RLS liegen die meisten Arbeiten vor. Bei dessen Langzeittherapie kommt es zu einer deutlichen Beschwerdeabnahme mit Verbesserung der Lebens- und Schlafqualität. Der Nachteil der L-DOP A-Therapie besteht jedoch darin, daß bei manchen Patienten die Wirkung nachlässt und/oder eine Verschiebung der RLS-Beschwerden in die Morgenstunden (Rebound) oder in die Nachmittagsstunden (Augmentation) auftritt.In therapeutic studies, monotherapies with dopamine agonists, opiates, benzodiazepines, carbamazepine, clonidine or levodopa (L-DOPA) in combination with a dopa decarboxylase inhibitor have shown varying degrees of success. Most of the work on L-DOPA applications in RLS is available. In his long-term therapy, there is a significant decrease in complaints with an improvement in the quality of life and sleep. The disadvantage of L-DOP A therapy, however, is that in some patients, the effect wears off and / or a shift of RLS complaints in the morning (rebound) or in the afternoon (augmentation) occurs.
Es hat sich nun in großen klinischen, randomisierten Studien gezeigt, das Pramipexol bei Patienten, die unter moderater bis schwerer RLS leiden, zu einer schnellen Erleichterung der RLS-Symptomatik führt. Von moderater bis schwerer RLS spricht man dann, wenn Patienten auf der internationalen RLS Skala einen Punktwert > 15 erreichen. Die Skala reicht von 0 (keine RLS Symptome) bis 40 (schwerste Form der RLS). So treten bei moderater bis schwerer RLS die Symptome in der Regel mehr als zweimal pro Woche auf.It has now been shown in large clinical randomized trials that pramipexole leads to rapid relief of RLS symptoms in patients with moderate to severe RLS. Moderate to severe RLS are referred to when patients achieve a score> 15 on the international RLS scale. The scale ranges from 0 (no RLS symptoms) to 40 (most severe form of RLS). Symptoms of moderate to severe RLS usually occur more than twice a week.
Behandelte Patienten berichten bereits nach einer Woche von deutlichen Verbesserungen in allen Symptombereichen wie Schlafqualität, Unruhezustände der Beine etc.Treated patients report after one week of significant improvements in all symptom areas such as sleep quality, restlessness of the legs etc.
Im Sinn der vorliegenden Erfindung wird unter dem Begriff Verbesserungen der Symptomatik des RLS, verstanden, dass Pramipexol den Punktwert auf der RLSRS Skala nach 3 Wochen Behandlungszeit um wenigstens 10 Punkte, bevorzugt um wenigstens 12 Punkte, stärker bevorzugt um wenigstens 14 und noch stärker bevorzugt um wenigstens 15 Punkte vermindern kann und dieser Wert auch darüber hinaus anhält. So zeigte sich, dass Pramipexol in Einzeldosierungen in Form von Tabletten mit 0,1 bis 1,5 mg, bevorzugt 0,1 bis 1 mg, stärker bevorzugt 0,125 mg, bis 0,75 mg Wirkstoff, die einmal pro Tag genommen werden, äußerst effizient und gut verträglich ist. Bei kontinuierlicher Gabe von Pramipexol
hält die Verbesserung der Symptomatik bei RLS Patienten mindestens über 6 Monate und mehr an (nachhaltiger Effekt).For the purposes of the present invention, the term improvements in the symptoms of RLS is understood to mean that pramipexole increases the score on the RLSRS scale after 3 weeks of treatment by at least 10 points, preferably by at least 12 points, more preferably by at least 14, and even more preferably by can reduce at least 15 points and this value continues beyond that. Thus, it has been found that pramipexole in single doses in the form of tablets containing 0.1 to 1.5 mg, preferably 0.1 to 1 mg, more preferably 0.125 mg, to 0.75 mg of active ingredient taken once a day, extremely efficient and well tolerated. With continuous administration of pramipexole Remains the symptom improvement in RLS patients for at least 6 months or more (sustained effect).
