EP1910525A4 - Modulation de la signalisation de la sphingosine kinase - Google Patents

Modulation de la signalisation de la sphingosine kinase

Info

Publication number
EP1910525A4
EP1910525A4 EP06752621A EP06752621A EP1910525A4 EP 1910525 A4 EP1910525 A4 EP 1910525A4 EP 06752621 A EP06752621 A EP 06752621A EP 06752621 A EP06752621 A EP 06752621A EP 1910525 A4 EP1910525 A4 EP 1910525A4
Authority
EP
European Patent Office
Prior art keywords
modulation
sphingosine kinase
kinase signalling
signalling
sphingosine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP06752621A
Other languages
German (de)
English (en)
Other versions
EP1910525A1 (fr
Inventor
Stuart M Pitson
Paul A Moretti
Matthew Alexander Vadas
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Medvet Science Pty Ltd
Original Assignee
Medvet Science Pty Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from AU2005903258A external-priority patent/AU2005903258A0/en
Application filed by Medvet Science Pty Ltd filed Critical Medvet Science Pty Ltd
Publication of EP1910525A1 publication Critical patent/EP1910525A1/fr
Publication of EP1910525A4 publication Critical patent/EP1910525A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/01—Phosphotransferases with an alcohol group as acceptor (2.7.1)
    • C12Y207/01091—Sphinganine kinase (2.7.1.91)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Pulmonology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Vascular Medicine (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Enzymes And Modification Thereof (AREA)
EP06752621A 2005-06-21 2006-06-21 Modulation de la signalisation de la sphingosine kinase Withdrawn EP1910525A4 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AU2005903258A AU2005903258A0 (en) 2005-06-21 A method of modulating enzymatic activity and agents for use therein
PCT/AU2006/000867 WO2006135969A1 (fr) 2005-06-21 2006-06-21 Modulation de la signalisation de la sphingosine kinase

Publications (2)

Publication Number Publication Date
EP1910525A1 EP1910525A1 (fr) 2008-04-16
EP1910525A4 true EP1910525A4 (fr) 2009-05-06

Family

ID=37570028

Family Applications (1)

Application Number Title Priority Date Filing Date
EP06752621A Withdrawn EP1910525A4 (fr) 2005-06-21 2006-06-21 Modulation de la signalisation de la sphingosine kinase

Country Status (4)

Country Link
EP (1) EP1910525A4 (fr)
JP (1) JP2008546393A (fr)
CA (1) CA2612773A1 (fr)
WO (1) WO2006135969A1 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8324237B2 (en) 2005-05-20 2012-12-04 Smith Charles D Methods for the treatment and prevention of inflammatory diseases
EP2166094A1 (fr) 2008-09-23 2010-03-24 Ecole Normale Superieure De Lyon Procédés pour le prolongement des avantages sanitaires déclenchés par une restriction alimentaire utilisant un inhibiteur de la sphingosine kinase

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006135968A1 (fr) * 2005-06-21 2006-12-28 Medvet Science Pty. Ltd. Modulation de la signalisation de la sphingosine kinase

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006135968A1 (fr) * 2005-06-21 2006-12-28 Medvet Science Pty. Ltd. Modulation de la signalisation de la sphingosine kinase

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
FUJITA TOSHITADA ET AL: "delta-Catenin/NPRAP (neural plakophilin-related armadillo repeat protein) interacts with and activates sphingosine kinase 1", BIOCHEMICAL JOURNAL, vol. 382, no. Part 2, 1 September 2004 (2004-09-01), pages 717 - 723, XP002520682, ISSN: 0264-6021 *
FUKUDA Y ET AL: "Identification of PECAM-1 association with sphingosine kinase 1 and its regulation by agonist-induced phosphorylation", BIOCHIMICA AND BIOPHYSICA ACTA. MOLECULAR AND CELL BIOLOGY OFLIPIDS, ELSEVIER, AMSTERDAM, NL, vol. 1636, no. 1, 27 February 2004 (2004-02-27), pages 12 - 21, XP004492617, ISSN: 1388-1981 *
GRAND EFFIE K ET AL: "Identification of a novel gene, FGFR1OP2, fused to FGFR1 in 8p11 myeloproliferative syndrome", GENES CHROMOSOMES & CANCER, vol. 40, no. 1, May 2004 (2004-05-01), pages 78 - 83, XP002520683, ISSN: 1045-2257 *
LECLERCQ TAMARA M ET AL: "Eukaryotic elongation factor 1A interacts with sphingosine kinase and directly enhances its catalytic activity", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 283, no. 15, April 2008 (2008-04-01), pages 9606 - 9614, XP002510631, ISSN: 0021-9258 *
MACEYKA M ET AL: "Aminoacylase 1 is a sphingosine kinase 1-interacting protein", FEBS LETTERS, ELSEVIER, AMSTERDAM, NL, vol. 568, no. 1-3, 18 June 2004 (2004-06-18), pages 30 - 34, XP004516402, ISSN: 0014-5793 *
See also references of WO2006135969A1 *

Also Published As

Publication number Publication date
EP1910525A1 (fr) 2008-04-16
JP2008546393A (ja) 2008-12-25
WO2006135969A1 (fr) 2006-12-28
CA2612773A1 (fr) 2006-12-28

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Inventor name: VADAS, MATTHEW, ALEXANDER

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