EP1920770A4 - Therapeutic agent for inflammatory bowel disease and tnf- alpha production inhibitor - Google Patents

Therapeutic agent for inflammatory bowel disease and tnf- alpha production inhibitor

Info

Publication number
EP1920770A4
EP1920770A4 EP06780740A EP06780740A EP1920770A4 EP 1920770 A4 EP1920770 A4 EP 1920770A4 EP 06780740 A EP06780740 A EP 06780740A EP 06780740 A EP06780740 A EP 06780740A EP 1920770 A4 EP1920770 A4 EP 1920770A4
Authority
EP
European Patent Office
Prior art keywords
tnf
therapeutic agent
inflammatory bowel
bowel disease
production inhibitor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP06780740A
Other languages
German (de)
French (fr)
Other versions
EP1920770A1 (en
Inventor
Hideki Matsumoto
Tomohisa Okutsu
Tomoko Takeda
Hideki Suzuki
Tetsuo Yano
Masaki Hashimoto
Miho Ono
Manabu Suzuki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ajinomoto Co Inc
Original Assignee
Ajinomoto Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ajinomoto Co Inc filed Critical Ajinomoto Co Inc
Publication of EP1920770A1 publication Critical patent/EP1920770A1/en
Publication of EP1920770A4 publication Critical patent/EP1920770A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4172—Imidazole-alkanecarboxylic acids, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Oncology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Communicable Diseases (AREA)
  • Ophthalmology & Optometry (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Dermatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pulmonology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Transplantation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
EP06780740A 2005-07-01 2006-07-03 Therapeutic agent for inflammatory bowel disease and tnf- alpha production inhibitor Withdrawn EP1920770A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2005193591 2005-07-01
PCT/JP2006/313236 WO2007004613A1 (en) 2005-07-01 2006-07-03 THERAPEUTIC AGENT FOR INFLAMMATORY BOWEL DISEASE AND TNF-α PRODUCTION INHIBITOR

Publications (2)

Publication Number Publication Date
EP1920770A1 EP1920770A1 (en) 2008-05-14
EP1920770A4 true EP1920770A4 (en) 2010-09-29

Family

ID=37604474

Family Applications (1)

Application Number Title Priority Date Filing Date
EP06780740A Withdrawn EP1920770A4 (en) 2005-07-01 2006-07-03 Therapeutic agent for inflammatory bowel disease and tnf- alpha production inhibitor

Country Status (4)

Country Link
US (3) US20080108684A1 (en)
EP (1) EP1920770A4 (en)
JP (1) JPWO2007004613A1 (en)
WO (1) WO2007004613A1 (en)