Bevorzugte Tagesdosierungen liegen zwischen 0,08 und 1 mg. Bevorzugt ist die nachfolgende Tagesdosierungen und alle dazwischen liegenden Werte: 0,088 mg, 0,18 mg, 0,125 mg, 0,25 mg; 0,35 mg, 0,5 mg; 0,7mg, 0,75 mg.Preferred daily dosages are between 0.08 and 1 mg. Preferably, the following daily dosages and all intermediate values are: 0.088 mg, 0.18 mg, 0.125 mg, 0.25 mg; 0.35 mg, 0.5 mg; 0.7 mg, 0.75 mg.
Ganz besonders bevorzugt sind Tagesdosierungen von 0,18 mg bis 0,5 mg, stärker bevorzugt von 0,25 mg bis 0,5 mg.Very particular preference is given to daily dosages of from 0.18 mg to 0.5 mg, more preferably from 0.25 mg to 0.5 mg.
Diese Verbesserung spiegelt sich auch bei dem subjektive Eindruck der behandelten Patienten wieder, die mehrheitlich eine stark verbesserte oder sehr stark verbesserte Veränderung wahrnehmen.This improvement is also reflected in the subjective impression of the treated patients, most of whom perceive a greatly improved or greatly improved change.
Es zeigte sich in offenen Studien, dass der nachhaltige klinische Effekt auch noch nach 12 Monaten anhält.It has been shown in open studies that the sustained clinical effect persists even after 12 months.
Zur internationalen RLS-Skala wird verwiesen auf:For the international RLS scale reference is made to:
1. Allen, R. P., Picchietti, D., Hening, W. A., Trenkwalder, Allen, R. P., Picchietti, D., Hening, W. A., Trenkwalder, C, Walters, A. S., Montplaisir, J.: Restless legs Syndrome: diagnostic criteria, special considerations, and epidemiology. A report from the restless legs Syndrome diagnosis and epidemiology Workshop at the National Institutes of Health. Sleep Med. 4 (2003), 101-120.1. Allen, RP, Picchietti, D., Hening, WA, Trenkwalder, Allen, RP, Picchietti, D., Hening, WA, Trenkwalder, C, Walters, AS, Montplaisir, J .: Restless legs syndrome: diagnostic criteria, special considerations, and epidemiology. A report from the restless legs Syndrome diagnosis and epidemiology Workshop at the National Institutes of Health. Sleep Med. 4 (2003), 101-120.
2. Walters, A. S. and the International Restless Legs Syndrome Study Group: Towards a better defmition of the Restless Legs Syndrome. Mov. Disord. 10 (1995), 634-642.2. Walters, A.S. and the International Restless Legs Syndrome Study Group: Towards a Better Definition of the Restless Legs Syndrome. Mov. Disord. 10 (1995), 634-642.
Pramipexol wird bevorzugt als freie Base, 2-Amino-6-n-propylamino-4, 5,6,7- tetrahydrobenzothiazolin oder in Form eines pharmakologisch verträglichen Salzes gegeben. Besonders bevorzugt sind Salze mit Salzsäure, insbesondere das Dihydrochlorid.Pramipexole is preferably added as free base, 2-amino-6-n-propylamino-4, 5,6,7-tetrahydrobenzothiazoline or in the form of a pharmacologically acceptable salt. Particular preference is given to salts with hydrochloric acid, in particular the dihydrochloride.
Neben den bereits genannten Tabletten sind andere galenische Zubereitungen wie beispielsweise Tabletten, Dragees, Suppositorien, Lösungen für die Injektion oder Tropfen aus dem Stand der Technik bekannt.
Klinische UntersuchungIn addition to the tablets already mentioned, other pharmaceutical preparations such as tablets, dragees, suppositories, solutions for injection or drops of the prior art are known. Clinical examination
In einer Multicenter, Plazebo-kontrollierten, doppel-blinden, randomisierten Studie in Deutschland wurde der nachhaltige Effekt von Pramipexole auf Patienten mit RLS untersucht. Alle Patienten, die in der Studie eingeschlossen waren, hatten zunächst über 6 Monate Pramipexol eingenommen, bevor sie randomisiert einer doppel-blinden kontrollierten Entzugsphase zugeführt worden waren.In a multicenter, placebo-controlled, double-blind, randomized trial in Germany, the long-term effect of pramipexole on patients with RLS was investigated. All patients included in the study initially took pramipexole for 6 months before being randomized to a double-blind, controlled withdrawal phase.
