EP1905845A3 - Method for detecting multiple myeloma and method for inhibiting the same - Google Patents

Method for detecting multiple myeloma and method for inhibiting the same Download PDF

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Publication number
EP1905845A3
EP1905845A3 EP20070018522 EP07018522A EP1905845A3 EP 1905845 A3 EP1905845 A3 EP 1905845A3 EP 20070018522 EP20070018522 EP 20070018522 EP 07018522 A EP07018522 A EP 07018522A EP 1905845 A3 EP1905845 A3 EP 1905845A3
Authority
EP
European Patent Office
Prior art keywords
multiple myeloma
inhibiting
same
detecting multiple
cancer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP20070018522
Other languages
German (de)
French (fr)
Other versions
EP1905845A2 (en
Inventor
Chen Zhao
Jun Inoue
Issei Imoto
Johji Inazawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujifilm Corp
Tokyo Medical and Dental University NUC
Original Assignee
Fujifilm Corp
Tokyo Medical and Dental University NUC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujifilm Corp, Tokyo Medical and Dental University NUC filed Critical Fujifilm Corp
Publication of EP1905845A2 publication Critical patent/EP1905845A2/en
Publication of EP1905845A3 publication Critical patent/EP1905845A3/en
Withdrawn legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Engineering & Computer Science (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

It is an object of the present invention to identify a gene that relates to exhibition of behavior peculiar to cancer such as multiple myeloma to provide a method for detecting cancer and a cell-growth inhibitor. The present invention provides a method for detecting cancer which comprises detecting and/or typing tumorigenesis of a specimen by employing gene amplification in the chromosome 11 q23 region of the specimen as an indicator.
EP20070018522 2006-09-21 2007-09-20 Method for detecting multiple myeloma and method for inhibiting the same Withdrawn EP1905845A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2006255155A JP2008072939A (en) 2006-09-21 2006-09-21 Method for detecting and controlling multiple myeloma

Publications (2)

Publication Number Publication Date
EP1905845A2 EP1905845A2 (en) 2008-04-02
EP1905845A3 true EP1905845A3 (en) 2008-09-17

Family

ID=38924734

Family Applications (1)

Application Number Title Priority Date Filing Date
EP20070018522 Withdrawn EP1905845A3 (en) 2006-09-21 2007-09-20 Method for detecting multiple myeloma and method for inhibiting the same

Country Status (4)

Country Link
US (1) US20080182250A1 (en)
EP (1) EP1905845A3 (en)
JP (1) JP2008072939A (en)
CN (1) CN101392285A (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5331404B2 (en) * 2008-08-01 2013-10-30 国立大学法人 東京医科歯科大学 Method for detecting chromosomal deletions in congenital anomalies
WO2013111897A1 (en) * 2012-01-27 2013-08-01 国立大学法人大阪大学 Novel antitumor agent and method for screening same
US20190391152A1 (en) * 2016-05-16 2019-12-26 Checkmab S.R.L. Markers selectively deregulated in tumor-infiltrating regulatory t cells
CN108179181B (en) * 2017-12-29 2020-12-15 北京泱深生物信息技术有限公司 Application of RDX gene in clinical medication
CN112236159B (en) * 2018-05-03 2024-06-11 犹他大学研究基金会 OCA-B peptide conjugates and methods of treatment
CN110197701B (en) * 2019-04-22 2021-08-10 福建医科大学附属第一医院 Novel multiple myeloma nomogram construction method

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995032284A1 (en) * 1994-05-24 1995-11-30 Ciba-Geigy Ag Factor interacting with nuclear proteins
WO2005005980A2 (en) * 2003-07-14 2005-01-20 Imed Ab Methods for tumor evaluation, identification of anti-tumor agents and treatment
WO2006028867A2 (en) * 2004-09-01 2006-03-16 The Board Of Trustees Of The University Of Arkansas Diagnosis, prognosis and identification of potential therapeutic targets of multiple myeloma based on gene expression profiling