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IL172896A0 (en) * 2005-12-29 2006-06-11 Yeda Res & Dev Cxcr4 inhibition
JP2008203250A (en) * 2007-01-24 2008-09-04 Ajinomoto Co Inc Evaluation method of ibd, and amino acid information processor, processing method, processing system, and processing program, and recording medium
GB2449064A (en) * 2007-04-27 2008-11-12 Brandhandling Internat Ltd Item of footwear for rehabiliation of leg-muscle tone
EP2106791A1 (en) * 2008-03-31 2009-10-07 Biotempt B.V. Glutamine or glutamine-containing dipeptide in a specific dosage for the treatment of inflammation
JP5668271B2 (en) * 2008-12-25 2015-02-12 ユーハ味覚糖株式会社 Cystine-amino acid complex and method for producing the same
KR101080271B1 (en) * 2009-03-31 2011-11-08 주식회사 웰스킨 Ultraviolet-induced reaction controlling cosmetic composition containing dipeptide
JP2011016728A (en) * 2009-07-07 2011-01-27 Yamaguchi Univ Prophylactic agent and/or therapeutic agent for inflammatory disease
WO2011126163A1 (en) * 2010-04-08 2011-10-13 주식회사 웰스킨 Skin-whitening composition containing dipeptide
KR102069790B1 (en) 2010-09-24 2020-01-23 유니버시티 오브 플로리다 리서치 파운데이션, 인크. Materials and methods for improving gastrointestinal function
JP5837315B2 (en) * 2011-03-25 2015-12-24 イーエヌ大塚製薬株式会社 Nutritional composition for inflammatory diseases
WO2012133198A1 (en) * 2011-03-25 2012-10-04 イーエヌ大塚製薬株式会社 Nutritional composition for inflammatory diseases
PT2861229T (en) * 2012-06-15 2021-01-05 Conaris Res Institute Ag A pharmaceutical composition containing nicotinic acid and/or nicotinamide and/or tryptophan for positively influencing the intestinal microbiota
CN110522744B (en) 2013-03-11 2023-04-07 佛罗里达大学研究基金会有限公司 Materials and methods for improving lung function and for preventing and/or treating radiation-induced pulmonary complications
WO2015051337A2 (en) * 2013-10-04 2015-04-09 Emory University Methods of treating gastrointestinal disorders
US10758552B2 (en) 2013-12-13 2020-09-01 Conaris Research Institute Ag Pharmaceutical composition containing combinations of nicotinamide and 5-aminosalicylic acid for beneficially influencing the intestinal microbiota and/or treating gastrointestinal inflammation
DK3079675T3 (en) 2013-12-13 2020-04-20 Conaris Res Institute Ag Pharmaceutical composition containing nicotinic acid and / or nicotinamide for use in beneficial effect of blood lipid levels by modifying the gut microbiota
WO2016029043A1 (en) 2014-08-21 2016-02-25 The General Hospital Corporation Tumor necrosis factor superfamily and tnf-like ligand muteins and methods of preparing and using the same
TWI588128B (en) 2015-01-13 2017-06-21 財團法人國家衛生研究院 5-methoxytryptophan and its derivatives and uses thereof
JP2016132622A (en) * 2015-01-16 2016-07-25 イーエヌ大塚製薬株式会社 Sepsis therapeutic or prophylactic nutritional composition
EP3247343A1 (en) * 2015-01-23 2017-11-29 Nestec S.A. Nutritional composition useful in the treatment of ibd patients
WO2017094705A1 (en) * 2015-11-30 2017-06-08 公益財団法人野口研究所 Gm3-promoted inflammation inhibitor and inflammatory cytokine production inhibitor
JOP20190146A1 (en) 2016-12-19 2019-06-18 Axcella Health Inc Amino acid compositions and methods for the treatment of liver diseases
BR112020002419A2 (en) 2017-08-14 2020-07-28 Axcella Health Inc. amino acid for the treatment of liver disease
CN109718234A (en) * 2017-10-31 2019-05-07 中国农业大学 L-Trp is alleviating the application in intestinal inflammation and barrier function disorder
US11324774B2 (en) * 2018-01-05 2022-05-10 Augusta University Research Institute, Inc. Compositions of oral alkaline salts and metabolic acid inducers and uses thereof
MA52971A (en) 2018-06-20 2021-04-28 Axcella Health Inc COMPOSITIONS AND METHODS FOR THE TREATMENT OF FAT INFILTRATION IN THE MUSCLE
WO2019246310A1 (en) * 2018-06-20 2019-12-26 Axcella Health Inc. Compositions and methods for the reduction or treatment of inflammation
CA3185236A1 (en) * 2020-07-09 2022-01-13 Ido LIVNEH Tyrosine, tryptophan and phenylalanine as mtor agonists mediating proteasome dynamics, compositions, methods and uses thereof in therapy, and prognostic methods for drug-resistance
CN112402405A (en) * 2020-09-29 2021-02-26 中国农业大学 Use of glycine for the prevention and/or treatment of inflammatory bowel disease

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JP2003533436A (en) * 2000-02-04 2003-11-11 ソシエテ デ プロデユイ ネツスル ソシエテ アノニム Methods for maintaining or improving mucin synthesis
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KAYA E ET AL: "L-glutamine enames attenuate mucosal injury in experimental colitis", DISEASES OF THE COLON AND RECTUM, J.B. LIPPINCOT CO., PHILADELPHIA, US LNKD- DOI:10.1007/BF02238577, vol. 42, no. 9, 1 September 1999 (1999-09-01), pages 1209 - 1215, XP003008838, ISSN: 0012-3706 *
RABBANI G H ET AL: "Antiinflammatory effects of L-histidine in experimental colitis due to Shigella flexneri infection in rabbits", FASEB JOURNAL, FED. OF AMERICAN SOC. FOR EXPERIMENTAL BIOLOGY, US, vol. 15, no. 4, 1 January 2001 (2001-01-01), pages A587, XP003008835, ISSN: 0892-6638 *
RABBANI G H ET AL: "L-histidine improves colitis in experimental shigellosis in rabbit", FASEB JOURNAL, FED. OF AMERICAN SOC. FOR EXPERIMENTAL BIOLOGY, US, vol. 14, no. 4, 1 January 2000 (2000-01-01), pages A186, XP003008836, ISSN: 0892-6638 *
See also references of WO2007004613A1 *
TSUNE ET AL: "Dietary glycine prevents chemical-induced experimental colitis in the rat", GASTROENTEROLOGY, ELSEVIER, PHILADELPHIA, PA, vol. 125, no. 3, 1 September 2003 (2003-09-01), pages 775 - 785, XP005313503, ISSN: 0016-5085, DOI: 10.1016/S0016-5085(03)01067-9 *
YAMAMOTO TAKAYUKI ET AL: "Impact of elemental diet on mucosal inflammation in patients with active Crohn's disease: cytokine production and endoscopic and histological findings.", INFLAMMATORY BOWEL DISEASES JUN 2005 LNKD- PUBMED:15905706, vol. 11, no. 6, June 2005 (2005-06-01), pages 580 - 588, XP002596907, ISSN: 1078-0998 *

Also Published As

Publication number Publication date
EP1920770A1 (en) 2008-05-14
US8168669B2 (en) 2012-05-01
US20080108684A1 (en) 2008-05-08
WO2007004613A1 (en) 2007-01-11
US20100076044A1 (en) 2010-03-25
US20120329846A1 (en) 2012-12-27
JPWO2007004613A1 (en) 2009-01-29

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