Alle Patienten die nach der 6-monatigen Behandlung die vordefinierten Behandlungseffekte gezeigt haben wurden in die kontrollierte zweite Studienphase eingeschlossen Dabei wurden 150 Patienten mit idiopathischem RLS, die auf die Behandlung angesprochen hatten nach dem Zufallsprinzip ausgewählt und für 3 weitere Monate mit Plazebo (n = 72) oder Pramipexole (n = 78) in individualisierten Dosen von 0.125 bis 0.75 mg behandelt. Es wurde erwartet, dass in der Plazebo-Gruppe die RLS-Symptome erneut bzw. verstärkt auftreten würden während in der Pramipexol-Gruppe die Patienten weiterhin von der bereits eingeleiteten Behandlung profitieren würden. Der Schweregrad der Symptome wurde anhand des Unterschieds zwischen dem Zeitpunkt der Randomisation nach 6 Monaten und dem Ergebnis nach Beendigung der Studie gemäß der internationalen RLS Skala ermittelt. Die Ergebnisse von 147 Patienten wurden ausgewertet. Die Patienten hatten ein Durchschnittsalter von 59.6 Jahren, 72.8 % waren weiblich, die Symptome bestanden durchschnittlich seit 5.6 Jahren. Die Schwere der RLS Symptome nahm über die Studiendauer in der Plazebo-Gruppe signifikant deutlicher zu als in der Pramipexol-Gruppe. Die angepasste mittlere Abweichung (SE) von der Basislinie gemäß der internationalen RLS Skala betrug +14.86 für die Plazebo- Gruppe und +2.03 für die Pramipexol-Gruppe. Die Studie zeigt, dass eine kontinuierliche Behandlung mit Pramipexole auch über 6 Monate und mehr zu einer nachhaltigen Verbesserung der RLS Symptome führt.
All patients who demonstrated the predefined treatment effects after the 6-month treatment were included in the controlled second-stage study. 150 patients with idiopathic RLS who had responded to treatment were randomly selected and treated with placebo (n = 72 ) or pramipexole (n = 78) in individualized doses of 0.125 to 0.75 mg. In the placebo group, RLS symptoms were expected to be recurrent or increased whereas in the pramipexole group, patients would continue to benefit from treatment already initiated. The severity of the symptoms was determined by the difference between the time of randomization at 6 months and the result after completion of the study according to the international RLS scale. The results of 147 patients were evaluated. The patients had a mean age of 59.6 years, 72.8% were female, the symptoms had been on average for 5.6 years. The severity of RLS symptoms increased significantly more significantly over the study period in the placebo group than in the pramipexole group. The adjusted mean deviation (SE) from the baseline according to the international RLS scale was +14.86 for the placebo group and +2.03 for the pramipexole group. The study shows that continuous treatment with pramipexole for more than 6 months and more leads to a sustained improvement in RLS symptoms.
Claims
1. Verwendung des Wirkstoffs 2-Amino-6-n-propylamino-4, 5,6,7- tetrahydrobenzothiazol, seinem (-)- oder (+)-Enantiomer, sowie seiner pharmakologisch verträglichen Salze zur Herstellung eines Medikaments zur Behandlung des moderaten bis schweren Restless Legs Syndroms.1. Use of the active ingredient 2-amino-6-n-propylamino-4, 5,6,7-tetrahydrobenzothiazole, its (-) - or (+) - enantiomer, and its pharmacologically acceptable salts for the manufacture of a medicament for the treatment of the moderate until severe Restless Legs Syndrome.
2. Verwendung nach Anspruch 1, dadurch gekennzeichnet, dass moderate bis schwere RLS vorliegt, wenn die betroffenen und unbehandelten Patienten auf der internationalen RLS Skala einen Punktwert > 15 erreichen, bevorzugt > 20.2. Use according to claim 1, characterized in that moderate to severe RLS is present when the affected and untreated patients on the international RLS scale score> 15, preferably> 20.
3. Verwendung nach Anspruch 1, dadurch gekennzeichnet, dass moderate bis schwere RLS vorliegt, wenn die Symptome in der Regel mehr als zweimal pro Woche auftreten.3. Use according to claim 1, characterized in that moderate to severe RLS is present when the symptoms usually occur more than twice a week.