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995032284A1 (en) * 1994-05-24 1995-11-30 Ciba-Geigy Ag Factor interacting with nuclear proteins
WO2005005980A2 (en) * 2003-07-14 2005-01-20 Imed Ab Methods for tumor evaluation, identification of anti-tumor agents and treatment
WO2006028867A2 (en) * 2004-09-01 2006-03-16 The Board Of Trustees Of The University Of Arkansas Diagnosis, prognosis and identification of potential therapeutic targets of multiple myeloma based on gene expression profiling

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
BECK R C ET AL: "Evaluation of immunoglobulin (Ig) mRNA and the nuclear factors Oct2 and BOB.1 in nonsecretory multiple myeloma (NSMM).", MODERN PATHOLOGY, vol. 16, no. 1, January 2003 (2003-01-01), & 92ND ANNUAL MEETING OF THE UNITED STATES AND CANADIAN ACADEMY OF PATHOLOGY; WASHINGTON, D.C., USA; MARCH 22-28, 2003, pages 226A, XP008094779, ISSN: 0893-3952 *
CREMER ET AL: "High incidence and intraclonal heterogeneity of chromosome 11 aberrations in patients with newly diagnosed multiple myeloma detected by multiprobe interphase FISH", CANCER GENETICS AND CYTOGENETICS, ELSEVIER SCIENCE PUBLISHING, NEW YORK, NY, US, vol. 161, no. 2, September 2005 (2005-09-01), pages 116 - 124, XP005027551, ISSN: 0165-4608 *
CREMER F ET AL.: "Delineation of distinct subgroups of multiple myeloma and a model for clonal evolution based on interphase cytogenetics", GENES CHROMOSOMES & CANCER, vol. 44, no. 2, October 2005 (2005-10-01), pages 194 - 203, XP002472759 *
DATABASE EMBL [online] 24 February 2003 (2003-02-24), "Homo sapiens radixin, mRNA (cDNA clone MGC:48283 IMAGE:5284438), complete cds.", XP002472762, retrieved from EBI accession no. EMBL:BC047109 Database accession no. BC047109 *
GREINER A ET AL: "Up-regulation of BOB.1/OBF.1 expression in normal germinal center B cells and germinal center-derived lymphomas", AMERICAN JOURNAL OF PATHOLOGY, PHILADELPHIA, PA, US, vol. 156, no. 2, 1 February 2000 (2000-02-01), pages 501 - 507, XP002301442, ISSN: 0002-9440 *
HANAMURA ICHIRO ET AL: "Identification of three novel chromosomal translocation partners involving the immunoglobulin loci in newly diagnosed myeloma and human myeloma cell", BLOOD, vol. 106, no. 11, Part 1, November 2005 (2005-11-01), & 47TH ANNUAL MEETING OF THE AMERICAN-SOCIETY-OF-HEMATOLOGY; ATLANTA, GA, USA; DECEMBER 10 -13, 2005, pages 445A, XP008094783, ISSN: 0006-4971 *
HECKMAN C A ET AL: "Oct transcription factors mediate t(14;18) lymphoma cell survival by directly regulating bcl-2 expression", ONCOGENE, vol. 25, no. 6, February 2006 (2006-02-01), pages 888 - 898, XP002489872, ISSN: 0950-9232 *
TOKUNOU M ET AL.: "Altered expression of the ERM proteins in lung adenocarcinoma", LABORATORY INVESTIGATION, vol. 80, no. 11, November 2000 (2000-11-01), pages 1643 - 1650, XP002472760 *
VAISKUNAITE R. ET AL: "Conformational activation of radixin by G13 protein alpha subunit", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 275, no. 34, 25 August 2000 (2000-08-25), pages 26206 - 26212, XP002472761 *

Also Published As

Publication number Publication date
US20080182250A1 (en) 2008-07-31
JP2008072939A (en) 2008-04-03
EP1905845A2 (en) 2008-04-02
CN101392285A (en) 2009-03-25

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