4. Verwendung des Wirkstoffs 2-Amino-6-n-propylamino-4, 5,6,7- tetrahydrobenzothiazol, seinem (-)- oder (+)-Enantiomer, sowie seiner pharmakologisch verträglichen Salze zur Herstellung eines Medikaments zur Verbesserung der RLS-Symptomatik, die über einen Zeitraum von 6 Monaten und/oder mehr, besonders über einen Zeitraum von wenigstens 7 Monaten, insbesondere über einen Zeitraum von wenigsten 8 Monaten anhält, wobei der Wirkstoff in einer Dosierung von 0,1 bis 1,5 mg einmal täglich über den gleichen Zeitraum verabreicht wird.4. Use of the active ingredient 2-amino-6-n-propylamino-4, 5,6,7-tetrahydrobenzothiazole, its (-) - or (+) - enantiomer, as well as its pharmacologically acceptable salts for the manufacture of a medicament for the improvement of RLS Symptomatology which persists for a period of 6 months and / or more, especially over a period of at least 7 months, more particularly over a period of at least 8 months, the active ingredient being dosed at 0.1 to 1.5 mg once administered daily over the same period.
5. Verwendung nach Anspruch 4, dadurch gekennzeichnet, dass die RLS eine moderate bis schwere RLS ist, bevorzugt, dass die betroffenen und unbehandelten Patienten auf der internationalen RLS Skala einen Punktwert > 15 erreichen, bevorzugt > 20.5. Use according to claim 4, characterized in that the RLS is a moderate to severe RLS, it is preferred that the affected and untreated patients on the international RLS scale score> 15, preferably> 20.
6. Verwendung nach Anspruch 4, dadurch gekennzeichnet, dass die RLS eine moderate bis schwere RLS ist, bevorzugt, dass die Symptome mehr als zweimal pro Woche auftreten. 6. Use according to claim 4, characterized in that the RLS is a moderate to severe RLS, it is preferred that the symptoms occur more than twice a week.
7. Verwendung des Wirkstoffs 2-Amino-6-n-propylamino-4, 5,6,7- tetrahydrobenzothiazol, seinem (-)- oder (+)-Enantiomer, sowie seiner pharmakologisch verträglichen Salze zur Herstellung eines Medikaments zur Verbesserung der RLS-Symptomatik innerhalb eines Zeitraums von 1 Woche, wobei der Wirkstoff in einer Dosierung von 0, 1 bis 1 mg einmal täglich über den gleichen Zeitraum verabreicht wird.7. Use of the active ingredient 2-amino-6-n-propylamino-4, 5,6,7-tetrahydrobenzothiazole, its (-) - or (+) - enantiomer, as well as its pharmacologically acceptable salts for the manufacture of a medicament for the improvement of RLS Symptoms within a 1-week period, with the active ingredient being administered at a dosage of 0, 1 to 1 mg once daily over the same period of time.
8. Verwendung nach Anspruch 8, dadurch gekennzeichnet, dass die RLS eine moderate bis schwere RLS ist, bevorzugt, dass die betroffenen und unbehandelten Patienten auf der internationalen RLS Skala einen Punktwert > 15 erreichen, bevorzugt > 20.8. Use according to claim 8, characterized in that the RLS is a moderate to severe RLS, it is preferred that the affected and untreated patients on the international RLS scale score> 15, preferably> 20.
9. Verwendung nach Anspruch 8, dadurch gekennzeichnet, dass die RLS eine moderate bis schwere RLS ist, bevorzugt, dass die Symptome mehr als zweimal pro Woche auftreten. 9. Use according to claim 8, characterized in that the RLS is a moderate to severe RLS, it is preferred that the symptoms occur more than twice a week.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US72798505P | 2005-10-18 | 2005-10-18 | |
PCT/EP2006/067408 WO2007045620A1 (en) | 2005-10-18 | 2006-10-16 | Use of pramipexol for treating moderate to severe restless legs syndrome (rls) |
Publications (1)
Publication Number | Publication Date |
---|---|
EP1940398A1 true EP1940398A1 (en) | 2008-07-09 |
Family
ID=37671401
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP06807270A Withdrawn EP1940398A1 (en) | 2005-10-18 | 2006-10-16 | Use of pramipexol for treating moderate to severe restless legs syndrome (rls) |
Country Status (5)
Country | Link |
---|---|
US (1) | US20080262053A1 (en) |
EP (1) | EP1940398A1 (en) |
JP (1) | JP2009511618A (en) |
CA (1) | CA2626249A1 (en) |
WO (1) | WO2007045620A1 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2308464A1 (en) | 2009-10-06 | 2011-04-13 | Sanovel Ilac Sanayi ve Ticaret A.S. | Orally disintegrating compositions of pramipexole |
Families Citing this family (60)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2611314T3 (en) * | 2006-12-14 | 2017-05-08 | Knopp Biosciences Llc | Compositions and procedures for using (R) -pramipexole |
US8519148B2 (en) | 2007-03-14 | 2013-08-27 | Knopp Neurosciences, Inc. | Synthesis of chirally purified substituted benzothiazole diamines |
EP2167080A1 (en) * | 2007-05-25 | 2010-03-31 | Boehringer Ingelheim International GmbH | Pharmaceutical formulation comprising pramipexole |
WO2010022140A1 (en) | 2008-08-19 | 2010-02-25 | Knopp Neurosciences, Inc. | Compositions and methods of using (r)-pramipexole |
WO2014037832A2 (en) | 2012-09-06 | 2014-03-13 | Mahesh Kandula | Compositions and methods for the treatment of epilepsy and neurological diseases |
WO2013096816A1 (en) | 2011-12-22 | 2013-06-27 | Biogen Idec Ma Inc. | Improved synthesis of amine substituted 4,5,6,7-tetrahydrobenzothiazole compounds |
AU2013257742A1 (en) | 2012-05-07 | 2014-11-27 | Cellixbio Private Limited | Compositions and methods for treatment of neuromuscular disorders and neurodegenerative disorders |
JP2015519333A (en) | 2012-05-07 | 2015-07-09 | セリックスビオ プライヴェート リミテッド | Compositions and methods for the treatment of neurological disorders |
WO2013167990A1 (en) | 2012-05-07 | 2013-11-14 | Mahesh Kandula | Compositions and methods for the treatment of depression |
WO2013168025A1 (en) | 2012-05-08 | 2013-11-14 | Mahesh Kandula | Compositions and methods for treatment of blood clotting disorders |
US9434704B2 (en) | 2012-05-08 | 2016-09-06 | Cellix Bio Private Limited | Compositions and methods for the treatment of neurological degenerative disorders |
US9403826B2 (en) | 2012-05-08 | 2016-08-02 | Cellix Bio Private Limited | Compositions and methods for the treatment of inflammatory disorders |
WO2013167991A1 (en) | 2012-05-08 | 2013-11-14 | Mahesh Kandula | Compositions and methods for the treatment of metabolic disorders |
US9266823B2 (en) | 2012-05-08 | 2016-02-23 | Cellix Bio Private Limited | Compositions and methods for the treatment of parkinson's disease |
WO2013168005A2 (en) | 2012-05-10 | 2013-11-14 | Mahesh Kandula | Compositions and methods for the treatment of restless leg syndrome and fibromyalgia |
US9499527B2 (en) | 2012-05-10 | 2016-11-22 | Cellix Bio Private Limited | Compositions and methods for the treatment of familial amyloid polyneuropathy |
US9315461B2 (en) | 2012-05-10 | 2016-04-19 | Cellix Bio Private Limited | Compositions and methods for the treatment of neurologic diseases |
US9321775B2 (en) | 2012-05-10 | 2016-04-26 | Cellix Bio Private Limited | Compositions and methods for the treatment of moderate to severe pain |
WO2013168011A1 (en) | 2012-05-10 | 2013-11-14 | Mahesh Kandula | Compositions and methods for the treatment of chronic pain |
US9394288B2 (en) | 2012-05-10 | 2016-07-19 | Cellix Bio Private Limited | Compositions and methods for the treatment of asthma and allergy |
WO2013168000A1 (en) | 2012-05-10 | 2013-11-14 | Mahesh Kandula | Compositions and methods for the treatment of severe pain |
WO2013168016A1 (en) | 2012-05-10 | 2013-11-14 | Mahesh Kandula | Compositions and methods for the treatment of metabolic syndrome |
US9346742B2 (en) | 2012-05-10 | 2016-05-24 | Cellix Bio Private Limited | Compositions and methods for the treatment of fibromyalgia pain |
US9315478B2 (en) | 2012-05-10 | 2016-04-19 | Cellix Bio Private Limited | Compositions and methods for the treatment of metabolic syndrome |
WO2013168033A1 (en) | 2012-05-10 | 2013-11-14 | Mahesh Kandula | Compositions and methods for treatment of neurologic diseases |
US9233161B2 (en) | 2012-05-10 | 2016-01-12 | Cellix Bio Private Limited | Compositions and methods for the treatment of neurological conditions |
WO2013168012A1 (en) | 2012-05-10 | 2013-11-14 | Mahesh Kandula | Compositions and methods for the treatment of respiratory disorders |
WO2013175344A2 (en) | 2012-05-23 | 2013-11-28 | Mahesh Kandula | Compositions and methods for the treatment of periodontitis and rheumatoid arthritis |
US9492409B2 (en) | 2012-05-23 | 2016-11-15 | Cellix Bio Private Limited | Compositions and methods for the treatment of local pain |
SG11201407322QA (en) | 2012-05-23 | 2014-12-30 | Cellix Bio Private Ltd | Compositions and methods for the treatment of multiple sclerosis |
US9498461B2 (en) | 2012-05-23 | 2016-11-22 | Cellix Bio Private Limited | Compositions and methods for the treatment of inflammatory bowel disease |
US9227974B2 (en) | 2012-05-23 | 2016-01-05 | Cellex Bio Private Limited | Compositions and methods for the treatment of respiratory disorders |
EP2852571A4 (en) | 2012-05-23 | 2015-11-25 | Cellix Bio Private Ltd | Compositions and methods for the treatment of mucositis |
US9108942B1 (en) | 2014-11-05 | 2015-08-18 | Mahesh Kandula | Compositions and methods for the treatment of moderate to severe pain |
US9187427B2 (en) | 2012-08-03 | 2015-11-17 | Cellix Bio Private Limited | N-substituted nicotinamide compounds and compositions for the treatment migraine and neurologic diseases |
WO2014037833A2 (en) | 2012-09-06 | 2014-03-13 | Mahesh Kandula | Compositions and methods for the treatment inflammation and lipid disorders |
JP2015529218A (en) | 2012-09-08 | 2015-10-05 | セリックスビオ プライヴェート リミテッド | Compositions and methods for the treatment of inflammation and lipid disorders |
US9662313B2 (en) | 2013-02-28 | 2017-05-30 | Knopp Biosciences Llc | Compositions and methods for treating amyotrophic lateral sclerosis in responders |
US9333187B1 (en) | 2013-05-15 | 2016-05-10 | Cellix Bio Private Limited | Compositions and methods for the treatment of inflammatory bowel disease |
EP3004049B1 (en) | 2013-06-04 | 2018-09-05 | Cellixbio Private Limited | Compositions and methods for the treatment of diabetes and pre-diabetes |
US9468630B2 (en) | 2013-07-12 | 2016-10-18 | Knopp Biosciences Llc | Compositions and methods for treating conditions related to increased eosinophils |
LT3019167T (en) | 2013-07-12 | 2021-03-25 | Knopp Biosciences Llc | Treating elevated levels of eosinophils and/or basophils |
CA2921381A1 (en) | 2013-08-13 | 2015-02-19 | Knopp Biosciences Llc | Compositions and methods for treating chronic urticaria |
EP3038467B1 (en) | 2013-08-13 | 2020-07-29 | Knopp Biosciences LLC | Compositions and methods for treating plasma cell disorders and b-cell prolymphocytic disorders |
US9096537B1 (en) | 2014-12-31 | 2015-08-04 | Mahesh Kandula | Compositions and methods for the treatment of mucositis |
WO2016046835A1 (en) | 2014-09-26 | 2016-03-31 | Cellix Bio Private Limited | Compositions and methods for the treatment of epilepsy and neurological disorders |
CN107207403A (en) | 2014-09-29 | 2017-09-26 | 塞尔利克斯生物私人有限公司 | Composition and method for treating multiple sclerosis |
JP6564868B2 (en) | 2014-10-27 | 2019-08-21 | セリックス バイオ プライヴェート リミテッドCellix Bio Private Limited | Three component salts of fumaric acid monomethyl ester and piperazine or ethylenediamine for the treatment of multiple sclerosis |
US9284287B1 (en) | 2014-11-05 | 2016-03-15 | Cellix Bio Private Limited | Compositions and methods for the suppression of carbonic anhydrase activity |
US9290486B1 (en) | 2014-11-05 | 2016-03-22 | Cellix Bio Private Limited | Compositions and methods for the treatment of epilepsy |
US9150557B1 (en) | 2014-11-05 | 2015-10-06 | Cellix Bio Private Limited | Compositions and methods for the treatment of hyperglycemia |
US9321716B1 (en) | 2014-11-05 | 2016-04-26 | Cellix Bio Private Limited | Compositions and methods for the treatment of metabolic syndrome |
US9173877B1 (en) | 2014-11-05 | 2015-11-03 | Cellix Bio Private Limited | Compositions and methods for the treatment of local pain |
US9175008B1 (en) | 2014-11-05 | 2015-11-03 | Cellix Bio Private Limited | Prodrugs of anti-platelet agents |
US10208014B2 (en) | 2014-11-05 | 2019-02-19 | Cellix Bio Private Limited | Compositions and methods for the treatment of neurological disorders |
US9932294B2 (en) | 2014-12-01 | 2018-04-03 | Cellix Bio Private Limited | Compositions and methods for the treatment of multiple sclerosis |
US9206111B1 (en) | 2014-12-17 | 2015-12-08 | Cellix Bio Private Limited | Compositions and methods for the treatment of neurological diseases |
EP3242869B1 (en) | 2015-01-06 | 2021-10-27 | Cellixbio Private Limited | Compositions and methods for the treatment of inflammation and pain |
US11103691B2 (en) | 2019-10-03 | 2021-08-31 | Noctrix Health, Inc. | Peripheral nerve stimulation for restless legs syndrome |
WO2018129351A1 (en) | 2017-01-05 | 2018-07-12 | Shriram Raghunathan | Restless leg syndrome or overactive nerve treatment |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE45735T1 (en) * | 1984-12-22 | 1989-09-15 | Thomae Gmbh Dr K | TETRAHYDRO-BENZTHIAZOLE, THEIR PRODUCTION AND USE AS INTERMEDIATE OR MEDICINAL PRODUCTS. |
DE3937271A1 (en) * | 1989-11-09 | 1991-05-16 | Boehringer Ingelheim Kg | TRANSDERMAL APPLICATION OF 2-AMINO-6-N-PROPYLAMINO-4,5,6,7-TETRAHYDROBENZOTHIAZOLE |
DE4241013A1 (en) * | 1992-12-05 | 1994-06-09 | Boehringer Ingelheim Kg | Use of 2-amino-6-n-propylamino-4,5,6,7-tetrahydrobenzothiazole as antidepressant drug |
US5650420A (en) * | 1994-12-15 | 1997-07-22 | Pharmacia & Upjohn Company | Pramipexole as a neuroprotective agent |
US6001861A (en) * | 1998-01-16 | 1999-12-14 | Pharmacia & Upjohn Company | Use of pramipexole in the treatment of restless legs syndrome |
DE19701619B4 (en) * | 1997-01-17 | 2007-10-11 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Use of pramipexole for the treatment of restless legs syndrome |
AU2002360600B2 (en) * | 2001-12-11 | 2007-11-29 | University Of Virginia Patent Foundation | Use of pramipexole to treat amyotrophic lateral sclerosis |
-
2006
- 2006-10-16 EP EP06807270A patent/EP1940398A1/en not_active Withdrawn
- 2006-10-16 US US12/090,428 patent/US20080262053A1/en not_active Abandoned
- 2006-10-16 WO PCT/EP2006/067408 patent/WO2007045620A1/en active Application Filing
- 2006-10-16 JP JP2008536031A patent/JP2009511618A/en active Pending
- 2006-10-16 CA CA002626249A patent/CA2626249A1/en not_active Abandoned
Non-Patent Citations (1)
Title |
---|
See references of WO2007045620A1 * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2308464A1 (en) | 2009-10-06 | 2011-04-13 | Sanovel Ilac Sanayi ve Ticaret A.S. | Orally disintegrating compositions of pramipexole |
Also Published As
Publication number | Publication date |
---|---|
JP2009511618A (en) | 2009-03-19 |
WO2007045620A1 (en) | 2007-04-26 |
CA2626249A1 (en) | 2007-04-26 |
US20080262053A1 (en) | 2008-10-23 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO2007045620A1 (en) | Use of pramipexol for treating moderate to severe restless legs syndrome (rls) | |
DE60120104T2 (en) | New use of peptide compounds in the treatment of non-neuropathic inflammatory pain | |
DE69431729T2 (en) | MEDICINAL PRODUCTS CONTAINING BROMOCRYPTINE WITH ACCELERATED RELEASE | |
DE69930243T2 (en) | TREATMENT OF IATROGENIC AND AGE-CONDITIONED BLOOD HIGH PRESSURE WITH VITAMIN B6 DERIVATIVES, AND PHARMACEUTICAL COMPOSITIONS USE THEREOF | |
EP2148669B1 (en) | Tapentadol for treating pain from arthritis | |
DE69715862T2 (en) | USE OF A K-252A DERIVATIVE TO TREAT PERIPHERAL OR CENTRAL NERVOUS DISEASES AND EXCESSIVE CYTOKINE FORMATION | |
AT10974U1 (en) | USE OF ENANTIOMER-PURE ESCITALOPRAM | |
DE60218193T2 (en) | USE OF 2-OXO-1-PYRROLIDINE DERIVATIVES FOR THE PREPARATION OF A MEDICAMENT FOR THE TREATMENT OF DYSKINESIA | |
WO2000002542A2 (en) | Agents with an antidepressive effect containing pramipexol and an additional antidepressant drug | |
DE19938825A1 (en) | Active ingredient combination with clonidine | |
DE60111025T2 (en) | Use of topiramate for the treatment and diagnosis of respiratory disorders during sleep and means for performing the treatment and diagnosis | |
DE3023588A1 (en) | Means to quit smoking and lose obesity | |
DE3856295T2 (en) | TREATMENT OF PREMIUM OR LATE LUTEAL PHASE SYNDROME | |
DE3882135T2 (en) | USE OF MELATONIN OR ITS DERIVATIVES FOR THE PRODUCTION OF MEDICINAL PRODUCTS THAT ARE EFFECTIVE AGAINST AGE DISEASES. | |
DE2823174A1 (en) | MEDICINAL PRODUCTS FOR THE PROPHYLACTIC TREATMENT OF POSTOPERATIVE DEEP VEIN THROMBOSIS | |
DE60317935T2 (en) | ALPHA AMINOAMIDE DERIVATIVES AS AGENTS AGAINST MIGRAINE | |
DE10163667B4 (en) | Use of deoxypeganine for the treatment of clinical depression | |
DE60217870T2 (en) | USE OF 2-5- (4-FLUORPHENYL) -3-PYRIDYLMETHYLAMINOMETHYL-CHROMANE AND ITS PHYSIOLOGICALLY ACCEPTABLE SALTS | |
EP1513533A2 (en) | Pharmaceutical active substance combination and the use thereof | |
DE60125062T2 (en) | Quetiapine for the treatment of dyskinesia in non-psychotic patients | |
DE60207442T2 (en) | USE OF A COMBINATION COMPOSITION COMPRISING PROPIONYL L-CARNITINE AND OTHER ACTIVE SUBSTANCES FOR TREATING THE EFFECTIVE DYSFUNCTION | |
DE60117541T2 (en) | Candesartan for the treatment of migraine | |
DE69920679T2 (en) | NEW TREATMENTS FOR NERVOUS DISEASES | |
EP2120918B1 (en) | Pharmaceutical composition for treating incontinence | |
DE10318714B4 (en) | Drug combinations and therapies to combat alcohol abuse |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 20080519 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20110503 |